DMXB, an α7 nicotinic agonist, normalizes auditory gating in isolation-reared rats

Psychopharmacology

Volumn 169, Issue 3-4, 2003, Pages 332-339

  O'Neill, Heidi C ^b   Rieger, Kate ^b   Kem, William R ^c   Stevens, Karen E ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Auditory gating; DMXB (aka GTS 21); Schizophrenia; Sensory gating

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; ALPHA 7 NICOTINIC AGONIST; NICOTINIC AGENT; UNCLASSIFIED DRUG; 3-(2,4-DIMETHOXYBENZYLIDENE)ANABASEINE; BENZYLIDENE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; AUDITORY SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ELECTRODE; HEARING DISORDER; IMPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RECORDING; SCHIZOPHRENIA; SOCIAL ISOLATION; WAKEFULNESS; WEANING; ANIMAL; BRAIN; DISEASE MODEL; DOSE RESPONSE; ELECTROENCEPHALOGRAPHY; EVOKED AUDITORY RESPONSE; PERCEPTION DEAFNESS; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; AUDITORY DISEASES, CENTRAL; BENZYLIDENE COMPOUNDS; BRAIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; MALE; NICOTINIC AGONISTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA; SOCIAL ISOLATION; TIME FACTORS;

EID: 0141993546     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1482-2     Document Type: Article

References (59)

1. 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus. Brain Res 877:235-244
2. Adler LE, Pachtman E, Franks R, Pecevich M, Waldo M, Freedman R (1982) Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry 17:639-654
3. Adler LE, Rose G, Freedman R (1986) Neurophysiological studies of sensory gating in rats: effects of amphetamine, phencyclidine and haloperidol. Biol Psychiatry 21:787-798
4. Adler LE, Pang K, Gerhardt G, Rose GM (1988) Modulation of gating of auditory evoked potentials by norepinephrine: Pharmacological evidence obtained using selective neurotoxin. Biol Psychiatry 24:179-190
5. Adler LE, Hoffer LJ, Griffith J, Waldo MC, Freedman R (1992) Normalization of deficient auditory sensory gating in relatives of schizophrenics by nicotine. Biol Psychiatry 32:607-616
6. Adler LE, Hoffer LJ, Wiser A, Freedman R (1993) Transient normalization of a defect in auditory sensory processing in schizophrenics following cigarette smoking. Am J Psychiatry 150:1856-1861
7. Arendash GW, Senstock GJ, Sanberg PR, Kem WR (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res 674:252-259
8. Baker N, Adler LE, Franks RD, Waldo M, Berry S, Nagamoto H, Muckle A, Freedman R (1987) Neurophysiological assessment of gating of sensory input: comparison between schizophrenia and other diagnoses. Biol Psychiatry 22:603-617
9. Bickford PC, Wear KD (1995) Restoration of sensory gating of auditory evoked response by nicotine in fimbria-fornix lesioned rats. Brain Res 705:235-240
10. Bickford-Wimer PC, Nagamoto H, Johnson R, Adler LE, Egan M, Rose GM, Freedman R (1990) Auditory sensory gating in hippocampal neurons: a model system in the rat. Biol Psychiatry 27:183-192
11. Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia. Arch Gen Psychiatry 47:181-188
12. Coates RM, Kem WR, Abbott BC (1971) Isolation and structure of a hoplonemertine toxin. Toxicon 9:15-22
13. 7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-bungarotoxin. Neuron 5:847-856
14. 125I-α-bungarotoxin receptor subtypes. Mol Pharmacol 47:164-171
15. Erhardt S, Schwieler L, Engberg G (2002) Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse 43:227-237
16. Freedman R, Adler LE, Bickford PC, Waldo MC, Pachtman E, Franks RD (1983) Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug free patients. Biol Psychiatry 18:537-551
17. Fu Y, Matta SG, Sharp BM (1999) Local alpha-bungarotoxin-sensitive nicotinic receptors modulate hippocampal norepinephrine release by systemic nicotine. J Pharmacol Exp Ther 289:133-139
18. Gentsch C, Lichtsteiner M, Feer H (1981) Individual housing of rats causes divergent changes in spontaneous and reactive activity. Experientia 37:61-62
19. Gentsch C, Lichtsteiner M, Kraeuchi K, Feer H (1982) Different reaction patterns in individually and socially-reared rats during exposures to novel environments. Behav Brain Res 4:45-54
20. Geyer MA, Wilkinson LS, Humby T, Robbins TW (1993) Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry 34:361-372
21. Gilad GM, Mahon BD, Finkelstein Y, Koffler B, Gilad VH (1985) Stress-induced activation of the hippocampal cholinergic system and the pituitary-adrenocortical axis. Brain Res 347:404-408
22. 3H]dopamine release from synaptosomes prepared from mouse striatum. J Neurochem 59:848-856
23. 3H]dopamine release from mouse striatal synaptosomes. J Neurochem 62:1390-1398
24. Griffith JM, Freedman R (1995) Normalization of the auditory P50 gating deficit of schizophrenic patients after non-REM but not REM sleep. Psychiatry Res 56:271-278
25. Jones GH, Marsden CA, Robbins TW (1990) Increased sensitivity to amphetamine and reward related stimuli following isolation-rearing in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens. Psychopharmacology 102:364-372
26. Jones GH, Marsden CA, Robbins TW (1991) Behavioral rigidity and rule-learning following social isolation in rats: Neurochemical correlates. Behav Brain Res 43:35-50
27. Jones GH, Hernandez TD, Kendall DA, Marsden CA, Robbins TW (1992) Dopaminergic and serotonergic function following isolation rearing in rats: a study of behavioral responses and postmortem and in vivo neurochemistry. Pharmacol Biochem Behav 43:17-35
28. Kem WR (1971) A study of the occurrence of anabaseine in Paranemertes and other nemertines. Toxicon 9: 23-32
29. Kem WR (1997) Alzheimer's drug design based upon an invertebrate toxin (anabaseine), which is a potent nicotinic receptor agonist. Invert Neurosci 3:251-259
30. Kem WR, Mahnir VM, Papke RL, Lingle CJ (1997) Anabaseine is a potent agonist on muscle and neuronal α-bungarotoxin-sensitive nicotinic receptors. J Pharmacol Exp Ther 283:979-992
31. Luntz-Leybman V, Bickford PC, Freedman R (1992) Cholinergic gating of response to auditory stimuli in rat hippocampus. Brain Res 587:130-136
32. Mahnir V, Lin B, Prokai-Tatrai K, Kem WR (1998) Pharmacokinetics and urinary excretion of DMXBA (GTS-21), a compound enhancing cognition. Biopharm Drug Dispos 19:147-151
33. Meyer WM, de Fiebre CM, Hunter BE, Simpkins CE, Frauworth N, de Fiebre NE (1994) Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev Res 31:127-134
34. Morgan MJ, Einon D, Morris RGM (1977) Inhibition and isolation rearing in the rat: extinction and satiation. Physiol Behav 18:1-5
35. Nanri M, Kasahara N, Yamamoto J, Miyake H, Watanabe H (1998) A comparative study on the effects of nicotine and GTS-21, a new nicotinic agonist, on the locomotor activity and brain monoamine level. Jpn J Pharmacol 78:385-389
36. Papke RL, de Fiebre CM, Kem WR, Meyer EM (1994) The subunit specific effects of novel anabaseine-derived nicotinic agents. In: Giacobini E, Becker R (eds) Alzheimer disease: therapeutic strategies. Birkhauser, Boston, pp 206-211
37. Pauly JR, Collins AC (1993) An autoradiographic analysis of alterations in nicotinic cholinergic receptors following 1 week of corticosterone supplementation. Neuroendocrinolology 57:262-274
38. Pauly JR, Ullman EA, Collins AC (1988) Adrenocortical hormone regulation of nicotine sensitivity in mice. Physiol Behav 44:109-116
39. Pauly JR, Grun EU, Collins AC (1990) Chronic corticosterone administration modulates nicotine sensitivity and brain nicotinic receptor binding in C3H mice. Psychopharmacology 101:310-316
40. 7 antisense oligonucleotides. Soc Neurosci Abstr 19:837
41. Sahakian BJ, Robbins TW (1977) Isolation rearing enhances tail-pinch induced oral behavior in the rat. Physiol Behav 18:53-58
42. 7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biol Psychiatry 50:493-500
43. Smith JK, Neill JC, Costall B (1997) Post-weaning housing conditions influence the behavioural effects of cocaine and d-amphetamine. Psychopharmacology 131:23-33
44. Stevens KE, Bullock AE, Collins AC (2001) Chronic corticosterone treatment alters sensory gating in C3H mice. Pharmacol Biochem Behav 69:359-366
45. Stevens KE, Freedman R, Collins AC, Hall M, Leonard S, Marks M J, Rose GM (1996) Genetic correlation of hippocampal auditory evoked response and α-bungarotoxin binding in inbred mouse strains. Neuropsychopharmacology 15:152-162
46. Stevens KE, Fuller LL, Rose GM (1991) Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating potentials. Brain Res 555:91-98
47. 2 selective noradrenergic antagonist yohimbine. Biol Psychiatry 33:130-132
48. Stevens KE, Meltzer J, Rose GM (1995) Nicotinic cholinergic normalization of amphetamine-induced loss of auditory gating in freely moving rats. Psychopharmacology 119:163-170
49. Stevens KE, Johnson RG, Rose GM (1997) Rats reared in social isolation show schizophrenia-like changes in auditory gating. Pharmacol Biochem Behav 58:1031-1036
50. 7 nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136:320-327
51. Stevens KE, Wear KD (1997) Normalizing effects of nicotine and a novel nicotinic agonist on hippocampal auditory gating in two animal models. Pharmacol Biochem Behav 57:869-874
52. van Haaren F, Anderson KG, Haworth SC, Kem WR (1999) GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue. Pharmacol Biochem Behav 64:439-444
53. Venables P (1964) Input dysfunction in schizophrenia. In: Maher B (ed) Progress in experimental personality research. Academic Press, Orlando, pp 1-47
54. Venables P (1992) Hippocampal function and schizophrenia: experimental psychological evidence. Ann NY Acad Sci 658:111-127
55. Wheeler JW, Olubajo O, Storm CB, Duffield RM (1981) Anabaseine: venom alkaloid of Aphaenogaster ants. Science 211:1051-1052
56. Wilkinson LS, Killcross SS, Humby T, Hall FS, Geyer MA, Robbins TW (1994) Isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting, latent inhibition. Neuropsychopharmacology 10:61-72
57. Wilson CL, Babb TL, Halgren E, Wang ML, Crandall PH (1984) Habituation of human limbic neuronal response to sensory stimulation. Exp Neurol 84:74-79
58. Woodruff-Pak DS, Yong-Tong L, Kem WR (1994) A nicotinic agonist (GTS-21), eyeblink classical conditioning and nicotinic receptor binding in rabbit brain. Brain Res 645:309-317
59. Zhou FM, Liang Y, Dani JA (2001) Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nature Neurosci 4:1224-1229