Nicotine cue: Lack of effect of the α7 nicotinic receptor antagonist methyllycaconitine

European Journal of Pharmacology

Volumn 301, Issue 1-3, 1996, Pages 1-5

  Brioni, Jorge D ^a   Kim, David J B ^a   O'Neill, Alyssa B ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Drug discrimination; Mecamylamine; Methyllycaconitine; Nicotine

Indexed keywords

MECAMYLAMINE; METHYLACONITINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG ANTAGONISM; DRUG DISCRIMINATION; INSTRUMENTAL CONDITIONING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029891213     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00010-6     Document Type: Article

References (16)

1. Alkondon, M., E. Pereira, S. Wonnacott and E. Albuquerque, 1992, Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist, Mol. Pharmacol. 41, 802.
2. Brioni, J.D., D.J.B. Kim, A.B. O'Neill, J.E.G. Williams and M.W. Decker, 1994, Clozapine attenuates the discriminative stimulus properties of (-)-nicotine, Brain Res. 643, 1.
3. Brioni, J., M. Decker, J. Sullivan and S. Arneric, 1995a, Preclinical pharmacology of the novel cholinergic channel activator ABT-418, Nicotine Symposium, Fourth International Behavioral Neuroscience Conference, Santiago, Spain.
4. Brioni, J.D., D.B.J. Kim, M.S. Brodie, M.W. Decker and S.P. Arneric, 1995b, ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity, Psychopharmacology 107, 368.
5. Brioni, J., M. Decker, J. Sullivan and S. Arneric, 1996, The pharmacology of (-)-nicotine and novel cholinergic channel activators. Adv. Pharmacol. (in press).
6. Clarke, P.B.S., 1992, The fall and rise of neuronal α-bungarotoxin binding proteins, Trends Pharmacol. Sci. 13, 407.
7. Courturier, S., D. Bertrand, J.M. Matter, M.-C. Herandez, S. Bertrand, N. Miller, S. Valera, T. Barkas and M. Ballivet, 1990, A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric ion channel blocked by α-BTX, Neuron 5, 847.
8. Decker, M., J. Brioni, A. Bannon and S. Arneric, 1995, Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics. Life Sci. 56, 545.
9. Elgoyhen, A., D. Johnson, J. Boulter, D. Vetter and S. Heinemann, 1994, α9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79, 705.
10. Flores, C.M., S.W. Rogers, L.A. Pabreza, B.B. Wolfe and K.J. Kellar, 1992, A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment, Mol. Pharmacol. 41, 31.
11. Macallan, D., G. Lunt, S. Wonnacott, K. Swanson, H. Rapoport and E. Albuquerque, 1988, Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous system, FEBS Lett. 226, 357.
12. Rosecrans, J.A. and W.T. Chance, 1977, Cholinergic and non-cholinergic aspects of the discriminative stimulus properties of nicotine, in: Discriminative Stimulus Properties of Drugs, ed. H. Lal (Plenum Press, New York) p. 155.
13. Sargent, P.B., 1993, The diversity of neuronal nicotinic acetylcholine receptors, Annu. Rev. Neurosci. 16, 403.
14. Spencer, D.G. and M.W. Emmett-Oglesby, 1985, Parallel processing strategies in the application of microcomputers to the behavioral laboratory, Behav. Res. Meth. Instrument. 17, 294.
15. Stolerman, I., 1990, Behavioural pharmacology of nicotine in animals, in: Nicotine Psychopharmacology, eds. S. Wonnacot, M. Russell and I. Stolerman (Oxford University Press, Oxford) p. 279.
16. Ward, J., V. Cockcroft, G. Lunt, F. Smillie and S. Wonnacott, 1990, Methyllycaconitine: a selective probe for neuronal α-bungarotoxin binding sites, FEBS Lett. 270, 45.