PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 37, 2010, Pages 16066-16071

  Pluciennik, Anna ^a   Dzantiev, Leonid ^a,b   Iyer, Ravi R ^a   Constantin, Nicoleta ^a   Kadyrov, Farid A ^a,c   Modrich, Paul ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Meso Scale Discovery   (United States)

^c SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Genetic instability; MutLalpha; Triplet repeats

Indexed keywords

ADENOSINE TRIPHOSPHATE; CIRCULAR DNA; CYCLINE; ENDONUCLEASE; HETERODUPLEX; MUTL ALPHA ENDONUCLEASE; NUCLEASE; REPLICATION FACTOR C; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DNA STRAND BREAKAGE; ENZYME MECHANISM; MISMATCH REPAIR; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRINUCLEOTIDE REPEAT; ENZYME ACTIVATION; METABOLISM;

DNA MISMATCH REPAIR; ENDONUCLEASES; ENZYME ACTIVATION; PROLIFERATING CELL NUCLEAR ANTIGEN; REPLICATION PROTEIN C;

EID: 77957979862     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010662107     Document Type: Article

References (33)

1. Iyer RR, Pluciennik A, Burdett V, Modrich PL (2006) DNA mismatch repair: functions and mechanisms. Chem Rev 106:302-323. (Pubitemid 43316559)
2. Modrich P (2006) Mechanisms in eukaryotic mismatch repair. J Biol Chem 281:30305-30309.
3. Jiricny J (2006) The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 7:335-346.
4. Hsieh P, Yamane K (2008) DNA mismatch repair: Molecular mechanism, cancer, and ageing. Mech Ageing Dev 129:391-407.
5. Dzantiev L, et al. (2004) A defined human system that supports bidirectional mismatch-provoked excision. Mol Cell 15:31-41.
6. Constantin N, Dzantiev L, Kadyrov FA, Modrich P (2005) Human mismatch repair: Reconstitution of a nick-directed bidirectional reaction. J Biol Chem 280:39752-39761.
7. Kadyrov FA, Dzantiev L, Constantin N, Modrich P (2006) Endonucleolytic function of MutLalpha in human mismatch repair. Cell 126:297-308. (Pubitemid 44092957)
8. Kadyrov FA, et al. (2007) Saccharomyces cerevisiae MutLα is a mismatch repair endonuclease. J Biol Chem 282:37181-37190.
9. Iyer RR, et al. (2010) MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. J Biol Chem 285:11730-11739.
10. Genschel J, Modrich P (2003) Mechanism of 5′-directed excision in human mismatch repair. Mol Cell 12:1077-1086.
11. Genschel J, Bazemore LR, Modrich P (2002) Human exonuclease I is required for 5′ and 3′ mismatch repair. J Biol Chem 277:13302-13311.
12. Wei K, et al. (2003) Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev 17:603-614. (Pubitemid 36307545)
13. Kadyrov FA, et al. (2009) A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. Proc Natl Acad Sci USA 106:8495-8500.
14. Umar A, et al. (1996) Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell 87:65-73.
15. Lee SD, Alani E (2006) Analysis of interactions between mismatch repair initiation factors and the replication processivity factor PCNA. J Mol Biol 355:175-184.
16. Gomes XV, Gary SL, Burgers PM (2000) Overproduction in Escherichia coli and characterization of yeast replication factor C lacking the ligase homology domain. J Biol Chem 275:14541-14549.
17. Podust VN, Chang LS, Ott R, Dianov GL, Fanning E (2002) Reconstitution of human DNA polymerase δ using recombinant baculoviruses: The p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme. J Biol Chem 277:3894-3901.
18. Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J (1996) Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87:297-306. (Pubitemid 26359007)
19. Iyer RR, et al. (2008) The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. J Biol Chem 283:13310-13319.
20. Podust LM, Podust VN, Sogo JM, Hubscher U (1995) Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA. Mol Cell Biol 15:3072-3081.
21. Cai J, et al. (1996) Reconstitution of human replication factor C from its five subunits in baculovirus-infected insect cells. Proc Natl Acad Sci USA 93:12896-12901.
22. Yao N, Leu FP, Anjelkovic J, Turner J, O'Donnell M (2000) DNA structure requirements for the Escherichia coligamma complex clamp loader and DNA polymerase III holoenzyme. J Biol Chem 275:11440-11450.
23. Kelman Z, Naktinis V, O'Donnell M (1995) Radiolabeling of proteins for biochemical studies. Method Enzymol 262:430-442.
24. Yao N, Hurwitz J, O'Donnell M (2000) Dynamics of beta and proliferating cell nuclear antigen sliding clamps in traversing DNA secondary structure. J Biol Chem 275:1421-1432. (Pubitemid 30051202)
25. Kong XP, Onrust R, O'Donnell M, Kuriyan J (1992) Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp. Cell 69:425-437.
26. Bowman GD, O'Donnell M, Kuriyan J (2004) Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 429:724-730. (Pubitemid 38833117)
27. Georgescu RE, et al. (2008) Structure of a sliding clamp on DNA. Cell 132:43-54.
28. Yao N, et al. (1996) Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coliand T4 replicases. Genes Cells 1:101-113.
29. Blackwell LJ, Wang S, Modrich P (2001) DNA chain length dependence of formation and dynamics of hMutSa-hMutLa-heteroduplex complexes. J Biol Chem 276:33233-33240.
30. Brouwer JR, Willemsen R, Oostra BA (2009) Microsatellite repeat instability and neurological disease. Bioessays 31:71-83.
31. Lopez Castel A, Cleary JD, Pearson CE (2010) Repeat instability as the basis for human diseases and as a potential target for therapy. Nat Rev Mol Cell Biol 11:165-170.
32. Gomes-Pereira M, Fortune MT, Ingram L, McAbney JP, Monckton DG (2004) Pms2 is a genetic enhancer of trinucleotide CAG. CTG repeat somatic mosaicism: Implications for the mechanism of triplet repeat expansion. Hum Mol Genet 13:1815-1825.
33. Gonitel R, et al. (2008) DNA instability in postmitotic neurons. Proc Natl Acad Sci USA 105:3467-3472.