Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: High mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene

American Journal of Human Genetics

Volumn 72, Issue 5, 2003, Pages 1088-1100

  Wagner, Anja ^a,b   Barrows, Alicia ^c   Wijnen, Juul Th ^a   Van Der Klift, Heleen ^a   Franken, Patrick F ^a   Verkuijlen, Paul ^a   Nakagawa, Hidewaki ^d   Geugien, Marjan ^a   Jaghmohan Changur, Shantie ^a   Breukel, Cor ^a   Meijers Heijboer, Hanne ^b   Morreau, Hans ^a   Van Puijenbroek, Marjo ^a   Burn, John ^e   Coronel, Stephany ^c   Kinarski, Yulia ^c   Okimoto, Ross ^c   Watson, Patrice ^c   Lynch, Jane F ^c   De La Chapelle, Albert ^d   Lynch, Henry T ^c   Fodde, Riccardo ^a   more..

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME REARRANGEMENT; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; DIAGNOSTIC TEST; EXON; FAMILY; FOUNDER EFFECT; GENE; GENE DELETION; GENE MLH1; GENE MSH2; GENE MSH6; GENE MUTATION; GENEALOGY; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GERM LINE; GERM LINE MUTATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR MISMATCH REPAIR GENE; MISMATCH REPAIR; MOLECULAR ANALYSIS; MUTATION DETECTION; MUTATION RATE; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SOUTHERN BLOTTING; UNITED STATES;

EID: 0037730214     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/373963     Document Type: Article

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