메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 231-244

Successes and future outlook for microfluidics-based cardiovascular drug discovery

Author keywords

Cardiovascular; Drug discovery; Lab on a chip; Microfluidics

Indexed keywords

CARDIOVASCULAR AGENT;

EID: 84923364082     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2015.1001736     Document Type: Review
Times cited : (30)

References (82)
  • 1
    • 34249652891 scopus 로고    scopus 로고
    • Effects of fluid flow on voltagedependent calcium channels in rat vascular myocytes: Fluid flow as a shear stress and a source of artifacts during patch-clamp studies
    • Park SW, Byun D, Bae YM, et al. Effects of fluid flow on voltagedependent calcium channels in rat vascular myocytes: fluid flow as a shear stress and a source of artifacts during patch-clamp studies. Biochem Biophys Res Commun 2007;358(4):1021-7
    • (2007) Biochem Biophys Res Commun , vol.358 , Issue.4 , pp. 1021-1027
    • Park, S.W.1    Byun, D.2    Bae, Y.M.3
  • 2
    • 24744448516 scopus 로고    scopus 로고
    • Facilitation of L-type Ca2+ currents by fluid flow in rabbit cerebral artery myocytes
    • Amano S, Ishikawa T, Nakayama K. Facilitation of L-type Ca2+ currents by fluid flow in rabbit cerebral artery myocytes. J Pharmacol Sci 2005;98(4):425-9
    • (2005) J Pharmacol Sci , vol.98 , Issue.4 , pp. 425-429
    • Amano, S.1    Ishikawa, T.2    Nakayama, K.3
  • 3
    • 84913588095 scopus 로고    scopus 로고
    • Mechanoresponsive networks controlling vascular inflammation
    • Bryan MT, Duckles H, Feng S, et al. Mechanoresponsive networks controlling vascular inflammation. Arterioscler Thromb Vasc Biol 2014;34(10):2199-205
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , Issue.10 , pp. 2199-2205
    • Bryan, M.T.1    Duckles, H.2    Feng, S.3
  • 4
    • 84900992096 scopus 로고    scopus 로고
    • Shear stress regulated gene expression and angiogenesis in vascular endothelium
    • Wragg JW, Durant S, McGettrick HM, et al. Shear stress regulated gene expression and angiogenesis in vascular endothelium. Microcirculation 2014;21(4):290-300
    • (2014) Microcirculation , vol.21 , Issue.4 , pp. 290-300
    • Wragg, J.W.1    Durant, S.2    McGettrick, H.M.3
  • 5
    • 84903889718 scopus 로고    scopus 로고
    • Shear stress and atherosclerosis
    • Heo KS, Fujiwara K, Abe J. Shear stress and atherosclerosis. Mol Cells 2014;37(6):435-40
    • (2014) Mol Cells , vol.37 , Issue.6 , pp. 435-440
    • Heo, K.S.1    Fujiwara, K.2    Abe, J.3
  • 6
    • 84856223002 scopus 로고    scopus 로고
    • Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited
    • Wolberg AS, Aleman MM, Leiderman K, Machlus KR. Procoagulant activity in hemostasis and thrombosis: virchow's triad revisited. Anesth Analg 2012;114(2):275-85
    • (2012) Anesth Analg , vol.114 , Issue.2 , pp. 275-285
    • Wolberg, A.S.1    Aleman, M.M.2    Leiderman, K.3    Machlus, K.R.4
  • 7
    • 84938093513 scopus 로고    scopus 로고
    • Increased erythrocyte adhesion to VCAM-1 during pulsatile flow: Application of a microfluidic flow adhesion bioassay
    • In Press
    • White J, Lancelot M, Sarnaik S, Hines P. Increased erythrocyte adhesion to VCAM-1 during pulsatile flow: application of a microfluidic flow adhesion bioassay. Clin Hemorheol Microcirc 2014. In Press. doi: 10.3233/CH-141847
    • (2014) Clin Hemorheol Microcirc
    • White, J.1    Lancelot, M.2    Sarnaik, S.3    Hines, P.4
  • 8
    • 84905754409 scopus 로고    scopus 로고
    • Microfluidic organs-on-chips
    • Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotechnol 2014;32(8):760-72
    • (2014) Nat Biotechnol , vol.32 , Issue.8 , pp. 760-772
    • Bhatia, S.N.1    Ingber, D.E.2
  • 9
    • 33947625690 scopus 로고    scopus 로고
    • Vascular mimetics based on microfluidics for imaging the leukocyte - endothelial inflammatory response
    • Schaff UY, Xing MM, Lin KK, et al. Vascular mimetics based on microfluidics for imaging the leukocyte - endothelial inflammatory response. Lab Chip 2007;7(4):448-56
    • (2007) Lab Chip , vol.7 , Issue.4 , pp. 448-456
    • Schaff, U.Y.1    Xing, M.M.2    Lin, K.K.3
  • 10
    • 0027421845 scopus 로고
    • Fabrication of in vitro microvascular blood flow systems by photolithography
    • Cokelet GR, Soave R, Pugh G, Rathbun L. Fabrication of in vitro microvascular blood flow systems by photolithography. Microvasc Res 1993;46(3):394-400
    • (1993) Microvasc Res , vol.46 , Issue.3 , pp. 394-400
    • Cokelet, G.R.1    Soave, R.2    Pugh, G.3    Rathbun, L.4
  • 11
    • 70549088948 scopus 로고    scopus 로고
    • A physiologically realistic in vitro model of microvascular networks
    • Rosano JM, Tousi N, Scott RC, et al. A physiologically realistic in vitro model of microvascular networks. Biomed Microdevices 2009;11(5):1051-7
    • (2009) Biomed Microdevices , vol.11 , Issue.5 , pp. 1051-1057
    • Rosano, J.M.1    Tousi, N.2    Scott, R.C.3
  • 12
    • 84887536962 scopus 로고    scopus 로고
    • Advances in microfluidic cell culture systems for studying angiogenesis
    • Young EW. Advances in microfluidic cell culture systems for studying angiogenesis. J Lab Autom 2013;18(6):427-36
    • (2013) J Lab Autom , vol.18 , Issue.6 , pp. 427-436
    • Young, E.W.1
  • 14
    • 81055157068 scopus 로고    scopus 로고
    • Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature
    • Prabhakarpandian B, Shen MC, Pant K, Kiani MF. Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. Microvasc Res 2011;82(3):210-20
    • (2011) Microvasc Res , vol.82 , Issue.3 , pp. 210-220
    • Prabhakarpandian, B.1    Shen, M.C.2    Pant, K.3    Kiani, M.F.4
  • 15
    • 84863793836 scopus 로고    scopus 로고
    • Endothelialized microfluidics for studying microvascular interactions in hematologic diseases
    • Myers DR, Sakurai Y, Tran R, et al. Endothelialized microfluidics for studying microvascular interactions in hematologic diseases. J Vis Exp 2012;64
    • (2012) J Vis Exp , pp. 64
    • Myers, D.R.1    Sakurai, Y.2    Tran, R.3
  • 16
    • 84881062682 scopus 로고    scopus 로고
    • Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system
    • Yu JQ, Liu XF, Chin LK, et al. Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system. Lab Chip 2013;13(14):2693-700
    • (2013) Lab Chip , vol.13 , Issue.14 , pp. 2693-2700
    • Yu, J.Q.1    Liu, X.F.2    Chin, L.K.3
  • 17
    • 84906256618 scopus 로고    scopus 로고
    • Bioinspired microfluidic assay for in vitro modeling of leukocyteendothelium interactions
    • Lamberti G, Prabhakarpandian B, Garson C, et al. Bioinspired microfluidic assay for in vitro modeling of leukocyteendothelium interactions. Anal Chem 2014;86(16):8344-51
    • (2014) Anal Chem , vol.86 , Issue.16 , pp. 8344-8351
    • Lamberti, G.1    Prabhakarpandian, B.2    Garson, C.3
  • 18
    • 84862197029 scopus 로고    scopus 로고
    • In vitro microvessels for the study of angiogenesis and thrombosis
    • Zheng Y, Chen J, Craven M, et al. In vitro microvessels for the study of angiogenesis and thrombosis. Proc Natl Acad Sci USA 2012;109(24):9342-7
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.24 , pp. 9342-9347
    • Zheng, Y.1    Chen, J.2    Craven, M.3
  • 19
    • 84055222446 scopus 로고    scopus 로고
    • Endothelial cell culture model of carotid artery atherosclerosis
    • Estrada R, Giridharan G, Prabhu SD, Sethu P. Endothelial cell culture model of carotid artery atherosclerosis. IEEE Eng Med Bio 2011;2011:186-9
    • (2011) IEEE Eng Med Bio , vol.2011 , pp. 186-189
    • Estrada, R.1    Giridharan, G.2    Prabhu, S.D.3    Sethu, P.4
  • 20
    • 33745686447 scopus 로고    scopus 로고
    • Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes
    • Kane BJ, Zinner MJ, Yarmush ML, Toner M. Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal Chem 2006;78(13):4291-8
    • (2006) Anal Chem , vol.78 , Issue.13 , pp. 4291-4298
    • Kane, B.J.1    Zinner, M.J.2    Yarmush, M.L.3    Toner, M.4
  • 21
    • 77954038080 scopus 로고    scopus 로고
    • Reconstituting organ-level lung functions on a chip
    • Huh D, Matthews BD, Mammoto A, et al. Reconstituting organ-level lung functions on a chip. Science 2010;328(5986):1662-8
    • (2010) Science , vol.328 , Issue.5986 , pp. 1662-1668
    • Huh, D.1    Matthews, B.D.2    Mammoto, A.3
  • 22
    • 84876719079 scopus 로고    scopus 로고
    • Engineering a 3D vascular network in hydrogel for mimicking a nephron
    • Mu X, Zheng W, Xiao L, et al. Engineering a 3D vascular network in hydrogel for mimicking a nephron. Lab Chip 2013;13(8):1612-18
    • (2013) Lab Chip , vol.13 , Issue.8 , pp. 1612-1618
    • Mu, X.1    Zheng, W.2    Xiao, L.3
  • 23
    • 72649085963 scopus 로고    scopus 로고
    • Study of the crosstalk between hepatocytes and endothelial cells using a novel multicompartmental bioreactor: A comparison between connected cultures and cocultures
    • Guzzardi MA, Vozzi F, Ahluwalia AD. Study of the crosstalk between hepatocytes and endothelial cells using a novel multicompartmental bioreactor: a comparison between connected cultures and cocultures. Tissue Eng Part A 2009;15(11):3635-44
    • (2009) Tissue Eng Part A , vol.15 , Issue.11 , pp. 3635-3644
    • Guzzardi, M.A.1    Vozzi, F.2    Ahluwalia, A.D.3
  • 24
    • 84874894377 scopus 로고    scopus 로고
    • Microfabricated mammalian organ systems and their integration into models of whole animals and humans
    • Sung JH, Esch MB, Prot JM, et al. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 2013;13(7):1201-12
    • (2013) Lab Chip , vol.13 , Issue.7 , pp. 1201-1212
    • Sung, J.H.1    Esch, M.B.2    Prot, J.M.3
  • 25
    • 72049119863 scopus 로고    scopus 로고
    • Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
    • Zhang C, Zhao Z, Abdul Rahim NA, et al. Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab Chip 2009;9(22):3185-92
    • (2009) Lab Chip , vol.9 , Issue.22 , pp. 3185-3192
    • Zhang, C.1    Zhao, Z.2    Abdul Rahim, N.A.3
  • 26
    • 84882253484 scopus 로고    scopus 로고
    • Integrating biological vasculature into a multi-organ-chip microsystem
    • Schimek K, Busek M, Brincker S, et al. Integrating biological vasculature into a multi-organ-chip microsystem. Lab Chip 2013;13(18):3588-98
    • (2013) Lab Chip , vol.13 , Issue.18 , pp. 3588-3598
    • Schimek, K.1    Busek, M.2    Brincker, S.3
  • 27
    • 84879980292 scopus 로고    scopus 로고
    • In vitro perfused human capillary networks
    • Moya ML, Hsu YH, Lee AP, et al. In vitro perfused human capillary networks. Tissue Eng Part C-Methods 2013;19(9):730-7
    • (2013) Tissue Eng Part C-Methods , vol.19 , Issue.9 , pp. 730-737
    • Moya, M.L.1    Hsu, Y.H.2    Lee, A.P.3
  • 28
    • 84907303250 scopus 로고    scopus 로고
    • Microfluidic device to culture 3D in vitro human capillary networks
    • Moya ML, Alonzo LF, George SC. Microfluidic device to culture 3D in vitro human capillary networks. Methods Mol Biol 2014;1202:21-7
    • (2014) Methods Mol Biol , vol.1202 , pp. 21-27
    • Moya, M.L.1    Alonzo, L.F.2    George, S.C.3
  • 29
    • 84899850161 scopus 로고    scopus 로고
    • Shear forces enhance Toxoplasma gondii tachyzoite motility on vascular endothelium
    • Harker KS, Jivan E, McWhorter FY, et al. Shear forces enhance Toxoplasma gondii tachyzoite motility on vascular endothelium. mBio 2014;5(2):e01111-13
    • (2014) mBio , vol.5 , Issue.2 , pp. e01111-e01113
    • Harker, K.S.1    Jivan, E.2    McWhorter, F.Y.3
  • 30
    • 84870724071 scopus 로고    scopus 로고
    • Accelerated endothelial wound healing on microstructured substrates under flow
    • Franco D, Milde F, Klingauf M, et al. Accelerated endothelial wound healing on microstructured substrates under flow. Biomaterials 2013;34(5):1488-97
    • (2013) Biomaterials , vol.34 , Issue.5 , pp. 1488-1497
    • Franco, D.1    Milde, F.2    Klingauf, M.3
  • 31
    • 84879536016 scopus 로고    scopus 로고
    • Using shape effects to target antibodycoated nanoparticles to lung and brain endothelium
    • Kolhar P, Anselmo AC, Gupta V, et al. Using shape effects to target antibodycoated nanoparticles to lung and brain endothelium. Proc Natl Acad Sci USA 2013;110(26):10753-8
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.26 , pp. 10753-10758
    • Kolhar, P.1    Anselmo, A.C.2    Gupta, V.3
  • 32
    • 84890819967 scopus 로고    scopus 로고
    • Microfluidic evaluation of red cells collected and stored in modified processing solutions used in blood banking
    • Wang Y, Giebink A, Spence DM. Microfluidic evaluation of red cells collected and stored in modified processing solutions used in blood banking. Integr Biol (Camb) 2014;6(1):65-75
    • (2014) Integr Biol (Camb) , vol.6 , Issue.1 , pp. 65-75
    • Wang, Y.1    Giebink, A.2    Spence, D.M.3
  • 33
    • 84896758506 scopus 로고    scopus 로고
    • Endothelium-derived nitric oxide production is increased by ATP released from red blood cells incubated with hydroxyurea
    • Lockwood SY, Erkal JL, Spence DM. Endothelium-derived nitric oxide production is increased by ATP released from red blood cells incubated with hydroxyurea. Nitric Oxide 2014;38:1-7 • This paper showcases the use of microfluidics for assessment of paracrine signaling within the vasculature.
    • (2014) Nitric Oxide , vol.38 , pp. 1-7
    • Lockwood, S.Y.1    Erkal, J.L.2    Spence, D.M.3
  • 34
    • 84883264594 scopus 로고    scopus 로고
    • The use of microfluidics in hemostasis: Clinical diagnostics and biomimetic models of vascular injury
    • Neeves KB, Onasoga AA, Wufsus AR. The use of microfluidics in hemostasis: clinical diagnostics and biomimetic models of vascular injury. Curr Opin Hematol 2013;20(5):417-23
    • (2013) Curr Opin Hematol , vol.20 , Issue.5 , pp. 417-423
    • Neeves, K.B.1    Onasoga, A.A.2    Wufsus, A.R.3
  • 35
    • 84904093484 scopus 로고    scopus 로고
    • Lab-on-CD microfluidic platform for rapid separation and mixing of plasma from whole blood
    • Kuo JN, Li BS. Lab-on-CD microfluidic platform for rapid separation and mixing of plasma from whole blood. Biomed Microdevices 2014;16(4):549-58
    • (2014) Biomed Microdevices , vol.16 , Issue.4 , pp. 549-558
    • Kuo, J.N.1    Li, B.S.2
  • 36
    • 84910064689 scopus 로고    scopus 로고
    • A sample-to-result system for blood coagulation tests on a microfluidic disk analyzer
    • Lin CH, Liu CY, Shih CH, Lu CH. A sample-to-result system for blood coagulation tests on a microfluidic disk analyzer. Biomicrofluidics 2014;8(5):052105
    • (2014) Biomicrofluidics , vol.8 , Issue.5 , pp. 052105
    • Lin, C.H.1    Liu, C.Y.2    Shih, C.H.3    Lu, C.H.4
  • 37
    • 84915750359 scopus 로고    scopus 로고
    • A cartridge based sensor array platform for multiple coagulation measurements from plasma
    • Cakmak O, Ermek E, Kilinc N, et al. A cartridge based sensor array platform for multiple coagulation measurements from plasma. Lab Chip 2014;15(1):113-20
    • (2014) Lab Chip , vol.15 , Issue.1 , pp. 113-120
    • Cakmak, O.1    Ermek, E.2    Kilinc, N.3
  • 38
    • 84910085671 scopus 로고    scopus 로고
    • Real-time measurement of thrombin generation using continuous droplet microfluidics
    • Yu J, Tao D, Ng EX, et al. Real-time measurement of thrombin generation using continuous droplet microfluidics. Biomicrofluidics 2014;8(5):052108
    • (2014) Biomicrofluidics , vol.8 , Issue.5 , pp. 052108
    • Yu, J.1    Tao, D.2    Ng, E.X.3
  • 39
    • 84915785104 scopus 로고    scopus 로고
    • Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay
    • Zhu S, Diamond SL. Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay. Thromb Res 2014;134(6):1335-43
    • (2014) Thromb Res , vol.134 , Issue.6 , pp. 1335-1343
    • Zhu, S.1    Diamond, S.L.2
  • 40
    • 56749092145 scopus 로고    scopus 로고
    • Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shearresistance of platelet aggregates
    • Neeves KB, Maloney SF, Fong KP, et al. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shearresistance of platelet aggregates. J Thromb Haemost 2008;6(12):2193-201
    • (2008) J Thromb Haemost , vol.6 , Issue.12 , pp. 2193-2201
    • Neeves, K.B.1    Maloney, S.F.2    Fong, K.P.3
  • 41
    • 84907855075 scopus 로고    scopus 로고
    • Blood coagulation screening using a paper-based microfluidic lateral flow device
    • Li H, Han D, Pauletti GM, Steckl AJ. Blood coagulation screening using a paper-based microfluidic lateral flow device. Lab Chip 2014;14(20):4035-41
    • (2014) Lab Chip , vol.14 , Issue.20 , pp. 4035-4041
    • Li, H.1    Han, D.2    Pauletti, G.M.3    Steckl, A.J.4
  • 42
    • 84923381543 scopus 로고    scopus 로고
    • Rapid onchip recalcification and drug dosing of citrated whole blood using microfluidic buffer sheath flow
    • Muthard RW, Diamond SL. Rapid onchip recalcification and drug dosing of citrated whole blood using microfluidic buffer sheath flow. Biorheology 2014;51(2-3):227-37
    • (2014) Biorheology , vol.51 , Issue.2-3 , pp. 227-237
    • Muthard, R.W.1    Diamond, S.L.2
  • 43
    • 84863286346 scopus 로고    scopus 로고
    • Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood
    • Li M, Ku DN, Forest CR. Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood. Lab Chip 2012;12(7):1355-62
    • (2012) Lab Chip , vol.12 , Issue.7 , pp. 1355-1362
    • Li, M.1    Ku, D.N.2    Forest, C.R.3
  • 44
    • 75149121866 scopus 로고    scopus 로고
    • A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood
    • Tovar-Lopez FJ, Rosengarten G, Westein E, et al. A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip 2010;10(3):291-302
    • (2010) Lab Chip , vol.10 , Issue.3 , pp. 291-302
    • Tovar-Lopez, F.J.1    Rosengarten, G.2    Westein, E.3
  • 45
    • 54749127812 scopus 로고    scopus 로고
    • Interactions between multiple cell types in parallel microfluidic channels: Monitoring platelet adhesion to an endothelium in the presence of an antiadhesion drug
    • Ku CJ, Oblak TD, Spence DM. Interactions between multiple cell types in parallel microfluidic channels: monitoring platelet adhesion to an endothelium in the presence of an antiadhesion drug. Anal Chem 2008;80(19):7543-8
    • (2008) Anal Chem , vol.80 , Issue.19 , pp. 7543-7548
    • Ku, C.J.1    Oblak, T.D.2    Spence, D.M.3
  • 46
    • 19444380695 scopus 로고    scopus 로고
    • Agonist-induced calcium response in single human platelets assayed in a microfluidic device
    • Tran L, Farinas J, Ruslim-Litrus L, et al. Agonist-induced calcium response in single human platelets assayed in a microfluidic device. Anal Biochem 2005;341(2):361-8
    • (2005) Anal Biochem , vol.341 , Issue.2 , pp. 361-368
    • Tran, L.1    Farinas, J.2    Ruslim-Litrus, L.3
  • 47
    • 84893588068 scopus 로고    scopus 로고
    • Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway
    • Li W, Tang X, Yi W, et al. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway. PLoS One 2013;8(12):e85120
    • (2013) PLoS One , vol.8 , Issue.12 , pp. e85120
    • Li, W.1    Tang, X.2    Yi, W.3
  • 48
    • 84905921965 scopus 로고    scopus 로고
    • Modulation of platelet activation and thrombus formation using a pan-PI3K inhibitor S14161
    • Yi W LQ, Shen J, Ren L, et al. Modulation of platelet activation and thrombus formation using a pan-PI3K inhibitor S14161. PLoS One 2014;9(8):e102394
    • (2014) PLoS One , vol.9 , Issue.8 , pp. e102394
    • Yi, W.L.Q.1    Shen, J.2    Ren, L.3
  • 49
    • 84896752543 scopus 로고    scopus 로고
    • Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses
    • Li M, Hotaling NA, Ku DN, Forest CR. Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses. PLoS One 2014;9(1):e82493
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e82493
    • Li, M.1    Hotaling, N.A.2    Ku, D.N.3    Forest, C.R.4
  • 50
    • 52649129923 scopus 로고    scopus 로고
    • Design, fabrication and implementation of a novel multiparameter control microfluidic platform for three-dimensional cell culture and real-time imaging
    • Vickerman V, Blundo J, Chung S, Kamm R. Design, fabrication and implementation of a novel multiparameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab Chip 2008;8(9):1468-77
    • (2008) Lab Chip , vol.8 , Issue.9 , pp. 1468-1477
    • Vickerman, V.1    Blundo, J.2    Chung, S.3    Kamm, R.4
  • 51
    • 80053894424 scopus 로고    scopus 로고
    • Microfluidic assay of endothelial cell migration in 3D interpenetrating polymer semi-network HA-Collagen hydrogel
    • Jeong GS, Kwon GH, Kang AR, et al. Microfluidic assay of endothelial cell migration in 3D interpenetrating polymer semi-network HA-Collagen hydrogel. Biomed Microdevices 2011;13(4):717-23
    • (2011) Biomed Microdevices , vol.13 , Issue.4 , pp. 717-723
    • Jeong, G.S.1    Kwon, G.H.2    Kang, A.R.3
  • 52
    • 84915793469 scopus 로고    scopus 로고
    • A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs
    • Kim C, Kasuya J, Jeon J, et al. A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs. Lab Chip 2014;15(1):301-10
    • (2014) Lab Chip , vol.15 , Issue.1 , pp. 301-310
    • Kim, C.1    Kasuya, J.2    Jeon, J.3
  • 53
    • 84892372328 scopus 로고    scopus 로고
    • A bioengineered array of 3D microvessels for vascular permeability assay
    • Lee H, Kim S, Chung M, et al. A bioengineered array of 3D microvessels for vascular permeability assay. Microvasc Res 2014;91:90-8
    • (2014) Microvasc Res , vol.91 , pp. 90-98
    • Lee, H.1    Kim, S.2    Chung, M.3
  • 54
    • 4344654280 scopus 로고    scopus 로고
    • A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings
    • Werdich AA, Lima EA, Ivanov B, et al. A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings. Lab Chip 2004;4(4):357-62
    • (2004) Lab Chip , vol.4 , Issue.4 , pp. 357-362
    • Werdich, A.A.1    Lima, E.A.2    Ivanov, B.3
  • 55
    • 33747587891 scopus 로고    scopus 로고
    • Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers
    • Ganitkevich V, Reil S, Schwethelm B, et al. Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers. Circ Res 2006;99(2):165-71
    • (2006) Circ Res , vol.99 , Issue.2 , pp. 165-171
    • Ganitkevich, V.1    Reil, S.2    Schwethelm, B.3
  • 56
    • 77951201263 scopus 로고    scopus 로고
    • Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes
    • Cheng W, Klauke N, Smith G, Cooper JM. Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis 2010;31(8):1405-13
    • (2010) Electrophoresis , vol.31 , Issue.8 , pp. 1405-1413
    • Cheng, W.1    Klauke, N.2    Smith, G.3    Cooper, J.M.4
  • 57
    • 34548023278 scopus 로고    scopus 로고
    • An onchip cardiomyocyte cell network assay for stable drug screening regarding community effect of cell network size
    • Kaneko T, Kojima K, Yasuda K. An onchip cardiomyocyte cell network assay for stable drug screening regarding community effect of cell network size. Analyst 2007;132(9):892-8
    • (2007) Analyst , vol.132 , Issue.9 , pp. 892-898
    • Kaneko, T.1    Kojima, K.2    Yasuda, K.3
  • 58
    • 34548694284 scopus 로고    scopus 로고
    • Muscular thin films for building actuators and powering devices
    • Feinberg AW, Feigel A, Shevkoplyas SS, et al. Muscular thin films for building actuators and powering devices. Science 2007;317(5843):1366-70
    • (2007) Science , vol.317 , Issue.5843 , pp. 1366-1370
    • Feinberg, A.W.1    Feigel, A.2    Shevkoplyas, S.S.3
  • 59
    • 84882240631 scopus 로고    scopus 로고
    • Microfluidic heart on a chip for higher throughput pharmacological studies
    • Agarwal A, Goss JA, Cho A, et al. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip 2013;13(18):3599-608
    • (2013) Lab Chip , vol.13 , Issue.18 , pp. 3599-3608
    • Agarwal, A.1    Goss, J.A.2    Cho, A.3
  • 60
    • 84857964726 scopus 로고    scopus 로고
    • Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
    • Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip 2011;11(24):4165-73
    • (2011) Lab Chip , vol.11 , Issue.24 , pp. 4165-4173
    • Grosberg, A.1    Alford, P.W.2    McCain, M.L.3    Parker, K.K.4
  • 61
    • 84899489485 scopus 로고    scopus 로고
    • Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues
    • McCain ML, Agarwal A, Nesmith HW, et al. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Biomaterials 2014;35(21):5462-71
    • (2014) Biomaterials , vol.35 , Issue.21 , pp. 5462-5471
    • McCain, M.L.1    Agarwal, A.2    Nesmith, H.W.3
  • 62
    • 84875669562 scopus 로고    scopus 로고
    • Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators
    • Shin SR, Jung SM, Zalabany M, et al. Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators. ACS Nano 2013;7(3):2369-80
    • (2013) ACS Nano , vol.7 , Issue.3 , pp. 2369-2380
    • Shin, S.R.1    Jung, S.M.2    Zalabany, M.3
  • 63
    • 84911805267 scopus 로고    scopus 로고
    • Fishing on chips: Up-and-coming technological advances in analysis of zebrafish and Xenopus embryos
    • Zhu F, Skommer J, Huang Y, et al. Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos. Cytometry A 2014;85(11):921-32
    • (2014) Cytometry A , vol.85 , Issue.11 , pp. 921-932
    • Zhu, F.1    Skommer, J.2    Huang, Y.3
  • 64
    • 84922582785 scopus 로고    scopus 로고
    • Microfluidic devices for imaging trafficking events in vivo using genetic model organisms
    • Mondal S, Koushika SP. Microfluidic devices for imaging trafficking events in vivo using genetic model organisms. Methods Mol Biol 2014;1174:375-96
    • (2014) Methods Mol Biol , vol.1174 , pp. 375-396
    • Mondal, S.1    Koushika, S.P.2
  • 65
    • 84899652386 scopus 로고    scopus 로고
    • Zebrafish on a chip: A novel platform for real-time monitoring of drug-induced developmental toxicity
    • Li Y, Yang F, Chen Z, et al. Zebrafish on a chip: a novel platform for real-time monitoring of drug-induced developmental toxicity. PLoS One 2014;9(4):e94792
    • (2014) PLoS One , vol.9 , Issue.4 , pp. e94792
    • Li, Y.1    Yang, F.2    Chen, Z.3
  • 66
    • 84905694065 scopus 로고    scopus 로고
    • OpenSource lab-on-a-chip physiometer for accelerated zebrafish embryo biotests
    • editorial board, J Paul Robinson, managing editor [et al.] Unit944 .
    • Akagi J, Hall CJ, Crosier KE, et al. OpenSource lab-on-a-chip physiometer for accelerated zebrafish embryo biotests. Curr Protoc Cytom/editorial board, J Paul Robinson, managing editor [et al.] 2014;67:Unit 9 44
    • (2014) Curr Protoc Cytom , vol.67
    • Akagi, J.1    Hall, C.J.2    Crosier, K.E.3
  • 67
    • 84877907923 scopus 로고    scopus 로고
    • Toward embedded laboratory automation for smart Lab-on-a-Chip embryo arrays
    • Wang KI, Salcic Z, Yeh J, et al. Toward embedded laboratory automation for smart Lab-on-a-Chip embryo arrays. Biosens Bioelectron 2013;48:188-96
    • (2013) Biosens Bioelectron , vol.48 , pp. 188-196
    • Wang, K.I.1    Salcic, Z.2    Yeh, J.3
  • 68
    • 84875764544 scopus 로고    scopus 로고
    • Zebrafish Entrapment By Restriction Array (ZEBRA) device: A low-cost, agarose-free zebrafish mounting technique for automated imaging
    • Bischel LL, Mader BR, Green JM, et al. Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab Chip 2013;13(9):1732-6
    • (2013) Lab Chip , vol.13 , Issue.9 , pp. 1732-1736
    • Bischel, L.L.1    Mader, B.R.2    Green, J.M.3
  • 69
    • 84861011083 scopus 로고    scopus 로고
    • Miniaturized embryo array for automated trapping, immobilization and microperfusion of zebrafish embryos
    • Akagi J, Khoshmanesh K, Evans B, et al. Miniaturized embryo array for automated trapping, immobilization and microperfusion of zebrafish embryos. PLoS One 2012;7(5):e36630
    • (2012) PLoS One , vol.7 , Issue.5 , pp. e36630
    • Akagi, J.1    Khoshmanesh, K.2    Evans, B.3
  • 70
    • 84901462721 scopus 로고    scopus 로고
    • Integrated chip-based physiometer for automated fish embryo toxicity biotests in pharmaceutical screening and ecotoxicology
    • Akagi J, Zhu F, Hall CJ, et al. Integrated chip-based physiometer for automated fish embryo toxicity biotests in pharmaceutical screening and ecotoxicology. Cytometry A 2014;85(6):537-47
    • (2014) Cytometry A , vol.85 , Issue.6 , pp. 537-547
    • Akagi, J.1    Zhu, F.2    Hall, C.J.3
  • 71
    • 84890050288 scopus 로고    scopus 로고
    • Real-time, aptamer-based tracking of circulating therapeutic agents in living animals
    • Ferguson BS, Hoggarth DA, Maliniak D, et al. Real-time, aptamer-based tracking of circulating therapeutic agents in living animals. Sci Transl Med 2013;5(213):213ra165
    • (2013) Sci Transl Med , vol.5 , Issue.213 , pp. 213ra165
    • Ferguson, B.S.1    Hoggarth, D.A.2    Maliniak, D.3
  • 72
    • 67749086547 scopus 로고    scopus 로고
    • Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamerbased sensor
    • Swensen JS, Xiao Y, Ferguson BS, et al. Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamerbased sensor. J Am Chem Soc 2009;131(12):4262-6
    • (2009) J Am Chem Soc , vol.131 , Issue.12 , pp. 4262-4266
    • Swensen, J.S.1    Xiao, Y.2    Ferguson, B.S.3
  • 73
    • 84880627888 scopus 로고    scopus 로고
    • Liposome sensing and monitoring by organic electrochemical transistors integrated in microfluidics
    • Tarabella G, Balducci AG, Coppede N, et al. Liposome sensing and monitoring by organic electrochemical transistors integrated in microfluidics. Biochim Biophys Acta 2013;1830(9):4374-80
    • (2013) Biochim Biophys Acta , vol.1830 , Issue.9 , pp. 4374-4380
    • Tarabella, G.1    Balducci, A.G.2    Coppede, N.3
  • 74
    • 84893379013 scopus 로고    scopus 로고
    • Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics
    • Lafreniere NM, Shih SC, Abu-Rabie P, et al. Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics. Bioanalysis 2014;6(3):307-18
    • (2014) Bioanalysis , vol.6 , Issue.3 , pp. 307-318
    • Lafreniere, N.M.1    Shih, S.C.2    Abu-Rabie, P.3
  • 75
    • 84892921738 scopus 로고    scopus 로고
    • Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis
    • Kim Y, Lobatto ME, Kawahara T, et al. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Proc Natl Acad Sci USA 2014;111(3):1078-83
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.3 , pp. 1078-1083
    • Kim, Y.1    Lobatto, M.E.2    Kawahara, T.3
  • 76
    • 84878658941 scopus 로고    scopus 로고
    • Enhanced Intracellular Delivery of a Model Drug Using Microbubbles Produced by a Microfluidic Device
    • Dixon AJ, Dhanaliwala AH, Chen JL, Hossack JA. Enhanced Intracellular Delivery of a Model Drug Using Microbubbles Produced by a Microfluidic Device. Ultrasound Med Biol 2013;39(7):1267-76
    • (2013) Ultrasound Med Biol , vol.39 , Issue.7 , pp. 1267-1276
    • Dixon, A.J.1    Dhanaliwala, A.H.2    Chen, J.L.3    Hossack, J.A.4
  • 77
    • 84878589144 scopus 로고    scopus 로고
    • Liquid flooded flowfocusing microfluidic device for in situ generation of monodisperse microbubbles
    • Dhanaliwala AH, Chen JL, Wang SY, Hossack JA. Liquid flooded flowfocusing microfluidic device for in situ generation of monodisperse microbubbles. Microfluid Nanofluidics 2013;14(3-4):457-67
    • (2013) Microfluid Nanofluidics , vol.14 , Issue.3-4 , pp. 457-467
    • Dhanaliwala, A.H.1    Chen, J.L.2    Wang, S.Y.3    Hossack, J.A.4
  • 78
    • 84886716941 scopus 로고    scopus 로고
    • Microand nanobubbles: A versatile non-viral platform for gene delivery
    • Cavalli R, Bisazza A, Lembo D. Microand nanobubbles: a versatile non-viral platform for gene delivery. Int J Pharm 2013;456(2):437-45
    • (2013) Int J Pharm , vol.456 , Issue.2 , pp. 437-445
    • Cavalli, R.1    Bisazza, A.2    Lembo, D.3
  • 79
    • 84901541035 scopus 로고    scopus 로고
    • Procedure for the development of multi-depth circular cross-sectional endothelialized microchannels-on-a-chip
    • Li X, Mearns SM, Martins-Green M, Liu Y. Procedure for the development of multi-depth circular cross-sectional endothelialized microchannels-on-a-chip. J Vis Exp 2013(80):e50771
    • (2013) J Vis Exp , Issue.80 , pp. e50771
    • Li, X.1    Mearns, S.M.2    Martins-Green, M.3    Liu, Y.4
  • 80
    • 84902550157 scopus 로고    scopus 로고
    • The endothelial glycocalyx: A review of the vascular barrier
    • Alphonsus CS, Rodseth RN. The endothelial glycocalyx: a review of the vascular barrier. Anaesthesia 2014;69(7):777-84
    • (2014) Anaesthesia , vol.69 , Issue.7 , pp. 777-784
    • Alphonsus, C.S.1    Rodseth, R.N.2
  • 81
    • 79952575609 scopus 로고    scopus 로고
    • Rheological analysis of non-Newtonian blood flow using a microfluidic device
    • Zeng H, Zhao Y. Rheological analysis of non-Newtonian blood flow using a microfluidic device. Sens Actuators A Phys 2011;166(2):207-13
    • (2011) Sens Actuators A Phys , vol.166 , Issue.2 , pp. 207-213
    • Zeng, H.1    Zhao, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.