메뉴 건너뛰기




Volumn 20, Issue 5, 2013, Pages 417-423

The use of microfluidics in hemostasis: Clinical diagnostics and biomimetic models of vascular injury

Author keywords

biorheology; coagulation; endothelium; microfluidics; platelets

Indexed keywords

VON WILLEBRAND FACTOR;

EID: 84883264594     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283642186     Document Type: Review
Times cited : (45)

References (53)
  • 1
    • 13244268264 scopus 로고    scopus 로고
    • Recollections of the development of flow devices for studying mechanisms of hemostasis and thrombosis in flowing whole blood
    • Sakariassen KS, Turitto VT, Baumgartner HR. Recollections of the development of flow devices for studying mechanisms of hemostasis and thrombosis in flowing whole blood. J Thromb Haemost 2004; 2:1681-1690.
    • (2004) J Thromb Haemost , vol.2 , pp. 1681-1690
    • Sakariassen, K.S.1    Turitto, V.T.2    Baumgartner, H.R.3
  • 2
    • 36349004705 scopus 로고    scopus 로고
    • Can blood flow assays help to identify clinically relevant differences in von Willebrand factor functionality in von Willebrand disease types 1-3?
    • Zwaginga JJ, Sakariassen KS, King MR, et al. Can blood flow assays help to identify clinically relevant differences in von Willebrand factor functionality in von Willebrand disease types 1-3? J Thromb Haemost 2007; 5:2547-2549.
    • (2007) J Thromb Haemost , vol.5 , pp. 2547-2549
    • Zwaginga, J.J.1    Sakariassen, K.S.2    King, M.R.3
  • 3
    • 80055104453 scopus 로고    scopus 로고
    • The Biorheology Subcommittee of the SSC of the ISTH. Flow, chamber-based assays to measure thrombus formation in vitro: Requirements for standardization
    • Roest M, Reininger A, Zwaginga JJ, et al., the Biorheology Subcommittee of the SSC of the ISTH. Flow chamber-based assays to measure thrombus formation in vitro: requirements for standardization. J Thromb Haemost 2011; 9:2322-2324.
    • (2011) J Thromb Haemost , vol.9 , pp. 2322-2324
    • Roest, M.1    Reininger, A.2    Zwaginga, J.J.3
  • 4
    • 81055157068 scopus 로고    scopus 로고
    • Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature
    • Prabhakarpandian B, Shen M-C, Pant K, Kiani MF. Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. Microvasc Res 2011; 82:210-220.
    • (2011) Microvasc Res , vol.82 , pp. 210-220
    • Prabhakarpandian, B.1    Shen, M.-C.2    Pant, K.3    Kiani, M.F.4
  • 5
    • 84867013545 scopus 로고    scopus 로고
    • Monitoring in vitro thrombus formation with novel microfluidic devices
    • Westein E, De Witt S, Lamers M, et al. Monitoring in vitro thrombus formation with novel microfluidic devices. Platelets 2012; 23:501-509.
    • (2012) Platelets , vol.23 , pp. 501-509
    • Westein, E.1    De Witt, S.2    Lamers, M.3
  • 6
    • 84878374503 scopus 로고    scopus 로고
    • High content evaluation of shear dependent platelet function in a microfluidic flow assay
    • Hansen RR, Wufsus AR, Barton ST, et al. High content evaluation of shear dependent platelet function in a microfluidic flow assay. Ann Biomed Eng 2013; 41:250-262.
    • (2013) Ann Biomed Eng , vol.41 , pp. 250-262
    • Hansen, R.R.1    Wufsus, A.R.2    Barton, S.T.3
  • 7
    • 52749092747 scopus 로고    scopus 로고
    • Microfluidic devices for studies of shear-dependent platelet adhesion
    • Gutierrez E, Petrich BG, Shattil SJ, et al. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip 2008; 8:1486-1495.
    • (2008) Lab Chip , vol.8 , pp. 1486-1495
    • Gutierrez, E.1    Petrich, B.G.2    Shattil, S.J.3
  • 8
    • 56749092145 scopus 로고    scopus 로고
    • Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates
    • Neeves KB, Maloney SF, Fong KP, et al. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost 2008; 6:2193-2201.
    • (2008) J Thromb Haemost , vol.6 , pp. 2193-2201
    • Neeves, K.B.1    Maloney, S.F.2    Fong, K.P.3
  • 9
    • 67650284727 scopus 로고    scopus 로고
    • Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis
    • Zhu L, Stalker T, Fong K, et al. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscl Thromb Vasc Biol 2009; 29:1039-1045.
    • (2009) Arterioscl Thromb Vasc Biol , vol.29 , pp. 1039-1045
    • Zhu, L.1    Stalker, T.2    Fong, K.3
  • 10
    • 75849146048 scopus 로고    scopus 로고
    • Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
    • Schmaier AA, Zou Z, Kazlauskas A, et al. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A 2009; 106:21167-21172.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21167-21172
    • Schmaier, A.A.1    Zou, Z.2    Kazlauskas, A.3
  • 11
    • 78650455518 scopus 로고    scopus 로고
    • Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D
    • Wannemacher K, Zhu L, Jiang H, et al. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood 2010; 116:5707.
    • (2010) Blood , vol.116 , pp. 5707
    • Wannemacher, K.1    Zhu, L.2    Jiang, H.3
  • 12
    • 23044514300 scopus 로고    scopus 로고
    • Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count
    • Lisman T, Adelmeijer J, Cauwenberghs S, et al. Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count. J Thromb Haemost 2005; 3:742-751.
    • (2005) J Thromb Haemost , vol.3 , pp. 742-751
    • Lisman, T.1    Adelmeijer, J.2    Cauwenberghs, S.3
  • 13
    • 78751551208 scopus 로고    scopus 로고
    • Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow
    • Cosemans J, Schols S, Stefanini L, et al. Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood 2011; 117:651.
    • (2011) Blood , vol.117 , pp. 651
    • Cosemans, J.1    Schols, S.2    Stefanini, L.3
  • 14
    • 43749119174 scopus 로고    scopus 로고
    • Protein C supports platelet binding and activation under flow: Role of glycoprotein Ib and apolipoprotein e receptor 2
    • White TC, Berny MA, Tucker EI, et al. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. J Thromb Haemost 2008; 6:995-1002.
    • (2008) J Thromb Haemost , vol.6 , pp. 995-1002
    • White, T.C.1    Berny, M.A.2    Tucker, E.I.3
  • 15
    • 30944451960 scopus 로고    scopus 로고
    • Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model
    • Tseng P-Y, Rele SS, Sun X-L, Chaikof EL. Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model. Biomaterials 2006; 27:2637-2650.
    • (2006) Biomaterials , vol.27 , pp. 2637-2650
    • Tseng, P.-Y.1    Rele, S.S.2    Sun, X.-L.3    Chaikof, E.L.4
  • 16
    • 35348953113 scopus 로고    scopus 로고
    • Characterization of the threshold response of initiation of blood clotting to stimulus patch size
    • Kastrup C, Shen F, Runyon M, Ismagilov R. Characterization of the threshold response of initiation of blood clotting to stimulus patch size. Biophys J 2007; 93:2969-2977.
    • (2007) Biophys J , vol.93 , pp. 2969-2977
    • Kastrup, C.1    Shen, F.2    Runyon, M.3    Ismagilov, R.4
  • 17
    • 79551659654 scopus 로고    scopus 로고
    • Dilutional control of prothrombin activation at physiologically relevant shear rates
    • Haynes LM, Dubief YC, Orfeo T, Mann KG. Dilutional control of prothrombin activation at physiologically relevant shear rates. Biophy J 2011; 100:765-773.
    • (2011) Biophy J , vol.100 , pp. 765-773
    • Haynes, L.M.1    Dubief, Y.C.2    Orfeo, T.3    Mann, K.G.4
  • 18
    • 41449101562 scopus 로고    scopus 로고
    • Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations
    • Runyon M, Kastrup C, Johnson-Kerner B, et al. Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations. J Am Chem Soc 2008; 130:3458-3464.
    • (2008) J Am Chem Soc , vol.130 , pp. 3458-3464
    • Runyon, M.1    Kastrup, C.2    Johnson-Kerner, B.3
  • 19
    • 55449124272 scopus 로고    scopus 로고
    • Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate
    • Shen F, Kastrup CJ, Liu Y, Ismagilov RF. Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate. Arterioscler Thromb Vasc Biol 2008; 28:2035-2041.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2035-2041
    • Shen, F.1    Kastrup, C.J.2    Liu, Y.3    Ismagilov, R.F.4
  • 20
    • 33750481224 scopus 로고    scopus 로고
    • From the cover: Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis
    • Kastrup CJ, Runyon MK, Shen F, Ismagilov RF. From the cover: modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis. Proc Natl Acad Sci U S A 2006; 103:15747-15752.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 15747-15752
    • Kastrup, C.J.1    Runyon, M.K.2    Shen, F.3    Ismagilov, R.F.4
  • 21
    • 42549087101 scopus 로고    scopus 로고
    • A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood
    • Neeves KB, Diamond SL. A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood. Lab Chip 2008; 8:701-709.
    • (2008) Lab Chip , vol.8 , pp. 701-709
    • Neeves, K.B.1    Diamond, S.L.2
  • 22
    • 77950635369 scopus 로고    scopus 로고
    • Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow
    • Neeves KB, Illing DAR, Diamond SL. Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow. Biophys J 2010; 98:1344-1352.
    • (2010) Biophys J , vol.98 , pp. 1344-1352
    • Neeves, K.B.1    Dar, I.2    Diamond, S.L.3
  • 23
    • 43549100702 scopus 로고    scopus 로고
    • Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: Amplification of 100 fM circulating tissue factor requires flow
    • Okorie UM, Denney WS, Chatterjee MS, et al. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood 2008; 111:3507-3513.
    • (2008) Blood , vol.111 , pp. 3507-3513
    • Okorie, U.M.1    Denney, W.S.2    Chatterjee, M.S.3
  • 24
    • 80054803602 scopus 로고    scopus 로고
    • Relipidated tissue factor linked to collagen surfaces potentiates platelet adhesion and fibrin formation in a microfluidic model of vessel injury
    • Colace TV, Jobson J, Diamond SL. Relipidated tissue factor linked to collagen surfaces potentiates platelet adhesion and fibrin formation in a microfluidic model of vessel injury. Bioconjugate Chem 2011; 22:2104-2109.
    • (2011) Bioconjugate Chem , vol.22 , pp. 2104-2109
    • Colace, T.V.1    Jobson, J.2    Diamond, S.L.3
  • 25
    • 84861529620 scopus 로고    scopus 로고
    • Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: Role of thrombin with and without fibrin
    • Colace TV, Muthard RW, Diamond SL. Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: role of thrombin with and without fibrin. Arterioscler Thromb Vasc Biol 2012; 32:1466-1476.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1466-1476
    • Colace, T.V.1    Muthard, R.W.2    Diamond, S.L.3
  • 26
    • 84870067114 scopus 로고    scopus 로고
    • Blood clots are rapidly assembled hemodynamic sensors: Flow arrest triggers intraluminal thrombus contraction
    • Muthard RW, Diamond SL. Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction. Arterioscler Thromb Vasc Biol 2012; 32:2938-2945.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2938-2945
    • Muthard, R.W.1    Diamond, S.L.2
  • 27
    • 73149086151 scopus 로고    scopus 로고
    • Macro- and microscale fluid flow systems for endothelial cell biology
    • Young EWK, Simmons CA. Macro- and microscale fluid flow systems for endothelial cell biology. Lab Chip 2010; 10:143.
    • (2010) Lab Chip , vol.10 , pp. 143
    • Young, E.W.K.1    Simmons, C.A.2
  • 28
    • 79955037366 scopus 로고    scopus 로고
    • Using well plate microfluidic devices to conduct shear-based thrombosis assays
    • Conant CG, Nevill JT, Zhou Z, et al. Using well plate microfluidic devices to conduct shear-based thrombosis assays. Jala-J Lab Autom 2011; 16:148-152.
    • (2011) Jala-J Lab Autom , vol.16 , pp. 148-152
    • Conant, C.G.1    Nevill, J.T.2    Zhou, Z.3
  • 29
    • 80054040264 scopus 로고    scopus 로고
    • Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads
    • Conant CG, Schwartz MA, Beecher JE, et al. Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads. Biotechnol Bioeng 2011; 108:2978-2987.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 2978-2987
    • Conant, C.G.1    Schwartz, M.A.2    Beecher, J.E.3
  • 30
    • 75749147056 scopus 로고    scopus 로고
    • A small-molecule inhibitor of integrin a2 b1 introduces a new strategy for antithrombotic therapy
    • Nissinen L, Pentikäinen OT, Jouppila A, et al. A small-molecule inhibitor of integrin a2 b1 introduces a new strategy for antithrombotic therapy. Thromb Haemost 2010; 103:387-397.
    • (2010) Thromb Haemost , vol.103 , pp. 387-397
    • Nissinen, L.1    Pentikäinen, O.T.2    Jouppila, A.3
  • 31
    • 78650415305 scopus 로고    scopus 로고
    • The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation
    • Philipose S, Konya V, Sreckovic I, et al. The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol 2010; 30:2416.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2416
    • Philipose, S.1    Konya, V.2    Sreckovic, I.3
  • 32
    • 33751233256 scopus 로고    scopus 로고
    • Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow
    • Okorie UM, Diamond SL. Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow. Biophys J 2006; 91:3474-3481.
    • (2006) Biophys J , vol.91 , pp. 3474-3481
    • Okorie, U.M.1    Diamond, S.L.2
  • 33
    • 34147120222 scopus 로고    scopus 로고
    • Micropatterned surfaces for controlling cell adhesion and rolling under flow
    • Nalayanda DD, Kalukanimuttam M, Schmidtke DW. Micropatterned surfaces for controlling cell adhesion and rolling under flow. Biomed Microdevices 2007; 9:207-214.
    • (2007) Biomed Microdevices , vol.9 , pp. 207-214
    • Nalayanda, D.D.1    Kalukanimuttam, M.2    Schmidtke, D.W.3
  • 34
    • 77950435140 scopus 로고    scopus 로고
    • P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions
    • Maloney SF, Brass LF, Diamond SL. P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integr Biol 2010; 2:183.
    • (2010) Integr Biol , vol.2 , pp. 183
    • Maloney, S.F.1    Brass, L.F.2    Diamond, S.L.3
  • 35
    • 80053390777 scopus 로고    scopus 로고
    • A novel automated microchip flowchamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions
    • Hosokawa K, Ohnishi T, Kondo T, et al. A novel automated microchip flowchamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions. J Thromb Haemost 2011; 9:2029-2037.
    • (2011) J Thromb Haemost , vol.9 , pp. 2029-2037
    • Hosokawa, K.1    Ohnishi, T.2    Kondo, T.3
  • 36
    • 84868210869 scopus 로고    scopus 로고
    • Evaluation of a novel flow chamber system to assess clot formation in factor VIII-deficient mouse and antifactor IXa-treated human blood
    • Ogawa S, Szlam F, Dunn AL, et al. Evaluation of a novel flow chamber system to assess clot formation in factor VIII-deficient mouse and antifactor IXa-treated human blood. Haemophilia 2012; 18:926-932.
    • (2012) Haemophilia , vol.18 , pp. 926-932
    • Ogawa, S.1    Szlam, F.2    Dunn, A.L.3
  • 37
    • 84863286346 scopus 로고    scopus 로고
    • Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood
    • Li M, Ku DN, Forest CR. Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood. Lab Chip 2012; 12:1355.
    • (2012) Lab Chip , vol.12 , pp. 1355
    • Li, M.1    Ku, D.N.2    Forest, C.R.3
  • 38
    • 84872785980 scopus 로고    scopus 로고
    • Sources of variability in platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays
    • Neeves KB, Onasoga AA, Hansen RR, et al. Sources of variability in platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays. PLoS One 2013; 8:e54680.
    • (2013) PLoS One , vol.8
    • Neeves, K.B.1    Onasoga, A.A.2    Hansen, R.R.3
  • 39
    • 0034663181 scopus 로고    scopus 로고
    • Platelet adhesion to collagen in healthy volunteers is influenced by variation of both alpha(2)beta(1) density and von Willebrand factor
    • Roest M, Sixma JJ, Wu YP, et al. Platelet adhesion to collagen in healthy volunteers is influenced by variation of both alpha(2)beta(1) density and von Willebrand factor. Blood 2000; 96:1433-1437.
    • (2000) Blood , vol.96 , pp. 1433-1437
    • Roest, M.1    Sixma, J.J.2    Wu, Y.P.3
  • 40
    • 79953309468 scopus 로고    scopus 로고
    • Collagen surfaces to measure thrombus formation under flow: Possibilities for standardization
    • Heemskerk JWM, Sakariassen KS, Zwaginga JJ, et al. Collagen surfaces to measure thrombus formation under flow: possibilities for standardization. J Thromb Haemost 2011; 9:856-858.
    • (2011) J Thromb Haemost , vol.9 , pp. 856-858
    • Jwm, H.1    Sakariassen, K.S.2    Zwaginga, J.J.3
  • 41
    • 0032879824 scopus 로고    scopus 로고
    • Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow
    • Savage B, Ginsberg MH, Ruggeri ZM. Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow. Blood 1999; 94:2704-2715.
    • (1999) Blood , vol.94 , pp. 2704-2715
    • Savage, B.1    Ginsberg, M.H.2    Ruggeri, Z.M.3
  • 42
    • 77953922179 scopus 로고    scopus 로고
    • Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood
    • Pugh N, Simpson AMC, Smethurst PA, et al. Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. Blood 2010; 115:5069-5079.
    • (2010) Blood , vol.115 , pp. 5069-5079
    • Pugh, N.1    Amc, S.2    Smethurst, P.A.3
  • 43
    • 80755176796 scopus 로고    scopus 로고
    • Characterization of collagen thin films for von Willebrand factor binding and platelet adhesion
    • Hansen RR, Tipnis AA, White-Adams TC, et al. Characterization of collagen thin films for von Willebrand factor binding and platelet adhesion. Langmuir 2011; 27:13648-13658.
    • (2011) Langmuir , vol.27 , pp. 13648-13658
    • Hansen, R.R.1    Tipnis, A.A.2    White-Adams, T.C.3
  • 44
    • 84855468373 scopus 로고    scopus 로고
    • In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
    • Tsai M, Kita A, Leach J, et al. In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology. J Clin Invest 2011; 122:408-418.
    • (2011) J Clin Invest , vol.122 , pp. 408-418
    • Tsai, M.1    Kita, A.2    Leach, J.3
  • 45
    • 70549088948 scopus 로고    scopus 로고
    • A physiologically realistic in vitro model of microvascular networks
    • Rosano JM, Tousi N, Scott RC, et al. A physiologically realistic in vitro model of microvascular networks. Biomed Microdevices 2009; 11:1051-1057.
    • (2009) Biomed Microdevices , vol.11 , pp. 1051-1057
    • Rosano, J.M.1    Tousi, N.2    Scott, R.C.3
  • 46
    • 84862197029 scopus 로고    scopus 로고
    • In vitro microvessels for the study of angiogenesis and thrombosis
    • Zheng Y, Chen J, Craven M, et al. In vitro microvessels for the study of angiogenesis and thrombosis. Proc Natl Acad Sci U S A 2012; 109:9342-9347.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 9342-9347
    • Zheng, Y.1    Chen, J.2    Craven, M.3
  • 47
    • 67149093849 scopus 로고    scopus 로고
    • A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    • Nesbitt W, Westein E, Tovar-Lopez F, et al. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med 2009; 15:665-673.
    • (2009) Nat Med , vol.15 , pp. 665-673
    • Nesbitt, W.1    Westein, E.2    Tovar-Lopez, F.3
  • 48
    • 75149121866 scopus 로고    scopus 로고
    • A microfluidics device to monitor platelet aggregation dynamics in response to strain rate microgradients in flowing blood
    • Tovar-Lopez FJ, Rosengarten G, Westein E, et al. A microfluidics device to monitor platelet aggregation dynamics in response to strain rate microgradients in flowing blood. Lab Chip 2010; 10:291.
    • (2010) Lab Chip , vol.10 , pp. 291
    • Tovar-Lopez, F.J.1    Rosengarten, G.2    Westein, E.3
  • 49
    • 84872867886 scopus 로고    scopus 로고
    • Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner
    • Westein E, van derMeer AD, KuijpersMJE, et al. Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner. Proc Natl Acad Sci U S A 2013; 110: 1357-1362.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1357-1362
    • Westein, E.1    Van Dermeer, A.D.2    Kuijpers, M.J.E.3
  • 50
    • 84864832183 scopus 로고    scopus 로고
    • Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels
    • Korin N, Kanapathipillai M, Matthews BD, et al. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science 2012; 337:738-742.
    • (2012) Science , vol.337 , pp. 738-742
    • Korin, N.1    Kanapathipillai, M.2    Matthews, B.D.3
  • 51
    • 67650462010 scopus 로고    scopus 로고
    • Design considerations for a microfluidic device to quantify the platelet adhesion to collagen at physiological shear rates
    • Sarvepalli DP, Schmidtke DW, Nollert MU. Design considerations for a microfluidic device to quantify the platelet adhesion to collagen at physiological shear rates. Ann Biomed Eng 2009; 37:1331-1341.
    • (2009) Ann Biomed Eng , vol.37 , pp. 1331-1341
    • Sarvepalli, D.P.1    Schmidtke, D.W.2    Nollert, M.U.3
  • 52
    • 79952015516 scopus 로고    scopus 로고
    • Shear-mediated platelet adhesion analysis in less than 100mL of blood: Toward a POC platelet diagnostic
    • Kent NJ, O'Brien S, Basabe-Desmonts L, et al. Shear-mediated platelet adhesion analysis in less than 100mL of blood: toward a POC platelet diagnostic. IEEE Trans Biomed Eng 2011; 58:826-830.
    • (2011) IEEE Trans Biomed Eng , vol.58 , pp. 826-830
    • Kent, N.J.1    O'brien, S.2    Basabe-Desmonts, L.3
  • 53
    • 0642311549 scopus 로고    scopus 로고
    • Blood flow in arteries
    • Ku D. Blood flow in arteries. Annul Rev Fluid Mechanics 1997; 29:399-434.
    • (1997) Annul Rev Fluid Mechanics , vol.29 , pp. 399-434
    • Ku, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.