Rapid on-chip recalcification and drug dosing of citrated whole blood using microfluidic buffer sheath flow

Biorheology

Volumn 51, Issue 2-3, 2014, Pages 227-237

  Muthard, Ryan W ^a   Diamond, Scott L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

citrate; fibrin; platelet; Thrombosis

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ALBUMIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 12A; CALCIUM CHELATING AGENT; CITRATE SODIUM; CITRIC ACID; FIBRIN; PHARMACOLOGICAL BIOMARKER;

BLOOD; BLOOD CLOTTING; BLOOD SAMPLING; CALCIFICATION; CONFERENCE PAPER; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN CELL; IC50; LAMINAR FLOW; MICROFLUIDICS; NANOFABRICATION; PHLEBOTOMY; SHEAR STRESS; THROMBOCYTE; THROMBOCYTE FUNCTION; THROMBOSIS; METABOLISM; MICROFLUIDIC ANALYSIS; PHYSIOLOGY; PROCEDURES; THROMBOCYTE ADHESION;

BIOMARKERS, PHARMACOLOGICAL; BLOOD COAGULATION; CITRATES; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROFLUIDICS; PLATELET ADHESIVENESS;

EID: 84923381543     PISSN: 0006355X     EISSN: 18785034     Source Type: Journal    
DOI: 10.3233/BIR-140658     Document Type: Conference Paper

References (29)

1. O.K. Baskurt, D. Gelmont and H.J. Meiselman, Red blood cell deformability in sepsis, Am. J. Respir. Crit. Care Med. 157 (1998), 421-427.
2. O.K. Baskurt and H.J. Meiselman, Blood rheology and hemodynamics, Semin. Thromb. Hemost. 29 (2003), 435-450.
3. O.K. Baskurt, A. Temiz and H.J. Meiselman, Red blood cell aggregation in experimental sepsis, J. Lab. Clin. Med. 130 (1997), 183-190.
4. A. Baurand, P. Raboisson, M. Freund, C. Léon, J.P. Cazenave, J.J. Bourguignon and C. Gachet, Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist, Eur. J. Pharmacol. 412 (2001), 213-221.
5. D. Dirkmann, A.A. Hanke, K. Görlinger and J. Peters, Hypothermia and acidosis synergistically impair coagulation in human whole blood, Anesth. Analg. 106 (2008), 1627-1632.
6. A. Ferrara, J.D. MacArthur, H.K. Wright, I.M. Modlin and M.A. McMillen, Hypothermia and acidosis worsen coagu-lopathy in the patient requiring massive transfusion, Am. J. Surg. 160 (1990), 515-518.
7. B. Furie and B.C. Furie, Thrombus formation in vivo, J. Clin. Invest. 115 (2005), 3355-3362.
8. P. Galambos and F.K. Forster, Micro-fluidic diffusion coefficient measurement, in: Micro Total Analysis Systems, D.J. Harrison and A. van den Berg, eds, Kluwer Academic Publishers, Dordrecht, 1998, pp. 189-192.
9. S.R. Hanson and E.I. Tucker, Blood coagulation and blood-materials interactions, in: Biomaterials Science: An Introduction to Materials in Medicine, B.D. Ratner, A.S. Hoffman, F.J. Schoen and J.E. Lemons, eds, Academic Press, UK, 2012, pp. 551-557.
10. L.B. Hoeltke, Phlebotomy Procedures and Practices, Cengage Learning, CT, 2012.
11. R.D. Langdell, R.H. Wagner and K.M. Brinkhous, Effect of antihemophilic factor on one-stage clotting tests; a presumptive test for hemophilia and a simple one-stage antihemophilic factor assy procedure, J. Lab. Clin. Med. 41 (1953), 637-647.
12. C. Lee, C. Chang, Y. Wang and L. Fu, Microfluidic mixing: a review. Int. J. Mol. Sci. 12 (2011), 3263-3287.
13. H.H. Lipowsky, Shear stress in the circulation, in: Flow-Dependent Regulation of Vascular Function, J.A. Bevan, G. Kaley and G.M. Rubanyi, eds, Oxford Univ. Press, New York, 1995, pp. 28-45.
14. S.F. Maloney, L.F. Brass and S.L. Diamond, P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions, Integr. Biol. 2 (2010), 183-192.
15. E.F. Mammen, P.C. Comp, R. Gosselin, C. Greenberg, W.K. Hoots, C.M. Kessler, E.C. Larkin, D. Liles and D.J. Nugent, PFA-100 system: a new method for assessment of platelet dysfunction, Semin. Thromb. Hemost. 24 (1998), 195-202.
16. K.G. Mann, M.F. Whelihan, S. Butenas and T. Orfeo, Citrate anticoagulation and the dynamics of thrombin generation, J. Thromb. Haemost. 5 (2007), 2055-2061.
17. N. Muramatsu and A.P. Minton, Tracer diffusion of globular proteins in concentrated protein solutions, PNAS 85 (1988), 2984-2988.
18. R.W. Muthard and S.L. Diamond, Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intralu-minal thrombus contraction, Arterioscler. Thromb. Vasc. Biol. 32 (2012), 2938-2945.
19. R.W. Muthard and S.L. Diamond, Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient, Lab. Chip. 13 (2013), 1883-1891.
20. K.B. Neeves, S.F. Maloney, K.P. Fong, A.A. Schmaier, M.L. Kahn, L.F. Brass and S.L. Diamond, Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates, J. Thromb. Haemost. 6 (2008), 2193-2201.
21. M. Nordin and T. Laurell, Two-hundredfold volume concentration of dilute cell and particle suspensions using chip integrated multistage acoustophoresis, Lab. Chip. 12 (2012), 4610-4616.
22. A.J. Quick, M. Stanley-Brown and F.W. Bancroft, A study of the coagulation defect in hemophilia and in jaundice, Am. J. Med. Sci. 190 (1934), 501-510.
23. M.D. Rand, J.B. Lock, C. van't Veer, D.P. Gaffney and K.G. Mann, Blood clotting in minimally altered whole blood, Blood 88 (1996), 3432-3445.
24. M. Roest, A. Reininger, J.J. Zwaginga, M.R. King and J.W.M. Heemskerk, Biorheology Subcommittee of the SSC of the ISTH. Flow chamber-based assays to measure thrombus formation in vitro: requirements for standardization, J. Thromb. Haemost. 9 (2011), 2322-2324.
25. J.R. Soohoo and G.M. Walker, Microfluidic aqueous two phase system for leukocyte concentration from whole blood, Biomed. Microdevices 11 (2009), 323-329.
26. T.M. Squires and S.R. Quake, Microfluidics: fluid physics on the nanoliter scale, Rev. Mod. Phys. 77 (2005), 977-1026.
27. P. Vanýsek, Ionic conductivity and diffusion at infinite dilution, in: CRC Handbook of Chemistry and Physics, W.M. Haynes, ed., CRC Press, Boca Raton, 2012, pp. 5-77-5-79.
28. S.P. Watson and P. Harrison, The vascular function of platelets, in: Postgraduate Haematology, A.V. Hoffbrand, D. Catovsky, E.G.D. Tuddenham and A.R. Green, eds, Wiley, UK, 2010, pp. 772-792.
29. R.E. Wells and E.W. Merrill, Influence of flow properties of blood upon viscosity-hematocrit relationships, J. Clin. Invest. 41 (1962), 1591-1598.