Miniaturized embryo array for automated trapping, immobilization and microperfusion of zebrafish embryos

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Akagi, Jin ^a   Khoshmanesh, Khashayar ^a,b   Evans, Barbara ^a   Hall, Chris J ^a   Crosier, Kathryn E ^a   Cooper, Jonathan M ^c   Crosier, Philip S ^a   Wlodkowic, Donald ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b RMIT UNIVERSITY   (Australia)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMER; TIVOZANIB;

ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL TRAPPING; ANTIANGIOGENIC ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG SCREENING; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO RESEARCH; IMMOBILIZATION; LAB ON A CHIP; LABORATORY AUTOMATION; MICROARRAY ANALYSIS; MICROFLUIDIC ANALYSIS; NONHUMAN; PERFUSION; PRODUCT DEVELOPMENT; SHEAR STRESS; TIME LAPSE IMAGING; ZEBRA FISH; ANGIOGENESIS; ANIMAL; ANIMAL MODEL; COMPUTER SYSTEM; DRUG DELIVERY SYSTEM; ELECTRONICS; EQUIPMENT DESIGN; GENETICS; HYDRODYNAMICS; INSTRUMENTATION; METHODOLOGY; PRENATAL DEVELOPMENT; TRANSGENIC ANIMAL; VALIDATION STUDY;

ANIMALIA; DANIO RERIO; MAMMALIA; METAZOA;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; COMPUTER SYSTEMS; DRUG DELIVERY SYSTEMS; EMBRYO CULTURE TECHNIQUES; EQUIPMENT DESIGN; HYDRODYNAMICS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MINIATURIZATION; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; PERFUSION; TIME-LAPSE IMAGING; ZEBRAFISH;

EID: 84861011083     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036630     Document Type: Article

References (36)

1. Wlodkowic D, Khoshmanesh K, Akagi J, Williams DE, Cooper JM, (2011) Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms. Cytometry Part A 79: 799-813.
2. Wheeler GN, Brandli AW, (2009) Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. Dev Dyn 238: 1287-1308.
3. Zon LI, Peterson RT, (2005) In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 4: 35-44.
4. Chakraborty C, Hsu CH, Wen ZH, Lin CS, Agoramoorthy G, (2009) Zebrafish: a complete animal model for in vivo drug discovery and development. Curr Drug Metab 10: 116-124.
5. Parng C, Seng WL, Semino C, McGrath P, (2002) Zebrafish: a preclinical model for drug screening. Assay Drug Dev Technol 1: 41-48.
6. Lammer E, Carr GJ, Wendler K, Rawlings JM, Belanger SE, et al. (2009) Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test? Comparative biochemistry and physiology Toxicology & pharmacology: CBP 149: 196-209.
7. Lammer E, Kamp HG, Hisgen V, Koch M, Reinhard D, et al. (2009) Development of a flow-through system for the fish embryo toxicity test (FET) with the zebrafish (Danio rerio). Toxicology in vitro 23: 1436-1442.
8. Strahle U, Scholz S, Geisler R, Greiner P, Hollert H, et al. (2011) Zebrafish embryos as an alternative to animal experiments-A commentary on the definition of the onset of protected life stages in animal welfare regulations. Reproductive toxicology:http://dx.doi.org/10.1016/j.reprotox.2011.06.121.
9. Giacomotto J, Segalat L, (2010) High-throughput screening and small animal models, where are we? Br J Pharmacol 160: 204-216.
10. Pulak R, (2002) Automated drug screening using zebrafish- Tutorial: COPAS XL allows for increased throughput. Genetic Engineering News 22: 32.
11. Pulak R, (2006) Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. Methods Mol Biol 351: 275-286.
12. Chung K, Crane MM, Lu H, (2008) Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans. Nat Methods 5: 637-643.
13. Hulme SE, Shevkoplyas SS, McGuigan AP, Apfeld J, Fontana W, et al. (2010) Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans. Lab Chip 10: 589-597.
14. Khoshmanesh K, Kiss N, Nahavandi S, Evans CW, Cooper JM, et al. (2011) Trapping and imaging of micron-sized embryos using dielectrophoresis. Electrophoresis 32: 3129-3132.
15. Lucchetta EM, Munson MS, Ismagilov RF, (2006) Characterization of the local temperature in space and time around a developing Drosophila embryo in a microfluidic device. Lab Chip 6: 185-190.
16. Funfak A, Brosing A, Brand M, Kohler JM, (2007) Micro fluid segment technique for screening and development studies on Danio rerio embryos. Lab Chip 7: 1132-1138.
17. Son SU, Garrell RL, (2009) Transport of live yeast and zebrafish embryo on a droplet digital microfluidic platform. Lab Chip 9: 2398-2401.
18. Wielhouwer EM, Ali S, Al-Afandi A, Blom MT, Riekerink MB, et al. (2011) Zebrafish embryo development in a microfluidic flow-through system. Lab on a chip 11: 1815-1824.
19. Yang F, Chen ZG, Pan JB, Li XC, Feng J, et al. (2011) An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics. Biomicrofluidics 5: 24115.
20. Pardo-Martin C, Chang TY, Koo BK, Gilleland CL, Wasserman SC, et al. (2010) High-throughput in vivo vertebrate screening. Nat Methods 7: 634-636.
21. Lawson ND, Weinstein BM, (2002) In vivo imaging of embryonic vascular development using transgenic zebrafish. Developmental Biology 248: 307-318.
22. Wlodkowic D, Faley S, Skommer J, McGuinness D, Cooper JM, (2009) Biological implications of polymeric microdevices for live cell assays. Anal Chem 81: 9828-9833.
23. Wlodkowic D, Faley S, Zagnoni M, Wikswo JP, Cooper JM, (2009) Microfluidic single-cell array cytometry for the analysis of tumor apoptosis. Analytical Chemistry 81: 5517-5523.
24. Hall C, Flores MV, Chien A, Davidson A, Crosier K, et al. (2009) Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages. Journal of leukocyte biology 85: 751-765.
25. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF, (1995) Stages of embryonic development of the zebrafish. Developmental dynamics: an official publication of the American Association of Anatomists 203: 253-310.
26. Fraysse B, Mons R, Garric J, (2006) Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals. Ecotoxicology and environmental safety 63: 253-267.
27. Buchanan CM, Shih JH, Astin JW, Rewcastle GW, Flanagan JU, et al. (2012) DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. Clin Sci (Lond) 122: 449-457.
28. Nakamura K, Taguchi E, Miura T, Yamamoto A, Takahashi K, et al. (2006) KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res 66: 9134-9142.
29. Kobel S, Valero A, Latt J, Renaud P, Lutolf M, (2010) Optimization of microfluidic single cell trapping for long-term on-chip culture. Lab Chip 10: 857-863.
30. Yin H, Zhang X, Pattrick N, Klauke N, Cordingley HC, et al. (2007) Influence of hydrodynamic conditions on quantitative cellular assays in microfluidic systems. Analytical Chemistry 79: 7139-7144.
31. Rubinstein AL, Cook MA, Chen SLJN, Rubinstein AL, (2003) Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arteriosclerosis Thrombosis and Vascular Biology 23: 911-912.
32. Serbedzija GN, Flynn E, Willett CE, (1999) Zebrafish angiogenesis: a new model for drug screening. Angiogenesis 3: 353-359.
33. Evensen L, Link W, Lorens JB, (2010) Imaged-based High-Throughput Screening for Anti-Angiogenic Drug Discovery. Current Pharmaceutical Design 16: 3958-3963.
34. Kidd KR, Weinstein BM, (2003) Fishing for novel angiogenic therapies. Br J Pharmacol 140: 585-594.
35. Vogt A, Cholewinski A, Shen X, Nelson SG, Lazo JS, et al. (2009) Automated image-based phenotypic analysis in zebrafish embryos. Dev Dyn 238: 656-663.
36. Tanyeri M, Ranka M, Sittipolkul N, Schroeder CM, (2011) A microfluidic-based hydrodynamic trap: design and implementation. Lab on a chip 11: 1786-1794.