Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Kim, Tae Jin ^a   Kim, Miju ^b   Kim, Hye Mi ^b   Lim, Seon Ah ^a   Kim, Eun Ok ^a   Kim, Kwanghee ^a,d   Song, Kwang Hoon ^b   Kim, Jiyoung ^a   Kumar, Vinay ^c   Yee, Cassian ^d   Doh, Junsang ^b   Lee, Kyung Mi ^a,b  

^a Korea University College of Medicine   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL; C57BL MOUSE; CELL COMMUNICATION; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; FEMALE; IMMUNOLOGY; INNATE IMMUNITY; MOUSE; NATURAL KILLER CELL; PHYSIOLOGY; TUMOR MICROENVIRONMENT;

ANIMALS; CELL COMMUNICATION; CELL COUNT; CELL PROLIFERATION; CELLS, CULTURED; CELLULAR MICROENVIRONMENT; CYTOKINES; FEMALE; IMMUNITY, INNATE; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL;

EID: 84923348290     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07157     Document Type: Article

References (43)

1. Smyth, M. J., Hayakawa, Y., Takeda, K. & Yagita, H. New aspects of natural-killercell surveillance and therapy of cancer. Nat. Rev. Cancer. 2, 850-861 (2002).
2. Sun, J. C. & Lanier, L. L. NK cell development, homeostasis and function: parallels with CD8 T cells. Nat. Rev. Immunol. 11, 645-657 (2011).
3. Lanier, L. L. Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9, 495-502 (2008).
4. Trinchieri, G. et al. Response of resting human peripheral blood natural killer cells to interleukin 2. J. Exp. Med. 160, 1147-1169 (1984).
5. Chiossone, L. et al. Maturation of mouse NK cells is a 4-stage developmental program. Blood 113, 5488-5496 (2009).
6. Alter, G., Malenfant, J. M. & Altfeld, M. CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods. 294, 15-22 (2004).
7. Doh, J., Kim, M. & Krummel, M. F. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials 31, 3422-3428 (2010).
8. Cho, J. H., Kim, H. O., Surh, C. D. & Sprent, J. T cell receptor-dependent regulation of lipid rafts controls naive CD81 T cell homeostasis. Immunity 32, 214-226 (2010).
9. Sabatos, C. A. et al. A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity 29, 238-248 (2008).
10. Lee, K. M. et al. Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood 107, 3181-3188 (2006).
11. Kim, E. O. et al. Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells. J. Leukoc. Biol. 88, 707-714 (2010).
12. Mortier, E. et al. Macrophage-and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD81 T cell subsets. Immunity 31, 811-822 (2009).
13. Alexopoulou, L., Holt, A. C.,Medzhitov, R.& Flavell, R. A. Recognition of doublestranded RNA and activation of NF-kB by Toll-like receptor 3. Nature 413, 732-738 (2001).
14. Doh, J. & Krummel, M. Immunological synapses within context: patterns of cellcell communication and their application in TT interactions. Curr. Topics in Microbiol. Immunol. 340, 25-50 (2010).
15. Gérard, A. et al. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD81 T cells. Nat. Immunol. 14, 356-365 (2013).
16. Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. & Salazar-Mather, T. P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189-220 (1999).
17. Sidorenko, S. P. & Clark, E. A. The dual-function CD150 receptor subfamily: the viral attraction. Nat. Immunol. 4, 19-24 (2003).
18. Morra, M. et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J 20, 5840-5852 (2001).
19. Blackburn, S. D. et al. Coregulation of CD81 T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29-37 (2009).
20. Raziorrouh, B. et al. The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD81 T-cell function. Hepatology 52, 1934-1947 (2010).
21. West, E. E. et al. Tight regulation of memory CD8(1) T cells limits their effectiveness during sustained high viral load. Immunity 35, 285-298 (2011).
22. Lee, K. M. et al. 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor onmouse natural killer cells. J. Exp. Med. 199, 1245-1254 (2004).
23. Waggoner, S. N., Taniguchi, R. T., Mathew, P. A., Kumar, V. & Welsh, R. M. Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD81 T cells, leading to prolonged viral persistence and altered pathogenesis. J. Clin. Invest. 120, 1925-1938 (2010).
24. Chlewicki, L. K., Velikovsky, C. A., Balakrishnan, V., Mariuzza, R. A. & Kumar, V. Molecular basis of the dual functions of 2B4 (CD244). J. Immunol. 180, 8159-8167 (2008).
25. Sayos, J. et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395, 462-469 (1998).
26. Bida, A. T. et al. 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. Mol. Immunol. 48, 1149-1159 (2011).
27. Bloch-Queyrat, C. et al. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J. Exp. Med. 202, 181-192 (2005).
28. Kim, H. S., Das, A., Gross, C. C., Bryceson, Y. T. & Long, E. O. Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Immunity 32, 175-186 (2010).
29. Tassi, I. & Colonna, M. The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J. Immunol. 175, 7996-8002 (2005).
30. Wang, D. et al. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity 13, 25-35 (2000).
31. Colonna, M. Fine-tuning NK cell responses: it's a family affair. Nat. Immunol. 6, 961-962 (2005).
32. Taniguchi, R. T., Guzior, D. & Kumar, V. 2B4 inhibits NK-cell fratricide. Blood 110, 2020-2023 (2007).
33. Assarsson, E. et al.NK cells stimulate proliferation of T and NK cells through 2B4/ CD48 interactions. J. Immunol. 173, 174-180 (2004).
34. Stefanová, I., Dorfman, J. R. & Germain, R. N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420, 429-434 (2002).
35. Hochweller, K. et al. Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc. Natl. Acad. Sci. USA. 107, 5931-5936 (2010).
36. Römer, P. S. et al. Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412. Blood 118, 6772-6782 (2011).
37. Miller, M. J., Hejazi, A. S., Wei, S. H., Cahalan, M. D. & Parker, I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA. 101, 998-1003 (2004).
38. Deguine, J., Breart, B., Lemaitre, F., Di Santo, J. P. & Bousso, P. Intravital imaging reveals distinct dynamics for natural killer and CD8(1) T cells during tumor regression. Immunity 33, 632-644 (2010).
39. Kang, S. J., Liang, H. E., Reizis, B. & Locksley, R. M. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29, 819-833 (2008).
40. Granucci, F. et al. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J. Exp. Med. 200, 287-295 (2004).
41. Hanna, J. et al. Novel APC-like properties of human NK cells directly regulate T cell activation. J. Clin. Invest. 114, 1612-1623 (2004).
42. Pham, T. N. et al. Enhancement of antitumor effect using dendritic cells activated with natural killer cells in the presence of Toll-like receptor agonist ExpMol Med. 42(6), 407-419 (2010).
43. Lee, S. et al. Expression and Function of TLR2 on CD4 Versus CD8 T Cells. Immune Network. 9(4), 127-132 (2009).