Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells

Journal of Leukocyte Biology

Volumn 88, Issue 4, 2010, Pages 707-714

  Kim, Eun Ok ^a   Kim, Nayoung ^a   Kim, Tae Jin ^a   Kim, Kwanghee ^a   Kim, Tae Woo ^a   Kumar, Vinay ^b   Lee, Kyung Mi ^a  

^a Korea University College of Medicine   (South Korea)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

IFN gamma; Innate immunity; Natural cytotoxity; NK activating receptors

Indexed keywords

CD244 ANTIGEN; CD48 ANTIGEN; CD48 MONOCLONAL ANTIBODY; CYTOKINE; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; CD244 PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL LINE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; CYTOTOXICITY; EFFECTOR CELL; FEMALE; LYMPHOCYTE ACTIVATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL SEPARATION; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM;

MURINAE; MUS;

ANIMALS; ANTIGENS, CD; CELL SEPARATION; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 77957868235     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0410198     Document Type: Article

References (28)

1. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Bioassoni, R., Moretta, L. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197-223.
2. Assarsson, E., Kambayashi, T., Persson, C. M., Ljunggren, H. G., Chambers, B. J. (2005) 2B4 co-stimulation: NK cells and their control of adaptive immune responses. Mol. Immunol. 42, 419-423.
3. Kato, K., Tamura, N., Okumura, K., Yagita, H. (1993) Identification of the T cell surface signal-transducing glycoprotein sgp-60 as CD48, a counter-receptor for mouse CD2. Eur. J. Immunol. 23, 1412-1415.
4. Sivori, S., Falco, M., Marcenaro, E., Parolini, S., Biassoni, R., Bottino, C., Moretta, L., Moretta, A. (2002) Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. USA 99, 4526-4531.
5. Lee, K. M., McNerney, M. E., Stepp, S. E., Mathew, P. A., Schatzle, J. D., Bennett, M., Kumar, V. (2004) 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J. Exp. Med. 199, 1245-1254.
6. Taniguchi, R. T., Guzior, D., Kumar, V. (2007) 2B4 inhibits NK-cell fratricide. Blood 110, 2020-2023.
7. Lee, K. M., Forman, J. P., McNerney, M. E., Stepp, S., Kuppireddi, S., Guzior, D., Latchman, Y. E., Sayegh, M. H., Yagita, H., Park, C. K., Oh, S. B., Wulfing, C., Schatzle, J., Mathew, P. A., Sharpe, A. H., Kumar, V. (2006) Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood 107, 3181-3188.
8. Chlewicki, L. K., Velikovsky, C. A., Balakrishnan, V., Mariuzza, R. A., Kumar, V. (2008) Molecular basis of the dual functions of 2B4 (CD244). J. Immunol. 180, 8159-8167.
9. Kambayashi, T., Assarsson, E., Chambers, B. J., Ljunggren, H. G. (2001) Cutting edge: regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions. J. Immunol. 167, 6706-6710.
10. Assarsson, E., Kambayashi, T., Schatzle, J. D., Cramer, S. O., von Bonin, A., Jensen, P. E., Ljunggren, H. G., Chambers, B. J. (2004) NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions. J. Immunol. 173, 174-180.
11. Messmer, B., Eissmann, P., Stark, S., Watzl, C. (2006) CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. J. Immunol. 176, 4646-4650.
12. Fukushima, K., Ikehara, Y., Yamashita, K. (2005) Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-γ production. J. Biol. Chem. 280, 18056-18062.
13. Lee, K. M., Bhawan, S., Majima, T., Wei, H., Nishimura, M. I., Yagita, H., Kumar, V. (2003) Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J. Immunol. 170, 4881-4885.
14. Lee, H., Hong, C., Shin, J., Oh, S., Jung, S., Park, Y. K., Hong, S., Lee, G. R., Park, S. H. (2009) The presence of CD8+ invariant NKT cells in mice. Exp. Mol. Med. 41, 866-872.
15. Guo, H., Kumar, P., Moran, T. M., Garcia-Sastre, A., Zhou, Y., Malarkannan, S. (2009) The functional impairment of natural killer cells during influenza virus infection. Immunol. Cell Biol. 87, 579-589.
16. Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., Okumura, K., Yagita, H. (1992) CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J. Exp. Med. 176, 1241-1249.
17. Toomey, J. A., Gays, F., Foster, D., Brooks, C. G. (2003) Cytokine requirements for the growth and development of mouse NK cells in vitro. J. Leukoc. Biol. 74, 233-242.
18. Giavedoni, L. D., Velasquillo, M. C., Parodi, L. M., Hubbard, G. B., Hodara, V. L. (2000) Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus. J. Virol. 74, 1648-1657.
19. Vosshenrich, C. A., Ranson, T., Samson, S. I., Corcuff, E., Colucci, F., Rosmaraki, E. E., Di Santo, J. P. (2005) Roles for common cytokine receptor γ-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J. Immunol. 174, 1213-1221.
20. Suzuki, H., Duncan, G. S., Takimoto, H., Mak, T. W. (1997) Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J. Exp. Med. 185, 499-505.
21. Betser-Cohen, G., Mizrahi, S., Elboim, M., Alsheich-Bartok, O., Mandelboim, O. (2010) The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells. J. Immunol. 184, 2761-2768.
22. Fauriat, C., Long, E. O., Ljunggren, H. G., Bryceson, Y. T. (2010) Regulation of human NK cell cytokine and chemokine productionby target cell recognition. Blood 115, 2167-2176.
23. Bryceson, Y. T., Ljunggren, H. G., Long, E. O. (2009) Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood 114, 2657-2666.
24. Feldmann, J., Callebaut, I., Raposo, G., Certain, S., Bacq, D., Dumont, C., Lambert, N., Ouachee-Chardin, M., Chedeville, G., Tamary, H., Minard-Colin, V., Vilmer, E., Blanche, S., Le Deist, F., Fischer, A., de Saint Basile, G. (2003) Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell 115, 461-473.
25. Menasche, G., Pastural, E., Feldmann, J., Certain, S., Ersoy, F., Dupuis, S., Wulffraat, N., Bianchi, D., Fischer, A., Le Deist, F., de Saint Basile, G. (2000) Mutations in RAB27A cause Griscelli syndrome associated with hemophagocytic syndrome. Nat. Genet. 25, 173-176.
26. Wood, S. M., Meeths, M., Chiang, S. C., Bechensteen, A. G., Boelens, J. J., Heilmann, C., Horiuchi, H., Rosthoj, S., Rutynowska, O., Winiarski, J., Stow, J. L., Nordenskjold, M., Henter, J. I., Ljunggren, H. G., Bryceson, Y. T. (2009) Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Blood 114, 4117-4127.
27. Watzl, C., Long, E. O. (2003) Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts. J. Exp. Med. 197, 77-85.
28. Eissmann, P., Beauchamp, L., Wooters, J., Tilton, J. C., Long, E. O., Watzl, C. (2005) Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood 105, 4722-4729.