Novel APC-like properties of human NK cells directly regulate T cell activation

Journal of Clinical Investigation

Volumn 114, Issue 11, 2004, Pages 1612-1623

  Hanna, Jacob ^a   Gonen Gross, Tsufit ^a   Fitchett, Jonathan ^b   Rowe, Tony ^b   Daniels, Mark ^b   Arnon, Tal I ^a   Gazit, Roi ^a   Joseph, Aviva ^a   Schjetne, Karoline W ^c   Steinle, Alexander ^d   Porgador, Angel ^e   Mevorach, Dror ^f   Goldman Wohl, Debra ^f   Yagel, Simcha ^f   LaBarre, Michael J ^b   Buckner, Jane H ^g   Mandelboim, Ofer ^a,h  

^a HEBREW UNIVERSITY   (Israel)

^b BIOGEN   (United States)

^c UNIVERSITY OF OSLO   (Norway)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^f HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^g BENAROYA RESEARCH INSTITUTE   (United States)

^h HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL SURFACE RECEPTOR; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TRANSPORTER ASSOCIATED PROCESSING ANTIGEN 2; UNCLASSIFIED DRUG; ANTIGEN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEOME;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DECIDUA; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; IN VIVO STUDY; MICROENVIRONMENT; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEOMICS; T LYMPHOCYTE ACTIVATION; TONSIL; CD4+ T LYMPHOCYTE; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; FEMALE; GENE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; PREGNANCY; T LYMPHOCYTE SUBPOPULATION;

ANTIGEN-PRESENTING CELLS; ANTIGENS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; FEMALE; GENES, MHC CLASS II; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PREGNANCY; PROTEOME; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS;

EID: 85047690749     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI22787     Document Type: Article

References (35)

1. Orange, J.S., Fassett, M.S., Koopman, L.A., Boyson, J.E., and Strominger, J.L. 2002. Viral evasion of natural killer cells. Nat. Immunol. 3:1006-1012.
2. Itano, A.A., and Jenkins, M.K. 2003. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4:733-739.
3. Mocikat, R., et al. 2003. Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CDS T cell responses. Immunity. 19:561-569.
4. Regnault, A., et al. 1999. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp. Med. 189:371-380.
5. Schjetne, K.W., et al. 2003. Cutting edge. Link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. J. Immunol. 171:32-36.
6. Mandelboim, O., et al. 2001. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature. 409:1055-1060.
7. Hanna, J., et al. 2003. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16-human natural killer cells. Blood. 102:1569-1577.
8. Markel, G., et al. 2002. Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. J. Clin. Invest. 110:943-953. doi:10.1172/JCI200215643.
9. Fehniger, T.A., et al. 2003. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood. 101:3052-3057.
10. Ferlazzo, G., et al. 2002. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195:343-351.
11. Cooper, M.A., Fehniger, T.A., and Caligiuri, M.A. 2001. The biology of human natural killer-cell subsets. Trends Immunol. 22:633-640.
12. Falk, K., Rotzschke, O., and Strominger, J.L. 2000. Antigen-specific elimination of T cells induced by oligomerized hemagglutinin (HA) 306-318. Eur. J. Immunol. 30:3012-3020.
13. Muntasell, A., et al. 2002. HLA-DR4 molecules in neuroendocrine epithelial cells associate to a heterogeneous repertoire of cytoplasmic and surface self peptides. J. Immunol. 169:5052-5060.
14. Andre, P., et al. 2004. Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur. J. Immunol. 34:961-971.
15. Rothenfusser, S., et al. 2004. CpG-A and CpG-B oligonucleocides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood. 103:2162-2169.
16. Carlin, L.M., Eleme, K., McCann, F.E., and Davis, D.M. 2001. Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses. J. Exp. Med. 194:1507-1517.
17. Pende, D., et al. 2002. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res. 62:6178-6186.
18. Salih, H.R., et al. 2003. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood. 102:1389-1396.
19. Cella, M., et al. 1997. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J. Exp. Med. 185:1743-1751.
20. Arnon, T.I., et al. 2003. The mechanisms controlling the recognition of tumor and virus infected cells by NKp46. Blood. 103:664-672.
21. Koopman, L.A., et al. 2003. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J. Exp. Med. 198:1201-1212.
22. Markel, G., et al. 2004. The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients. Blood. 103:1770-1778.
23. Croft, M. 2003. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3:609-620.
24. Cooper, M.A., Fehniger, T.A., Fuchs, A., Colonna, M., and Caligiuri, M.A. 2004. NK cell and DC interactions. Trends Immunol. 25:47-52.
25. Celestin, J., et al. 2001. IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils. J. Immunol. 167:6097-6104.
26. Ferlazzo, G., et al. 2004. The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J. Immunol. 172:1455-1462.
27. Homann, D., et al. 2002. CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity. 16:403-415.
28. Blattman, J.N., and Greenberg, P.D. 2004. Cancer immunotherapy: a treatment for the masses. Science. 305:200-205.
29. Yu, P., et al. 2004. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat. Immunol. 5:141-149.
30. Crotzer, V.L., Mabardy, A.S., Weiss, A., and Brodsky, F.M. 2004. T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J. Exp. Med. 199:981-991.
31. Yee, C., et al. 2002. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl. Acad. Sci. U. S. A. 99:16168-16173.
32. Salio, M., et al. 2003. Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells. Int. Immunol. 15:1265-1273.
33. Shevchenko, A., Wilm, M., Vorm, O., and Mann, M. 1996. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68:850-858.
34. Perkins, D.N., Pappin, D.J., Creasy, D.M., and Cottrell, J.S. 1999. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis. 20:3551-3567.
35. Gebe, J.A., et al. 2001. T cell selection and differential activation on structurally related HLA-DR4 ligands. J. Immunol. 167:3250-3256.