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Volumn 5, Issue , 2014, Pages

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBENZAMIDINE; AMINOGUANIDINE; ARGININE; BLOOD CLOTTING FACTOR 10A; COUMARIN; ETHANOLAMINE; MERCAPTAMINE; NITROGEN; NUCLEOPHILE; OXYGEN; PROPYLAMINE; PROTEINASE; SERINE PROTEINASE; SULFUR; THIOL DERIVATIVE; PEPTIDE FRAGMENT;

EID: 84923334436     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6170     Document Type: Article
Times cited : (13)

References (39)
  • 2
    • 33847381100 scopus 로고    scopus 로고
    • A decade of fragment-based drug design: Strategic advances and lessons learned
    • Hajduk, P. J. & Greer, J. A decade of fragment-based drug design: strategic advances and lessons learned. Nat. Rev. Drug Discov. 6, 211-219 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 211-219
    • Hajduk, P.J.1    Greer, J.2
  • 4
    • 46349096029 scopus 로고    scopus 로고
    • Fragment-based approach to drug lead discovery
    • Fattori, D., Squarcia, A. & Bartoli, S. Fragment-based approach to drug lead discovery. Drugs RD 9, 217-227 (2008).
    • (2008) Drugs RD , vol.9 , pp. 217-227
    • Fattori, D.1    Squarcia, A.2    Bartoli, S.3
  • 5
    • 5344229414 scopus 로고    scopus 로고
    • Organic protein chemistry: Drug discovery through the chemical modification of proteins
    • Rademann, J. Organic protein chemistry: drug discovery through the chemical modification of proteins. Angew. Chem. Int. Ed. 43, 4554-4556 (2004).
    • (2004) Angew. Chem. Int. E.d. , vol.43 , pp. 4554-4556
    • Rademann, J.1
  • 6
    • 33750002664 scopus 로고    scopus 로고
    • Dynamic combinatorial chemistry
    • Corbett, P. T. et al. Dynamic combinatorial chemistry. Chem. Rev. 106, 3652-3711 (2006).
    • (2006) Chem. Rev. , vol.106 , pp. 3652-3711
    • Corbett, P.T.1
  • 7
    • 33751204422 scopus 로고    scopus 로고
    • Fragment-based lead discovery: A chemical update
    • Erlanson, D. A. Fragment-based lead discovery: a chemical update. Curr. Opin. Biotechnol. 17, 643-652 (2006).
    • (2006) Curr. Opin. Biotechnol. , vol.17 , pp. 643-652
    • Erlanson, D.A.1
  • 8
    • 68749088518 scopus 로고    scopus 로고
    • Dynamic template-Assisted strategies in fragment-based drug discovery
    • Schmidt, M. F. & Rademann, J. Dynamic template-Assisted strategies in fragment-based drug discovery. Trends Biotechnol. 27, 512-521 (2009).
    • (2009) Trends Biotechnol. , vol.27 , pp. 512-521
    • Schmidt, M.F.1    Rademann, J.2
  • 9
    • 0029836953 scopus 로고    scopus 로고
    • Discovering high-Affinity ligands for proteins: SAR by NMR
    • Shuker, S. B., Hajduk, P. J., Meadows, R. P. & Fesik, S. W. Discovering high-Affinity ligands for proteins: SAR by NMR. Science 274, 1531-1534 (1996).
    • (1996) Science , vol.274 , pp. 1531-1534
    • Shuker, S.B.1    Hajduk, P.J.2    Meadows, R.P.3    Fesik, S.W.4
  • 10
    • 33846687723 scopus 로고    scopus 로고
    • Dynamic combinatorial resolution: Direct asymmetric lipase-mediated screening of dynamic nitroaldol library
    • Vongvilai, P., Angelin, M., Larsson, R. & Ramstrom, O. Dynamic combinatorial resolution: direct asymmetric lipase-mediated screening of dynamic nitroaldol library. Angew. Chem. Int. Ed. 46, 948-950 (2007).
    • (2007) Angew. Chem. Int. Ed. , vol.46 , pp. 948-950
    • Vongvilai, P.1    Angelin, M.2    Larsson, R.3    Ramstrom, O.4
  • 11
    • 0033773899 scopus 로고    scopus 로고
    • Discovering novel ligands for macromolecules using X-ray crystallographic screening
    • Nienaber, V. L. et al. Discovering novel ligands for macromolecules using X-ray crystallographic screening. Nat. Biotechnol. 18, 1105-1108 (2000).
    • (2000) Nat. Biotechnol. , vol.18 , pp. 1105-1108
    • Nienaber, V.L.1
  • 12
    • 0036051992 scopus 로고    scopus 로고
    • High-Throughput crystallography for lead discovery in drug design
    • Blundell, T. L., Jhoti, H. & Abell, C. High-Throughput crystallography for lead discovery in drug design. Nat. Rev. Drug Discov. 1, 45-54 (2002).
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 45-54
    • Blundell, T.L.1    Jhoti, H.2    Abell, C.3
  • 13
    • 0038198865 scopus 로고    scopus 로고
    • High-Throughput crystallographyto enhance drug discovery
    • Sharff, A. & Jhoti, H. High-Throughput crystallographyto enhance drug discovery. Curr. Opin. Chem. Biol. 7, 340-345 (2003).
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 340-345
    • Sharff, A.1    Jhoti, H.2
  • 14
    • 12144288664 scopus 로고    scopus 로고
    • Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-Throughput X-ray crystallographic screening and structure-directed lead optimization
    • Sanders, W. J. et al. Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-Throughput X-ray crystallographic screening and structure-directed lead optimization. J. Med. Chem. 47, 1709-1718 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 1709-1718
    • Sanders, W.J.1
  • 15
    • 34347226326 scopus 로고    scopus 로고
    • Substrate activity screening (SAS): A general procedure for the preparation and screening of a fragmentbased non-peptidic protease substrate library for inhibitor discovery
    • Patterson, A. W., Wood, W. J. L. & Ellman, J. A. Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragmentbased non-peptidic protease substrate library for inhibitor discovery. Nat. Protoc. 2, 424-433 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 424-433
    • Patterson, A.W.1    Wood, W.J.L.2    Ellman, J.A.3
  • 16
    • 0000705433 scopus 로고
    • Substrate side chain guanidines as model of the binding of amidines and studies on the active center of trypsin
    • Mares-Guia, M. & Shaw, E. Substrate side chain guanidines as model of the binding of amidines and studies on the active center of trypsin. J. Biol. Chem. 240, 1579-1585 (1965).
    • (1965) J. Biol. Chem. , vol.240 , pp. 1579-1585
    • Mares-Guia, M.1    Shaw, E.2
  • 17
    • 44949155667 scopus 로고    scopus 로고
    • Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening
    • Schmidt, M. F. et al. Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening. Angew. Chem. Int. Ed. 47, 3275-3278 (2008).
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 3275-3278
    • Schmidt, M.F.1
  • 18
    • 70349907092 scopus 로고    scopus 로고
    • Selective identification of cooperatively binding fragments in a high-Throughput ligation assay enables development of a picomolar caspase-3 inhibitor
    • Schmidt, M. F., El-Dahshan, A., Keller, S. & Rademann, J. Selective identification of cooperatively binding fragments in a high-Throughput ligation assay enables development of a picomolar caspase-3 inhibitor. Angew. Chem. Int. Ed. 48, 6346-6349 (2009).
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 6346-6349
    • Schmidt, M.F.1    El-Dahshan, A.2    Keller, S.3    Rademann, J.4
  • 19
    • 81555205139 scopus 로고    scopus 로고
    • Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases
    • Schmidt, M. F., Groves, M. & Rademann, J. Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases. Chembiochem 12, 2640-2646 (2011).
    • (2011) Chembiochem , vol.12 , pp. 2640-2646
    • Schmidt, M.F.1    Groves, M.2    Rademann, J.3
  • 20
    • 33745906224 scopus 로고    scopus 로고
    • An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors
    • Al-Gharabli, S. I. et al. An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors. Chembiochem 7, 1048-1055 (2006).
    • (2006) Chembiochem , vol.7 , pp. 1048-1055
    • Al-Gharabli, S.I.1
  • 22
    • 79851493080 scopus 로고    scopus 로고
    • Oxidative kinetic self-sorting of a dynamic imine library
    • Osowska, K. & Miljanic, O. S. Oxidative kinetic self-sorting of a dynamic imine library. J. Am. Chem. Soc. 133, 724-727 (2011).
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 724-727
    • Osowska, K.1    Miljanic, O.S.2
  • 23
    • 68149159184 scopus 로고    scopus 로고
    • Dynamic mixtures and combinatorial libraries: Imines as probes for molecular evolution at the interface between chemistry and biology
    • Hermann, A. Dynamic mixtures and combinatorial libraries: imines as probes for molecular evolution at the interface between chemistry and biology. Org. Biomol. Chem. 7, 3195-3204 (2009).
    • (2009) Org. Biomol. Chem. , vol.7 , pp. 3195-3204
    • Hermann, A.1
  • 24
    • 34848889573 scopus 로고    scopus 로고
    • Template-directed synthesis employing reversible imine bond formation
    • Meyer, C. D., Joiner, C. S. & Stoddart, J. F. Template-directed synthesis employing reversible imine bond formation. Chem. Soc. Rev. 36, 1705-1723 (2007).
    • (2007) Chem. Soc. Rev. , vol.36 , pp. 1705-1723
    • Meyer, C.D.1    Joiner, C.S.2    Stoddart, J.F.3
  • 25
    • 55349124942 scopus 로고    scopus 로고
    • Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution
    • Rodriguez-Decampo, Z. & Otto, S. Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution. Chem. Commun. 5301-5303 (2008).
    • (2008) Chem. Commun. , pp. 5301-5303
    • Rodriguez-Decampo, Z.1    Otto, S.2
  • 26
    • 77949360886 scopus 로고    scopus 로고
    • Bisaryl hydrazones as exchangeable biocompatible linkers
    • Dirksen, A., Yegneswaran, S. & Dawson, P. E. Bisaryl hydrazones as exchangeable biocompatible linkers. Angew. Chem. Int. Ed. 49, 2023-2027 (2010).
    • (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 2023-2027
    • Dirksen, A.1    Yegneswaran, S.2    Dawson, P.E.3
  • 27
    • 65349106518 scopus 로고    scopus 로고
    • Constitutional dynamic systems of ionic and molecular liquids
    • Soutullo, M. D., O'Brien, R. A., Gaines, K. E. & Davis, Jr J. H. Constitutional dynamic systems of ionic and molecular liquids. Chem. Commun. 2529-2531 (2009).
    • (2009) Chem. Commun. , pp. 2529-2531
    • Soutullo, M.D.1    O'Brien, R.A.2    Gaines, K.E.3    Davis, J.H.4
  • 28
    • 70350712183 scopus 로고    scopus 로고
    • Hemiacetals in dynamic covalent chemistry: Formation, exchange, selection and modulation processes
    • Drahonovsky, D. & Lehn, J.-M. Hemiacetals in dynamic covalent chemistry: formation, exchange, selection and modulation processes. J. Org. Chem. 74, 8428-8432 (2009).
    • (2009) J. Org. Chem. , vol.74 , pp. 8428-8432
    • Drahonovsky, D.1    Lehn, J.-M.2
  • 29
    • 74549200492 scopus 로고    scopus 로고
    • Direct STD NMR identification of b-galactosidase inhibitors from a virtual dynamic hemithioacetal system
    • Caraballo, R., Dong, H., Ribeiro, J. P., Jimenez-Barbero, J. & Ramstrom, O. Direct STD NMR identification of b-galactosidase inhibitors from a virtual dynamic hemithioacetal system. Angew. Chem. Int. Ed. 49, 589-593 (2010).
    • (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 589-593
    • Caraballo, R.1    Dong, H.2    Ribeiro, J.P.3    Jimenez-Barbero, J.4    Ramstrom, O.5
  • 30
    • 25844440059 scopus 로고    scopus 로고
    • Metathesis reaction of formaldehyde acetals: An easy entry into the dynamic covalent chemistry of cyclophane formation
    • Cacciapaglia, R., Di Stefano, S. & Mandolini, L. Metathesis reaction of formaldehyde acetals: an easy entry into the dynamic covalent chemistry of cyclophane formation. J. Am. Chem. Soc. 127, 13666-13671 (2005).
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 13666-13671
    • Cacciapaglia, R.1    Di Stefano, S.2    Mandolini, L.3
  • 31
    • 41149127182 scopus 로고    scopus 로고
    • Facile acetal dynamic combinatorial library
    • Berkovich-Berger, D. & Lemcoff, N. G. Facile acetal dynamic combinatorial library. Chem. Commun. 1686-1688 (2008).
    • (2008) Chem. Commun. , pp. 1686-1688
    • Berkovich-Berger, D.1    Lemcoff, N.G.2
  • 32
    • 4544244707 scopus 로고    scopus 로고
    • Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library
    • Larsson, R., Pei, Z. & Ramstrom, O. Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library. Angew. Chem. Int. Ed. 43, 3716-3718 (2004).
    • (2004) Angew. Chem. Int. Ed. , vol.43 , pp. 3716-3718
    • Larsson, R.1    Pei, Z.2    Ramstrom, O.3
  • 33
    • 14644411748 scopus 로고    scopus 로고
    • Reversible Michael addition of thiols as a new tool for dynamic combinatorial chemistry
    • Shi, B. & Greaney, M. F. Reversible Michael addition of thiols as a new tool for dynamic combinatorial chemistry. Chem. Commun. 886-888 (2005).
    • (2005) Chem. Commun. , pp. 886-888
    • Shi, B.1    Greaney, M.F.2
  • 35
    • 1842611389 scopus 로고    scopus 로고
    • Trypsin specificity as elucidated by LIE calculations X-ray structures and association constant measurements
    • Schroder Leiros, H.-H. et al. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Sci. 13, 1056-1070 (2004).
    • (2004) Protein Sci. , vol.13 , pp. 1056-1070
    • Schroder Leiros, H.-H.1
  • 36
    • 0034654216 scopus 로고    scopus 로고
    • Proline-catalyzed direct asymmetric aldol reactions
    • List, B., Lerner, R. A. & Barbas, III C. F. Proline-catalyzed direct asymmetric aldol reactions. J. Am. Chem. Soc. 122, 2395-2396 (2000).
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 2395-2396
    • List, B.1    Lerner, R.A.2    Barbas, C.F.3
  • 37
    • 84872841710 scopus 로고    scopus 로고
    • Organocatalysis of C'N/C'N and C'C/C'N exchange in dynamic covalent chemistry
    • Wilhelms, N., Kuchat, S. & Lehn, J.-M. Organocatalysis of C'N/C'N and C'C/C'N exchange in dynamic covalent chemistry. Helv. Chim. Acta 95, 2635-2651 (2012).
    • (2012) Helv. Chim. Acta , vol.95 , pp. 2635-2651
    • Wilhelms, N.1    Kuchat, S.2    Lehn, J.-M.3
  • 38
    • 33745697764 scopus 로고    scopus 로고
    • Catalyst-free conjugate addition of thiols to a, b-unsaturated carbonyl compounds in water
    • Khatik, G. L., Kumar, R. & Chakraborti, A. K. Catalyst-free conjugate addition of thiols to a, b-unsaturated carbonyl compounds in water. Org. Lett. 8, 2433-2436 (2006).
    • (2006) Org. Lett. , vol.8 , pp. 2433-2436
    • Khatik, G.L.1    Kumar, R.2    Chakraborti, A.K.3


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