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Volumn 21, Issue 3-4, 2015, Pages 767-781

Effects of a ceramic biomaterial on immune modulatory properties and differentiation potential of human mesenchymal stromal cells of different origin

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CHEMICAL ACTIVATION; FLOWCHARTING; HYDROXYAPATITE; MACHINERY; SCAFFOLDS (BIOLOGY); T-CELLS;

EID: 84923273831     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2014.0269     Document Type: Article
Times cited : (19)

References (57)
  • 1
    • 82155192237 scopus 로고    scopus 로고
    • Regulation of bone by the adaptive immune system in arthritis
    • Okamoto, K., and Takayanagi, H. Regulation of bone by the adaptive immune system in arthritis. Arthritis Res Ther 13, 219, 2011.
    • (2011) Arthritis Res Ther , vol.13 , pp. 219
    • Okamoto, K.1    Takayanagi, H.2
  • 2
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology Shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi, H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7, 292, 2007.
    • (2007) Nat Rev Immunol , vol.7 , pp. 292
    • Takayanagi, H.1
  • 4
    • 84857920401 scopus 로고    scopus 로고
    • Fracture healing under healthy and inflammatory conditions
    • Claes, L., Recknagel, S., and Ignatius, A. Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol 8, 133, 2012.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 133
    • Claes, L.1    Recknagel, S.2    Ignatius, A.3
  • 5
    • 24344446369 scopus 로고    scopus 로고
    • Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures
    • Audigé, L., Griffin, D., Bhandari, M., Kellam, J., and Rüedi, T.P. Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures. Clin Orthop Relat Res 438, 221, 2005.
    • (2005) Clin Orthop Relat Res , vol.438 , pp. 221
    • Audigé, L.1    Griffin, D.2    Bhandari, M.3    Kellam, J.4    Rüedi, T.P.5
  • 6
    • 79957652421 scopus 로고    scopus 로고
    • Bone regeneration: Current concepts and future directions
    • Dimitriou, R., Jones, E., McGonagle, D., and Giannoudis P.V. Bone regeneration: current concepts and future directions. BMC Med 9, 66, 2011.
    • (2011) BMC Med , vol.9 , pp. 66
    • Dimitriou, R.1    Jones, E.2    McGonagle, D.3    Giannoudis, P.V.4
  • 7
    • 73949155457 scopus 로고    scopus 로고
    • Revision with dynamic compression plate and cancellous bone graft for aseptic nonunion after surgical treatment of humeral shaft fracture
    • Lin, C.-L., Fang, C.-K., Chiu, F.-Y., Chen, C.-M., and Chen, T.-H. Revision with dynamic compression plate and cancellous bone graft for aseptic nonunion after surgical treatment of humeral shaft fracture. J Trauma 67, 1393, 2009.
    • (2009) J Trauma , vol.67 , pp. 1393
    • Lin, C.-L.1    Fang, C.-K.2    Chiu, F.-Y.3    Chen, C.-M.4    Chen, T.-H.5
  • 8
    • 0024832051 scopus 로고
    • Harvesting autogenous iliac bone grafts a review of complications and techniques
    • Kurz, L.T., Garfin, S.R., and Booth, R.E. Harvesting autogenous iliac bone grafts. A review of complications and techniques. Spine 14, 1324, 1989.
    • (1989) Spine , vol.14 , pp. 1324
    • Kurz, L.T.1    Garfin, S.R.2    Booth, R.E.3
  • 9
    • 83455206893 scopus 로고    scopus 로고
    • Autogenous bone graft: Donor sites and techniques
    • Myeroff, C., and Archdeacon, M. Autogenous bone graft: donor sites and techniques. J Bone Joint Surg Am 93, 2227, 2011.
    • (2011) J Bone Joint Surg Am , vol.93 , pp. 2227
    • Myeroff, C.1    Archdeacon, M.2
  • 10
    • 75049084827 scopus 로고    scopus 로고
    • Cell-free and cell-based approaches for bone regeneration
    • Bueno, E.M., and Glowacki, J. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol 5, 685, 2009.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 685
    • Bueno, E.M.1    Glowacki, J.2
  • 13
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli, A., Moretta, L., and Pistoia, V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 8, 726, 2008.
    • (2008) Nat Rev Immunol , vol.8 , pp. 726
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 15
    • 77954529350 scopus 로고    scopus 로고
    • Osteogenic differentiation and immune response of human bone-marrow-derived mesenchymal stem cells on injectable calcium-silicate-based bone grafts
    • Ding, S.J., Shie, M.Y., Hoshiba, T., Kawazoe, N., Chen, G., and Chang, H.C. Osteogenic differentiation and immune response of human bone-marrow-derived mesenchymal stem cells on injectable calcium-silicate-based bone grafts. Tissue Eng Part A 16, 2343, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 2343
    • Ding, S.J.1    Shie, M.Y.2    Hoshiba, T.3    Kawazoe, N.4    Chen, G.5    Chang, H.C.6
  • 16
    • 33846078448 scopus 로고    scopus 로고
    • Immunogenicity and immune modulation of osteogenic differentiated mesenchymal stem cells from banna minipig inbred line
    • Wang, L., Lu, X.F., Lu, Y.R., Liu, J., Gao, K., Zeng, Y.Z., Li, S.F., Li, Y.P., Cheng, J.Q., Tan, W.D., and Wan, L. Immunogenicity and immune modulation of osteogenic differentiated mesenchymal stem cells from Banna minipig inbred line. Transplant Proc 38, 2267, 2006.
    • (2006) Transplant Proc , vol.38 , pp. 2267
    • Wang, L.1    Lu, X.F.2    Lu, Y.R.3    Liu, J.4    Gao, K.5    Zeng, Y.Z.6    Li, S.F.7    Li, Y.P.8    Cheng, J.Q.9    Tan, W.D.10    Wan, L.11
  • 17
    • 0141484485 scopus 로고    scopus 로고
    • Hla expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
    • Le Blanc, K., Tammik, C., Rosendahl, K., Zetterberg, E., and Ringden, O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 31, 890, 2003.
    • (2003) Exp Hematol , vol.31 , pp. 890
    • Le Blanc, K.1    Tammik, C.2    Rosendahl, K.3    Zetterberg, E.4    Ringden, O.5
  • 20
    • 84863338204 scopus 로고    scopus 로고
    • Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: A randomized controlled trial
    • Tan, J., Wu, W., Xu, X., Liao, L., Zheng, F., Messinger, S., Sun, X., Chen, J., Yang, S., Cai, J., Gao, X., Pileggi, A., and Ricordi, C. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA 307, 1169, 2012.
    • (2012) JAMA , vol.307 , pp. 1169
    • Tan, J.1    Wu, W.2    Xu, X.3    Liao, L.4    Zheng, F.5    Messinger, S.6    Sun, X.7    Chen, J.8    Yang, S.9    Cai, J.10    Gao, X.11    Pileggi, A.12    Ricordi, C.13
  • 21
    • 84862864636 scopus 로고    scopus 로고
    • Replenishing cartilage from endogenous stem cells
    • Marini, J.C., and Forlino, A. Replenishing cartilage from endogenous stem cells. N Engl J Med 366, 2522, 2012.
    • (2012) N Engl J Med , vol.366 , pp. 2522
    • Marini, J.C.1    Forlino, A.2
  • 23
    • 43649097427 scopus 로고    scopus 로고
    • Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels
    • Xu, J., Wang, W., Ludeman, M., Cheng, K., Hayami, T., Lotz, J.C., and Kapila, S. Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels. Tissue Eng Part A 14, 667, 2008.
    • (2008) Tissue Eng Part A , vol.14 , pp. 667
    • Xu, J.1    Wang, W.2    Ludeman, M.3    Cheng, K.4    Hayami, T.5    Lotz, J.C.6    Kapila, S.7
  • 25
    • 84868625266 scopus 로고    scopus 로고
    • Immunological evaluation of polystyrene and poly(ether imide) cell culture inserts with different roughness
    • Roch, T., Krüger, A., Kratz, K., Ma, N., Jung, F., and Lendlein, A. Immunological evaluation of polystyrene and poly(ether imide) cell culture inserts with different roughness. Clin Hemorheol Microcirc 52, 375, 2012.
    • (2012) Clin Hemorheol Microcirc , vol.52 , pp. 375
    • Roch, T.1    Krüger, A.2    Kratz, K.3    Ma, N.4    Jung, F.5    Lendlein, A.6
  • 27
    • 84881092225 scopus 로고    scopus 로고
    • Immunological characterization of multipotent mesenchymal stromal cells-The international society for cellular therapy (isct) working proposal
    • Krampera, M., Galipeau, J., Shi, Y., Tarte, T., and Sensebe, L. Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy 15, 1054, 2013.
    • (2013) Cytotherapy , vol.15 , pp. 1054
    • Krampera, M.1    Galipeau, J.2    Shi, Y.3    Tarte, T.4    Sensebe, L.5
  • 28
    • 84860636948 scopus 로고    scopus 로고
    • Mesenchymalstem-cell-induced immunoregulation involves fas-ligand-/ fas-mediated t cell apoptosis
    • Akiyama, K., Chen, C., Wang, D., Xu, X., Qu, C., Yamaza, T., Cai, T., Chen, W., Sun, L., and Shi, S. Mesenchymalstem-cell-induced immunoregulation involves FAS-ligand-/ FAS-mediated T cell apoptosis. Cell Stem Cell 10, 544, 2012.
    • (2012) Cell Stem Cell , vol.10 , pp. 544
    • Akiyama, K.1    Chen, C.2    Wang, D.3    Xu, X.4    Qu, C.5    Yamaza, T.6    Cai, T.7    Chen, W.8    Sun, L.9    Shi, S.10
  • 30
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress t-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P.D., Matteucci, P., Grisanti, S., and Gianni, A.M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99, 3838, 2002.
    • (2002) Blood , vol.99 , pp. 3838
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 32
    • 84859745736 scopus 로고    scopus 로고
    • Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: Production process, content and identification of active components
    • Fekete, N., Gadelorge, M., Furst, D., Maurer, C., Dausend, J., Fleury-Cappellesso, S., Mailander, V., Lotfi, R., Ignatius, A., Sensebe, L., Bourin, P., Schrezenmeier, H., and Rojewski, M.T. Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components. Cytotherapy 14, 540, 2012.
    • (2012) Cytotherapy , vol.14 , pp. 540
    • Fekete, N.1    Gadelorge, M.2    Furst, D.3    Maurer, C.4    Dausend, J.5    Fleury-Cappellesso, S.6    Mailander, V.7    Lotfi, R.8    Ignatius, A.9    Sensebe, L.10    Bourin, P.11    Schrezenmeier, H.12    Rojewski, M.T.13
  • 35
    • 77649252163 scopus 로고    scopus 로고
    • Regenerative medicine special feature: Human stem cell delivery for treatment of large segmental bone defects
    • Dupont, K.M., Sharma, K., Stevens, H.Y., Boerckel, J.D., Garcia, A.J., and Guldberg, R.E. Regenerative medicine special feature: human stem cell delivery for treatment of large segmental bone defects. PNAS 107, 3305, 2010.
    • (2010) PNAS , vol.107 , pp. 3305
    • Dupont, K.M.1    Sharma, K.2    Stevens, H.Y.3    Boerckel, J.D.4    Garcia, A.J.5    Guldberg, R.E.6
  • 37
    • 67349118913 scopus 로고    scopus 로고
    • The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles
    • Atkins, G.J., Welldon, K.J., Holding, C.A., Haynes, D.R., Howie, D.W., and Findlay, D.M. The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles. Biomaterials 30, 3672, 2009.
    • (2009) Biomaterials , vol.30 , pp. 3672
    • Atkins, G.J.1    Welldon, K.J.2    Holding, C.A.3    Haynes, D.R.4    Howie, D.W.5    Findlay, D.M.6
  • 38
    • 79952187770 scopus 로고    scopus 로고
    • Behaviour of mesenchymal stem cells, fibroblasts and osteoblasts on smooth surfaces
    • Lavenus, S., Pilet, P., Guicheux, J., Weiss, P., Louarn, G., and Layrolle, P. Behaviour of mesenchymal stem cells, fibroblasts and osteoblasts on smooth surfaces. Acta Biomater 30, 1525, 2011.
    • (2011) Acta Biomater , vol.30 , pp. 1525
    • Lavenus, S.1    Pilet, P.2    Guicheux, J.3    Weiss, P.4    Louarn, G.5    Layrolle, P.6
  • 39
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern, S., Eichler, H., Stoeve, J., Klüter, H., and Bieback, K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24, 1294, 2006.
    • (2006) Stem Cells , vol.24 , pp. 1294
    • Kern, S.1    Eichler, H.2    Stoeve, J.3    Klüter, H.4    Bieback, K.5
  • 40
    • 84855918446 scopus 로고    scopus 로고
    • The potential of human fetal mesenchymal stem cells for off-The-shelf bone tissue engineering application
    • Zhang, Z.-Y., Teoh, S.-H., Hui, J.H.P., Fisk, N.M., Choolani, M., and Chan, J.K.Y. The potential of human fetal mesenchymal stem cells for off-The-shelf bone tissue engineering application. Biomaterials 33, 2656, 2012.
    • (2012) Biomaterials , vol.33 , pp. 2656
    • Zhang, Z.-Y.1    Teoh, S.-H.2    Hui, J.H.P.3    Fisk, N.M.4    Choolani, M.5    Chan, J.K.Y.6
  • 41
    • 84873730138 scopus 로고    scopus 로고
    • Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential
    • Al-Nbaheen, M., Vishnubalaji, R., Ali, D., Bouslimi, A., Al-Jassir, F., Megges, M., Prigione, A., Adjaye, J., Kassem, M., and Aldahmash, A. Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential. Stem Cell Rev 9, 32, 2013.
    • (2013) Stem Cell Rev , vol.9 , pp. 32
    • Al-Nbaheen, M.1    Vishnubalaji, R.2    Ali, D.3    Bouslimi, A.4    Al-Jassir, F.5    Megges, M.6    Prigione, A.7    Adjaye, J.8    Kassem, M.9    Aldahmash, A.10
  • 42
    • 78549268107 scopus 로고    scopus 로고
    • Electroporation-mediated transfer of runx2 and osterix genes to enhance osteogenesis of adipose stem cells
    • Lee, J.-S., Lee, J.-M., and Im, G.-I. Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells. Biomaterials 32, 760, 2011.
    • (2011) Biomaterials , vol.32 , pp. 760
    • Lee, J.-S.1    Lee, J.-M.2    Im, G.-I.3
  • 43
    • 84861702531 scopus 로고    scopus 로고
    • Local injections of adipose-derived mesenchymal stem cells modulate inflammation and increase angiogenesis ameliorating the dystrophic phenotype in dystrophin-deficient skeletal muscle
    • Pinheiro, C.H., de Queiroz, J.C., Guimaraes-Ferreira, L., Vitzel, K.F., Nachbar, R.T., de Sousa, L.G., de Souza-Jr, A.L., Nunes, M.T., and Curi, R. Local injections of adipose-derived mesenchymal stem cells modulate inflammation and increase angiogenesis ameliorating the dystrophic phenotype in dystrophin-deficient skeletal muscle. Stem Cell Rev 8, 363, 2012.
    • (2012) Stem Cell Rev , vol.8 , pp. 363
    • Pinheiro, C.H.1    De Queiroz, J.C.2    Guimaraes-Ferreira, L.3    Vitzel, K.F.4    Nachbar, R.T.5    De Sousa, L.G.6    De Souza-Jr., A.L.7    Nunes, M.T.8    Curi, R.9
  • 44
    • 11144350098 scopus 로고    scopus 로고
    • A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation
    • Arinzeh, T.L., Tran, T., Mcalary, J., and Daculsi, G. A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation. Biomaterials 26, 3631, 2005.
    • (2005) Biomaterials , vol.26 , pp. 3631
    • Arinzeh, T.L.1    Tran, T.2    McAlary, J.3    Daculsi, G.4
  • 46
    • 78049322005 scopus 로고    scopus 로고
    • Mandibular segmental defect regenerated with macroporous biphasic calcium phosphate, collagen membrane, and bone marrow graft in dogs
    • Jégoux, F., Goyenvalle, E., Cognet, R., Malard, O., Moreau, F., Daculsi, G., and Aguado, E. Mandibular segmental defect regenerated with macroporous biphasic calcium phosphate, collagen membrane, and bone marrow graft in dogs. Arch Otolaryngol Head Neck Surg 136, 971, 2010.
    • (2010) Arch Otolaryngol Head Neck Surg , vol.136 , pp. 971
    • Jégoux, F.1    Goyenvalle, E.2    Cognet, R.3    Malard, O.4    Moreau, F.5    Daculsi, G.6    Aguado, E.7
  • 47
    • 84875829954 scopus 로고    scopus 로고
    • Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors
    • Eyckmans, J., Roberts, S.J., Bolander, J., Schrooten, J., Chen, C.S., and Luyten, F.P. Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors. Biomaterials 34, 4612, 2013.
    • (2013) Biomaterials , vol.34 , pp. 4612
    • Eyckmans, J.1    Roberts, S.J.2    Bolander, J.3    Schrooten, J.4    Chen, C.S.5    Luyten, F.P.6
  • 50
    • 84874223600 scopus 로고    scopus 로고
    • Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of t cells for human b cell maturation
    • Lang, J., Kelly, M., Freed, B.M., McCarter, M.D., Kedl, R.M., Torres, R.M., and Pelanda, R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol 190, 2090, 2013.
    • (2013) J Immunol , vol.190 , pp. 2090
    • Lang, J.1    Kelly, M.2    Freed, B.M.3    McCarter, M.D.4    Kedl, R.M.5    Torres, R.M.6    Pelanda, R.7
  • 51
    • 0024404270 scopus 로고
    • Human osteoblast-like cells expressing mhc class ii determinants stimulate allogeneic and autologous peripheral blood mononuclear cells and function as antigen-presenting cells
    • Skjødt, H., Møller, T., and Freiesleben, S.F. Human osteoblast-like cells expressing MHC class II determinants stimulate allogeneic and autologous peripheral blood mononuclear cells and function as antigen-presenting cells. Immunology 68, 416, 1989.
    • (1989) Immunology , vol.68 , pp. 416
    • Skjødt, H.1    Møller, T.2    Freiesleben, S.F.3
  • 53
    • 84873130447 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of accelerated fracture healing by cox2 gene therapy: Studies in a mouse model of multiple fractures
    • Lau, K.H., Kothari, V., Das, A., Zhang, X.B., and Baylink, D.J. Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy: studies in a mouse model of multiple fractures. Bone 53, 369, 2013.
    • (2013) Bone , vol.53 , pp. 369
    • Lau, K.H.1    Kothari, V.2    Das, A.3    Zhang, X.B.4    Baylink, D.J.5
  • 54
    • 27744543102 scopus 로고    scopus 로고
    • Inflammatory cells during wound repair: The good, the bad and the ugly
    • Martin, P., and Leibovich, S.J. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 15, 599, 2005.
    • (2005) Trends Cell Biol , vol.15 , pp. 599
    • Martin, P.1    Leibovich, S.J.2
  • 55
    • 80053141199 scopus 로고    scopus 로고
    • Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells
    • Huang, H., Zhao, N., Xu, X., Xu, Y., Li, S., Zhang, J., and Yang, P. Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells. Cell Prolif 44, 420, 2011.
    • (2011) Cell Prolif , vol.44 , pp. 420
    • Huang, H.1    Zhao, N.2    Xu, X.3    Xu, Y.4    Li, S.5    Zhang, J.6    Yang, P.7
  • 56
    • 84855517156 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based tissue regeneration is governed by recipient t lymphocytes via ifn-g and tnf-A
    • Liu, Y., Wang, L., Kikuiri, T., Akiyama, K., Chen, C., Xu, X., Yang, R., Chen, W., Wang, S., and Shi, S. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-g and TNF-A. Nat Med 17, 1594, 2011.
    • (2011) Nat Med , vol.17 , pp. 1594
    • Liu, Y.1    Wang, L.2    Kikuiri, T.3    Akiyama, K.4    Chen, C.5    Xu, X.6    Yang, R.7    Chen, W.8    Wang, S.9    Shi, S.10
  • 57


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.