Immunologic properties of human fetal mesenchymal stem cells

American Journal of Obstetrics and Gynecology

Volumn 190, Issue 1, 2004, Pages 239-245

  Götherström, Cecilia ^a   Ringdén, Olle ^a   Tammik, Charlotte ^a   Zetterberg, Eva ^a   Westgren, Magnus ^a   Le Blanc, Katarina ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Fetal stem cells; HLA expression; Intrauterine transplantation; Mixed lymphocyte cultures; Stromal cells

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2;

ADIPOCYTE; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURFACE; CONTROLLED STUDY; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HLA SYSTEM; IMMUNOREACTIVITY; MESENCHYME CELL; MIXED LYMPHOCYTE CULTURE; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL;

EID: 0742304267     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2003.07.022     Document Type: Article

References (23)

1. Campagnoli C, Roberts IA, Kumar S, Bennett PR, Bellantuono I, Fisk NM. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001;98:2396-402.
2. Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000;109:235-42.
3. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone 1992;13:81-8.
4. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
5. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-4.
6. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992;13:69-80.
7. Hobbs JR. Bone marrow transplantation for inborn errors. Lancet 1981;2:735-9.
8. Krivit W, Shapiro EG, Lockman LA, et al. Bone marrow transplantation: treatment for globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystophy and Hurler syndrome, In: Moser HW, Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology. Vol 22. Amsterdam: Elsevier; 1996.
9. Ringdén O, Groth CG, Erikson A, Granqvist S, Mansson JE, Sparrelid E. Ten years' experience of bone marrow transplantation for Gaucher disease. Transplantation 1995;59:864-70.
10. Westgren M, Ringden O, Bartmann P, Bui TH, Lindton B, Mattsson J, et al. Prenatal T-cell reconstitution after in utero transplantation with fetal liver cells in a patient with X-linked severe combined immunodeficiency. Am J Obstet Gynecol 2002; 187:475-82.
11. Renda MC, Fecarotta E, Dieli F, Markling L, Westgren M, Damiani G, et al. Evidence of alloreactive T lymphocytes in fetal liver: implications for fetal hematopoietic stem cell transplantation. Bone Marrow Transplant 2000;25:135-41.
12. Lindton B, Markling L, Ringdén O, Kjaeldgaard A, Gustafson O, Westgren M. Mixed lymphocyte culture of human fetal liver cells. Fetal Diagn Ther 2000;15:71-8.
13. Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003;57: 11-20.
14. Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002;30:42-8.
15. Devine SM, Bartholomew AM, Mahmud N, Nelson M, Patil S, Hardy W, et al. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp Hematol 2001;29:244-55.
16. Westgren M, Ek S, Bui TH, Hagenfeldt L, Markling L, Pschera H, et al. Establishment of a tissue bank for fetal stem cell transplantation. Acta Obstet Gynecol Scand 1994;73:385-8.
17. Götherström C, Rìngdén O, Westgren M, Tammik C, Le Blanc K. Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells. Bone Marrow Transplant 2003;32:265-72.
18. Mackenzie TC, Campagnoli C, Almeida-Porada G, Radu A, Fisk N, Flake AW. Circulating human fetal stromal cells engraft and differentiate in multiple tissues following transplantation into preimmune lamb fetuses. Blood 2001;98:3319a.
19. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002;99:3838-43.
20. Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003;101:3722-9.
21. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003; 101:2999-3001.
22. Koc ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 2002;30:215-22.
23. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A 2002;99:8932-7.