Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model

Nature Communications

Volumn 5, Issue , 2014, Pages

  Delekate, Andrea ^a   Füchtemeier, Martina ^a,b   Schumacher, Toni ^a   Ulbrich, Cordula ^a   Foddis, Marco ^b   Petzold, Gabor C ^a,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM; GAP JUNCTION PROTEIN; NUCLEOTIDE; PURINERGIC P2 RECEPTOR; PURINERGIC P2X RECEPTOR; PURINERGIC P2Y1 RECEPTOR; ADENOSINE TRIPHOSPHATE; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; P2RY1 PROTEIN, MOUSE;

BRAIN; CALCIUM; INHIBITION; NERVOUS SYSTEM DISORDER; RODENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN BLOOD FLOW; BRAIN CORTEX; CALCIUM SIGNALING; CONTROLLED STUDY; GROWTH INHIBITION; HYPERACTIVITY; IN VIVO STUDY; MOUSE; NERVE CELL NETWORK; NEUROTRANSMISSION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; AMYLOID PLAQUE; ANIMAL; BRAIN CIRCULATION; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; MULTIPHOTON MICROSCOPY; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; CALCIUM SIGNALING; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PLAQUE, AMYLOID; RECEPTORS, PURINERGIC P2Y1; SIGNAL TRANSDUCTION;

EID: 84923273155     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6422     Document Type: Article

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