DNA methylation profile and expression of surfactant protein A2 gene in lung cancer

Experimental Lung Research

Volumn 41, Issue 2, 2015, Pages 93-102

  Grageda, Melissa ^a,b   Silveyra, Patricia ^a   Thomas, Neal J ^a   Diangelo, Susan L ^a   Floros, Joanna ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b RICHMOND UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenocarcinoma; Methylation; SP A; Squamous cell carcinoma

Indexed keywords

BIOLOGICAL MARKER; BISULFITE; CCAAT ENHANCER BINDING PROTEIN BETA; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; RETINOID X RECEPTOR ALPHA; SERUM RESPONSE FACTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; SURFACTANT PROTEIN A; SURFACTANT PROTEIN A1; SURFACTANT PROTEIN A2; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR PEA3; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; SFTPA2 PROTEIN, HUMAN; TRANSCRIPTOME; TUMOR MARKER;

ARTICLE; CANCER DIAGNOSIS; CANCER TISSUE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG PARENCHYMA; PILOT STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SQUAMOUS CELL LUNG CARCINOMA; ADENOCARCINOMA; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; BASE SEQUENCE; BIOMARKERS, TUMOR; CARCINOMA, SQUAMOUS CELL; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; PILOT PROJECTS; PROMOTER REGIONS, GENETIC; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; RNA, MESSENGER; TRANSCRIPTOME;

EID: 84923271015     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2014.976298     Document Type: Article

References (61)

1. Silveyra P, Floros J: Air pollution and epigenetics: effects on SP-A and innate host defence in the lung. Swiss Med Wkly. 2012; 142: w13579. PubMed PMID: 22553125. eng.
2. Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E: Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol. 2013; 26 (4): 465-484. PubMed PMID: 23307060. PMCID: PMC3637979. eng.
3. Liu Y, Li H, Xiao T, Lu Q: Epigenetics in immunemediated pulmonary diseases. Clin Rev Allergy Immunol. 2013; 45 (3): 314-330. PubMed PMID: 24242359. eng.
4. Herceg Z, Vaissière T: Epigenetic mechanisms and cancer: an interface between the environment and the genome. Epigenetics. 2011; 6 (7): 804-819. PubMed PMID: 21758002. eng.
5. Song J, Teplova M, Ishibe-Murakami S, Patel DJ: Structurebased mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science. 2012; 335 (6069): 709-712. PubMed PMID: 22323818. eng.
6. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.Nature. 2002; 416 (6880): 552-556. PubMed PMID: 11932749. eng.
7. Jakopovic M, Thomas A, Balasubramaniam S, Schrump D, Giaccone G, Bates SE: Targeting the Epigenome in Lung Cancer: Expanding Approaches to Epigenetic Therapy. Front Oncol. 2013; 3: 261. PubMed PMID: 24130964. PMCID: PMC3793201. eng.
8. Vaid M, Floros J: Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review). Oncol Rep. 2009; 21 (1): 3-11. PubMed PMID: 19082436. PMCID: PMC2899699. eng.
9. Risch A, Plass C: Lung cancer epigenetics and genetics. Int J Cancer. 2008; 123 (1): 1-7. PubMed PMID: 18425819. eng.
10. Chen C, Yin N, Yin B, Lu Q: DNA methylation in thoracic neoplasms. Cancer Lett. 2011; 301 (1): 7-16. PubMed PMID: 21087818. eng.
11. Pogribny IP, Beland FA: DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci. 2009; 66 (14): 2249-2261. PubMed PMID: 19326048. eng.
12. Ferguson LR, Tatham AL, Lin Z, Denny WA: Epigenetic regulation of gene expression as an anticancer drug target. Curr Cancer Drug Targets. 2011; 11 (2): 199-212. PubMed PMID: 21158714. eng.
13. Carvalho RH, Hou J, Haberle V, Aerts J, Grosveld F, Lenhard B, Philipsen SP: Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas. J Thorac Oncol. 2013; 8 (5): 562-573. PubMed PMID: 23524404. eng.
14. Nikolaidis G, Raji OY, Markopoulou S, Gosney JR, Bryan J, Warburton C, Walshaw M, Sheard J, Field JK, Liloglou T: DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. Cancer Res. 2012; 72 (22): 5692-5701. PubMed PMID: 22962272. PMCID: PMC3500566. eng.
15. Suzuki M, Yoshino I: Aberrant methylation in non-small cell lung cancer. SurgToday. 2010; 40 (7): 602-607. PubMed PMID: 20582509. eng.
16. Bayarsaihan D: Epigenetic mechanisms in inflammation. J Dent Res. 2011; 90 (1): 9-17. PubMed PMID: 21178119. PMCID: PMC3144097. eng.
17. Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC: bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993; 82 (6): 1820-1828. PubMed PMID: 8104532. eng.
18. Medvedeva YA, Khamis AM, Kulakovskiy IV, Ba-Alawi W, Bhuyan MS, Kawaji H, Lassmann T, Harbers M, Forrest AR, Bajic VB: Effects of cytosine methylation on transcription factor binding sites. BMC Genomics. 2014; 15: 119. PubMed PMID: 24669864. PMCID: PMC3986887. eng.
19. Lin Z, Thomas NJ, Bibikova M, Seifart C, Wang Y, Guo X, Wang G, Vollmer E, Goldmann T, Garcia EW, Zhou L, Fan JB, Floros J: DNA methylation markers of surfactant proteins in lung cancer. Int J Oncol. 2007; 31 (1): 181-191. PubMed PMID: 17549420. eng.
20. Floros J, Wang G, Mikerov AN: Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SPA1) and SP-A2-impact on function. Crit Rev Eukaryot Gene Expr. 2009; 19 (2): 125-137. PubMed PMID: 19392648. PMCID: PMC2967201. eng.
21. Phelps DS: Surfactant regulation of host defense function in the lung: a question of balance. Pediatr Pathol Mol Med. 2001; 20 (4): 269-292. PubMed PMID: 11486734. eng.
22. Wright JR: Immunoregulatory functions of surfactant proteins. Nat Rev Immunol. 2005; 5 (1): 58-68. PubMed PMID: 15630429. Epub 2005/01/05. eng.
23. Wang J, Reid K: The immunoregulatory roles of lung surfactant collectins SP-A, and SP-D, in allergen-induced airway inflammation. Immunobiology. 2007; 212 (4-5): 417-425. PubMed PMID: 17544824. eng.
24. Williams MC, Hawgood S, Hamilton RL: Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C. Am J Respir Cell Mol Biol. 1991; 5 (1): 41-50. PubMed PMID: 1878252. eng.
25. Condon J, Jeyasuria P, Faust J, Mendelson CR: Surfactant protein secreted by thematuringmouse fetal lung acts as a hormone that signals the initiation of parturition. Proc Natl Acad Sci U S A. 2004; 101 (14): 4978-4983.
26. Wang G, Guo X, Diangelo S, Thomas N, Floros J: Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: Formation of tubularmyelin in vivo requires both gene products. J Biol Chem. 2010. PubMed PMID: 20048345. eng.
27. Wang G, Myers C, Mikerov A, Floros J: Effect of cysteine 85 on biochemical properties and biological function of human surfactant protein A variants. Biochemistry. 2007; 46 (28): 8425-8435. PubMed PMID: 17580966. PMCID: PMC2531219. eng.
28. Floros J, Wang G, Lin Z: Genetic diversity of human SP-A, a molecule with innate host defense and surfactant-related functions; characteristics, primary function, and significance. Curr. Pharmacogenomics. 2005; 3: 87-95.
29. Mikerov A, Wang G, Umstead T, Zacharatos M, Thomas N, Phelps D, Floros J: Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. Infect Immun. 2007; 75 (3): 1403-1412. PubMed PMID: 17220308. PMCID: PMC1828577. eng.
30. Mikerov A, Umstead T, Gan X, Huang W, Guo X, Wang G, Phelps D, Floros J: Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants. Am J Physiol Lung Cell Mol Physiol. 2008; 294 (1): L121-L130. PubMed PMID: 17981957. eng.
31. Anglim PP, Alonzo TA, Laird-Offringa IA: DNA methylationbased biomarkers for early detection of non-small cell lung cancer: an update. Mol Cancer. 2008; 7: 81. PubMed PMID: 18947422. PMCID: PMC2585582. eng.
32. Haroun RA, Zakhary NI, Mohamed MR, Abdelrahman AM, Kandil EI, Shalaby KA: Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p16 in non-small cell lung cancer in Egyptian patients. Asian Pac J Cancer Prev. 2014; 15 (10): 4281-4287. PubMed PMID: 24935385. eng.
33. Topaloglu O, Hoque MO, Tokumaru Y, Lee J, Ratovitski E, Sidransky D, Moon CS: Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin Cancer Res. 2004; 10 (7): 2284-2288. PubMed PMID: 15073103. eng.
34. Laird PW: Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet. 2010; 11 (3): 191-203. PubMed PMID: 20125086. eng.
35. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods. 2001; 25 (4): 402-408. PubMed PMID: 11846609. eng.
36. Matys V, Fricke E, Geffers R, Gössling E, Haubrock M, Hehl R, Hornischer K, Karas D, Kel AE, Kel-Margoulis OV, Kloos DU, Land S, Lewicki-Potapov B, Michael H, Münch R, Reuter I, Rotert S, Saxel H, Scheer M, Thiele S, Wingender E: TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res. 2003; 31 (1): 374-3-78. PubMed PMID: 12520026. PMCID: PMC165555. eng.
37. Rivera MP: Lung cancer in women: differences in epidemiology, biology, histology, and treatment outcomes. Semin Respir Crit Care Med. 2013; 34 (6): 792-801. PubMed PMID: 24258569. eng.
38. Floros J, Thomas N: Genetic variations of surfactant proteins and lung injury. In: Nakos G, Papathanasiou A, eds. Surfactant Pathogenesis and Treatment of Lung Diasease. India: Research Signpost K, 2009: 25-48.
39. Silveyra P, Floros J: Genetic variant associations of human SPA and SP-D with acute and chronic lung injury. Front Biosci. 2012; 17: 407-429. PubMed PMID: 22201752. eng.
40. D'Ovidio F, Kaneda H, Chaparro C, Mura M, Lederer D, Di Angelo S, Takahashi H, Gutierrez C, Hutcheon M, Singer LG, Waddell TK, Floros J, Liu M, Keshavjee S: Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome. Am J Transplant. 2013. PubMed PMID: 24007361. ENG.
41. Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J: Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol. 2007; 292 (5): L1052-L1063. PubMed PMID: 17189324. Epub 2006/12/26. eng.
42. Wang Y, Voelker DR, Lugogo NL, Wang G, Floros J, Ingram JL, Chu HW, Church TD, Kandasamy P, Fertel D, Wright JR, KraftM: Surfactant protein-A is defective in abrogating inflammation in asthma. Am J Physiol Lung Cell Mol Physiol. 2011. PubMed PMID: 21784968. eng.
43. Kuroki Y, Takahashi H, Chiba H, Akino T: Surfactant proteins A and D: disease markers. Biochim Biophys Acta. 1998; 1408 (2-3): 334-345. PubMed PMID: 9813383. eng.
44. Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK: Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. J Biol Chem. 2010; 285 (29): 22103-22113. PubMed PMID: 20466729. PMCID: PMC2903395. eng.
45. Wang Y, Kuan PJ, Xing C, Cronkhite JT, Torres F, Rosenblatt RL, DiMaio JM, Kinch LN, Grishin NV, Garcia CK: Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet. 2009; 84 (1): 52-59. PubMed PMID: 19100526. PMCID: PMC2668050. eng.
46. Rountree MR, Bachman KE, Herman JG, Baylin SB: DNA methylation, chromatin inheritance, and cancer. Oncogene. 2001; 20 (24): 3156-3165. PubMed PMID: 11420732. eng.
47. Gomes A, Reis-Silva M, Alarcão A, Couceiro P, Sousa V, Carvalho L: Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung. Rev Port Pneumol. 2013. PubMed PMID: 24360395. eng/por.
48. Li L, Shen Y, Wang M, Tang D, Luo Y, JiaoW, Wang Z, Yang R, Tian K: Identification of the methylation of p14ARF promoter as a novel non-invasive biomarker for early detection of lung cancer. Clin Transl Oncol. 2013. PubMed PMID: 24154929. eng.
49. Baccarelli A, Wright RO, Bollati V, Tarantini L, Litonjua AA, Suh HH, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J: Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med. 2009; 179 (7): 572-578. PubMed PMID: 19136372. PMCID: PMC2720123. eng.
50. Kim H, Kwon YM, Kim JS, Han J, Shim YM, Park J, Kim DH: Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer. Cancer. 2006; 107 (5): 1042-1049. PubMed PMID: 16888795. eng.
51. Lin RK, Hsu HS, Chang JW, Chen CY, Chen JT, Wang YC: Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer. 2007; 55 (2): 205-213. PubMed PMID: 17140695. eng.
52. Vallb öhmer D, Brabender J, YangD, Schneider PM, MetzgerR, Danenberg KD, Hölscher AH, Danenberg PV: DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value. Clin Lung Cancer. 2006; 8 (1): 39-44. PubMed PMID: 16870044. eng.
53. Hakuma N, Kinoshita I, Shimizu Y, Yamazaki K, Yoshida K, Nishimura M, Dosaka-Akita H: E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cells. Cancer Res. 2005; 65 (23): 10776-10782. PubMed PMID: 16322223. eng.
54. Hiroumi H, Dosaka-Akita H, Yoshida K, Shindoh M, Ohbuchi T, Fujinaga K, Nishimura M: Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion. Int J Cancer. 2001; 93 (6): 786-791. PubMed PMID: 11519038. eng.
55. Ratovitski EA: LKB1/PEA3/Np63 pathway regulates PTGS-2 (COX-2) transcription in lung cancer cells upon cigarette smoke exposure.Oxid Med Cell Longev. 2010; 3 (5): 317-324. PubMed PMID: 21150337. PMCID: PMC3154041. eng.
56. Upadhyay S, Liu C, Chatterjee A, Hoque MO, Kim MS, Engles J, Westra W, Trink B, Ratovitski E, Sidransky D: LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. Cancer Res. 2006; 66 (16): 7870-7879. PubMed PMID: 16912160. eng.
57. Rehan VK, Torday JS, Peleg S, Gennaro L, Vouros P, Padbury J, Rao DS, Reddy GS: 1Alpha, 25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha, 25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells.Mol GenetMetab. 2002; 76 (1): 46-56. PubMed PMID: 12175780. eng.
58. Li S, Huang X, Zhang D, Huang Q, Pei G, Wang L, Jiang W, Hu Q, Tan R, Hua ZC: Requirement of PEA3 for Transcriptional Activation of FAK Gene in TumorMetastasis. PLoS One. 2013; 8 (11): e79336. PubMed PMID: 24260201. PMCID: PMC3832605. eng.
59. Kim SH, Chen G, King AN, Jeon CK, Christensen PJ, Zhao L, Simpson RU, Thomas DG, Giordano TJ, Brenner DE, Hollis B, Beer DG, Ramnath N: Characterization of vitamin D receptor (VDR) in lung adenocarcinoma. Lung Cancer. 2012; 77 (2): 265-271. PubMed PMID: 22564539. PMCID: PMC3396768. eng.
60. Phokela SS, Peleg S, Moya FR, Alcorn JL: Regulation of human pulmonary surfactant protein gene expression by 1alpha, 25-dihydroxyvitamin D3. Am J Physiol Lung Cell Mol Physiol. 2005; 289 (4): L617-L626. PubMed PMID: 15951333. eng.
61. Takai D, Jones PA: Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA. 2002; 99 (6): 3740-3745. PubMed PMID: 11891299. PMCID: PMC122594. eng.