Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Li, Shufeng ^a   Huang, Xiaofeng ^a   Zhang, Dapeng ^a   Huang, Qilai ^a,b   Pei, Guoshun ^a   Wang, Lixiang ^a   Jiang, Wenhui ^a   Hu, Qingang ^a   Tan, Renxiang ^a   Hua, Zi Chun ^a,b  

^a NANJING UNIVERSITY   (China)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FOCAL ADHESION PROTEIN-TYROSINE KINASES; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 84894216714     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079336     Document Type: Article

References (43)

1. Dunn KB, Heffler M, Golubovskaya VM (2010) Evolving therapies and FAK inhibitors for the treatment of cancer. Anticancer Agents Med Chem 10: 722-734.
2. Kurio N, Shimo T, Fukazawa T, Okui T, Hassan NM, et al. (2012) Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. Oral Oncol 48: 1159-1170.
3. Schaller MD (2010) Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci 123: 1007-1013.
4. Sood AK, Coffin JE, Schneider GB, Fletcher MS, DeYoung BR, et al. (2004) Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol 165: 1087-1095. (Pubitemid 39297716)
5. Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, et al. (2012) FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol 196: 223-232.
6. Schaller MD, Parsons JT (1994) Focal adhesion kinase and associated proteins. Curr Opin Cell Biol 6: 705-710. (Pubitemid 24295304)
7. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, et al. (1994) Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14: 1680-1688.
8. Zhao JH, Reiske H, Guan JL (1998) Regulation of the cell cycle by focal adhesion kinase. J Cell Biol 143: 1997-2008. (Pubitemid 29022619)
9. Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, et al. (2003) Differential regulation of cell motility and invasion by FAK. J Cell Biol 160: 753-767. (Pubitemid 36298270)
10. Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K (2003) JNK phosphorylates paxillin and regulates cell migration. Nature 424: 219-223. (Pubitemid 36858692)
11. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, et al. (2005)The role of focal-adhesion kinase in cancer: a new therapeutic opportunity. Nat Rev Cancer 5: 505-515. (Pubitemid 40942827)
12. Aronsohn MS, Brown HM, Hauptman G, Kornberg LJ (2003) Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx. Laryngoscope 113: 1944-1948. (Pubitemid 37409682)
13. Owens LV, Xu L, Craven RJ, Dent GA, Weiner TM, et al. (1995) Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55: 2752-2755.
14. Golubovskaya V, Kaur A, Cance W (2004) Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochim Biophys Acta 1678: 111-125. (Pubitemid 38626172)
15. Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, et al. (2007) N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem 282: 12503-12516. (Pubitemid 47100625)
16. Li S, Dong W, Zong Y, Yin W, Jin G, et al. (2007) Polyethylenimine- complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther 15: 515-523.
17. Sementchenko VI, Watson DK (2000) ETS target genes: past, present and future. Oncogene 19: 6533-6548. (Pubitemid 32108443)
18. Hollenhorst PC, McIntosh LP, Graves BJ (2011) Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem 80: 437-471.
19. O'Hagan RC, Hassell JA (1998) The PEA3 ETS transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase. Oncogene 16: 301-310. (Pubitemid 28052284)
20. Fidler IJ (1973). Selection of successive tumour lines for metastasis.Nat New Biol. 242: 148-149.
21. Watanabe T, Kuramochi H, Takahashi A, Imai K, Katsuta N, Nakayama T, Fujiki H, Suganuma M. (2012) Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (-)-epigallocatechin gallate-treated cells. J Cancer Res Clin Oncol. 138: 859-866.
22. Corsi JM, Rouer E, Girault JA, Enslen H (2006) Organization and posttranscriptional processing of focal adhesion kinase gene. BMC Genomics 7: 198.
23. O'Hagan RC, Tozer RG, Symons M, McCormick F, Hassell JA (1996) The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades. Oncogene 13(6): 1323-1333. (Pubitemid 26343586)
24. de Launoit Y, Baert JL, Chotteau-Lelievre A, Monte D, Coutte L, et al. (2006) The ETS transcription factors of the PEA3 group: transcriptional regulators in metastasis. Biochim Biophys Acta 1766: 79-87. (Pubitemid 44202569)
25. Bieche I, Tozlu S, Girault I, Onody P, Driouch K, et al. (2004) Expression of PEA3/E1AF/ETV4, an ETS-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expression. Carcinogenesis 25: 405-411. (Pubitemid 38351094)
26. Hanzawa M, Shindoh M, Higashino F, Yasuda M, Inoue N, et al. (2000) Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes. Carcinogenesis 21: 1079-1085. (Pubitemid 30389331)
27. Takeuchi Y, Suzawa M, Kikuchi T, Nishida E, Fujita T, et al. (1997) Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem 272: 29309-29316. (Pubitemid 27498224)
28. Shepherd TG, Kockeritz L, Szrajber MR, Muller WJ, Hassell JA (2001) The pea3 subfamily ETS genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol 11: 1739-1748. (Pubitemid 33092162)
29. Subbaramaiah K, Norton L, Gerald W, Dannenberg AJ (2002) Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. J Biol Chem 277: 18649-18657. (Pubitemid 34952420)
30. Howe LR, Crawford HC, Subbaramaiah K, Hassell JA, Dannenberg AJ, et al. (2001) PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. J Biol Chem 276: 20108-20115.
31. Rorth P, Nerlov C, Blasi F, Johnsen M (1990) Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester. Nucleic Acids Res 18: 5009-5017.
32. D'Orazio D, Besser D, Marksitzer R, Kunz C, Hume DA, et al. (1997) Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2. Gene 201: 179-187. (Pubitemid 27504092)
33. Davidson B, Goldberg I, Tell L, Vigdorchik S, Baekelandt M, et al. (2004) The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions. Clin Exp Metastasis 21: 191-199. (Pubitemid 39158496)
34. Benz CC, O'Hagan RC, Richter B, Scott GK, Chang CH, et al. (1997) HER2/Neu and the ETS transcription activator PEA3 are coordinately upregulated in human breast cancer. Oncogene 15: 1513-1525. (Pubitemid 27464644)
35. Taguchi K, Yoshida K, Sasaki F, Fujinaga K (1997) Two transcription factors, E1AF and N-myc, correlate with the invasiveness of neuroblastoma cell lines. Jpn J Cancer Res 88: 394-400. (Pubitemid 27219948)
36. Hiroumi H, Dosaka-Akita H, Yoshida K, Shindoh M, Ohbuchi T, et al. (2001) Expression of E1AF/PEA3, an ETS-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion. Int J Cancer 93: 786-791. (Pubitemid 32761692)
37. Katayama S, Nakayama T, Ito M, Naito S, Sekine I (2005) Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern. Histol Histopathol 20: 119-126. (Pubitemid 40028990)
38. Zabuawala T, Taffany DA, Sharma SM, Merchant A, Adair B, et al. (2010) An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res 70: 1323-1333.
39. Mylona EE, Alexandrou PT, Giannopoulou IA, Rafailidis PI, Markaki S, et al. (2006) Study of the topographic distribution of ETS-1 protein expression in invasive breast carcinomas in relation to tumor phenotype. Cancer Detect Prev 30: 111-117. (Pubitemid 43786288)
40. Zhu X, Jiang J, Shen H, Wang H, Zong H, et al. (2005) Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. J Biol Chem 280: 12503-12516.
41. Zhao J, Pestell R, Guan JL (2001) Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell 12: 4066-4077. (Pubitemid 34001092)
42. Tafolla E, Wang S, Wong B, Leong J, Kapila YL (2005) JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem 280: 19992-19999. (Pubitemid 41379528)
43. Liu E, Cote JF, Vuori K (2003). Negative regulation of FAK signaling by SOCS proteins. EMBO J 22: 5036-5046. (Pubitemid 37222024)