Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress

Journal of Biological Chemistry

Volumn 285, Issue 29, 2010, Pages 22103-22113

  Maitra, Meenakshi ^a   Wang, Yongyu ^a   Gerard, Robert D ^b   Mendelson, Carole R ^b   Garcia, Christine Kim ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A549 CELLS; ALVEOLAR EPITHELIAL CELLS; CULTURE MEDIUM; DEGRADATION PATHWAYS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ER STRESS; ISOFORMS; LYSATES; MUTANT PROTEINS; NORMAL FAMILY; PATHOGENIC MECHANISMS; PROTEIN INSTABILITY; PROTEOLYTIC DIGESTION; PULMONARY FIBROSIS; SURFACTANT PROTEINS; TYPE II; WILD TYPES;

CELL CULTURE; CELLS; GENE ENCODING; OLIGOMERS; SURFACE ACTIVE AGENTS; TRANSCRIPTION;

PROTEINS;

GLUCOSE REGULATED PROTEIN 78; GLYCINE; LECTIN; SURFACTANT PROTEIN A2; UNCLASSIFIED DRUG; VALINE; X BOX BINDING PROTEIN 1;

ARTICLE; CASE REPORT; CELL CULTURE; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL TYPE 2; LUNG FIBROSIS; MALE; MUTANT; OLIGOMERIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN STABILITY; TRANSCRIPTION REGULATION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CELL EXTRACTS; CELL LINE, TUMOR; DETERGENTS; DOGS; ENDOPLASMIC RETICULUM; FEMALE; HUMANS; LEUPEPTINS; MALE; MUTANT PROTEINS; MUTATION; PEDIGREE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PULMONARY ALVEOLI; PULMONARY FIBROSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; SOLUBILITY; STRESS, PHYSIOLOGICAL;

EID: 77954589474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.121467     Document Type: Article

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