Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p16 in non-small cell lung cancer in Egyptian patients

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 10, 2014, Pages 4281-4287

  Haroun, Riham Abdel Hamid ^a   Zakhary, Nadia Iskandar ^b   Mohamed, Mohamed Ragaa ^a   Abdelrahman, Abdelrahman Mohamed ^b   Kandil, Eman Ibrahim ^a   Shalaby, Kamal Ali ^a  

^a Ain Shams University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Fragile histidine triad; Glutathione S transferase P1; P16; Promoter methylation

Indexed keywords

ACID ANHYDRIDE HYDROLASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FRAGILE HISTIDINE TRIAD PROTEIN; GLUTATHIONE TRANSFERASE P1; GSTP1 PROTEIN, HUMAN; MESSENGER RNA; TUMOR MARKER; TUMOR PROTEIN;

ADULT; AGED; BIOSYNTHESIS; DNA METHYLATION; EGYPT; FEMALE; GENETICS; HUMAN; LUNG TUMOR; MALE; MIDDLE AGED; NON SMALL CELL LUNG CANCER; PROGNOSIS; PROMOTER REGION; SMOKING;

ACID ANHYDRIDE HYDROLASES; ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; EGYPT; FEMALE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SMOKING; TUMOR MARKERS, BIOLOGICAL;

EID: 84903526701     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.10.4281     Document Type: Article

References (39)

1. Bhat IA, Pandith AA, Bhat BA, et al (2013). Lack of association of a common polymorphism in the 3'-UTR of interleukin 8 with non small cell lung cancer in Kashmir. Asian Pac J Cancer Prev, 14, 4403-8.
2. Cantlay AM, Smith CA, Wallace WA, et al (1994). Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung. Thorax, 49, 1010-4.
3. Cauchi S, Han W, Kumar SV, et al (2006). Haplotypeenvironment interactions that regulate the human glutathione S-transferase P1 promoter. Cancer Res, 66, 6439-48.
4. Cecener G, Tunca B, Egeli U, et al (2008). Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer. Tumori, 94, 845-8.
5. D'Agostini F, Izzotti A, Balansky R, et al (2006). Early loss of fhit in the respiratory tract of rodents exposed to environmental cigarette smoke. Cancer Res, 66, 3936-41.
6. Geradts J, Fong KM, Zimmerman PV, et al (2000). Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features. Br J Cancer, 82, 1191-7.
7. Han W, Pentecost BT, Pietropaolo RL, et al (2005). Estrogen receptor a increases basal and cigarette smoke extractinduced expression of CYP1A1 and CYP1B1, but not GSTP1, in normal human bronchial epithelial cells. Mol Carcinog, 44, 202-11.
8. Henshall SM, Quinn DI, Lee CS, et al (2001). Overexpression of the Cell Cycle Inhibitor p16INK4A In High-grade Prostatic Intraepithelial Neoplasia Predicts Early Relapse in Prostate Cancer Patients. Clin Cancer Res, 7, 544-50.
9. Herman JG, Graff JR, Myohanen S, et al (1996). Methylationspecific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA, 93, 9821-6.
10. Ki KD, Lee SK, Tong SY, et al (2008). Role of 5'-CpG island hypermethylation of the FHIT gene in cervical carcinoma. J Gynecol Oncol, 19, 117-22.
11. Kim JS, Kim H, Shim YM, et al (2004). Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung. Carcinogenesis, l25, 2165-71.
12. Li J, Poi MJ, Tsai MD (2011). Regulatory mechanisms of tumor suppressor P16INK4A and their relevance to cancer. Biochemistry, 50, 5566-82.
13. Li W, Deng J, Jiang P, et al (2010). Association of 5' CpG island hypermethylation of the FHIT gene with lung cancer in southern-central Chinese population. Cancer Biology & Therapy, 10, 997-1000.
14. Lin J, Yao DM, Qian J, et al (2008). Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome. Leuk Res, 32, 1541-5.
15. Liu Y-J, Lin Y-F, Chen Y-F, et al (2013). MicroRNA-449a Enhances Radiosensitivity in CL1-0 Lung Adenocarcinoma Cells. PLoS ONE, 8, 62383.
16. -ΔΔ?Ct method. Methods, 25, 402-8.
17. Marie Loh M, Liem N, Vaithilingam A, et al (2014). DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach. BMC Gastroenterol, 14, 55.
18. Mascaux C, Martin B, Verdebout JM, et al (2003). Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53. Eur Respir J, 21, 753-8.
19. Masood N, Malik FA, Kayani MA (2011). Expression of xenobiotic metabolizing genes in head and neck cancer tissues. Asian Pac J Cancer Prev, 12, 377-82.
20. Maxwell A, McCudden CR, Wians F, et al (2009). Recent advances in the detection of prostate cancer using epigenetic markers in commonly collected laboratory samples. Lab Med, 40, 171-8.
21. Moyer AM, Salavaggione OE, Wu TY, et al (2008). Glutathione S-transferase P1: gene sequence variation and functional genomic studies. Cancer Res, 68, 4791-5001.
22. Prakash P Khandar M, Kumar M, et al (2013). Immunohistochemical detection of p16INK4a in Leukoplakia and Oral Squamous Cell Carcinoma. J Clin Diagn Res, 7, 2793-5.
23. Ritchie KJ, Henderson CJ, Wang XJ, et al (2007). Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. Cancer Res, 67, 9248-57.
24. Sargolzaei S, Farhadi S, Kazemi B, et al (2014). The correlation between p16 expression and INK4a locus mutation with grades and stages in oral squamous cell carcinoma. Indian J Pathol Microbiol, 57, 24-30.
25. Sinha R, Hussain S, Mehrotra R, et al (2013). Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in indian population. PLoS ONE, 8, 60142.
26. Slonchak AM, Cwieduk A, Rzerzowska-Wolny J, et al (2009). Crosstalk between transcription factors in regulation of the human glutathione S-transferase P1 gene expression in Me45 melanoma cells. Biopolymers and Cell, 25, 210-7.
27. Sozzi G, Pastorino U, Moiraghi L, et al (1998). Loss of FHIT function in lung cancer and preinvasive bronchial lesions. Cancer Res, 58, 5032-7.
28. Spivack SD, Hurteau GJ, Fasco MJ, et al (2003). Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors. Clin Cancer Res, 9, 6002-11.
29. Spivack SD, Hurteau GJ, Jain R, et al (2004). Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal-cells. Cancer Res, 64, 6805-13.
30. Stein CK, Glover TW, Palmer JL, et al (2002). Direct correlation between FRA3B expression and cigarette smoking. Gene Chromosomes Can, 34, 333-40.
31. Subramaniam S, Thakur RK, Yadav VK, et al (2013). Lung cancer biomarkers: State of the art. J Carcinog, 12, 3.
32. Sun N, Sun X, Chen B, et al (2010). MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer. Cancer Chemother Pharmacol, 65, 437-46.
33. Tseng JE, Kemp BL, Khuri FR, et al (1999). Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers. Cancer Res, 59, 4798-03.
34. Turella P, Pedersen JZ, Caccuri AM, et al (2003). Glutathione transferase superfamily behaves like storage proteins for dinitrosyl-diglutathionyl-iron complex in heterogeneous systems. J Biol Chem, 278, 42294-99.
35. Xie K-J, He H-E, Sun A-J, et al (2014). Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy. Asian Pac J Cancer Prev, 15, 2591-6.
36. Zhou C, Chen H, Han L, et al (2014). Screening of genes related to lung cancer caused by smoking with RNA-Seq. Eur Rev Med Pharmacol Sci, 18, 117-25.
37. Zochbauer-Muller S, Fong KM, Maitra A, et al (2001). 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res, 61, 3581-5.
38. Zochbauer-Muller S, Wistuba II, Minna JD, et al (2000). Fragile histidine triad (FHIT) gene abnormalities in lung cancer. Clin Lung Cancer, 2, 141-5.
39. Zuo H, Chan GPW, Zhu J, et al (2013). Activation statedependent interaction between Gaq subunits and the Fhit tumor suppressor. Cell Commun Signal, 11, 59-75.