FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

Biochemical Journal

Volumn 466, Issue , 2015, Pages 291-298

  Ma, Wei ^a   Fuentes, Gloria ^b   Shi, Xiaohe ^a   Verma, Chandra ^b,c,d   Radda, George K ^a   Han, Weiping ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b BIOINFORMATICS INSTITUTE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Leptin; Leptin resistance; Obesity; POMC; STAT3

Indexed keywords

LEPTIN; PROOPIOMELANOCORTIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR FKHR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; FOXO3 PROTEIN, MOUSE; LEPTIN RECEPTOR; LEPTIN RECEPTOR, HUMAN; MUTANT PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; STAT3 PROTEIN, MOUSE;

AMINO ACID SEQUENCE; ARTICLE; COMPETITIVE INHIBITION; COMPUTER MODEL; CONTROLLED STUDY; GENE MUTATION; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DOWN REGULATION; GENE DELETION; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR DOCKING; MOUSE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; SEQUENCE HOMOLOGY;

MAMMALIA;

ANIMALS; CONSERVED SEQUENCE; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; HEK293 CELLS; HUMANS; LEPTIN; MICE; MODELS, BIOLOGICAL; MOLECULAR DOCKING SIMULATION; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PRO-OPIOMELANOCORTIN; PROMOTER REGIONS, GENETIC; RECEPTORS, LEPTIN; RECOMBINANT PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 84923224429     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20141109     Document Type: Article

References (34)

1. Plum, L., Belgardt, B. F. and Bruning, J. C. (2006) Central insulin action in energy and glucose homeostasis. J. Clin. Invest. 116, 1761-1766 CrossRef PubMed
2. Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E. and Flier, J. S. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252 CrossRef PubMed
3. Coleman, D. L. (1978) Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141-148 CrossRef PubMed
4. Friedman, J. M. and Leibel, R. L. (1992) Tackling a weighty problem. Cell 69, 217-220 CrossRef PubMed
5. Munzberg, H. and Myers, Jr, M. G. (2005) Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 8, 566-570 CrossRef PubMed
6. Schwartz, M. W., Woods, S. C., Porte, Jr, D., Seeley, R. J. and Baskin, D. G. (2000) Central nervous system control of food intake. Nature 404, 661-671 PubMed
7. Munzberg, H. (2008) Differential leptin access into the brain-a hierarchical organization of hypothalamic leptin target sites? Physiol. Behav. 94, 664-669 CrossRef PubMed
8. Nillni, E. A. (2007) Regulation of prohormone convertases in hypothalamic neurons: implications for prothyrotropin-releasing hormone and proopiomelanocortin. Endocrinology 148, 4191-4200 CrossRef PubMed
9. Pritchard, L. E. and White, A. (2007) Neuropeptide processing and its impact on melanocortin pathways. Endocrinology 148, 4201-4207 CrossRef PubMed
10. Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E. et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856-859 CrossRef PubMed
11. Yang, G., Lim, C.-Y., Li, C., Xiao, X., Radda, G. K., Li, C., Cao, X. and Han, W. (2009) FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1. J. Biol. Chem. 284, 3719-3727 CrossRef PubMed
12. Weigel, D. and Jackle, H. (1990) The fork head domain: a novel DNA binding motif of eukaryotic transcription factors? Cell 63, 455-456 CrossRef PubMed
13. Weigelt, J., Climent, I., Dahlman-Wright, K. and Wikström, M. (2001) Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). Biochemistry 40, 5861-5869 CrossRef PubMed
14. Tsai, K. L., Sun, Y. J., Huang, C. Y., Yang, J. Y., Hung, M. C. and Hsiao, C. D. (2007) Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic. Acids Res. 35, 6984-6994 CrossRef PubMed
15. Biggs, 3rd, W. H., Meisenhelder, J., Hunter, T., Cavenee, W. K. and Arden, K. C. (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. U.S.A. 96, 7421-7426 CrossRef PubMed
16. Furuyama, T., Nakazawa, T., Nakano, I. and Mori, N. (2000) Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349, 629-634 CrossRef PubMed
17. Xuan, Z. and Zhang, M. Q. (2005) From worm to human: bioinformatics approaches to identify FOXO target genes. Mech. Ageing Dev. 126, 209-215 CrossRef PubMed
18. Dingwall, C. and Laskey, R. A. (1991) Nuclear targeting sequences-a consensus? Trends Biochem. Sci. 16, 478-481
19. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J. and Greenberg, M. E. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 CrossRef PubMed
20. Kitamura, T., Feng, Y., Kitamura, Y. I., Chua, Jr, S. C., Xu, A. W., Barsh, G. S., Rossetti, L. and Accili, D. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat. Med. 12, 534-540 CrossRef PubMed
21. Accili, D. and Arden, K. C. (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426 CrossRef PubMed
22. Plum, L., Lin, H. V., Dutia, R., Tanaka, J., Aizawa, K. S., Matsumoto, M., Kim, A. J., Cawley, N. X., Paik, J.-H., Loh, Y. P. et al. (2009) The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat. Med. 15, 1195-1201 CrossRef PubMed
23. Marti-Renom, M. A., Stuart, A. C., Fiser, A., Sánchez, R., Melo, F. and Sali, A. (2000) Comparative protein structure modeling of genes and genomes. Annu. Rev. Biophys. Biomol. Struct. 29, 291-325 CrossRef PubMed
24. Sali, A. and Blundell, T. L. (1993) Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815 CrossRef PubMed
25. Dominguez, C., Boelens, R. and Bonvin, A. M. (2003) HADDOCK: a protein-protein docking approach based on biochemical or biophysical information. J. Am. Chem. Soc. 125, 1731-1737 CrossRef PubMed
26. van Dijk, A. D., de Vries, S. J., Dominguez, C., Chen, H., Zhou, H.-X. and Bonvin, A. M. J. J. (2005) Data-driven docking: HADDOCK's adventures in CAPRI. Proteins 60, 232-238 CrossRef PubMed
27. de Vries, S. J., van Dijk, A. D. and Bonvin, A. M. (2006) WHISCY: what information does surface conservation yield? Application to data-driven docking. Proteins 63, 479-489 CrossRef PubMed
28. Hubbard, S. and Thorntom, J. (1993) NACCESS computer program. NACCESS Computer Program, Deppartment of Biochemistry and Molecular Biology, University College London 2
29. Kim, M. S., Pak, Y. K., Jang, P.-G., Namkoong, C., Choi, Y.-S., Won, J.-C., Kim, K.-S., Kim, S.-W., Kim, H.-S., Park, J.-Y. et al. (2006) Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat. Neurosci. 9, 901-906 CrossRef PubMed
30. Reich, N. C. (2007) STAT dynamics. Cytokine Growth Factor Rev. 18, 511-518 CrossRef PubMed
31. Becker, S., Groner, B. and Muller, C. W. (1998) Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394, 145-151 CrossRef PubMed
32. Leung, S., Li, X. and Stark, G. R. (1996) STATs find that hanging together can be stimulating. Science 273, 750-751 CrossRef PubMed
33. Mao, X., Ren, Z., Parker, G. N., Sondermann, H., Pastorello, M. A., Wang, W., McMurray, J. S., Demeler, B., Darnell, Jr, J. E. and Chen, X. (2005) Structural bases of unphosphorylated STAT1 association and receptor binding. Mol. Cell 17, 761-771 CrossRef PubMed
34. Lin, J., Buettner, R., Yuan, Y. C., Yip, R., Horne, D., Jove, R. and Vaidehi, N. (2009) Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3. J. Mol. Graph Model 28, 347-356 CrossRef PubMed