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Volumn 10, Issue 2, 2015, Pages

Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia

Author keywords

[No Author keywords available]

Indexed keywords

BENFOTIAMINE; CYCLOOXYGENASE 2; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 2; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BENPHOTHIAMINE; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; THIAMINE;

EID: 84923197617     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118372     Document Type: Article
Times cited : (81)

References (73)
  • 1
    • 84897424479 scopus 로고    scopus 로고
    • Microglial diversity by responses and responders
    • PMID: 24744702
    • Gertig U, Hanisch UK (2014) Microglial diversity by responses and responders. Front Cell Neurosci 8:101. doi: 10.3389/fncel.2014.00101 PMID: 24744702
    • (2014) Front Cell Neurosci , vol.8 , pp. 101
    • Gertig, U.1    Hanisch, U.K.2
  • 2
    • 78650233802 scopus 로고    scopus 로고
    • Microglia in the CNS: Immigrants from another world
    • PMID: 21125659
    • Prinz M, Mildner A (2011) Microglia in the CNS: immigrants from another world. Glia. 59:177-87. doi: 10.1002/glia.21104 PMID: 21125659
    • (2011) Glia , vol.59 , pp. 177-187
    • Prinz, M.1    Mildner, A.2
  • 3
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • PMID: 8843599
    • Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312-8. PMID: 8843599
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 4
    • 84879554454 scopus 로고    scopus 로고
    • The changing phenotype of microglia from homeostasis to disease
    • Luo XG, Chen SD (2012) The changing phenotype of microglia from homeostasis to disease. Transl Neurodegener. 24; 1:9. doi: 10.1186/2047-9158-1-9
    • (2012) Transl Neurodegener , vol.24 , Issue.1 , pp. 9
    • Luo, X.G.1    Chen, S.D.2
  • 5
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • PMID: 17180163
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 8:57-69. PMID: 17180163
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 8
    • 77649184973 scopus 로고    scopus 로고
    • Microglia: Biology and pathology
    • PMID: 20012873
    • Graeber MB, Streit WJ (2010) Microglia: biology and pathology. Acta Neuropathol 119:89-105. doi: 10.1007/s00401-009-0622-0 PMID: 20012873
    • (2010) Acta Neuropathol , vol.119 , pp. 89-105
    • Graeber, M.B.1    Streit, W.J.2
  • 9
    • 84907989990 scopus 로고    scopus 로고
    • NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?
    • Bordt EA, Polster BM (2014) NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair? Free Radic Biol Med 76C:34-46. doi: 10.1016/j.freeradbiomed.2014.07.033
    • (2014) Free Radic Biol Med , vol.76 C , pp. 34-46
    • Bordt, E.A.1    Polster, B.M.2
  • 10
    • 77950858637 scopus 로고    scopus 로고
    • Microglia in neurodegenerative disease
    • PMID: 20234358
    • Perry VH, Nicoll JA, Holmes C (2010) Microglia in neurodegenerative disease. Nat Rev Neurol. 6:193-201. doi: 10.1038/nrneurol.2010.17 PMID: 20234358
    • (2010) Nat Rev Neurol , vol.6 , pp. 193-201
    • Perry, V.H.1    Nicoll, J.A.2    Holmes, C.3
  • 11
    • 33744735681 scopus 로고    scopus 로고
    • Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders
    • PMID: 16513287
    • McCarty MF (2006) Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Med Hypotheses. 67:251-69. PMID: 16513287
    • (2006) Med Hypotheses , vol.67 , pp. 251-269
    • McCarty, M.F.1
  • 12
    • 0022364511 scopus 로고
    • Thiamine blockade of neuromuscular transmission
    • PMID: 2416387
    • Enomoto KI, Edwards C (1985) Thiamine blockade of neuromuscular transmission. Brain Research 358: 316-323. doi: 10.1016/0006-8993(85)90976-x PMID: 2416387
    • (1985) Brain Research , vol.358 , pp. 316-323
    • Enomoto, K.I.1    Edwards, C.2
  • 13
    • 55349116041 scopus 로고    scopus 로고
    • Metabolic and Structural Role of Thiamine in Nervous Tissues
    • PMID: 18642074
    • Ba A (2008) Metabolic and Structural Role of Thiamine in Nervous Tissues. Cellular and Molecular Neurobiology 28: 923-931. doi: 10.1007/s10571-008-9297-7 PMID: 18642074
    • (2008) Cellular and Molecular Neurobiology , vol.28 , pp. 923-931
    • Ba, A.1
  • 14
    • 84921027001 scopus 로고    scopus 로고
    • Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?
    • Pácal L, Kuricová K, Kaòková K (2014) Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes 15; 5: 288-295.
    • (2014) World J Diabetes , vol.15 , Issue.5 , pp. 288-295
    • Pácal, L.1    Kuricová, K.2    Kaòková, K.3
  • 16
    • 79951577180 scopus 로고    scopus 로고
    • Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism
    • PMID: 21130821
    • Jhala SS, Hazell AS (2011) Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism. Neurochem Int. 58:248-60. doi: 10.1016/j.neuint.2010.11.019 PMID: 21130821
    • (2011) Neurochem Int , vol.58 , pp. 248-260
    • Jhala, S.S.1    Hazell, A.S.2
  • 17
    • 0025321872 scopus 로고
    • Characteristics of the memory loss of a patient with Wernicke-Korsakoff's syndrome without alcoholism
    • Becker JT, Furman MMR, Panisset M, Smith C (1990). Characteristics of the memory loss of a patient with Wernicke-Korsakoff's syndrome without alcoholism. Neuropsychologica, 28:171-179.
    • (1990) Neuropsychologica , vol.28 , pp. 171-179
    • Becker, J.T.1    Furman, M.M.R.2    Panisset, M.3    Smith, C.4
  • 18
    • 78049253520 scopus 로고    scopus 로고
    • Microglial activation is a major contributor to neurologic dysfunction in thiamine deficiency
    • PMID: 20932820
    • Wang D, Hazell AS (2010) Microglial activation is a major contributor to neurologic dysfunction in thiamine deficiency. Biochem Biophys Res Commun. 402:123-8. doi: 10.1016/j.bbrc.2010.09.128 PMID: 20932820
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 123-128
    • Wang, D.1    Hazell, A.S.2
  • 19
    • 84907033451 scopus 로고    scopus 로고
    • Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: The involvement of CCL2
    • PMID: 25063874
    • Ji Z, Fan Z, Zhang Y, Yu R, Yang H, Zhou C et al. (2014) Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2. J Immunol. 193:2157-67. doi: 10.4049/jimmunol.1302702 PMID: 25063874
    • (2014) J Immunol , vol.193 , pp. 2157-2167
    • Ji, Z.1    Fan, Z.2    Zhang, Y.3    Yu, R.4    Yang, H.5    Zhou, C.6
  • 21
    • 0026077652 scopus 로고
    • Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative
    • PMID: 1776825
    • Bitsch R, Wolf M, Moller J, Heuzeroth L, Grüneklee D (1991) Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab, 35:292-296. PMID: 1776825
    • (1991) Ann Nutr Metab , vol.35 , pp. 292-296
    • Bitsch, R.1    Wolf, M.2    Moller, J.3    Heuzeroth, L.4    Grüneklee, D.5
  • 22
    • 0344837347 scopus 로고    scopus 로고
    • Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
    • PMID: 12592403
    • Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, et al. (2003) Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 9: 294-299. doi: 10.1038/nm834 PMID: 12592403
    • (2003) Nat Med , vol.9 , pp. 294-299
    • Hammes, H.P.1    Du, X.2    Edelstein, D.3    Taguchi, T.4    Matsumura, T.5    Ju, Q.6
  • 23
    • 30344475859 scopus 로고    scopus 로고
    • Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-α
    • PMID: 16260089
    • Wu S, Ren J (2006) Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-α . Neurosci Lett 394:158-162. doi: 10.1016/j.neulet.2005.10.022 PMID: 16260089
    • (2006) Neurosci Lett , vol.394 , pp. 158-162
    • Wu, S.1    Ren, J.2
  • 24
    • 0031766768 scopus 로고    scopus 로고
    • Benfotiamine in treatment of alcoholic polyneuropathy: An 8-week randomized controlled study (BAP I Study)
    • PMID: 9872352
    • Woelk H, Lehrl S, Bitsch R, Kopcke W (1998) Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). Alcohol Alcohol. 33:631-638. PMID: 9872352
    • (1998) Alcohol Alcohol , vol.33 , pp. 631-638
    • Woelk, H.1    Lehrl, S.2    Bitsch, R.3    Kopcke, W.4
  • 25
    • 46349088796 scopus 로고    scopus 로고
    • Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
    • PMID: 18549472
    • Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier RC, et al. (2008) Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacol 8:10. doi: 10.1186/1471-2210-8-10 PMID: 18549472
    • (2008) BMC Pharmacol , vol.8 , pp. 10
    • Volvert, M.L.1    Seyen, S.2    Piette, M.3    Evrard, B.4    Gangolf, M.5    Plumier, R.C.6
  • 26
    • 33646938091 scopus 로고    scopus 로고
    • Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose
    • PMID: 16452468
    • Berrone E, Beltramo E, Solimine C, Ape AU, Porta M (2006) Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. J Biol Chem 281: 9307-9313. doi: 10.1074/jbc.M600418200 PMID: 16452468
    • (2006) J Biol Chem , vol.281 , pp. 9307-9313
    • Berrone, E.1    Beltramo, E.2    Solimine, C.3    Ape, A.U.4    Porta, M.5
  • 27
    • 3643135920 scopus 로고
    • Allithiamine: A newly found derivative of vitamin B
    • Fujiwara M (1954) Allithiamine: a newly found derivative of vitamin B. Journal of Biochemistry (Tokyo) 2, 273-285.
    • (1954) Journal of Biochemistry (Tokyo) , vol.2 , pp. 273-285
    • Fujiwara, M.1
  • 28
    • 33644827653 scopus 로고    scopus 로고
    • High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus
    • Ceylan-Isik AF, Wu S, Li Q, Li SY, Ren J (2006) High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus. J ApplPhysiol 1: 150-156. doi: 10.1152/japplphysiol.00988.2005
    • (2006) J ApplPhysiol , vol.1 , pp. 150-156
    • Ceylan-Isik, A.F.1    Wu, S.2    Li, Q.3    Li, S.Y.4    Ren, J.5
  • 29
  • 30
    • 84887021897 scopus 로고    scopus 로고
    • Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence
    • PMID: 23992649
    • Manzardo AM, He J, Poje A, Penick EC, Campbell J, Butler MG (2013) Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. Drug Alcohol Depend. 133:562-70. doi: 10.1016/j.drugalcdep.2013.07.035 PMID: 23992649
    • (2013) Drug Alcohol Depend , vol.133 , pp. 562-570
    • Manzardo, A.M.1    He, J.2    Poje, A.3    Penick, E.C.4    Campbell, J.5    Butler, M.G.6
  • 31
    • 77951909056 scopus 로고    scopus 로고
    • Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice
    • PMID: 20385653
    • Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, et al. (2010) Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 133:1342-51. doi: 10.1093/brain/awq069 PMID: 20385653
    • (2010) Brain , vol.133 , pp. 1342-1351
    • Pan, X.1    Gong, N.2    Zhao, J.3    Yu, Z.4    Gu, F.5    Chen, J.6
  • 32
    • 84871448793 scopus 로고    scopus 로고
    • Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose
    • PMID: 22961478
    • Sun XJ, Zhao L, Zhao N, Pan XL, Fei GQ, Jin LR, et al. (2012) Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose. Neurosci Bull. 28:561-6. doi: 10.1007/s12264-012-1264-0 PMID: 22961478
    • (2012) Neurosci Bull , vol.28 , pp. 561-566
    • Sun, X.J.1    Zhao, L.2    Zhao, N.3    Pan, X.L.4    Fei, G.Q.5    Jin, L.R.6
  • 33
    • 65549085743 scopus 로고    scopus 로고
    • Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1
    • PMID: 19136698
    • Yadav UC, Subramanyam S, Ramana KV (2009) Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci 50:2276-82. doi: 10.1167/iovs.08-2816 PMID: 19136698
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2276-2282
    • Yadav, U.C.1    Subramanyam, S.2    Ramana, K.V.3
  • 34
    • 77951939021 scopus 로고    scopus 로고
    • Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages
    • PMID: 20219672
    • Yadav UC, Kalariya NM, Srivastava SK, Ramana KV (2010) Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med 48:1423-34. doi: 10.1016/j.freeradbiomed.2010.02.031 PMID: 20219672
    • (2010) Free Radic Biol Med , vol.48 , pp. 1423-1434
    • Yadav, U.C.1    Kalariya, N.M.2    Srivastava, S.K.3    Ramana, K.V.4
  • 35
    • 84655167299 scopus 로고    scopus 로고
    • Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages
    • PMID: 22067901
    • Shoeb M, Ramana KV (2012) Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med 52:182-190. doi: 10.1016/j.freeradbiomed.2011.10.444 PMID: 22067901
    • (2012) Free Radic Biol Med , vol.52 , pp. 182-190
    • Shoeb, M.1    Ramana, K.V.2
  • 36
    • 0025233694 scopus 로고
    • Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus
    • PMID: 2110186
    • Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27: 229-37. PMID: 2110186
    • (1990) J Neuroimmunol , vol.27 , pp. 229-237
    • Blasi, E.1    Barluzzi, R.2    Bocchini, V.3    Mazzolla, R.4    Bistoni, F.5
  • 37
    • 84885033968 scopus 로고    scopus 로고
    • Fluctuating vs. continuous exposure to H2O2: The effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia
    • PMID: 24124554
    • Bajić A, Spasić M, Andjus PR, Savić D, Parabucki A, Nikolić-Kokić A, et al. (2013) Fluctuating vs. continuous exposure to H2O2: the effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia. PLoS One 8:e76383. doi: 10.1371/journal.pone.0076383 PMID: 24124554
    • (2013) PLoS One , vol.8 , pp. e76383
    • Bajić, A.1    Spasić, M.2    Andjus, P.R.3    Savić, D.4    Parabucki, A.5    Nikolić-Kokić, A.6
  • 38
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • PMID: 17965659
    • Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-94. doi: 10.1038/nn1997 PMID: 17965659
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 40
    • 84886752759 scopus 로고    scopus 로고
    • Functional diversity of microglia - How heterogeneous are they to begin with?
    • PMID: 23717262
    • Hanisch UK (2013) Functional diversity of microglia - how heterogeneous are they to begin with? Front Cell Neurosci 7:65. doi: 10.3389/fncel.2013.00065 PMID: 23717262
    • (2013) Front Cell Neurosci , vol.7 , pp. 65
    • Hanisch, U.K.1
  • 41
    • 0033803755 scopus 로고    scopus 로고
    • Bacterial Endotoxin Induces Changes in the Organization and Expression of Actin and Modulation of the Cell Membrane of Microglia
    • Abd-El-Basset EM (2000) Bacterial Endotoxin Induces Changes in the Organization and Expression of Actin and Modulation of the Cell Membrane of Microglia. Med Principles Pract 9:81-90.
    • (2000) Med Principles Pract , vol.9 , pp. 81-90
    • Abd-El-Basset, E.M.1
  • 42
    • 5644290609 scopus 로고    scopus 로고
    • Up-Regulation of Cytoskeletal Proteins in Activated Microglia
    • PMID: 15467307
    • Abd-El-Basset EM, Prashanth J, Ananth Lakshmi KVV (2004) Up-Regulation of Cytoskeletal Proteins in Activated Microglia. Med Princ Pract 13:325-333. doi: 10.1159/000080469 PMID: 15467307
    • (2004) Med Princ Pract , vol.13 , pp. 325-333
    • Abd-El-Basset, E.M.1    Prashanth, J.2    Ananth Lakshmi, K.V.V.3
  • 43
    • 0035869474 scopus 로고    scopus 로고
    • Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors
    • PMID: 11245682
    • Honda S, Sasaki Y, Ohsawa K, Imai Y, Nakamura Y, Inoue K, et al. (2001) Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci. 21:1975-82. PMID: 11245682
    • (2001) J Neurosci , vol.21 , pp. 1975-1982
    • Honda, S.1    Sasaki, Y.2    Ohsawa, K.3    Imai, Y.4    Nakamura, Y.5    Inoue, K.6
  • 44
    • 0033986453 scopus 로고    scopus 로고
    • Production of nitric oxide by glial cells: Regulation and potential roles in the CNS
    • PMID: 10594918
    • Murphy S (2000) Production of nitric oxide by glial cells: regulation and potential roles in the CNS. Glia 29:1-13. PMID: 10594918
    • (2000) Glia , vol.29 , pp. 1-13
    • Murphy, S.1
  • 45
    • 77954624383 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • PMID: 20438856
    • Pautz A, Art J, Hahn S, Nowag S, Voss C, Kleinert H (2010) Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide 23:75-93. doi: 10.1016/j.niox.2010.04.007 PMID: 20438856
    • (2010) Nitric Oxide , vol.23 , pp. 75-93
    • Pautz, A.1    Art, J.2    Hahn, S.3    Nowag, S.4    Voss, C.5    Kleinert, H.6
  • 46
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • PMID: 15453089
    • Minghetti L (2004) Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 63:901-10. PMID: 15453089
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 901-910
    • Minghetti, L.1
  • 47
    • 84895514264 scopus 로고    scopus 로고
    • Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases
    • PMID: 24313320
    • Patterson H, Nibbs R, McInnes I, Siebert S (2014) Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases. Clin Exp Immunol. 176:1-10. doi: 10.1111/cei.12248 PMID: 24313320
    • (2014) Clin Exp Immunol , vol.176 , pp. 1-10
    • Patterson, H.1    Nibbs, R.2    McInnes, I.3    Siebert, S.4
  • 48
    • 17944371991 scopus 로고    scopus 로고
    • The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: Players, rules and the games
    • PMID: 15819693
    • Hehlgans T, Pfeffer K (2005) The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115: 1-20. doi: 10.1111/j.1365-2567.2005.02143.x PMID: 15819693
    • (2005) Immunology , vol.115 , pp. 1-20
    • Hehlgans, T.1    Pfeffer, K.2
  • 49
    • 77952291438 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
    • PMID: 20096353
    • Park KM, Bowers WJ (2010) Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal 22: 977-983. doi: 10.1016/j.cellsig.2010.01.010 PMID: 20096353
    • (2010) Cell Signal , vol.22 , pp. 977-983
    • Park, K.M.1    Bowers, W.J.2
  • 50
    • 0038017110 scopus 로고    scopus 로고
    • Brain activation of monocyte-lineage cells: Involvement of interleukin-6
    • PMID: 12759566
    • Shafer LL, McNulty JA, Young MR (2002) Brain activation of monocyte-lineage cells: involvement of interleukin-6. Neuroimmunomodulation 10:295-304. doi: 10.1159/000069973 PMID: 12759566
    • (2002) Neuroimmunomodulation , vol.10 , pp. 295-304
    • Shafer, L.L.1    McNulty, J.A.2    Young, M.R.3
  • 51
    • 0032996810 scopus 로고    scopus 로고
    • Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia
    • PMID: 10098850
    • Sawada M, Suzumura A, Hosoya H, Marunouchi T, Nagatsu T (1999) Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. J Neurochem 72: 1466-71. doi: 10.1046/j.1471-4159.1999.721466.x PMID: 10098850
    • (1999) J Neurochem , vol.72 , pp. 1466-1471
    • Sawada, M.1    Suzumura, A.2    Hosoya, H.3    Marunouchi, T.4    Nagatsu, T.5
  • 52
    • 2442718746 scopus 로고    scopus 로고
    • Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion
    • PMID: 15129165
    • Seo DR, Kim KY, Lee YB (2004) Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion. Neuroreport. 15:1157-61. PMID: 15129165
    • (2004) Neuroreport , vol.15 , pp. 1157-1161
    • Seo, D.R.1    Kim, K.Y.2    Lee, Y.B.3
  • 53
    • 68249159584 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells
    • PMID: 19175796
    • Huang WC, Lin YS, Wang CY, Tsai CC, Tseng HC, Chen CL, et al. (2009) Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells. Immunology 128:e275-e286. doi: 10.1111/j.1365-2567.2008.02959.x PMID: 19175796
    • (2009) Immunology , vol.128 , pp. e275-e286
    • Huang, W.C.1    Lin, Y.S.2    Wang, C.Y.3    Tsai, C.C.4    Tseng, H.C.5    Chen, C.L.6
  • 54
    • 78649739164 scopus 로고    scopus 로고
    • Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation
    • PMID: 20884649
    • Günzl P, Bauer K, Hainzl E, Matt U, Dillinger B, Mahr B, et al. (2010) Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation. J Leukoc Biol 88:1259-69. doi: 10.1189/jlb.0110001 PMID: 20884649
    • (2010) J Leukoc Biol , vol.88 , pp. 1259-1269
    • Günzl, P.1    Bauer, K.2    Hainzl, E.3    Matt, U.4    Dillinger, B.5    Mahr, B.6
  • 55
    • 73849096467 scopus 로고    scopus 로고
    • MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target
    • PMID: 19943344
    • Kaminska B, Gozdz A, Zawadzka M, Ellert-Miklaszewska A, Lipko M (2009) MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target.Anat Rec (Hoboken) 292:1902-13. doi: 10.1002/ar.21047 PMID: 19943344
    • (2009) Anat Rec (Hoboken) , vol.292 , pp. 1902-1913
    • Kaminska, B.1    Gozdz, A.2    Zawadzka, M.3    Ellert-Miklaszewska, A.4    Lipko, M.5
  • 56
    • 6344278016 scopus 로고    scopus 로고
    • The 15-deoxy-delta12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma
    • PMID: 15470065
    • Giri S, Rattan R, Singh AK, Singh I (2004) The 15-deoxy-delta12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol 173:5196-5208. doi: 10.4049/jimmunol.173.8.5196 PMID: 15470065
    • (2004) J Immunol , vol.173 , pp. 5196-5208
    • Giri, S.1    Rattan, R.2    Singh, A.K.3    Singh, I.4
  • 57
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • PMID: 17183360
    • Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62. PMID: 17183360
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 58
    • 84155162481 scopus 로고    scopus 로고
    • Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
    • PMID: 22024597
    • Smith JA, Das A, Ray SK, Banik NL (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 87: 10-20. doi: 10.1016/j.brainresbull.2011.10.004 PMID: 22024597
    • (2012) Brain Res Bull , vol.87 , pp. 10-20
    • Smith, J.A.1    Das, A.2    Ray, S.K.3    Banik, N.L.4
  • 59
    • 0036848107 scopus 로고    scopus 로고
    • Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells
    • PMID: 12417429
    • Fiebich BL, Lieb K, Engels S, Heinrich M (2002) Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells. J Neuroimmunol 132:18-24. PMID: 12417429
    • (2002) J Neuroimmunol , vol.132 , pp. 18-24
    • Fiebich, B.L.1    Lieb, K.2    Engels, S.3    Heinrich, M.4
  • 60
    • 0037088605 scopus 로고    scopus 로고
    • A differential role for the mitogen-activated proteinkinases in lipopolysaccharide signaling
    • PMID: 11786532
    • Watters J, Sommer J, Pfeiffer Z, Prabhu U, Guerra A, Bertics P (2002) A differential role for the mitogen-activated proteinkinases in lipopolysaccharide signaling. J Biol Chem 277: 9077-9087. PMID: 11786532
    • (2002) J Biol Chem , vol.277 , pp. 9077-9087
    • Watters, J.1    Sommer, J.2    Pfeiffer, Z.3    Prabhu, U.4    Guerra, A.5    Bertics, P.6
  • 61
    • 53149124406 scopus 로고    scopus 로고
    • Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures
    • PMID: 18717813
    • Horvath RJ, Nutile-McMenemy N, Alkaitis MS, Deleo JA (2008) Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. J Neurochem. 107: 557-69. doi: 10.1111/j.1471-4159.2008.05633.x PMID: 18717813
    • (2008) J Neurochem , vol.107 , pp. 557-569
    • Horvath, R.J.1    Nutile-McMenemy, N.2    Alkaitis, M.S.3    Deleo, J.A.4
  • 62
    • 78650033287 scopus 로고    scopus 로고
    • Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia
    • PMID: 20932499
    • Kim YH, Koh HK, Kim DS (2010) Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia. Int Immunopharmacol 10: 1560-72. doi: 10.1016/j.intimp.2010.09.007 PMID: 20932499
    • (2010) Int Immunopharmacol , vol.10 , pp. 1560-1572
    • Kim, Y.H.1    Koh, H.K.2    Kim, D.S.3
  • 63
    • 20044389119 scopus 로고    scopus 로고
    • c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia
    • PMID: 15739188
    • Waetzig V, Czeloth K, Hidding U, Mielke K, Kanzow M, Brecht S, et al. (2005) c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia. 50: 235-46. PMID: 15739188
    • (2005) Glia , vol.50 , pp. 235-246
    • Waetzig, V.1    Czeloth, K.2    Hidding, U.3    Mielke, K.4    Kanzow, M.5    Brecht, S.6
  • 64
    • 33847229036 scopus 로고    scopus 로고
    • Roles of NF-kappaB and MAPK signaling pathways in morphological and cytoskeletal responses of microglia to double-stranded RNA
    • PMID: 17284350
    • Nakamichi K, Saiki M, Kitani H, Kuboyama Y, Morimoto K, Takayama-Ito M, et al. (2007) Roles of NF-kappaB and MAPK signaling pathways in morphological and cytoskeletal responses of microglia to double-stranded RNA. Neurosci. Lett 414: 222-7. PMID: 17284350
    • (2007) Neurosci. Lett , vol.414 , pp. 222-227
    • Nakamichi, K.1    Saiki, M.2    Kitani, H.3    Kuboyama, Y.4    Morimoto, K.5    Takayama-Ito, M.6
  • 65
    • 84859635614 scopus 로고    scopus 로고
    • Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration
    • PMID: 22335470
    • Ohsawa K, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S (2012) Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration. J Neurochem. 121: 217-27. doi: 10.1111/j.1471-4159.2012.07693.x PMID: 22335470
    • (2012) J Neurochem , vol.121 , pp. 217-227
    • Ohsawa, K.1    Sanagi, T.2    Nakamura, Y.3    Suzuki, E.4    Inoue, K.5    Kohsaka, S.6
  • 66
    • 2342469986 scopus 로고    scopus 로고
    • Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain
    • PMID: 15135894
    • Waetzig V, Herdegen T (2004) Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain. Neurosci. Lett 361:64-7. doi: 10.1016/j.neulet.2004.02.041 PMID: 15135894
    • (2004) Neurosci. Lett , vol.361 , pp. 64-67
    • Waetzig, V.1    Herdegen, T.2
  • 67
    • 77649235966 scopus 로고    scopus 로고
    • LPS-induced iNOS expression in Bv-2 cells is suppressed by an oxidative mechanism acting on the JNK pathway - A potential role for neuroprotection
    • PMID: 20138851
    • Svensson C, Fernaeus SZ, Part K, Reis K, Land T (2010) LPS-induced iNOS expression in Bv-2 cells is suppressed by an oxidative mechanism acting on the JNK pathway - a potential role for neuroprotection. Brain Res 1322:1-7. doi: 10.1016/j.brainres.2010.01.082 PMID: 20138851
    • (2010) Brain Res , vol.1322 , pp. 1-7
    • Svensson, C.1    Fernaeus, S.Z.2    Part, K.3    Reis, K.4    Land, T.5
  • 68
    • 84894244981 scopus 로고    scopus 로고
    • Mechanisms of anti-inflammatory property of conserved dopamine neurotrophic factor: Inhibition of JNKsignaling in lipopolysaccharide-induced microglia
    • PMID: 24078520
    • Zhao H, Cheng L, Liu Y, Zhang W, Maharjan S, Cui Z, et al. (2014) Mechanisms of anti-inflammatory property of conserved dopamine neurotrophic factor: inhibition of JNKsignaling in lipopolysaccharide-induced microglia. J Mol Neurosci 52: 186-92. PMID: 24078520
    • (2014) J Mol Neurosci , vol.52 , pp. 186-192
    • Zhao, H.1    Cheng, L.2    Liu, Y.3    Zhang, W.4    Maharjan, S.5    Cui, Z.6
  • 70
    • 79952318766 scopus 로고    scopus 로고
    • Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
    • Kacimi R, Giffard RG, Yenari MA (2011) Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways. J Inflamm (Lond) 8:7. doi: 10.1186/1476-9255-8-7
    • (2011) J Inflamm (Lond) , vol.8 , pp. 7
    • Kacimi, R.1    Giffard, R.G.2    Yenari, M.A.3
  • 71
    • 50849096377 scopus 로고    scopus 로고
    • Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: Neuroprotective implications
    • PMID: 18657551
    • Nam KN, Son MS, Park JH, Lee EH (2008) Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications. Neuropharmacology 55:819-25. doi: 10.1016/j.neuropharm.2008.06.065 PMID: 18657551
    • (2008) Neuropharmacology , vol.55 , pp. 819-825
    • Nam, K.N.1    Son, M.S.2    Park, J.H.3    Lee, E.H.4
  • 72
    • 79954620950 scopus 로고    scopus 로고
    • Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells
    • PMID: 21510893
    • Wen J, Ribeiro R, Zhang Y (2011) Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells. J Neuroinflammation. 8:38. doi: 10.1186/1742-2094-8-38 PMID: 21510893
    • (2011) J Neuroinflammation , vol.8 , pp. 38
    • Wen, J.1    Ribeiro, R.2    Zhang, Y.3
  • 73
    • 32544439901 scopus 로고    scopus 로고
    • Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells
    • PMID: 16324785
    • Lee JY, Jhun BS, Oh YT, Lee JH, Choe W, Baik HH, et al. (2006) Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci Lett. 396:1-6. doi: 10.1016/j.neulet.2005.11.004 PMID: 16324785
    • (2006) Neurosci Lett , vol.396 , pp. 1-6
    • Lee, J.Y.1    Jhun, B.S.2    Oh, Y.T.3    Lee, J.H.4    Choe, W.5    Baik, H.H.6


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