Microglial activation is a major contributor to neurologic dysfunction in thiamine deficiency

Biochemical and Biophysical Research Communications

Volumn 402, Issue 1, 2010, Pages 123-128

  Wang, Dongmei ^a   Hazell, Alan S ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Inflammation; Microglia; Neurologic dysfunction; Oxidative stress; Vitamin B1; Wernicke encephalopathy

Indexed keywords

ACETYLCYSTEINE; CD11B ANTIGEN; CHLORDANE; GLYCOPROTEIN P 15095; MESSENGER RNA; MINOCYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FRONTAL CORTEX; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFERIOR COLLICULUS; MICROGLIA; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RIGHTING REFLEX; THALAMUS; THIAMINE DEFICIENCY; UPREGULATION; WERNICKE ENCEPHALOPATHY;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BRAIN; MALE; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; THIAMINE DEFICIENCY; WERNICKE ENCEPHALOPATHY;

ANIMALIA; RATTUS;

EID: 78049253520     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.09.128     Document Type: Article

References (31)

1. Carmichael E.A., Stern R.O. Korsakoff's syndrome its histopathology. Brain 1931, 54:189-213.
2. M. Victor, R.D. Adams and G.H. Collins, in: F.A. Davies(Ed.), The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders due to Alcoholism and Malnutrition, Philadelphia, 1989.
3. Collins G.H. Glial cell changes in the brain stem of thiamine-deficient rats. Am. J. Pathol. 1967, 50:791-814.
4. Robertson D.M., Manz H.J., Haas R.A., Meyers N. Glucose uptake in the brainstem of thiamine-deficient rats. Am. J. Pathol. 1975, 79:107-118.
5. Ke Z.J., Bowen W.M., Gibson G.E. Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochem. Int. 2006, 49:548-556.
6. Vemuganti R., Kalluri H., Yi J.-H., Bowen K.K., Hazell A.S. Gene expression changes in thalamus and inferior colliculus associated with inflammation Cellular stress, metabolism, and structural damage in thiamine deficiency. Eur. J. Neurosci. 2006, 23:1172-1188.
7. Karuppagounder S.S., Shi Q., Xu H., Gibson G.E. Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiol. Dis. 2007, 26:353-362.
8. Todd K.G., Butterworth R.F. Early microglial response in experimental thiamine deficiency: an immunohistochemical analysis. Glia 1999, 25:190-198.
9. Langlais P.J., Anderson G., Guo S.X., Bondy S.C. Increased cerebral free radical production during thiamine deficiency. Metab. Brain Dis. 1997, 12:137-143.
10. Calingasan N.Y., Chun W.J., Park L.C., Uchida K., Gibson G.E. Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. J. Neuropathol. Exp. Neurol. 1999, 58:946-958.
11. Kruse M., Navarro D., Desjardins P., Butterworth R.F. Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability. Neurochem. Int. 2004, 45:49-56.
12. Hazell A.S., Wang C. Downregulation of complexin I and complexin II in the medial thalamus is blocked by N-acetylcysteine in experimental Wernicke's encephalopathy. J. Neurosci. Res. 2005, 79:200-207.
13. Hazell A.S., Rama Rao K.V., Danbolt N.C., Pow D.V., Butterworth R.F. Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. J. Neurochem. 2001, 78:560-568.
14. Lee S.M., Yune T.Y., Kim S.J., Park D.W., Lee Y.K., Kim Y.C., Oh Y.J., Markelonis G.J., Oh T.H. Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J. Neurotrauma 2003, 20:1017-1027.
15. Xiong Y., Peterson P.L., Lee C.P. Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J. Neurotrauma 1999, 16:1067-1082.
16. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 2000, 132:365-386.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:263-275.
18. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego.
19. McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291.
20. Giulian D., Chen J., Ingeman J.E., George J.K., Noponen M. The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain. J. Neurosci. 1989, 9:4416-4429.
21. Morioka T., Kalehua A.N., Streit W.J. The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 1991, 11:966-973.
22. Raivich G., Jones L.L., Werner A., Blüthmann H., Doetschmann T., Kreutzberg G.W. Molecular signals for glial activation: pro- and anti-inflammatory cytokines in the injured brain. Acta Neurochir. Suppl. 1999, 73:21-30.
23. Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid. Redox Signaling 2005, 7:1223-1233.
24. Hazell A.S., Sheedy D., Oanea R., Aghourian M., Sun S., Jung J.Y., Wang D., Wang C. Loss of astrocytic glutamate transporters in Wernicke encephalopathy. Glia 2010, 58:148-156.
25. Yrjänheikki J., Tikka T., Keinänen R., Goldsteins G. A tetracycline derivative Minocycline, reduces inflammation and protects against focal cerebral ischemic with a wide therapeutic window. Proc. Natl. Acad. Sci. USA 1999, 96:13496-13500.
26. Bye N., Habgood M., Callaway J., Malakooti N., Potter A., Kossmann T., Morganti-Kossmann M. Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration. Exp. Neurol. 2007, 204:220-233.
27. Pi R., Li W., Lee N.T., Chan H.H., Pu Y., Chan L.N., Sucher N.J., Chang D.C., Li M., Han Y. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and akt pathways. J. Neurochem. 2004, 91:1219-1230.
28. Morimoto N., Shimazawa M., Yamashima T., Nagabi H., Hara H. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res. 2005, 1044:8-15.
29. Matsushima K., MacManus J.P., Hakim A.M. Apoptosis is restricted to the thalamus in thiamine-deficient rats. NeuroReport 1997, 8:867-870.
30. Wang J.J., Hua Z., Fentress H.M., Singleton C.K. JNK1 is inactivated during thiamine deficiency-induced apoptosis in human neuroblastoma cells. J. Nutr. Biochem. 2000, 11:208-215.
31. Chornyy S., Parkhomenko J., Chorna N. Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells. Acta Biochim. Pol. 2007, 54:315-322.