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Volumn 112, Issue 7, 2015, Pages 2145-2150

Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk

Author keywords

[No Author keywords available]

Indexed keywords

BRUTON TYROSINE KINASE; CALRETICULIN; CD47 ANTIGEN; TOLL LIKE RECEPTOR; AGAMMAGLOBULINAEMIA TYROSINE KINASE; PROTEIN TYROSINE KINASE;

EID: 84923166595     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424907112     Document Type: Article
Times cited : (207)

References (45)
  • 1
    • 84655167968 scopus 로고    scopus 로고
    • Programmed cell removal: A new obstacle in the road to developing cancer
    • Chao MP, Majeti R, Weissman IL (2012) Programmed cell removal: A new obstacle in the road to developing cancer. Nat Rev Cancer 12(1):58-67.
    • (2012) Nat Rev Cancer , vol.12 , Issue.1 , pp. 58-67
    • Chao, M.P.1    Majeti, R.2    Weissman, I.L.3
  • 2
    • 0027958313 scopus 로고
    • Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages
    • Lagasse E, Weissman IL (1994) bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 179(3):1047-1052.
    • (1994) J Exp Med , vol.179 , Issue.3 , pp. 1047-1052
    • Lagasse, E.1    Weissman, I.L.2
  • 3
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal S, et al. (2009) CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138(2):271-285.
    • (2009) Cell , vol.138 , Issue.2 , pp. 271-285
    • Jaiswal, S.1
  • 4
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, et al. (2009) CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138(2):286-299.
    • (2009) Cell , vol.138 , Issue.2 , pp. 286-299
    • Majeti, R.1
  • 5
    • 80855128780 scopus 로고    scopus 로고
    • Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy
    • Chao MP, et al. (2011) Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood 118(18):4890-4901.
    • (2011) Blood , vol.118 , Issue.18 , pp. 4890-4901
    • Chao, M.P.1
  • 6
    • 84860174226 scopus 로고    scopus 로고
    • The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    • Willingham SB, et al. (2012) The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci USA 109(17):6662-6667.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.17 , pp. 6662-6667
    • Willingham, S.B.1
  • 7
    • 79951845617 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
    • Chao MP, et al. (2011) Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res 71(4):1374-1384.
    • (2011) Cancer Res , vol.71 , Issue.4 , pp. 1374-1384
    • Chao, M.P.1
  • 8
    • 77956150056 scopus 로고    scopus 로고
    • Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma
    • Chao MP, et al. (2010) Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell 142(5):699-713.
    • (2010) Cell , vol.142 , Issue.5 , pp. 699-713
    • Chao, M.P.1
  • 9
    • 84860135764 scopus 로고    scopus 로고
    • Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma
    • Edris B, et al. (2012) Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci USA 109(17):6656-6661.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.17 , pp. 6656-6661
    • Edris, B.1
  • 10
    • 84871182464 scopus 로고    scopus 로고
    • Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
    • Kim D, et al. (2012) Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia 26(12):2538-2545.
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2538-2545
    • Kim, D.1
  • 11
    • 78650664067 scopus 로고    scopus 로고
    • Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    • Chao MP, et al. (2010) Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med 2(63):63ra94.
    • (2010) Sci Transl Med , vol.2 , Issue.63 , pp. 63ra94
    • Chao, M.P.1
  • 12
    • 26844468253 scopus 로고    scopus 로고
    • Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    • Gardai SJ, et al. (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123(2):321-334.
    • (2005) Cell , vol.123 , Issue.2 , pp. 321-334
    • Gardai, S.J.1
  • 13
    • 0035903289 scopus 로고    scopus 로고
    • C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    • Ogden CA, et al. (2001) C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 194(6):781-795.
    • (2001) J Exp Med , vol.194 , Issue.6 , pp. 781-795
    • Ogden, C.A.1
  • 14
    • 0028183398 scopus 로고
    • Bruton's tyrosine kinase is a key regulator in B-cell development
    • Rawlings DJ, Witte ON (1994) Bruton's tyrosine kinase is a key regulator in B-cell development. Immunol Rev 138:105-119.
    • (1994) Immunol Rev , vol.138 , pp. 105-119
    • Rawlings, D.J.1    Witte, O.N.2
  • 15
    • 61849183478 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase (Btk): Function, regulation, and transformation with special emphasis on the PH domain
    • Mohamed AJ, et al. (2009) Bruton's tyrosine kinase (Btk): Function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev 228(1):58-73.
    • (2009) Immunol Rev , vol.228 , Issue.1 , pp. 58-73
    • Mohamed, A.J.1
  • 16
    • 0000419304 scopus 로고
    • Agammaglobulinemia
    • Bruton OC (1952) Agammaglobulinemia. Pediatrics 9(6):722-728.
    • (1952) Pediatrics , vol.9 , Issue.6 , pp. 722-728
    • Bruton, O.C.1
  • 17
    • 0001744949 scopus 로고
    • A clinical and experimental study of agammaglobulinemia
    • Good RA, Varco RL (1955) A clinical and experimental study of agammaglobulinemia. J Lancet 75(6):245-271.
    • (1955) J Lancet , vol.75 , Issue.6 , pp. 245-271
    • Good, R.A.1    Varco, R.L.2
  • 18
    • 0028073220 scopus 로고
    • X-linked agammaglobulinemia and Bruton's tyrosine kinase
    • Tsukada S, Witte ON (1994) X-linked agammaglobulinemia and Bruton's tyrosine kinase. Adv Exp Med Biol 365:233-238.
    • (1994) Adv Exp Med Biol , vol.365 , pp. 233-238
    • Tsukada, S.1    Witte, O.N.2
  • 19
    • 0242557486 scopus 로고    scopus 로고
    • Defective Fc-, CR1- and CR3-mediated monocyte phagocytosis and chemotaxis in common variable immunodeficiency and X-linked agammaglobulinemia patients
    • Amoras AL, Kanegane H, Miyawaki T, Vilela MM (2003) Defective Fc-, CR1- and CR3-mediated monocyte phagocytosis and chemotaxis in common variable immunodeficiency and X-linked agammaglobulinemia patients. J Investig Allergol Clin Immunol 13(3):181-188.
    • (2003) J Investig Allergol Clin Immunol , vol.13 , Issue.3 , pp. 181-188
    • Amoras, A.L.1    Kanegane, H.2    Miyawaki, T.3    Vilela, M.M.4
  • 20
    • 84878232476 scopus 로고    scopus 로고
    • The history of Toll-like receptors - Redefining innate immunity
    • O'Neill LA, Golenbock D, Bowie AG (2013) The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol 13(6):453-460.
    • (2013) Nat Rev Immunol , vol.13 , Issue.6 , pp. 453-460
    • O'Neill, L.A.1    Golenbock, D.2    Bowie, A.G.3
  • 22
    • 84863213361 scopus 로고    scopus 로고
    • Anticancer TLR agonists on the ropes
    • Guha M (2012) Anticancer TLR agonists on the ropes. Nat Rev Drug Discov 11(7): 503-505.
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.7 , pp. 503-505
    • Guha, M.1
  • 23
    • 79960128733 scopus 로고    scopus 로고
    • TLR-induced activation of Btk-role for endosomal MHC class II molecules revealed
    • Ní Gabhann J, Jefferies CA (2011) TLR-induced activation of Btk-role for endosomal MHC class II molecules revealed. Cell Res 21(7):998-1001.
    • (2011) Cell Res , vol.21 , Issue.7 , pp. 998-1001
    • Ní Gabhann, J.1    Jefferies, C.A.2
  • 25
    • 37549021148 scopus 로고    scopus 로고
    • Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
    • Doyle SL, Jefferies CA, Feighery C, O'Neill LA (2007) Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem 282(51):36953-36960.
    • (2007) J Biol Chem , vol.282 , Issue.51 , pp. 36953-36960
    • Doyle, S.L.1    Jefferies, C.A.2    Feighery, C.3    O'Neill, L.A.4
  • 26
    • 33750840753 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for TLR-induced IL-10 production
    • Schmidt NW, Thieu VT, Mann BA, Ahyi AN, Kaplan MH (2006) Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol 177(10):7203-7210.
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 7203-7210
    • Schmidt, N.W.1    Thieu, V.T.2    Mann, B.A.3    Ahyi, A.N.4    Kaplan, M.H.5
  • 27
    • 84859564599 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response
    • Lee KG, et al. (2012) Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc Natl Acad Sci USA 109(15):5791-5796.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.15 , pp. 5791-5796
    • Lee, K.G.1
  • 28
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T, Koyasu S (2003) PI3K and negative regulation of TLR signaling. Trends Immunol 24(7):358-363.
    • (2003) Trends Immunol , vol.24 , Issue.7 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 29
    • 84893947749 scopus 로고    scopus 로고
    • Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection
    • Jabir MS, et al. (2014) Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection. Cell Host Microbe 15(2):214-227.
    • (2014) Cell Host Microbe , vol.15 , Issue.2 , pp. 214-227
    • Jabir, M.S.1
  • 30
    • 84885655403 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765)
    • Burger JA, Buggy JJ (2013) Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765). Leuk Lymphoma 54(11):2385-2391.
    • (2013) Leuk Lymphoma , vol.54 , Issue.11 , pp. 2385-2391
    • Burger, J.A.1    Buggy, J.J.2
  • 31
    • 84871740442 scopus 로고    scopus 로고
    • Ibrutinib (PCI-32765), the first BTK (Bruton's tyrosine kinase) inhibitor in clinical trials
    • Brown JR (2013) Ibrutinib (PCI-32765), the first BTK (Bruton's tyrosine kinase) inhibitor in clinical trials. Curr Hematol Malig Rep 8(1):1-6.
    • (2013) Curr Hematol Malig Rep , vol.8 , Issue.1 , pp. 1-6
    • Brown, J.R.1
  • 32
    • 0031038046 scopus 로고    scopus 로고
    • BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement
    • Yang W, Desiderio S (1997) BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc Natl Acad Sci USA 94(2):604-609.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.2 , pp. 604-609
    • Yang, W.1    Desiderio, S.2
  • 33
    • 0035903207 scopus 로고    scopus 로고
    • Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells
    • Mahajan S, et al. (2001) Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells. J Biol Chem 276(33):31216-31228.
    • (2001) J Biol Chem , vol.276 , Issue.33 , pp. 31216-31228
    • Mahajan, S.1
  • 34
    • 0033812701 scopus 로고    scopus 로고
    • Regulation of the phospholipase C-gamma2 pathway in B cells
    • Kurosaki T, et al. (2000) Regulation of the phospholipase C-gamma2 pathway in B cells. Immunol Rev 176:19-29.
    • (2000) Immunol Rev , vol.176 , pp. 19-29
    • Kurosaki, T.1
  • 35
    • 84877830625 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin
    • Byrne JC, et al. (2013) Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin. J Immunol 190(10): 5207-5215.
    • (2013) J Immunol , vol.190 , Issue.10 , pp. 5207-5215
    • Byrne, J.C.1
  • 36
    • 0036785571 scopus 로고    scopus 로고
    • Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: Calreticulin and CD91 as a common collectin receptor complex
    • Vandivier RW, et al. (2002) Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: Calreticulin and CD91 as a common collectin receptor complex. J Immunol 169(7):3978-3986.
    • (2002) J Immunol , vol.169 , Issue.7 , pp. 3978-3986
    • Vandivier, R.W.1
  • 37
    • 83455203338 scopus 로고    scopus 로고
    • Identification and manipulation of tumor associated macrophages in human cancers
    • Heusinkveld M, van der Burg SH (2011) Identification and manipulation of tumor associated macrophages in human cancers. J Transl Med 9:216.
    • (2011) J Transl Med , vol.9 , pp. 216
    • Heusinkveld, M.1    Van Der-Burg, S.H.2
  • 38
    • 84055193356 scopus 로고    scopus 로고
    • Infiltration of m2 tumor-associated macrophages in oral squamous cell carcinoma correlates with tumor malignancy
    • Mori K, Hiroi M, Shimada J, Ohmori Y (2011) Infiltration of m2 tumor-associated macrophages in oral squamous cell carcinoma correlates with tumor malignancy. Cancers (Basel) 3(4):3726-3739.
    • (2011) Cancers (Basel) , vol.3 , Issue.4 , pp. 3726-3739
    • Mori, K.1    Hiroi, M.2    Shimada, J.3    Ohmori, Y.4
  • 39
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 40
    • 77953020880 scopus 로고    scopus 로고
    • Macrophages as mediators of tumor immunosurveillance
    • Jaiswal S, Chao MP, Majeti R, Weissman IL (2010) Macrophages as mediators of tumor immunosurveillance. Trends Immunol 31(6):212-219.
    • (2010) Trends Immunol , vol.31 , Issue.6 , pp. 212-219
    • Jaiswal, S.1    Chao, M.P.2    Majeti, R.3    Weissman, I.L.4
  • 42
    • 84879733796 scopus 로고    scopus 로고
    • Anti-CD47 antibody-mediated phagocytosis of cancer bymacrophages primes an effective antitumor T-cell response
    • Tseng D, et al. (2013) Anti-CD47 antibody-mediated phagocytosis of cancer bymacrophages primes an effective antitumor T-cell response. Proc Natl Acad Sci USA 110(27):11103-11108.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.27 , pp. 11103-11108
    • Tseng, D.1
  • 43
    • 0034674421 scopus 로고    scopus 로고
    • Role of CD47 as a marker of self on red blood cells
    • Oldenborg PA, et al. (2000) Role of CD47 as a marker of self on red blood cells. Science 288(5473):2051-2054.
    • (2000) Science , vol.288 , Issue.5473 , pp. 2051-2054
    • Oldenborg, P.A.1
  • 44
    • 84869200371 scopus 로고    scopus 로고
    • Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts
    • Theocharides AP, et al. (2012) Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med 209(10):1883-1899.
    • (2012) J Exp Med , vol.209 , Issue.10 , pp. 1883-1899
    • Theocharides, A.P.1
  • 45
    • 84861170955 scopus 로고    scopus 로고
    • A transcription activator-like effector toolbox for genome engineering
    • Sanjana NE, et al. (2012) A transcription activator-like effector toolbox for genome engineering. Nat Protoc 7(1):171-192.
    • (2012) Nat Protoc , vol.7 , Issue.1 , pp. 171-192
    • Sanjana, N.E.1


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