RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain

GLIA

Volumn 63, Issue 2, 2015, Pages 216-228

  Tatsumi, Emiko ^a   Yamanaka, Hiroki ^a   Kobayashi, Kimiko ^a   Yagi, Hideshi ^a   Sakagami, Masafumi ^a   Noguchi, Koichi ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Chronic pain; Glial activation; Intracellular signaling cascade; P2 receptors; Peripheral nerve injury

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ACTIN BINDING PROTEIN; ADENOSINE DIPHOSPHATE; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; ENZYME INHIBITOR; METHYLTHIO-ADP; NUCLEOTIDE; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y RECEPTOR AGONIST;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NEURALGIA; PAIN THRESHOLD; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SPINAL CORD; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT;

ADENOSINE DIPHOSPHATE; ANIMALS; CALCIUM-BINDING PROTEINS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HYPERALGESIA; MALE; MICROFILAMENT PROTEINS; MICROGLIA; NEURALGIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN THRESHOLD; PHOSPHORYLATION; PURINERGIC P2Y RECEPTOR AGONISTS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2Y; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD INJURIES; THIONUCLEOTIDES;

EID: 84923104658     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22745     Document Type: Article

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