Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy

Journal of Allergy and Clinical Immunology

Volumn 129, Issue 6, 2012, Pages 1522-1528.e5

  Wen, Weiping ^a   Liu, Wenlong ^a   Zhang, Luo ^b   Bai, Jing ^a   Fan, Yunping ^a   Xia, Wentong ^a   Luo, Qing ^a   Zheng, Jing ^a   Wang, Hongtian ^c   Li, Zuwang ^a   Xia, Jiahong ^d   Jiang, Hongyan ^a   Liu, Zheng ^d   Shi, Jianbo ^a   Li, Huabin ^a   Xu, Geng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

inflammatory response; Nose; prognostic factor; response to therapy

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 5; PREDNISONE;

ADULT; ANALYSIS; CELL INFILTRATION; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FEMALE; FLOWCYTOMIX ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NEUTROPHILIA; NOSE POLYP; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; SYMPTOM;

EID: 84862826820     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.01.079     Document Type: Article

References (22)

1. W. Fokkens, V. Lund, and J. Mullol European Position Paper on Rhinosinusitis and Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps 2007 Rhinology 20 suppl 2007 1 136
2. J.M. Rowe-Jones, N. Trendell-Smith, M. Shembekar, and I.S. Mackay Polypoid rhinosinusitis in patients with host defence deficiencies: cellular infiltration and disease severity Rhinology 35 1997 113 117
3. A.E. Stoop, H.A. van der Heijden, J. Biewenga, and S. van der Baan Lymphocytes and nonlymphoid cells in human nasal polyps J Allergy Clin Immunol 87 1991 470 475
4. D.D. Tieu, A.T. Peters, R.G. Carter, L. Suh, D.B. Conley, and R. Chandra Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis J Allergy Clin Immunol 125 2010 667 675
5. N. Zhang, T. Van Zele, C. Perez-Novo, N. Van Bruaene, G. Holtappels, and N. DeRuyck Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease J Allergy Clin Immunol 122 2008 961 968
6. P.P. Cao, H.B. Li, B.F. Wang, S.B. Wang, X.J. You, and Y.H. Cui Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese J Allergy Clin Immunol 124 2009 478 484
7. C.M. van Drunen, S. Reinartz, J. Wigman, and W.J. Fokkens Inflammation in chronic rhinosinusitis and nasal polyposis Immunol Allergy Clin North Am 29 2009 621 629
8. S.T. Holgate, and R. Polosa The mechanisms, diagnosis, and management of severe asthma in adults Lancet 368 2006 780 793
9. M. Hew, P. Bhavsar, A. Torrego, S. Meah, N. Khorasani, and P.J. Barnes Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma Am J Respir Crit Care Med 174 2006 134 141
10. C.B. Small, P. Stryszak, M. Danzig, and A. Damiano Onset of symptomatic effect of mometasone furoate nasal spray in the treatment of nasal polyposis J Allergy Clin Immunol 121 2008 928 932
11. R. Jankowski, J.M. Klossek, V. Attali, A. Coste, and E. Serrano Long-term study of fluticasone propionate aqueous nasal spray in acute and maintenance therapy of nasal polyposis Allergy 64 2009 944 950
12. A.E. Stoop, H.A. van der Heijden, J. Biewenga, and S. van der Baan Eosinophils in nasal polyps and nasal mucosa: an immunohistochemical study J Allergy Clin Immunol 91 1993 616 622
13. C. Bachert, M. Wagenmann, U. Hauser, and C. Rudack IL-5 synthesis is upregulated in human nasal polyp tissue J Allergy Clin Immunol 99 1997 837 842
14. Y. Fan, W. Xia, W. Liu, R. Chen, X. Li, and R. Xu Increased nasal IL-5 levels act as a predisposing factor of asthma in southern China J Allergy Clin Immunol 127 2011 1312 1313
15. J.W. Kim, S.L. Hong, Y.K. Kim, C.H. Lee, Y.G. Min, and C.S. Rhee Histological and immunological features of non-eosinophilic nasal polyps Otolaryngol Head Neck Surg 137 2007 925 930
16. K. Ito, C. Herbert, J.S. Siegle, C. Vuppusetty, N. Hansbro, and P.S. Thomas Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma Am J Respir Cell Mol Biol 39 2008 543 550
17. K. Maneechotesuwan, S. Essilfie-Quaye, S.A. Kharitonov, I.M. Adcock, and P.J. Barnes Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils Chest 132 2007 98 105
18. M. Fukakusa, C. Bergeron, M.K. Tulic, P.O. Fiset, O. Al Dewachi, and M. Laviolette Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa J Allergy Clin Immunol 115 2005 280 286
19. J. Mullol, A. Obando, L. Pujols, and I. Alobid Corticosteroid treatment in chronic rhinosinusitis: the possibilities and the limits Immunol Allergy Clin North Am 29 2009 657 668
20. M.L. Kowalski Oral and nasal steroids for nasal polyps Curr Allergy Asthma Rep 11 2011 187 188
21. P. Hissaria, W. Smith, P.J. Wormald, J. Taylor, M. Vadas, and D. Gillis Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures J Allergy Clin Immunol 118 2006 128 133
22. T. Van Zele, P. Gevaert, G. Holtappels, A. Beule, P.J. Wormald, and S. Mayr Oral steroids and doxycycline: two different approaches to treat nasal polyps J Allergy Clin Immunol 125 2010 1069 1076