Pathophysiology of chronic rhinosinusitis with nasal polyp

American Journal of Rhinology and Allergy

Volumn 25, Issue 5, 2011, Pages 285-290

  Hsu, Joy ^a   Peters, Anju T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; SUPERANTIGEN; TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ARACHIDONIC ACID METABOLISM; ASPIRIN EXACERBATED RESPIRATORY DISEASE; BIOFILM; CHRONIC RHINOSINUSITIS; DISEASE EXACERBATION; EPITHELIUM CELL; HELPER CELL; HUMAN; INNATE IMMUNITY; LYMPHOCYTE FUNCTION; MOLECULAR PATHOLOGY; NONHUMAN; NOSE POLYP; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT DISEASE; REVIEW; RHINOSINUSITIS;

ADAPTIVE IMMUNITY; AIRWAY REMODELING; ANIMALS; ARACHIDONIC ACID; CHRONIC DISEASE; HUMANS; IMMUNITY, INNATE; INFECTION; NASAL POLYPS; RHINITIS; SINUSITIS; T-LYMPHOCYTES;

EID: 80053253661     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2011.25.3680     Document Type: Review

References (123)

1. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: Establishing definitions for clinical research and patient care. J Allergy Clin Immunol 114:155-212, 2004. (Pubitemid 39575875)
2. Slavin RG, Spector SL, Bernstein IL, et al. The diagnosis and management of sinusitis: A practice parameter update. J Allergy Clin Immunol 116:S13-S47, 2005. (Pubitemid 41715240)
3. Anand VK. Epidemiology and economic impact of rhinosinusitis. Ann Otol Rhinol Laryngol Suppl 193:3-5, 2004. (Pubitemid 38623547)
4. Gliklich RE, and Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 113:104-109, 1995.
5. Dykewicz MS, and Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 125:S103-S115, 2010.
6. Hutcheson PS, Schubert MS, and Slavin RG. Distinctions between allergic fungal rhinosinusitis and chronic rhinosinusitis. Am J Rhinol Allergy 24:405-408, 2010.
7. Bhattacharyya N. Bacterial infection in chronic rhinosinusitis: A controlled paired analysis. Am J Rhinol 19:544-548, 2005. (Pubitemid 43115798)
8. Niederfuhr A, Kirsche H, Riechelmann H, and Wellinghausen N. The bacteriology of chronic rhinosinusitis with and without nasal polyps. Arch Otolaryngol Head Neck Surg 135:131-136, 2009.
9. Schlosser RJ, London SD, Gwaltney JM Jr, and Gross CW. Microbiology of chronic frontal sinusitis. Laryngoscope 111:1330-1332, 2001. (Pubitemid 32730175)
10. Doyle PW, and Woodham JD. Evaluation of the microbiology of chronic ethmoid sinusitis. J Clin Microbiol 29:2396-2400, 1991.
11. Hoyt WH III. Bacterial patterns found in surgery patients with chronic sinusitis. J Am Osteopath Assoc 92:205, 9-12, 1992.
12. Hsu J, Lanza DC, and Kennedy DW. Antimicrobial resistance in bacterial chronic sinusitis. Am J Rhinol 12:243-248, 1998. (Pubitemid 128750966)
13. Biel MA, Brown CA, Levinson RM, et al. Evaluation of the microbiology of chronic maxillary sinusitis. Ann Otol Rhinol Laryngol 107:942-945, 1998.
14. Brook I, and Frazier EH. Correlation between microbiology and previous sinus surgery in patients with chronic maxillary sinusitis. Ann Otol Rhinol Laryngol 110:148-151, 2001. (Pubitemid 32147961)
15. Jiang RS, Lin JF, and Hsu CY. Correlation between bacteriology of the middle meatus and ethmoid sinus in chronic sinusitis. J Laryngol Otol 116:443-446, 2002.
16. Carenfelt C, Lundberg C, Nord CE, and Wretlind B. Bacteriology of maxillary sinusitis in relation to quality of the retained secretion. Acta Otolaryngol 86:298-302, 1978. (Pubitemid 9010143)
17. Klossek JM, Dubreuil L, Richet H, et al. Bacteriology of chronic purulent secretions in chronic rhinosinusitis. J Laryngol Otol 112:1162-1166, 1998. (Pubitemid 29004904)
18. Kim HJ, Lee K, Yoo JB, et al. Bacteriological findings and antimicrobial susceptibility in chronic sinusitis with nasal polyp. Acta Otolaryngol 126:489-497, 2006.
19. Corriveau MN, Zhang N, Holtappels G, et al. Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization. Am J Rhinol Allergy 23:461-465, 2009.
20. Gordts F, Halewyck S, Pierard D, et al. Microbiology of the middle meatus: A comparison between normal adults and children. J Laryngol Otol 114:184-188, 2000. (Pubitemid 30189335)
21. Finegold SM, Flynn MJ, Rose FV, et al. Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Clin Infect Dis 35:428-433, 2002. (Pubitemid 34852573)
22. Brook I. Bacteriology of chronic maxillary sinusitis in adults. Ann Otol Rhinol Laryngol 98:426-428, 1989. (Pubitemid 19157737)
23. Frederick J, and Braude AI. Anaerobic infection of the paranasal sinuses. N Engl J Med 290:135-137, 1974.
24. Brook I. Microbiology of sinusitis. Proc Am Thorac Soc 8:90-100, 2011.
25. Stewart PS, Rayner J, Roe F, and Rees WM. Biofilm penetration and disinfection efficacy of alkaline hypochlorite and chlorosulfamates. J Appl Microbiol 91:525-532, 2001. (Pubitemid 34205766)
26. Lewis K. Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5:48-56, 2007. (Pubitemid 44942303)
27. Lewis K. Multidrug tolerance of biofilms and persister cells. Curr Top Microbiol Immunol 322:107-131, 2008.
28. Suh JD, Cohen NA, and Palmer JN. Biofilms in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 18:27-31, 2010.
29. Palmer JN. Bacterial biofilms: Do they play a role in chronic sinusitis? Otolaryngol Clin North Am 38:1193-1201, viii, 2005.
30. Ferguson BJ, and Stolz DB. Demonstration of biofilm in human bacterial chronic rhinosinusitis. Am J Rhinol 19:452-457, 2005. (Pubitemid 41671811)
31. Perloff JR, and Palmer JN. Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis. Am J Rhinol 18:377-380, 2004. (Pubitemid 40259948)
32. Ramadan HH, Sanclement JA, and Thomas JG. Chronic rhinosinusitis and biofilms. Otolaryngol Head Neck Surg 132:414-417, 2005. (Pubitemid 40326693)
33. Sanderson AR, Leid JG, and Hunsaker D. Bacterial biofilms on the sinus mucosa of human subjects with chronic rhinosinusitis. Laryngoscope 116:1121-1126, 2006. (Pubitemid 44317935)
34. Sanclement JA, Webster P, Thomas J, and Ramadan HH. Bacterial biofilms in surgical specimens of patients with chronic rhinosinusitis. Laryngoscope 115:578-582, 2005. (Pubitemid 40530002)
35. Psaltis AJ, Weitzel EK, Ha KR, and Wormald PJ. The effect of bacterial biofilms on post-sinus surgical outcomes. Am J Rhinol 22:1-6, 2008. (Pubitemid 351310945)
36. Prince AA, Steiger JD, Khalid AN, et al. Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. Am J Rhinol 22:239-245, 2008. (Pubitemid 351863570)
37. Zernotti ME, Angel Villegas N, Roques Revol M, et al. Evidence of bacterial biofilms in nasal polyposis. J Investig Allergol Clin Immunol 20:380-385, 2010.
38. Bendouah Z, Barbeau J, Hamad WA, and Desrosiers M. Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis. Otolaryngol Head Neck Surg 134:991-996, 2006. (Pubitemid 43766544)
39. Bachert C, Gevaert P, Holtappels G, et al. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol 107:607-614, 2001. (Pubitemid 32397745)
40. Seiberling KA, Conley DB, Tripathi A, et al. Superantigens and chronic rhinosinusitis: Detection of staphylococcal exotoxins in nasal polyps. Laryngoscope 115:1580-1585, 2005. (Pubitemid 41330665)
41. van Zele T, Gevaert P, Watelet JB, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol 114:981-983, 2004. (Pubitemid 39330280)
42. van Zele T, Gevaert P, Holtappels G, et al. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy 37:1840-1847, 2007.
43. Conley DB, Tripathi A, Seiberling KA, et al. Superantigens and chronic rhinosinusitis: Skewing of T-cell receptor V beta-distributions in polyp-derived CD4+ and CD8+ T cells. Am J Rhinol 20:534-539, 2006. (Pubitemid 44575721)
44. Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 74:877-884, 1999. (Pubitemid 29430354)
45. Shin SH, and Ye MK. Effects of topical amphotericin B on expression of cytokines in nasal polyps. Acta Otolaryngol 124:1174-1177, 2004.
46. Kern RC, Conley DB, Walsh W, et al. Perspectives on the etiology of chronic rhinosinusitis: An immune barrier hypothesis. Am J Rhinol 22:549-559, 2008.
47. Stone KD, Prussin C, and Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 125:S73-S80, 2010.
48. Braun H, Buzina W, Freudenschuss K, et al. "Eosinophilic fungal rhinosinusitis": A common disorder in Europe? Laryngoscope 113:264-269, 2003. (Pubitemid 36176992)
49. Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: An enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol 114:1369-1375, 2004. (Pubitemid 39575892)
50. Orlandi RR, Marple BF, Georgelas A, et al. Immunologic response to fungus is not universally associated with rhinosinusitis. Otolaryngol Head Neck Surg 141:750-756 e1-2, 2009.
51. Ebbens FA, Georgalas C, Luiten S, et al. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: A multicenter randomized controlled study. Laryngoscope 119:401-408, 2009.
52. Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: Not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118:1149-1156, 2006. (Pubitemid 44666994)
53. Kennedy DW, Kuhn FA, Hamilos DL, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: A double blind, placebo-controlled study. Laryngoscope 115:1793-1799, 2005. (Pubitemid 41475891)
54. Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: A randomized, placebo-controlled, double-blind study. Am J Rhinol 22:52-58, 2008.
55. Ponikau JU, Sherris DA, Kita H, and Kern EB. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol 110:862-866, 2002. (Pubitemid 36005872)
56. Ponikau JU, Sherris DA, Weaver A, and Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol 115:125-131, 2005. (Pubitemid 40075432)
57. Weschta M, Rimek D, Formanek M, et al. Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 132:743-747, 2006. (Pubitemid 44086436)
58. Weschta M, Rimek D, Formanek M, et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial. J Allergy Clin Immunol 113:1122-1128, 2004. (Pubitemid 38857995)
59. Netea MG, Simon A, van de Veerdonk F, et al. IL-1beta processing in host defense: Beyond the inflammasomes. PLoS Pathog 6:e1000661, 2010.
60. Spencer LA, and Weller PF. Eosinophils and Th2 immunity: Contemporary insights. Immunol Cell Biol 88:250-256, 2010.
61. Wan YY. Multi-tasking of helper T cells. Immunology 130:166-171, 2010.
62. Chen Z, and O'Shea JJ. Th17 cells: A new fate for differentiating helper T cells. Immunol Res 41:87-102, 2008.
63. Matsuzaki G, and Umemura M. Interleukin-17 as an effector molecule of innate and acquired immunity against infections. Microbiol Immunol 51:1139-1147, 2007.
64. Tato CM, and O'Shea JJ. Immunology: What does it mean to be just 17? Nature 441:166-168, 2006.
65. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52:65-70, 2003. (Pubitemid 36020767)
66. van Bruaene N, Perez-Novo CA, Basinski TM, et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 121:1435-1441, 41 e1-3, 2008.
67. van Zele T, Claeys S, Gevaert P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61:1280-1289, 2006. (Pubitemid 44465587)
68. Zhang N, van Zele T, Perez-Novo C, et al. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 122:961-968, 2008.
69. Hamilos DL, Leung DY, Wood R, et al. Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol 96:537-544, 1995.
70. Miller SA, and Weinmann AS. Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families. Immunology 126:306-315, 2009.
71. Reh DD, Wang Y, Ramanathan M Jr, and Lane AP. Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33. Am J Rhinol Allergy 24:105-109, 2010.
72. Arend WP, Palmer G, and Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 223:20-38, 2008. (Pubitemid 351986169)
73. Cherry WB, Yoon J, Bartemes KR, et al. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol 121:1484-1490, 2008. (Pubitemid 351787349)
74. Castano R, Bosse Y, Endam LM, and Desrosiers M. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Am J Rhinol Allergy 23:377-384, 2009.
75. Nonaka M, Fukumoto A, Ogihara N, et al. Synergistic induction of thymic stromal lymphopoietin by tumor necrosis factor alpha and Th2 cytokine in nasal polyp fibroblasts. Am J Rhinol Allergy 24:e14-e18, 2010.
76. Ying S, O'Connor B, Ratoff J, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 174:8183-8190, 2005. (Pubitemid 40806330)
77. Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673-680, 2002. (Pubitemid 34752477)
78. Reh DD, Ramanathan M Jr, Sultan B, et al. The role of hepatocyte growth factor/c-Met in chronic rhinosinusitis with nasal polyps. Am J Rhinol Allergy 24:266-270, 2010.
79. Umetsu DT, and DeKruyff RH. The regulation of allergy and asthma. Immunol Rev 212:238-255, 2006. (Pubitemid 44116712)
80. Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453:236-240, 2008. (Pubitemid 351667978)
81. Taylor A, Verhagen J, Blaser K, et al. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells. Immunology 117:433-442, 2006.
82. Li X, Meng J, Qiao X, et al. Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis. J Allergy Clin Immunol 125:1061-1068, 2010.
83. Peters AT, Kato A, Zhang N, et al. Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 125:397-403, e10, 2010.
84. Chaplin DD. Overview of the immune response. J Allergy Clin Immunol 125:S3-S23, 2010.
85. Lane AP, Truong-Tran QA, Myers A, et al. Serum amyloid A, properdin, complement 3, and toll-like receptors are expressed locally in human sinonasal tissue. Am J Rhinol 20:117-123, 2006.
86. vandermeer J, Sha Q, Lane AP, and Schleimer RP. Innate immunity of the sinonasal cavity: Expression of messenger RNA for complement cascade components and toll-like receptors. Arch Otolaryngol Head Neck Surg 130:1374-1380, 2004. (Pubitemid 39603298)
87. Akira S, Takeda K, and Kaisho T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2:675-680, 2001. (Pubitemid 32747155)
88. RamanathanMJr, Lee WK, Dubin MG, et al. Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps. Am J Rhinol 21:110-116, 2007.
89. Takeshita F, Leifer CA, Gursel I, et al. Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol 167:3555-3558, 2001. (Pubitemid 32910795)
90. Lane AP, Truong-Tran QA, and Schleimer RP. Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps. Am J Rhinol 20:138-144, 2006.
91. Mackay F, Schneider P, Rennert P, and Browning J. BAFF AND APRIL: A tutorial on B cell survival. Annu Rev Immunol 21:231-264, 2003. (Pubitemid 37174532)
92. Moore PA, Belvedere O, Orr A, et al. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285:260-263, 1999. (Pubitemid 29330000)
93. Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 189:1747-1756, 1999. (Pubitemid 29272691)
94. Kato A, Peters A, Suh L, et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 121:1385-1392, 92 e1-2, 2008.
95. Pleass RJ, Lang ML, Kerr MA, and Woof JM. IgA is a more potent inducer of NADPH oxidase activation and degranulation in blood eosinophils than IgE. Mol Immunol 44:1401-1408, 2007. (Pubitemid 44415953)
96. Bartemes KR, Cooper KM, Drain KL, and Kita H. Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions. J Allergy Clin Immunol 116:827-835, 2005. (Pubitemid 41400548)
97. Oh JH, Hur GY, Ye YM, et al. Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitis. Allergy Asthma Proc 29:152-160, 2008.
98. Abu-Ghazaleh RI, Fujisawa T, Mestecky J, et al. IgA-induced eosinophil degranulation. J Immunol 142:2393-2400, 1989. (Pubitemid 19098252)
99. Patadia M, Dixon J, Conley D, et al. Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis. Am J Rhinol Allergy 24:11-16, 2010.
100. Toskala E, Nuutinen J, and Rautiainen M. Scanning electron microscopy findings of human respiratory cilia in chronic sinusitis and in recurrent respiratory infections. J Laryngol Otol 109:509-514, 1995.
101. Armengot M, Milara J, Mata M, et al. Cilia motility and structure in primary and secondary ciliary dyskinesia. Am J Rhinol Allergy 24:175-180, 2010.
102. Houtmeyers E, Gosselink R, Gayan-Ramirez G, and Decramer M. Regulation of mucociliary clearance in health and disease. Eur Respir J 13:1177-1188, 1999. (Pubitemid 29288948)
103. Meyer JE, Harder J, Sipos B, et al. Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue. Mucosal Immunol 1:239-243, 2008. (Pubitemid 351541309)
104. Glaser R, Harder J, Lange H, et al. Antimicrobial psoriasin (S100A7) protects human skin from E. coli infection. Nat Immunol 6:57-64, 2005. (Pubitemid 40136696)
105. Nisapakultorn K, Ross KF, and Herzberg MC. Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by Porphyromonas gingivalis. Infect Immun 69:4242-4247, 2001. (Pubitemid 32574419)
106. Michalek M, Gelhaus C, Hecht O, et al. The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes. Dev Comp Immunol 33:740-746, 2009.
107. Sohnle PG, Hahn BL, and Santhanagopalan V. Inhibition of Candida albicans growth by calprotectin in the absence of direct contact with the organisms. J Infect Dis 174:1369-1372, 1996. (Pubitemid 26393925)
108. Richer SL, Truong-Tran AQ, Conley DB, et al. Epithelial genes in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol 22:228-234, 2008. (Pubitemid 351846801)
109. Tieu DD, Peters AT, Carter RT, et al. Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. J Allergy Clin Immunol 125:667-675, 2010.
110. van Bruaene N, Derycke L, Perez-Novo CA, et al. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol 124:253-259, 9 e1-2, 2009.
111. Watelet JB, Claeys C, Perez-Novo C, et al. Transforming growth factor beta1 in nasal remodeling: Differences between chronic rhinosinusitis and nasal polyposis. Am J Rhinol 18:267-272, 2004. (Pubitemid 39618654)
112. Verrecchia F, and Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation. J Invest Dermatol 118:211-215, 2002. (Pubitemid 34158472)
113. Watelet JB, Bachert C, Claeys C, and van Cauwenberge P. Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: Expression in chronic sinusitis vs nasal polyposis. Allergy 59:54-60, 2004. (Pubitemid 38167952)
114. Wang JH, Kwon HJ, and Jang YJ. Staphylococcus aureus increases cytokine and matrix metalloproteinase expression in nasal mucosae of patients with chronic rhinosinusitis and nasal polyps. Am J Rhinol Allergy 24:422-427, 2010.
115. Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc 17:231-236, 1996. (Pubitemid 26403402)
116. Adamjee J, Suh YJ, Park HS, et al. Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. J Pathol 209:392-399, 2006. (Pubitemid 43997749)
117. Zander KA, Saavedra MT, West J, et al. Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis. Am J Rhinol Allergy 23:268-272, 2009.
118. Sladek K, Dworski R, Soja J, et al. Eicosanoids in bronchoalveolar lavage fluid of aspirin-intolerant patients with asthma after aspirin challenge. Am J Respir Crit Care Med 149:940-946, 1994. (Pubitemid 24108486)
119. Sousa AR, Parikh A, Scadding G, et al. Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis. N Engl J Med 347:1493-1499, 2002. (Pubitemid 35257588)
120. Ferreri NR, Howland WC, Stevenson DD, and Spiegelberg HL. Release of leukotrienes, prostaglandins, and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin. Am Rev Respir Dis 137:847-854, 1988. (Pubitemid 18099297)
121. Rizk H. Role of aspirin desensitization in the management of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 19:210-217, 2011.
122. Perez-Novo CA, Watelet JB, Claeys C, et al. Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol 115:1189-1196, 2005. (Pubitemid 40824588)
123. Gosepath J, Brieger J, and Mann WJ. New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis. Am J Rhinol 19:111-116, 2005. (Pubitemid 40775012)