Targeting interleukin-21 in rheumatoid arthritis

Molecular Biology Reports

Volumn 38, Issue 3, 2011, Pages 1717-1721

  Yuan, Feng Lai ^a   Hu, Wei ^b   Lu, Wei Guo ^a   Li, Xia ^a   Li, Jian Ping ^a   Xu, Rui Sheng ^a   Li, Cheng Wan ^a   Chen, Fei Hu ^b   Jin, Cheng ^a  

^a NANTONG UNIVERSITY   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

IL 21 receptor; Interleukin 21; Rheumatoid arthritis

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 21 RECEPTOR FC FUSION PROTEIN; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG TARGETING; HUMAN; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ARTHRITIS, RHEUMATOID; HUMANS; INTERLEUKINS; RECEPTORS, INTERLEUKIN-21; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 79951577186     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0285-x     Document Type: Article

References (34)

1. JD Ji WJ Lee KA Kong, et al. 2010 Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis Mol Biol Rep 37 141 147 1:CAS:528:DC%2BC3cXisFSkuw%3D%3D 10.1007/s11033-009-9553-z 19479340
2. PE Lipsky DM van der Heijde EW St Clair, et al. 2000 Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group N Engl J Med 343 1594 1602 1:CAS:528:DC%2BD3cXovVeltLk%3D 10.1056/NEJM200011303432202 11096166 (Pubitemid 32162982)
3. J Kay L Calabrese 2004 The role of interleukin-1 in the pathogenesis of rheumatoid arthritis Rheumatology (Oxf) 43 Suppl 3 iii2 iii9 10.1093/rheumatology/keh201
4. F Wolfe K Michaud 2004 Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients Arthritis Rheum 50 1740 1751 1:CAS:528:DC%2BD2cXlsFaqt7Y%3D 10.1002/art.20311 15188349 (Pubitemid 38725085)
5. JJ Gomez-Reino L Carmona VR Valverde, et al. 2003 Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicenter active-surveillance report Arthritis Rheum 48 2122 2127 1:CAS:528:DC%2BD3sXntVWgsLc%3D 10.1002/art.11137 12905464 (Pubitemid 36959191)
6. P Miossec T Korn VK Kuchroo 2009 Interleukin-17 and type 17 helper T cells N Engl J Med 361 888 898 1:CAS:528:DC%2BD1MXhtVKhtLrP 10.1056/ NEJMra0707449 19710487
7. A Jungel JH Distler M Kurowska-Stolarska, et al. 2004 Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis Arthritis Rheum 50 1468 1476 10.1002/art.20218 15146416 (Pubitemid 38608068)
8. G Monteleone F Pallone TT Macdonald 2009 Interleukin-21 as a new therapeutic target for immune-mediated diseases Trends Pharmacol Sci 30 441 447 1:CAS:528:DC%2BD1MXpt1KgsLk%3D 10.1016/j.tips.2009.05.006 19616319
9. J Parrish-Novak SR Dillon A Nelson, et al. 2000 Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function Nature 408 57 63 1:CAS:528:DC%2BD3cXotVaksrw%3D 10.1038/35040504 11081504
10. E Jang SH Cho H Park, et al. 2009 A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice J Immunol 182 4649 4656 1:CAS:528:DC%2BD1MXjvFOjtLs%3D 10.4049/jimmunol.0804350 19342640
11. R Spolski WJ Leonard 2008 The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer Curr Opin Immunol 20 295 301 1:CAS:528: DC%2BD1cXns1ahtrc%3D 10.1016/j.coi.2008.02.004 18554883
12. Y Hiromura T Kishida H Nakano, et al. 2007 IL-21 administration into the nostril alleviates murine allergic rhinitis J Immunol 179 7157 7165 1:CAS:528:DC%2BD2sXht1Crs7bP 17982108
13. R Ettinger S Kuchen PE Lipsky 2008 Interleukin 21 as a target of intervention in autoimmune disease Ann Rheum Dis 67 Suppl 3 iii83 iii86 1:CAS:528:DC%2BD1MXjt1OlsQ%3D%3D 10.1136/ard.2008.098400 19022821
14. DA Young M Hegen HL Ma, et al. 2007 Blockade of the interleukin-21/ interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis Arthritis Rheum 56 1152 1163 1:CAS:528:DC%2BD2sXltFKgsrY%3D 10.1002/art.22452 17393408 (Pubitemid 46608640)
15. J Parrish-Novak DC Foster RD Holly, et al. 2002 Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses J Leukoc Biol 72 856 863 1:CAS:528:DC%2BD38Xpt1Sju7w%3D 12429707 (Pubitemid 35365159)
16. K Brandt S Bulfone-Paus DC Foster, et al. 2003 Interleukin-21 inhibits dendritic cell activation and maturation Blood 102 4090 4098 1:CAS:528:DC%2BD3sXpsFals78%3D 10.1182/blood-2003-03-0669 12893770 (Pubitemid 37486993)
17. I Douagi F Colucci JP Di Santo, et al. 2002 Identification of the earliest prethymic bipotent T/NK progenitor in murine fetal liver Blood 99 463 471 1:CAS:528:DC%2BD38XmslGlsg%3D%3D 10.1182/blood.V99.2.463 11781226 (Pubitemid 34533080)
18. R Caruso D Fina I Peluso, et al. 2007 IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis J Immunol 178 5957 5965 1:CAS:528:DC%2BD2sXktlWhsbY%3D 17442980 (Pubitemid 46674393)
19. DJ Andorsky JM Timmerman 2008 Interleukin-21: biology and application to cancer therapy Expert Opin Biol Ther 8 1295 1307 1:CAS:528:DC%2BD1cXpslart7o%3D 10.1517/14712598.8.9.1295 18694350
20. DS Mehta AL Wurster MJ Grusby 2004 Biology of IL-21 and the IL-21 receptor Immunol Rev 202 84 95 1:CAS:528:DC%2BD2MXhs1OitQ%3D%3D 10.1111/j.0105-2896.2004.00201.x 15546387 (Pubitemid 39576906)
21. M Collins MJ Whitters DA Young 2003 IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity Immunol Res 28 131 140 1:CAS:528:DC%2BD3sXpslGntLk%3D 10.1385/IR:28:2:131 14610289
22. M Mizuguchi H Asao T Hara, et al. 2009 Transcriptional activation of the interleukin-21 and its receptor genes by human T-cell leukemia virus type 1 tax in human T-cells J Biol Chem 284 25501 25511 1:CAS:528:DC%2BD1MXhtFWhsbrJ 10.1074/jbc.M109.010959 19617351
23. T Habib A Nelson K Kaushansky 2003 IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses J Allergy Clin Immunol 112 1033 1045 1:CAS:528:DC%2BD2cXhtlGgsL4%3D 10.1016/j.jaci.2003.08.039 14657853 (Pubitemid 37549992)
24. T Habib S Senadheera K Weinberg, et al. 2002 The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3 Biochemistry 41 8725 8731 1:CAS:528:DC%2BD38XksVKgu7Y%3D 10.1021/bi0202023 12093291 (Pubitemid 34743313)
25. K Brandt PB Singh S Bulfone-Paus, et al. 2007 Interleukin-21: a new modulator of immunity, infection, and cancer Cytokine Growth Factor Rev 18 223 232 1:CAS:528:DC%2BD2sXmsFCmsro%3D 10.1016/j.cytogfr.2007.04.003 17509926 (Pubitemid 46891291)
26. K Ozaki K Kikly D Michalovich, et al. 2000 Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain Proc Natl Acad Sci USA 97 11439 11444 1:CAS:528:DC%2BD3cXnsF2qsrg%3D 10.1073/pnas.200360997 11016959
27. M Strengell S Matikainen J Siren, et al. 2003 IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells J Immunol 170 5464 5469 1:CAS:528:DC%2BD3sXjvVynt7Y%3D 12759422 (Pubitemid 36617833)
28. M Feldmann SR Maini 2008 Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics Immunol Rev 223 7 19 1:CAS:528:DC%2BD1cXptlGlsrY%3D 10.1111/j.1600-065X.2008.00626.x 18613827 (Pubitemid 351986171)
29. J Li W Shen K Kong, et al. 2006 Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis Scand J Immunol 64 515 522 1:CAS:528:DC%2BD28Xht1ahtLnJ 10.1111/j.1365-3083.2006.01795.x 17032244 (Pubitemid 44536336)
30. ID Davis K Skak MJ Smyth, et al. 2007 Interleukin-21 signaling: functions in cancer and autoimmunity Clin Cancer Res 13 6926 6932 1:CAS:528: DC%2BD2sXhtlyit7fK 10.1158/1078-0432.CCR-07-1238 18056166 (Pubitemid 350276871)
31. S Sarkar DA Fox 2010 Targeting IL-17 and Th17 cells in rheumatoid arthritis Rheum Dis Clin N Am 36 345 366 10.1016/j.rdc.2010.02.006
32. X Li FL Yuan WG Lu, et al. 2010 The role of interleukin-17 in mediating joint destruction in rheumatoid arthritis Biochem Biophys Res Commun 397 131 135 1:CAS:528:DC%2BC3cXotVChtbY%3D 10.1016/j.bbrc.2010.05.111 20513356
33. X Niu D He X Zhang, et al. 2010 IL-21 regulates Th17 cells in rheumatoid arthritis Hum Immunol 71 334 341 1:CAS:528:DC%2BC3cXjs1Wqtr4%3D 10.1016/j.humimm.2010.01.010 20079789
34. AK Andersson M Feldmann FM Brennan 2008 Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis Scand J Immunol 68 103 111 1:CAS:528:DC%2BD1cXovFertLs%3D 10.1111/j.1365-3083.2008. 02118.x 18482208 (Pubitemid 351798402)