메뉴 건너뛰기




Volumn 38, Issue 6, 2011, Pages 4077-4081

Interleukin-21 as a potential therapeutic target for systemic lupus erythematosus

Author keywords

IL 21; Systemic lupus erythematosus; Therapeutic target

Indexed keywords

DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT INTERLEUKIN 21 RECEPTOR FC FUSION PROTEIN; STAT PROTEIN; UNCLASSIFIED DRUG;

EID: 80052484466     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0527-y     Document Type: Article
Times cited : (22)

References (40)
  • 1
    • 33744945033 scopus 로고    scopus 로고
    • Mechanisms of disease: The complement system and the pathogenesis of systemic lupus erythematosus
    • DOI 10.1038/ncprheum0191, PII N0191
    • Cook HT, Botto M (2006) Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus. Nat Clin Pract Rheumatol 2:330-337. (Pubitemid 43842262)
    • (2006) Nature Clinical Practice Rheumatology , vol.2 , Issue.6 , pp. 330-337
    • Cook, H.T.1    Botto, M.2
  • 2
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, Dillon SR, Nelson A et al (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 4
  • 5
    • 45449104408 scopus 로고    scopus 로고
    • The Yin and Yang of interleukin- 21 in allergy, autoimmunity and cancer
    • Spolski R, Leonard WJ (2008) The Yin and Yang of interleukin- 21 in allergy, autoimmunity and cancer. Curr Opin Immunol 20:295-301.
    • (2008) Curr Opin Immunol , vol.20 , pp. 295-301
    • Spolski, R.1    Leonard, W.J.2
  • 7
    • 68049110512 scopus 로고    scopus 로고
    • A polymorphism within IL21R confers risk for systemic lupus erythematosus
    • Webb R, Merrill JT, Kelly JA et al (2009) A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum 60:2402-2407.
    • (2009) Arthritis Rheum , vol.60 , pp. 2402-2407
    • Webb, R.1    Merrill, J.T.2    Kelly, J.A.3
  • 8
    • 38049110981 scopus 로고    scopus 로고
    • Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4 +T cell-B cell collaboration
    • Kuchen S, Robbins R, Sims GP et al (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4 +T cell-B cell collaboration. J Immunol 179: 5886-5896.
    • (2007) J Immunol , vol.179 , pp. 5886-5896
    • Kuchen, S.1    Robbins, R.2    Sims, G.P.3
  • 10
    • 47549112840 scopus 로고    scopus 로고
    • IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    • Yang L, Anderson DE, Baecher-Allan C et al (2008) IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454:350-352.
    • (2008) Nature , vol.454 , pp. 350-352
    • Yang, L.1    Anderson, D.E.2    Baecher-Allan, C.3
  • 11
    • 34547156550 scopus 로고    scopus 로고
    • IL-21 enhances dendritic cell ability to induce interferon-γ production by natural killer T cells
    • DOI 10.1016/j.imbio.2007.03.007, PII S017129850700040X
    • Maeda M, Yanagawa Y, Iwabuchi K et al (2007) IL-21 enhances dendritic cell ability to induce interferon-gamma production by natural killer T cells. Immunobiology 212:537-547. (Pubitemid 47109160)
    • (2007) Immunobiology , vol.212 , Issue.7 , pp. 537-547
    • Maeda, M.1    Yanagawa, Y.2    Iwabuchi, K.3    Minami, K.4    Nakamaru, Y.5    Takagi, D.6    Fukuda, S.7    Onoe, K.8
  • 12
    • 0034633734 scopus 로고    scopus 로고
    • Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
    • Ozaki K, Kikly K, Michalovich D et al (2000) Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA 97:11439-11444.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11439-11444
    • Ozaki, K.1    Kikly, K.2    Michalovich, D.3
  • 13
    • 67849120058 scopus 로고    scopus 로고
    • Interleukin-21 as a new therapeutic target for immune-mediated diseases
    • Monteleone G, Pallone F, Macdonald TT (2009) Interleukin-21 as a new therapeutic target for immune-mediated diseases. Trends Pharmacol Sci 30:441-447.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 441-447
    • Monteleone, G.1    Pallone, F.2    Macdonald, T.T.3
  • 18
    • 38449117337 scopus 로고    scopus 로고
    • IL21 administration into the nostril alleviates murine allergic rhinitis
    • Hiromura Y, Kishida T, Nakano H et al (2007) IL21 administration into the nostril alleviates murine allergic rhinitis. J Immunol 179:7157-7165.
    • (2007) J Immunol , vol.179 , pp. 7157-7165
    • Hiromura, Y.1    Kishida, T.2    Nakano, H.3
  • 19
    • 47249097068 scopus 로고    scopus 로고
    • The role of IL-21 in regulating B-cell function in health and disease
    • DOI 10.1111/j.1600-065X.2008.00631.x
    • Ettinger R, Kuchen S, Lipsky PE (2008) The role of IL-21 in regulating B-cell function in health and disease. Immunol Rev 223:60-86. (Pubitemid 351986176)
    • (2008) Immunological Reviews , vol.223 , Issue.1 , pp. 60-86
    • Ettinger, R.1    Kuchen, S.2    Lipsky, P.E.3
  • 20
    • 33646070606 scopus 로고    scopus 로고
    • IL-21 dependent IgE production in human and mouse in vitro culture systems is cell density and cell division dependent and is augmented by IL-10
    • Caven TH, Shelburne A, Sato J et al (2005) IL-21 dependent IgE production in human and mouse in vitro culture systems is cell density and cell division dependent and is augmented by IL-10. Cell Immunol 238:123-134.
    • (2005) Cell Immunol , vol.238 , pp. 123-134
    • Caven, T.H.1    Shelburne, A.2    Sato, J.3
  • 21
    • 9644278059 scopus 로고    scopus 로고
    • Biology of IL-21 and the IL-21 receptor
    • DOI 10.1111/j.0105-2896.2004.00201.x
    • Mehta DS, Wurster AL, Grusby MJ (2004) Biology of IL-21 and the IL-21 receptor. Immunol Rev 202:84-95. (Pubitemid 39576906)
    • (2004) Immunological Reviews , vol.202 , pp. 84-95
    • Mehta, D.S.1    Wurster, A.L.2    Grusby, M.J.3
  • 22
    • 48649083489 scopus 로고    scopus 로고
    • Interleukin 21: A cytokine/cytokine receptor system that has come of age
    • Leonard WJ, Zeng R, Spolski R (2008) Interleukin 21: a cytokine/cytokine receptor system that has come of age. J Leukoc Biol 84:348-356.
    • (2008) J Leukoc Biol , vol.84 , pp. 348-356
    • Leonard, W.J.1    Zeng, R.2    Spolski, R.3
  • 23
    • 0041349288 scopus 로고    scopus 로고
    • Cytokine requirements for the growth and development of mouse NK cells in vitro
    • DOI 10.1189/jlb.0303097
    • Toomey JA, Gays F, Foster D et al (2003) Cytokine requirements for the growth and development of mouse NK cells in vitro. J Leukoc Biol 74:233-242. (Pubitemid 38040420)
    • (2003) Journal of Leukocyte Biology , vol.74 , Issue.2 , pp. 233-242
    • Toomey, J.A.1    Gays, F.2    Foster, D.3    Brooks, C.G.4
  • 24
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: Basic biology and implications for cancer and autoimmunity
    • Spolski R, Leonard WL (2007) Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 26:57-79.
    • (2007) Annu Rev Immunol , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.L.2
  • 25
    • 33847074166 scopus 로고    scopus 로고
    • + T lymphocytes
    • DOI 10.1016/j.cellsig.2006.10.003, PII S0898656806002749
    • Gagnon J, Ramanathan S, Leblanc C et al (2007) Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8 (+) T lymphocytes. Cell Signal 19:806-816. (Pubitemid 46275370)
    • (2007) Cellular Signalling , vol.19 , Issue.4 , pp. 806-816
    • Gagnon, J.1    Ramanathan, S.2    Leblanc, C.3    Ilangumaran, S.4
  • 26
    • 34248364008 scopus 로고    scopus 로고
    • The molecular basis of IL-21-mediated proliferation
    • DOI 10.1182/blood-2006-10-054973
    • Zeng R, Spolski R, Casas E et al (2007) The molecular basis of IL-21-mediated proliferation. Blood 109:4135-4142. (Pubitemid 46743374)
    • (2007) Blood , vol.109 , Issue.10 , pp. 4135-4142
    • Zeng, R.1    Spolski, R.2    Casas, E.3    Zhu, W.4    Levy, D.E.5    Leonard, W.J.6
  • 28
    • 33748494020 scopus 로고    scopus 로고
    • IL-21 inhibits IFN-γ production in developing Th1 cells through the repression of Eomesodermin expression
    • Suto A, Wurster AL, Reiner SL et al (2006) IL-21 inhibits IFN-c production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol 177:3721-3727. (Pubitemid 44359904)
    • (2006) Journal of Immunology , vol.177 , Issue.6 , pp. 3721-3727
    • Suto, A.1    Wurster, A.L.2    Reiner, S.L.3    Grusby, M.J.4
  • 30
    • 47149116300 scopus 로고    scopus 로고
    • Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus
    • DOI 10.1038/ncprheum0815, PII NCPRHEUM0815
    • Pan HF, Ye DQ, Li XP (2008) Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus. Nat Clin Pract Rheumatol 4:352-353. (Pubitemid 351974005)
    • (2008) Nature Clinical Practice Rheumatology , vol.4 , Issue.7 , pp. 352-353
    • Pan, H.F.1    Ye, D.Q.2    Li, X.P.3
  • 34
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier JA, Sproule TJ, Foreman O et al (2009) A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 106:1518-1523.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3
  • 36
    • 33644690387 scopus 로고    scopus 로고
    • Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus
    • Mitoma H, Horiuchi T, Kimoto Y et al (2005) Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. Int J Mol Med 16:609-615.
    • (2005) Int J Mol Med , vol.16 , pp. 609-615
    • Mitoma, H.1    Horiuchi, T.2    Kimoto, Y.3
  • 37
    • 1242307814 scopus 로고    scopus 로고
    • B cell abnormalities in systemic lupus erythematosus
    • Grammer AC, Lipsky PE (2003) B cell abnormalities in systemic lupus erythematosus. Arthritis Res Ther 5:S22-S27. (Pubitemid 38239913)
    • (2003) Arthritis Research and Therapy , vol.5 , Issue.SUPPL. 4
    • Grammer, A.C.1    Lipsky, P.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.