High glucose promotes tumor invasion and increases metastasis-associated protein expression in human lung epithelial cells by upregulating heme oxygenase-1 via reactive oxygen species or the TGF-β 1 /PI3K/akt signaling pathway

Cellular Physiology and Biochemistry

Volumn 35, Issue 3, 2015, Pages 1008-1022

  Kang, Xiaowen ^a   Kong, Fanwu ^a   Wu, Xiaomei ^a   Ren, Yeping ^a   Wu, Shijie ^b   Wu, Kaiming ^c   Jiang, Zhe ^a   Zhang, Wei ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Daqing Oil Field General Hospital   (China)

^c HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

CD147; High glucose (HG); HO 1 (heme oxygenase 1); Human lung epithelial cells; MMP 9; Reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; GLUCOSE; HEME OXYGENASE 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1;

A549 CELL LINE; ARTICLE; CELL INVASION; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS; PREMEDICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

CELL LINE, TUMOR; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; HEME OXYGENASE-1; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84923101622     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373928     Document Type: Article

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