Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of E-cadherin in pancreatic cancer cells

Current Medicinal Chemistry

Volumn 20, Issue 33, 2013, Pages 4142-4152

  Han, Liang ^a   Peng, Bo ^a   Ma, Qingyong ^a   Ma, Jiguang ^a   Li, Juntao ^a   Li, Wei ^a   Duan, Wanxing ^a   Chen, Chao ^a   Liu, Jiangbo ^a   Xu, Qinhong ^a   Laporte, Kyle ^b   Li, Zehui ^b   Wu, Erxi ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Cancer progression; COX 2; E cadherin; High glucose; Indometacin; Invasion; Pancreatic cancer; PI3K AKT; Proliferation; Therapeutic strategy

Indexed keywords

CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INDOMETACIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VASCULOTROPIN;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PANCREAS CANCER; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION;

CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHROMONES; DOWN-REGULATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOMETHACIN; MORPHOLINES; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84887967759     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990249     Document Type: Article

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