Obesity and Type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

Experimental and Clinical Endocrinology and Diabetes

Volumn 116, Issue SUPPL. 1, 2008, Pages

  Leroith, D ^a   Novosyadlyy, R ^a   Gallagher, E J ^a   Lann, D ^a   Vljayakumar, A ^a   Yakar, S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Diabetes; Epidemiology; Obesity

Indexed keywords

INSULIN; LEPTIN;

ANIMAL MODEL; BODY MASS; BREAST CANCER; CANCER MORTALITY; CANCER RISK; COLON CANCER; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH; WAIST CIRCUMFERENCE;

EID: 54549094827     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081488     Document Type: Review

References (15)

1. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med 2003; 348: 1625-1638
2. Adams TD, Gress RE, Smith SC et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007; 357: 753-761
3. Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol 2004; 159: 1160-1167
4. Polednak AP. Trends in incidence rates for obesity-associated cancers in the US. Cancer detection and prevention 2003; 27: 415-421
5. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer Statistics, 2007. CA Cancer J Clin 2007; 57: 43-66
6. Larsson SC, Woik A. Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. The Am J Clin Nutr 2007; 86: 556-565
7. Dignam JJ, Polite BN, Yothers G et al. Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 2006; 98: 1647-1654
8. Michels KB, Solomon CG, Hu FB et al. Type 2 Diabetes and subsequent incidence of breast cancer in the nurses' health study. Diabetes Care 2003; 26: 1752-1758
9. Ogden CL, Carroll MD, Curtin LR, MacDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States 1999-2004, Jama 2006; 295: 1549-1555
10. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4: 579-591
11. Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007; 28: 20-47
12. Ristow M. Oxidative metabolism in cancer growth. Curr Opin Clin Nutr Metab Care 2006; 9: 339-345
13. Yakar S, Nunez NP, Pennisi P et al. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology 2006; 147: 5826-5834
14. Fernandez AM, Kim JK, Yakar S et al. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev 2001; 15: 1926-1934
15. Novosyadlyy R, Lann D, Rowzee A, Lazzarino DA, Pennisi PA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D. Type 2 Diabetes Accelerates Normal Mammary Gland Development and Breast Cancer Progression. Abstract #1326-P American Diabetes Association Scientific Sessions June 2008