Inhibition of heme oxygenase-1 enhances the radiosensitivity in human nonsmall cell lung cancer A549 cells

Cancer Biotherapy and Radiopharmaceuticals

Volumn 26, Issue 5, 2011, Pages 639-645

  Zhang, Wenyi ^a   Qiao, Tiankui ^a   Zha, Lin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

A549 cells; heme oxygenase 1; radiosensitivity; zinc protoporphyrin IX

Indexed keywords

ENZYME INHIBITOR; HEME OXYGENASE 1; MESSENGER RNA; PROTOPORPHYRIN ZINC; PROTOPORPHYRIN ZINC IX; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CLONE; CELL CYCLE G1 PHASE; CELL SURVIVAL; CELL VIABILITY; CLONOGENIC ASSAY; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; X RAY;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; HEME OXYGENASE-1; HUMANS; LUNG NEOPLASMS; PROTOPORPHYRINS; RADIATION TOLERANCE; RNA, MESSENGER;

EID: 80054689840     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2010.0939     Document Type: Article

References (33)

1. Fang J, Akaike T, Maeda H. Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in an-ticancer treatment. Apoptosis 2004;9:27.
2. Goodman AI, Choudhury M, da Silva JL, et al. Over-expression of the heme oxygenase gene in renal cell carcinoma. Proc Soc Exp Biol Med 1997;214:54.
3. Maines MD, Abrahamsson PA. Expression of heme oxyge-nase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution. Urology 1996;47:727.
4. Berberat PO, Dambrauskas Z, Gulbinas A, et al. Inhibition of heme oxygease-l increase responsiveness of pancreatic cancer cells to anticancer treatment. Clin cancer Res 2005; 11:3790
5. Tan Ze ming, Wu Ying, Zhang Hua li, et al. CoCl2-induced chemotherapy resistance in SW480 cells and its mechanism. J Cent South Univ (Med Sci) 2006,31:345.
6. Shiraishi F, Curtis LM, Truong L, et al. Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol Renal Physiol 2000; 278:F726.
7. Yokoyama S, Mita S, Okabe A, et al. Prediction of radio-sensitivity in human esophageal squamous cell carcinomas with heme oxygenase-1: a clinicopathological and immu-nohistochemical study. Oncol Rep 2001;8:355.
8. Ryter SW, Choi AM. Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol 2009;41:251.
9. Durante W. Heme oxygenase-1 in growth control and its clinical application to vascular disease. J Cell Physiol 2003; 195:373.
10. Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 2002;27:8.
11. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications. Physiol Rev 2006;86:583.
12. Deshane J, Wright M, Agarwal A. Heme oxygenase-1 expression in disease states. Acta Biochim Pol 2005;52:273.
13. Yin XJ,Ma JY, Antonini JM, et al. Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles. Toxicol Sci 2004;82:143.
14. Jung ID, Lee JS, Lee CM, et al. Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation. Biochem Pharmacol 2010;80:491.
15. Fang J, Sawa T, Akaike T, et al. Enhancement of chemo-therapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin. Int J Cancer 2004; 109:1.
16. Doi K, Akaike T, Fujii S, et al. Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth. Br J Cancer 1999; 80:1945.
17. Bao Wen Hua, Qi Zhen Yun, Zhong xiao Li. HO-1 mRNA expression in lung cancers. Hei Long Jiang Med Pharm 2006,29:59.
18. Gao-Jue Wu, Lin Lin, Hong-Jie Zhang, et al. Effect of interference in heme oxygenase on colonic dysfunction of diabetic rats. World Chin J Digestol 2007;15:14.
19. -DDCT Method. Methods 2001;25:402.
20. Kikuchi A, Yamaya M, Suzuki S, et al.Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Hum Genet 2005;116:354.
21. Shibahara S, Sato M, Muller RM, et al. Structural organization of the human heme oxygenase gene and the function of its promoter. Eur J Biochem 1989;179:557.
22. Yamada N, Yamaya M, Okinaga S, et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000;66:187.
23. Jozkowicz A, Was H, Dulak J. Heme oxygenase-1 in tumors: Is it a false friend? Antioxid Redox Signal 2007;9:2099.
24. Zhang Junkai, Wang Zhongyu, Ding Dapeng, et al. Effect of astragulus injection on chemosensitivity of drug-resistant hepatic carcinoma Bel/Fu cell line. Chin J Surg Integr Tradit West Med 2008;14:398.
25. Hirai K, Sasahira T, Ohmori H, et al. Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice. Int J Cancer 2007;120:500.
26. Polyak K, Waldman T, He TC, et al. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev 1996; 10:1945.
27. Lowe SW, Schmitt EM, Smith SW, et al. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993;362:847.
28. Clarke AR, Purdie CA, Harrison DJ, et al. Thymocyte apo-ptosis induced by p53-dependent and independent pathways. Nature 1993;362:849.
29. Merritt AJ, Potten CS, Kemp CJ, et al. The Role of p53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p53-deficient Mice. Cancer Res 1994;54:614.
30. Brugarolas J, Chandrasekaran C, Gordon JI, et al. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 1995;377:552.
31. Deng C, Zhang P, Harper JW, et al. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995;82:675.
32. Waldman T, Kinzler KW,Vogelstein B. P21 is necessary for the P53-mediated G1 arrest in human cancer cells. Cancer Res 1995;55:5187.
33. Yang G, Nguyen X, Ou J, et al. Unique effects of zinc pro-toporphyrin on HO-1 induction and apoptosis. Blood 2001; 97:1306.