Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction

Oncology Reports

Volumn 32, Issue 4, 2014, Pages 1585-1593

  Di, Weihua ^a,b   Khan, Muhamad ^c   Rasul, Azhar ^d   Sun, Meiyan ^a   Sui, Yujie ^a   Zhong, Lili ^a   Yang, Longfei ^a   Zhu, Qi ^a   Feng, Liangtao ^b   Ma, Tonghui ^a,c  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF SARGODHA   (Pakistan)

Author keywords

Apoptosis pathways; Bax; Bcl 2; DR5; Isoalantolactone; Osteosarcoma

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE 8; CYCLIN B1; DEATH RECEPTOR 5; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOALANTOLACTONE; LACTONE DERIVATIVE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; SESQUITERPENE;

APOPTOSIS; ARTICLE; CELL STRAIN; CELL STRAIN MG 63; CELL STRAIN SAOS 2; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SUBSTRATE; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE POTENTIAL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; S PHASE CELL CYCLE CHECKPOINT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; U2OS CELL LINE; UPREGULATION; BONE TUMOR; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MITOCHONDRION; OSTEOSARCOMA; TUMOR CELL LINE;

APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-KAPPA B; OSTEOSARCOMA; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84923068436     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3368     Document Type: Article

References (48)

1. Broadhead ML, Clark JC, Myers DE, Dass CR and Choong PF: The molecular pathogenesis of osteosarcoma: a review. Sarcoma 2011: 959248, 2011.
2. Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer 115: 1531-1543, 2009.
3. Marina N, Gebhardt M, Teot L and Gorlick R: Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 9: 422-441, 2004. (Pubitemid 39014554)
4. Kempf-Bielack B, Bielack SS, Jürgens H, et al: Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS). J Clin Oncol 23: 559-568, 2005. (Pubitemid 46224233)
5. Wu M, Zhang H, Hu J, et al : Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction. PLoS One 8: e76000, 2013.
6. Khan M, Ding C, Rasul A, et al: Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. Int J Biol Sci 8: 533-547, 2012.
7. Konishi T, Shimada Y, Nagao T, Okabe H and Konoshima T: Antiproliferative sesquiterpene lactones from the roots of Inula helenium. Biol Pharm Bull 25: 1370-1372, 2002. (Pubitemid 39663205)
8. Rasul A, Khan M, Yu B, et al: Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res 36: 1262-1269, 2013.
9. Rasul A, Di J, Millimouno FM, et al: Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules 18: 9382-9396, 2013.
10. Seo JY, Park J, Kim HJ, et al: Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes. J Med Food 12: 1038-1045, 2009.
11. Fulda S and Debatin KM: Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25: 4798-4811, 2006. (Pubitemid 44187627)
12. Mühlethaler-Mottet A, Bourloud KB, Auderset K, Joseph JM and Gross N: Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-XL and RIP. Oncogene 23: 5415-5425, 2004. (Pubitemid 39044052)
13. Kamachi M, Le TM, Kim SJ, Geiger ME, Anderson P and Utz PJ: Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. J Exp Med 196: 1213-1225, 2002. (Pubitemid 35304187)
14. Tang D, Lahti JM and Kidd VJ: Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis. J Biol Chem 275: 9303-9307, 2000. (Pubitemid 30185152)
15. Khan M, Yi F, Rasul A, et al: Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 64: 783-794, 2012.
16. Lu YJ, Yang SH, Chien CM, et al: Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. Toxicol In Vitro 21: 90-98, 2007.
17. Torres K and Horwitz SB: Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 58: 3620-3626, 1998. (Pubitemid 28376560)
18. Gamet-Payrastre L, Li P, Lumeau S, et al: Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 60: 1426-1433, 2000. (Pubitemid 30152017)
19. Murray AW: Recycling the cell cycle: cyclins revisited. Cell 116: 221-234, 2004.
20. 2 progression, and results in apoptosis. Mol Biol Cell 8: 1129-1142, 1997.
21. Bodmer JL, Holler N, Reynard S, et al: TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2: 241-243, 2000.
22. Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA and Darwiche N: What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today 15: 668-678, 2010.
23. Lyss G, Knorre A, Schmidt TJ, Pahl HL and Merfort I: The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65. J Biol Chem 273: 33508-33516, 1998. (Pubitemid 29005734)
24. Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J and Hood L: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway. Immunity 7: 821-830, 1997. (Pubitemid 28064895)
25. Juan ME, Wenzel U, Daniel H and Planas JM: Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. J Agric Food Chem 56: 4813-4818, 2008. (Pubitemid 351999415)
26. Schumacker PT: Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10: 175-176, 2006.
27. Gu JQ, Gills JJ, Park EJ, et al: Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J Nat Prod 65: 532-536, 2002. (Pubitemid 34456938)
28. Koch E, Klaas CA, Rüngeler P, et al: Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-κB. Biochem Pharmacol 62: 795-801, 2001. (Pubitemid 32816998)
29. Nam NH: Naturally occurring NF-κB inhibitors. Mini Rev Med Chem 6: 945-951, 2006.
30. Lee SM, Kwon JI, Choi YH, Eom HS and Chi GY: Induction of G2/M arrest and apoptosis by water extract of Strychni Semen in human gastric carcinoma AGS cells. Phytother Res 22: 752-758, 2008. (Pubitemid 351955572)
31. Rasul A, Yu B, Zhong L, Khan M, Yang H and Ma T: Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep 27: 1481-1487, 2012.
32. Scott FL, Stec B, Pop C, et al: The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 457: 1019-1022, 2009.
33. Guicciardi ME and Gores GJ: Life and death by death receptors. FASEB J 23: 1625-1637, 2009.
34. Gaeta ML, Johnson DR, Kluger MS and Pober JS: The death domain of tumor necrosis factor receptor 1 is necessary but not sufficient for Golgi retention of the receptor and mediates receptor desensitization. Lab Invest 80: 1185-1194, 2000. (Pubitemid 30637058)
35. Sheikh MS and Fornace AJ Jr: Death and decoy receptors and p53-mediated apoptosis. Leukemia 14: 1509-1513, 2000. (Pubitemid 30601358)
36. Ramaswamy M, Efimova EV, Martinez O, Mulherkar NU, Singh SP and Prabhakar BS: IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC. Oncogene 23: 6083-6094, 2004. (Pubitemid 39178861)
37. MacEwan DJ: TNF ligands and receptors - a matter of life and death. Br J Pharmacol 135: 855-875, 2002.
38. Stanger BZ, Leder P, Lee TH, Kim E and Seed B: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513-523, 1995.
39. Hsu H, Shu HB, Pan MG and Goeddel DV: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84: 299-308, 1996. (Pubitemid 26042835)
40. Bharti AC, Donato N, Singh S and Aggarwal BB: Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101: 1053-1062, 2003. (Pubitemid 36139379)
41. Li Q, Yu YY, Zhu ZG, et al: Effect of NF-κB constitutive activation on proliferation and apoptosis of gastric cancer cell lines. European surgical research. Eur Surg Res 37: 105-110, 2005. (Pubitemid 40864173)
42. Shen HM and Tergaonkar V: NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 14: 348-363, 2009.
43. Jeong SY and Seol DW: The role of mitochondria in apoptosis. BMB Rep 41: 11-22, 2008.
44. Danial NN: BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin Cancer Res 13: 7254-7263, 2007.
45. Frenzel A, Grespi F, Chmelewskij W and Villunger A: Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis 14: 584-596, 2009.
46. Wei W, Huang H, Zhao S, et al: Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-κB inhibition and Bcr/Abl protein deletion. Apoptosis 18: 1060-1070, 2013.
47. Felty Q, Xiong WC, Sun D, et al: Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. Biochemistry 44: 6900-6909, 2005. (Pubitemid 40632408)
48. Jabs T: Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol 57: 231-245, 1999.