메뉴 건너뛰기




Volumn 6, Issue 4, 2015, Pages 2222-2234

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice

Author keywords

AKT; Hepatocellular carcinoma; Ras; SKP2

Indexed keywords

BETA CATENIN; CYCLIN DEPENDENT KINASE INHIBITOR 1C; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; N RAS PROTEIN; PROTEIN KINASE B; PROTEIN P27; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RAS PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG; PROTEIN P21; S PHASE KINASE ASSOCIATED PROTEIN;

EID: 84923064366     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2945     Document Type: Article
Times cited : (23)

References (47)
  • 2
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011; 365: 1118-1127.
    • (2011) N Engl J Med , pp. 1118-1127
    • El-Serag, H.B.1
  • 3
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: an update
    • Bruix J, Sherman M and American Association for the Study of Liver D. Management of hepatocellular carcinoma: an update. Hepatology. 2011; 53: 1020-1022.
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 7
    • 0031963692 scopus 로고    scopus 로고
    • Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha
    • Santoni-Rugiu E, Jensen MR and Thorgeirsson SS. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Cancer Res. 1998; 58: 123-134.
    • (1998) Cancer Res , vol.58 , pp. 123-134
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Thorgeirsson, S.S.3
  • 8
    • 84860790712 scopus 로고    scopus 로고
    • Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison
    • Calvisi DF, Frau M, Tomasi ML, Feo F and Pascale RM. Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison. Biochim Biophys Acta. 2012; 1826: 215-237.
    • (2012) Biochim Biophys Acta , vol.1826 , pp. 215-237
    • Calvisi, D.F.1    Frau, M.2    Tomasi, M.L.3    Feo, F.4    Pascale, R.M.5
  • 13
    • 74049095469 scopus 로고    scopus 로고
    • The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease
    • Calvisi DF, Pinna F, Ladu S, Muroni MR, Frau M, Demartis I, Tomasi ML, Sini M, Simile MM, Seddaiu MA, Feo F and Pascale RM. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Int J Cancer. 2010; 126: 1275-1281.
    • (2010) Int J Cancer , vol.126 , pp. 1275-1281
    • Calvisi, D.F.1    Pinna, F.2    Ladu, S.3    Muroni, M.R.4    Frau, M.5    Demartis, I.6    Tomasi, M.L.7    Sini, M.8    Simile, M.M.9    Seddaiu, M.A.10    Feo, F.11    Pascale, R.M.12
  • 15
    • 84859991158 scopus 로고    scopus 로고
    • Nuclear expression of S-phase kinase-associated protein 2 predicts poor prognosis of hepatocellular carcinoma
    • Shin E, Kim SH, Jeong HY, Jang JJ and Lee K. Nuclear expression of S-phase kinase-associated protein 2 predicts poor prognosis of hepatocellular carcinoma. APMIS. 2012; 120: 349-357.
    • (2012) APMIS , vol.120 , pp. 349-357
    • Shin, E.1    Kim, S.H.2    Jeong, H.Y.3    Jang, J.J.4    Lee, K.5
  • 16
    • 77955883766 scopus 로고    scopus 로고
    • Regulation of Skp2 expression and activity and its role in cancer progression
    • Chan CH, Lee SW, Wang J and Lin HK. Regulation of Skp2 expression and activity and its role in cancer progression. ScientificWorldJournal. 2010; 10: 1001-1015.
    • (2010) ScientificWorldJournal , vol.10 , pp. 1001-1015
    • Chan, C.H.1    Lee, S.W.2    Wang, J.3    Lin, H.K.4
  • 17
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
    • Frescas D and Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer. 2008; 8: 438-449.
    • (2008) Nat Rev Cancer , vol.8 , pp. 438-449
    • Frescas, D.1    Pagano, M.2
  • 18
    • 41149141967 scopus 로고    scopus 로고
    • Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
    • Hershko DD. Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer. Cancer. 2008; 112: 1415-1424.
    • (2008) Cancer , vol.112 , pp. 1415-1424
    • Hershko, D.D.1
  • 19
    • 67650657199 scopus 로고    scopus 로고
    • Ubiquitin-mediated control of oncogene and tumor suppressor gene products
    • Kitagawa K, Kotake Y and Kitagawa M. Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 2009; 100: 1374-1381.
    • (2009) Cancer Sci , vol.100 , pp. 1374-1381
    • Kitagawa, K.1    Kotake, Y.2    Kitagawa, M.3
  • 20
    • 84885642498 scopus 로고    scopus 로고
    • A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer
    • Satija YK, Bhardwaj A and Das S. A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer. Int J Cancer. 2013; 133: 2759-2768.
    • (2013) Int J Cancer , vol.133 , pp. 2759-2768
    • Satija, Y.K.1    Bhardwaj, A.2    Das, S.3
  • 21
    • 84860208090 scopus 로고    scopus 로고
    • Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
    • Wang G, Chan CH, Gao Y and Lin HK. Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chin J Cancer. 2012; 31: 169-177.
    • (2012) Chin J Cancer , vol.31 , pp. 169-177
    • Wang, G.1    Chan, C.H.2    Gao, Y.3    Lin, H.K.4
  • 22
    • 84902159925 scopus 로고    scopus 로고
    • Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma
    • Xu H, Choe C, Shin SH, Park SW, Kim HS, Jung SH, Yim SH, Kim TM and Chung YJ. Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma. Exp Mol Med. 2014; 46: e97.
    • (2014) Exp Mol Med , vol.46
    • Xu, H.1    Choe, C.2    Shin, S.H.3    Park, S.W.4    Kim, H.S.5    Jung, S.H.6    Yim, S.H.7    Kim, T.M.8    Chung, Y.J.9
  • 23
    • 80053583197 scopus 로고    scopus 로고
    • Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21
    • e1-5
    • Huang Y, Tong S, Tai AW, Hussain M and Lok AS. Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21. Gastroenterology. 2011; 141: 1412-1421, 1421 e1-5.
    • (2011) Gastroenterology , vol.141 , pp. 1412-1421+1421
    • Huang, Y.1    Tong, S.2    Tai, A.W.3    Hussain, M.4    Lok, A.S.5
  • 27
    • 77953408308 scopus 로고    scopus 로고
    • Physiological regulation of Akt activity and stability
    • Liao Y and Hung MC. Physiological regulation of Akt activity and stability. Am J Transl Res. 2010; 2: 19-42.
    • (2010) Am J Transl Res , vol.2 , pp. 19-42
    • Liao, Y.1    Hung, M.C.2
  • 30
    • 0032885751 scopus 로고    scopus 로고
    • Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
    • Nhieu JT, Renard CA, Wei Y, Cherqui D, Zafrani ES and Buendia MA. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol. 1999; 155: 703-710.
    • (1999) Am J Pathol , vol.155 , pp. 703-710
    • Nhieu, J.T.1    Renard, C.A.2    Wei, Y.3    Cherqui, D.4    Zafrani, E.S.5    Buendia, M.A.6
  • 31
    • 42249098060 scopus 로고    scopus 로고
    • Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer
    • Lee SA, Ho C, Roy R, Kosinski C, Patil MA, Tward AD, Fridlyand J and Chen X. Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology. 2008; 47: 1200-1210.
    • (2008) Hepatology , vol.47 , pp. 1200-1210
    • Lee, S.A.1    Ho, C.2    Roy, R.3    Kosinski, C.4    Patil, M.A.5    Tward, A.D.6    Fridlyand, J.7    Chen, X.8
  • 34
    • 84897846435 scopus 로고    scopus 로고
    • Hydrodynamic transfection for generation of novel mouse models for liver cancer research
    • Chen X and Calvisi DF. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol. 2014; 184: 912-923.
    • (2014) Am J Pathol , vol.184 , pp. 912-923
    • Chen, X.1    Calvisi, D.F.2
  • 37
    • 0037379776 scopus 로고    scopus 로고
    • Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate
    • Shim EH, Johnson L, Noh HL, Kim YJ, Sun H, Zeiss C and Zhang H. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Cancer Res. 2003; 63: 1583-1588.
    • (2003) Cancer Res , vol.63 , pp. 1583-1588
    • Shim, E.H.1    Johnson, L.2    Noh, H.L.3    Kim, Y.J.4    Sun, H.5    Zeiss, C.6    Zhang, H.7
  • 38
    • 84857439515 scopus 로고    scopus 로고
    • AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways
    • Ho C, Wang C, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X and Calvisi DF. AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways. Hepatology. 2012; 55: 833-845.
    • (2012) Hepatology , vol.55 , pp. 833-845
    • Ho, C.1    Wang, C.2    Mattu, S.3    Destefanis, G.4    Ladu, S.5    Delogu, S.6    Armbruster, J.7    Fan, L.8    Lee, S.A.9    Jiang, L.10    Dombrowski, F.11    Evert, M.12    Chen, X.13    Calvisi, D.F.14
  • 41
    • 80155126652 scopus 로고    scopus 로고
    • Cell-cycle regulator Cks1 promotes hepatocellular carcinoma by supporting NF-kappaB-dependent expression of interleukin-8
    • Lee EK, Kim DG, Kim JS and Yoon Y. Cell-cycle regulator Cks1 promotes hepatocellular carcinoma by supporting NF-kappaB-dependent expression of interleukin-8. Cancer Res. 2011; 71: 6827-6835.
    • (2011) Cancer Res , vol.71 , pp. 6827-6835
    • Lee, E.K.1    Kim, D.G.2    Kim, J.S.3    Yoon, Y.4
  • 44
    • 33644863486 scopus 로고    scopus 로고
    • Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
    • Lin YW and Yang JL. Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J Biol Chem. 2006; 281: 915-926.
    • (2006) J Biol Chem , vol.281 , pp. 915-926
    • Lin, Y.W.1    Yang, J.L.2
  • 47
    • 0141961143 scopus 로고    scopus 로고
    • Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes
    • Prange W, Breuhahn K, Fischer F, Zilkens C, Pietsch T, Petmecky K, Eilers R, Dienes HP and Schirmacher P. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol. 2003; 201: 250-259.
    • (2003) J Pathol , vol.201 , pp. 250-259
    • Prange, W.1    Breuhahn, K.2    Fischer, F.3    Zilkens, C.4    Pietsch, T.5    Petmecky, K.6    Eilers, R.7    Dienes, H.P.8    Schirmacher, P.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.