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Volumn 120, Issue 5, 2012, Pages 349-357

Nuclear expression of S-phase kinase-associated protein 2 predicts poor prognosis of hepatocellular carcinoma

Author keywords

Hepatocellular carcinoma; Prognosis; S phase kinase associated protein 2

Indexed keywords

S PHASE KINASE ASSOCIATED PROTEIN 2;

EID: 84859991158     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2011.02838.x     Document Type: Article
Times cited : (15)

References (30)
  • 2
    • 18544385653 scopus 로고    scopus 로고
    • Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis
    • Pascale RM, Simile MM, De Miglio MR, Muroni MR, Calvisi DF, Asara G, et al. Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. Hepatology 2002;35:1341-50.
    • (2002) Hepatology , vol.35 , pp. 1341-1350
    • Pascale, R.M.1    Simile, M.M.2    De Miglio, M.R.3    Muroni, M.R.4    Calvisi, D.F.5    Asara, G.6
  • 3
    • 32944469316 scopus 로고    scopus 로고
    • Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer
    • Pascale RM, Simile MM, Calvisi DF, Frau M, Muroni MR, Seddaiu MA, et al. Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. Hepatology 2005;42:1310-9.
    • (2005) Hepatology , vol.42 , pp. 1310-1319
    • Pascale, R.M.1    Simile, M.M.2    Calvisi, D.F.3    Frau, M.4    Muroni, M.R.5    Seddaiu, M.A.6
  • 4
    • 41149141967 scopus 로고    scopus 로고
    • Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
    • Hershko DD. Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer. Cancer 2008;112:1415-24.
    • (2008) Cancer , vol.112 , pp. 1415-1424
    • Hershko, D.D.1
  • 5
    • 70350104779 scopus 로고    scopus 로고
    • SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis
    • e1-10.
    • Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, et al. SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. Gastroenterology 2009;137:1816-26. e1-10.
    • (2009) Gastroenterology , vol.137 , pp. 1816-1826
    • Calvisi, D.F.1    Ladu, S.2    Pinna, F.3    Frau, M.4    Tomasi, M.L.5    Sini, M.6
  • 6
    • 75049085839 scopus 로고    scopus 로고
    • The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma
    • Lu M, Ma J, Xue W, Cheng C, Wang Y, Zhao Y, et al. The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma. Pathol Oncol Res 2009;15:679-87.
    • (2009) Pathol Oncol Res , vol.15 , pp. 679-687
    • Lu, M.1    Ma, J.2    Xue, W.3    Cheng, C.4    Wang, Y.5    Zhao, Y.6
  • 7
    • 77149153065 scopus 로고    scopus 로고
    • CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover: an independent prognosticator with potential p27 (Kip1)-independent oncogenic attributes?
    • Huang CW, Lin CY, Huang HY, Liu HW, Chen YJ, Shih DF, et al. CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover: an independent prognosticator with potential p27 (Kip1)-independent oncogenic attributes? Ann Surg Oncol 2010;17:907-22.
    • (2010) Ann Surg Oncol , vol.17 , pp. 907-922
    • Huang, C.W.1    Lin, C.Y.2    Huang, H.Y.3    Liu, H.W.4    Chen, Y.J.5    Shih, D.F.6
  • 8
    • 0036491845 scopus 로고    scopus 로고
    • The restriction point of the cell cycle
    • Blagosklonny MV, Pardee AB. The restriction point of the cell cycle. Cell Cycle 2002;1:103-10.
    • (2002) Cell Cycle , vol.1 , pp. 103-110
    • Blagosklonny, M.V.1    Pardee, A.B.2
  • 9
    • 0036847690 scopus 로고    scopus 로고
    • Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
    • Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM, et al. Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Clin Cancer Res 2002;8:3419-26.
    • (2002) Clin Cancer Res , vol.8 , pp. 3419-3426
    • Yang, G.1    Ayala, G.2    De Marzo, A.3    Tian, W.4    Frolov, A.5    Wheeler, T.M.6
  • 10
    • 21644448195 scopus 로고    scopus 로고
    • Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors
    • Li JQ, Wu F, Masaki T, Kubo A, Fujita J, Dixon DA, et al. Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int J Oncol 2004;25:87-95.
    • (2004) Int J Oncol , vol.25 , pp. 87-95
    • Li, J.Q.1    Wu, F.2    Masaki, T.3    Kubo, A.4    Fujita, J.5    Dixon, D.A.6
  • 11
    • 50649122298 scopus 로고    scopus 로고
    • The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype
    • Voduc D, Nielsen TO, Cheang MC, Foulkes WD. The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype. Hum Pathol 2008;39:1431-7.
    • (2008) Hum Pathol , vol.39 , pp. 1431-1437
    • Voduc, D.1    Nielsen, T.O.2    Cheang, M.C.3    Foulkes, W.D.4
  • 12
    • 33947604769 scopus 로고    scopus 로고
    • Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray
    • Li SH, Li CF, Sung MT, Eng HL, Hsiung CY, Huang WW, et al. Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray. Mod Pathol 2007;20:497-507.
    • (2007) Mod Pathol , vol.20 , pp. 497-507
    • Li, S.H.1    Li, C.F.2    Sung, M.T.3    Eng, H.L.4    Hsiung, C.Y.5    Huang, W.W.6
  • 13
    • 0036216526 scopus 로고    scopus 로고
    • Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis
    • Tannapfel A, Wittekind C. Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis. Virchows Arch 2002;440:345-52.
    • (2002) Virchows Arch , vol.440 , pp. 345-352
    • Tannapfel, A.1    Wittekind, C.2
  • 14
    • 0036645405 scopus 로고    scopus 로고
    • Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis
    • Masuda TA, Inoue H, Sonoda H, Mine S, Yoshikawa Y, Nakayama K, et al. Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res 2002;62:3819-25.
    • (2002) Cancer Res , vol.62 , pp. 3819-3825
    • Masuda, T.A.1    Inoue, H.2    Sonoda, H.3    Mine, S.4    Yoshikawa, Y.5    Nakayama, K.6
  • 15
    • 0037989911 scopus 로고    scopus 로고
    • Skp2 overexpression is a prognostic factor in patients with ovarian adenocarcinoma
    • Shigemasa K, Gu L, O'Brien TJ, Ohama K. Skp2 overexpression is a prognostic factor in patients with ovarian adenocarcinoma. Clin Cancer Res 2003;9:1756-63.
    • (2003) Clin Cancer Res , vol.9 , pp. 1756-1763
    • Shigemasa, K.1    Gu, L.2    O'Brien, T.J.3    Ohama, K.4
  • 16
    • 12144288298 scopus 로고    scopus 로고
    • Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker
    • Zhu CQ, Blackhall FH, Pintilie M, Iyengar P, Liu N, Ho J, et al. Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker. Clin Cancer Res 2004;10:1984-91.
    • (2004) Clin Cancer Res , vol.10 , pp. 1984-1991
    • Zhu, C.Q.1    Blackhall, F.H.2    Pintilie, M.3    Iyengar, P.4    Liu, N.5    Ho, J.6
  • 17
    • 0036309975 scopus 로고    scopus 로고
    • A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers
    • Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, et al. A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Am J Pathol 2002;161:207-16.
    • (2002) Am J Pathol , vol.161 , pp. 207-216
    • Yokoi, S.1    Yasui, K.2    Saito-Ohara, F.3    Koshikawa, K.4    Iizasa, T.5    Fujisawa, T.6
  • 19
    • 28444478038 scopus 로고    scopus 로고
    • Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas
    • Saigusa K, Hashimoto N, Tsuda H, Yokoi S, Maruno M, Yoshimine T, et al. Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas. Cancer Sci 2005;96:676-83.
    • (2005) Cancer Sci , vol.96 , pp. 676-683
    • Saigusa, K.1    Hashimoto, N.2    Tsuda, H.3    Yokoi, S.4    Maruno, M.5    Yoshimine, T.6
  • 20
    • 38349178697 scopus 로고    scopus 로고
    • A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer
    • Assoian RK, Yung Y. A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer. Cell Cycle 2008;7:24-7.
    • (2008) Cell Cycle , vol.7 , pp. 24-27
    • Assoian, R.K.1    Yung, Y.2
  • 21
    • 1642378661 scopus 로고    scopus 로고
    • Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
    • Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 2004;428:190-3.
    • (2004) Nature , vol.428 , pp. 190-193
    • Bashir, T.1    Dorrello, N.V.2    Amador, V.3    Guardavaccaro, D.4    Pagano, M.5
  • 22
    • 80053583197 scopus 로고    scopus 로고
    • Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21
    • Huang Y, Tong S, Tai AW, Hussain M, Lok AS. Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21. Gastroenterology 2011;141:1412-21.
    • (2011) Gastroenterology , vol.141 , pp. 1412-1421
    • Huang, Y.1    Tong, S.2    Tai, A.W.3    Hussain, M.4    Lok, A.S.5
  • 23
    • 55449109546 scopus 로고    scopus 로고
    • p27(Kip1)is overexpressed in very early stages of hepatocarcinogenesis
    • Yachida S, Sakamoto M, Imaida K, Yokohira M, Saoo K, Okano K, et al. p27(Kip1)is overexpressed in very early stages of hepatocarcinogenesis. Cancer Sci 2008;99:2152-9.
    • (2008) Cancer Sci , vol.99 , pp. 2152-2159
    • Yachida, S.1    Sakamoto, M.2    Imaida, K.3    Yokohira, M.4    Saoo, K.5    Okano, K.6
  • 24
    • 0035927502 scopus 로고    scopus 로고
    • A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT
    • Ganiatsas S, Dow R, Thompson A, Schulman B, Germain D. A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT. Oncogene 2001;20:3641-50.
    • (2001) Oncogene , vol.20 , pp. 3641-3650
    • Ganiatsas, S.1    Dow, R.2    Thompson, A.3    Schulman, B.4    Germain, D.5
  • 25
    • 0037108299 scopus 로고    scopus 로고
    • Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index
    • Lim MS, Adamson A, Lin Z, Perez-Ordonez B, Jordan RC, Tripp S, et al. Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index. Blood 2002;100:2950-6.
    • (2002) Blood , vol.100 , pp. 2950-2956
    • Lim, M.S.1    Adamson, A.2    Lin, Z.3    Perez-Ordonez, B.4    Jordan, R.C.5    Tripp, S.6
  • 26
    • 12444339727 scopus 로고    scopus 로고
    • Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients
    • Drobnjak M, Melamed J, Taneja S, Melzer K, Wieczorek R, Levinson B, et al. Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients. Clin Cancer Res 2003;9:2613-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 2613-2619
    • Drobnjak, M.1    Melamed, J.2    Taneja, S.3    Melzer, K.4    Wieczorek, R.5    Levinson, B.6
  • 27
    • 7444234290 scopus 로고    scopus 로고
    • Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship
    • Li Q, Murphy M, Ross J, Sheehan C, Carlson JA. Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship. J Cutan Pathol 2004;31:633-42.
    • (2004) J Cutan Pathol , vol.31 , pp. 633-642
    • Li, Q.1    Murphy, M.2    Ross, J.3    Sheehan, C.4    Carlson, J.A.5
  • 28
    • 79952229159 scopus 로고    scopus 로고
    • Cytoplasmic skp2 expression is increased in human melanoma and correlated with patient survival
    • Chen G, Cheng Y, Zhang Z, Martinka M, Li G. Cytoplasmic skp2 expression is increased in human melanoma and correlated with patient survival. PLoS ONE 2011;6:e17578.
    • (2011) PLoS ONE , vol.6
    • Chen, G.1    Cheng, Y.2    Zhang, Z.3    Martinka, M.4    Li, G.5
  • 29
    • 19444367346 scopus 로고    scopus 로고
    • Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer
    • Radke S, Pirkmaier A, Germain D. Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer. Oncogene 2005;24:3448-58.
    • (2005) Oncogene , vol.24 , pp. 3448-3458
    • Radke, S.1    Pirkmaier, A.2    Germain, D.3
  • 30
    • 64049087382 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
    • Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, et al. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol 2009;11:420-32.
    • (2009) Nat Cell Biol , vol.11 , pp. 420-432
    • Lin, H.K.1    Wang, G.2    Chen, Z.3    Teruya-Feldstein, J.4    Liu, Y.5    Chan, C.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.