메뉴 건너뛰기




Volumn 24, Issue 3, 2015, Pages 393-399

Receptor for advanced glycation endproduct modulators: A new therapeutic target in Alzheimer's disease

Author keywords

Alzheimer's disease; Clinical trials; Inflammation; Receptor for advanced glycation endproducts; amyloid

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR ANTAGONIST; AMYLOID BETA PROTEIN; LIPID; PF 4494700; ADVANCED GLYCATION END PRODUCT RECEPTOR; IMMUNOGLOBULIN RECEPTOR; LIGAND;

EID: 84923016150     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2015.1001490     Document Type: Review
Times cited : (66)

References (41)
  • 1
    • 84879077265 scopus 로고    scopus 로고
    • Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
    • Hebert LE, Weuve J, Scherr PA, et al. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology 2013;80:1778-83
    • (2013) Neurology , vol.80 , pp. 1778-1783
    • Hebert, L.E.1    Weuve, J.2    Scherr, P.A.3
  • 2
    • 84872570129 scopus 로고    scopus 로고
    • Alzheimer's disease and the quot;Valley of Deathquot;: Not enough guidance from human brain tissue?
    • Beach TG. Alzheimer's disease and the quot;Valley Of Deathquot;: not enough guidance from human brain tissue? J Alzheimers Dis 2013;33(Suppl 1):S219-33
    • (2013) J Alzheimers Dis , vol.33 , pp. S219-S233
    • Beach, T.G.1
  • 3
    • 84899019792 scopus 로고    scopus 로고
    • Amyloid-beta and tau: The trigger and bullet in Alzheimer disease pathogenesis
    • Bloom GS. Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 2014;71:505-8
    • (2014) JAMA Neurol , vol.71 , pp. 505-508
    • Bloom, G.S.1
  • 4
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-90
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 5
    • 0023109592 scopus 로고
    • Amyloid beta protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
    • Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987;235:880-4
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 6
    • 0034489963 scopus 로고    scopus 로고
    • Amyloid-beta and treatment opportunities for Alzheimer's disease
    • Sabbagh MN, Galasko D, Koo E, et al. Amyloid-beta and treatment opportunities for Alzheimer's disease. J Alzheimers Dis 2000;2:231-59
    • (2000) J Alzheimers Dis , vol.2 , pp. 231-259
    • Sabbagh, M.N.1    Galasko, D.2    Koo, E.3
  • 7
    • 84885456046 scopus 로고    scopus 로고
    • The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy
    • McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol 2013;126:479-97
    • (2013) Acta Neuropathol , vol.126 , pp. 479-497
    • McGeer, P.L.1    McGeer, E.G.2
  • 9
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000;408:982-5
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 10
    • 84883315336 scopus 로고    scopus 로고
    • Inflammatory components in human Alzheimer's disease and after active amyloid-beta42 immunization
    • Zotova E, Bharambe V, Cheaveau M, et al. Inflammatory components in human Alzheimer's disease and after active amyloid-beta42 immunization. Brain 2013;136:2677-96
    • (2013) Brain , vol.136 , pp. 2677-2696
    • Zotova, E.1    Bharambe, V.2    Cheaveau, M.3
  • 11
    • 84892695519 scopus 로고    scopus 로고
    • Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
    • Salloway S, Sperling R, Fox NC, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med 2014;370:322-33
    • (2014) N Engl J Med , vol.370 , pp. 322-333
    • Salloway, S.1    Sperling, R.2    Fox, N.C.3
  • 12
    • 0013615899 scopus 로고    scopus 로고
    • RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
    • Yan SD, Chen X, Fu J, et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 1996;382:685-91
    • (1996) Nature , vol.382 , pp. 685-691
    • Yan, S.D.1    Chen, X.2    Fu, J.3
  • 13
    • 44449179863 scopus 로고    scopus 로고
    • Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease
    • Takeuchi M, Yamagishi S. Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease. Curr Pharm Des 2008;14:973-8
    • (2008) Curr Pharm des , vol.14 , pp. 973-978
    • Takeuchi, M.1    Yamagishi, S.2
  • 14
    • 77950989148 scopus 로고    scopus 로고
    • The sour side of neurodegenerative disorders: The effects of protein glycation
    • Vicente MH, Outeiro TF. The sour side of neurodegenerative disorders: the effects of protein glycation. J Pathol 2010;221:13-25
    • (2010) J Pathol , vol.221 , pp. 13-25
    • Vicente, M.H.1    Outeiro, T.F.2
  • 15
    • 0028023944 scopus 로고
    • Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
    • Yan SD, Chen X, Schmidt AM, et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci USA 1994;91:7787-91
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7787-7791
    • Yan, S.D.1    Chen, X.2    Schmidt, A.M.3
  • 16
    • 0026659883 scopus 로고
    • Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
    • Neeper M, Schmidt AM, Brett J, et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992;267:14998-5004
    • (1992) J Biol Chem , vol.267 , pp. 14998-15004
    • Neeper, M.1    Schmidt, A.M.2    Brett, J.3
  • 17
    • 0344286498 scopus 로고    scopus 로고
    • Activation of receptor for advanced glycation end products: A mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis
    • Schmidt AM, Yan SD, Wautier JL, et al. Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 1999;84:489-97
    • (1999) Circ Res , vol.84 , pp. 489-497
    • Schmidt, A.M.1    Yan, S.D.2    Wautier, J.L.3
  • 18
    • 38349143353 scopus 로고    scopus 로고
    • RAGE: A potential target for Abetamediated cellular perturbation in Alzheimer's disease
    • Chen X, Walker DG, Schmidt AM, et al. RAGE: a potential target for Abetamediated cellular perturbation in Alzheimer's disease. Curr Mol Med 2007;7:735-42
    • (2007) Curr Mol Med , vol.7 , pp. 735-742
    • Chen, X.1    Walker, D.G.2    Schmidt, A.M.3
  • 19
    • 79954585505 scopus 로고    scopus 로고
    • Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
    • Srikanth V, Maczurek A, Phan T, et al. Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease. Neurobiol Aging 2011;32:763-77
    • (2011) Neurobiol Aging , vol.32 , pp. 763-777
    • Srikanth, V.1    Maczurek, A.2    Phan, T.3
  • 20
    • 42649088066 scopus 로고    scopus 로고
    • Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains
    • Nozaki I, Watanabe T, Kawaguchi M, et al. Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains. Arch Histol Cytol 2007;70:279-90
    • (2007) Arch Histol Cytol , vol.70 , pp. 279-290
    • Nozaki, I.1    Watanabe, T.2    Kawaguchi, M.3
  • 21
    • 70849087805 scopus 로고    scopus 로고
    • Ectodomain shedding of the receptor for advanced glycation end products: A novel therapeutic target for Alzheimer's disease
    • Zhang L, Postina R, Wang Y. Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer's disease. Cell Mol Life Sci 2009;66:3923-35
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3923-3935
    • Zhang, L.1    Postina, R.2    Wang, Y.3
  • 22
    • 46649112475 scopus 로고    scopus 로고
    • Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment
    • Ghidoni R, Benussi L, Glionna M, et al. Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment. J Neural Transm 2008;115:1047-50
    • (2008) J Neural Transm , vol.115 , pp. 1047-1050
    • Ghidoni, R.1    Benussi, L.2    Glionna, M.3
  • 23
    • 84908622726 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts (RAGE), its ligands, and soluble rage: Potential biomarkers for diagnosis and therapeutic targets for human renal diseases
    • Lee EJ, Park JH. Receptor for advanced glycation endproducts (RAGE), its ligands, and soluble rage: potential biomarkers for diagnosis and therapeutic targets for human renal diseases. Genomics Inform 2013;11:224-9
    • (2013) Genomics Inform , vol.11 , pp. 224-229
    • Lee, E.J.1    Park, J.H.2
  • 24
    • 54049094343 scopus 로고    scopus 로고
    • Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    • Miller MC, Tavares R, Johanson CE, et al. Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease. Brain Res 2008;1230:273-80
    • (2008) Brain Res , vol.1230 , pp. 273-280
    • Miller, M.C.1    Tavares, R.2    Johanson, C.E.3
  • 25
    • 0035847269 scopus 로고    scopus 로고
    • Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease
    • Sasaki N, Toki S, Chowei H, et al. Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease. Brain Res 2001;888:256-62
    • (2001) Brain Res , vol.888 , pp. 256-262
    • Sasaki, N.1    Toki, S.2    Chowei, H.3
  • 26
    • 0034840664 scopus 로고    scopus 로고
    • Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: Identification of a cellular activation mechanism
    • Lue LF, Walker DG, Brachova L, et al. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Exp Neurol 2001;171:29-45
    • (2001) Exp Neurol , vol.171 , pp. 29-45
    • Lue, L.F.1    Walker, D.G.2    Brachova, L.3
  • 27
    • 8144223671 scopus 로고    scopus 로고
    • RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice
    • Arancio O, Zhang HP, Chen X, et al. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J 2004;23:4096-105
    • (2004) EMBO J , vol.23 , pp. 4096-4105
    • Arancio, O.1    Zhang, H.P.2    Chen, X.3
  • 28
    • 77951647591 scopus 로고    scopus 로고
    • RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/ memory in a mouse model of Alzheimer's disease
    • Fang F, Lue LF, Yan S, et al. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/ memory in a mouse model of Alzheimer's disease. FASEB J 2010;24:1043-55
    • (2010) FASEB J , vol.24 , pp. 1043-1055
    • Fang, F.1    Lue, L.F.2    Yan, S.3
  • 29
    • 84903202395 scopus 로고    scopus 로고
    • RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment
    • Origlia N, Criscuolo C, Arancio O, et al. RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. J Neurosci 2014;34:8749-60
    • (2014) J Neurosci , vol.34 , pp. 8749-8760
    • Origlia, N.1    Criscuolo, C.2    Arancio, O.3
  • 30
    • 0037703255 scopus 로고    scopus 로고
    • RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
    • Deane R, Du YS, Submamaryan RK, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 2003;9:907-13
    • (2003) Nat Med , vol.9 , pp. 907-913
    • Deane, R.1    Du, Y.S.2    Submamaryan, R.K.3
  • 31
    • 4043061467 scopus 로고    scopus 로고
    • LRP/ amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
    • Deane R, Wu Z, Sagare A, et al. LRP/ amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 2004;43:333-44
    • (2004) Neuron , vol.43 , pp. 333-344
    • Deane, R.1    Wu, Z.2    Sagare, A.3
  • 32
    • 33749157416 scopus 로고    scopus 로고
    • RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
    • Donahue JE, Flaherty SL, Johanson CE, et al. RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. Acta Neuropathol 2006;112:405-15
    • (2006) Acta Neuropathol , vol.112 , pp. 405-415
    • Donahue, J.E.1    Flaherty, S.L.2    Johanson, C.E.3
  • 33
    • 53549086409 scopus 로고    scopus 로고
    • Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis
    • Jeynes B, Provias J. Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis. Curr Alzheimer Res 2008;5:432-7
    • (2008) Curr Alzheimer Res , vol.5 , pp. 432-437
    • Jeynes, B.1    Provias, J.2
  • 34
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease
    • Deane R, Bell RD, Sagare A, et al. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 2009;8:16-30
    • (2009) CNS Neurol Disord Drug Targets , vol.8 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3
  • 35
    • 48949117577 scopus 로고    scopus 로고
    • The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease
    • Deane R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des 2008;14:1601-5
    • (2008) Curr Pharm des , vol.14 , pp. 1601-1605
    • Deane, R.1    Sagare, A.2    Zlokovic, B.V.3
  • 36
    • 80052258842 scopus 로고    scopus 로고
    • PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease
    • Sabbagh MN, Agro A, Bell J, et al. PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease. Alzheimer Dis Assoc Disord 2011;25:206-12
    • (2011) Alzheimer Dis Assoc Disord , vol.25 , pp. 206-212
    • Sabbagh, M.N.1    Agro, A.2    Bell, J.3
  • 37
    • 84859723641 scopus 로고    scopus 로고
    • A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease
    • Deane R, Singh I, Sagare AP, et al. A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest 2012;122:1377-92
    • (2012) J Clin Invest , vol.122 , pp. 1377-1392
    • Deane, R.1    Singh, I.2    Sagare, A.P.3
  • 38
    • 84865822723 scopus 로고    scopus 로고
    • Hypertension induces brain betaamyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature
    • Carnevale D, Mascio G, D'Andrea I, et al. Hypertension induces brain betaamyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension 2012;60:188-97
    • (2012) Hypertension , vol.60 , pp. 188-197
    • Carnevale, D.1    Mascio, G.2    D'Andrea, I.3
  • 39
    • 84899516443 scopus 로고    scopus 로고
    • Effect of TTP488 in patients with mild to moderate Alzheimer's disease
    • Burstein AH, Grimes I, Galasko DR, et al. Effect of TTP488 in patients with mild to moderate Alzheimer's disease. BMC Neurol 2014;14:12
    • (2014) BMC Neurol , vol.14 , pp. 12
    • Burstein, A.H.1    Grimes, I.2    Galasko, D.R.3
  • 40
    • 84902173668 scopus 로고    scopus 로고
    • For the ADCS. Clinical trial of an inhibitor of RAGE-abeta interactions in Alzheimer's disease
    • Galasko D, Bell J, Mancuso J, et al. for the ADCS. Clinical trial of an inhibitor of RAGE-Abeta interactions in Alzheimer's disease. Neurology 2014;82(17):1536-42
    • (2014) Neurology , vol.82 , Issue.17 , pp. 1536-1542
    • Galasko, D.1    Bell, J.2    Mancuso, J.3
  • 41
    • 79955857718 scopus 로고    scopus 로고
    • Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'
    • Castellani RJ, Smith MA. Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'. J Pathol 2011;224(2):147-52
    • (2011) J Pathol , vol.224 , Issue.2 , pp. 147-152
    • Castellani, R.J.1    Smith, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.