The effects of Nigella sativa hydro-alcoholic extract on memory and brain tissues oxidative damage after repeated seizures in rats

Iranian Journal of Pharmaceutical Research

Volumn 14, Issue 2, 2015, Pages 547-557

  Vafaee, Farzaneh ^a   Hosseini, Mahmoud ^b   Hassanzadeh, Zahra ^c   Edalatmanesh, Mohammad Amin ^c   Sadeghnia, Hamid Reza ^d   Seghatoleslam, Masoumeh ^b   Mousavi, Seyed Mojtaba ^a   Amani, Atefeh ^b   Shafei, Mohammad Naser ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Memory; Nigella sativa; Oxidative stress; Pentylenetetrazole; Repeated seizures

Indexed keywords

ALCOHOL; MALONALDEHYDE; NIGELLA SATIVA EXTRACT; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ASSAY; ARTICLE; BLACK CUMIN; BRAIN TISSUE; CONTROLLED STUDY; LEARNING; LIPID PEROXIDATION; MALE; MEMORY; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE TEST; PENTYLENETETRAZOLE-INDUCED SEIZURE; RAT; SEIZURE;

EID: 84922983637     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Devi PU, Manocha A and Vohora D. Seizures, antiepileptics, antioxidants and oxidative stress: an insight for researchers. Expert. Opin. Pharmacother. (2008) 9: 3169-3177.
2. Kudin AP, Kudina TA, Seyfried J, Vielhaber S, Beck H, Elger CE and Kunz WS. Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. Eur. J. Neurosci. (2002) 15: 1105-1114.
3. Khodabandehloo F, Hosseini M, Rajaei Z, Soukhtanloo M, Farrokhi E and Rezaeipour M. Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats. Arquivos de Neuro-psiquiatria (2012) 71: 313-319.
4. Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR and Soukhtanloo M. Effects of the hydro-alcoholic extract of Nigella Sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chin. J. Integr. Med. Epub. (2014) 1742-1745.
5. Dodrill CB. Progressive cognitive decline in adolescents and adults with epilepsy. Prog. Brain Res. (2002) 135: 399-407.
6. Lamberty Y and Klitgaard H. Consequences of Pentylenetetrazole Kindling on Spatial Memory and Emotional Responding in the Rat. Epilepsy Behav. (2000) 1: 256-261.
7. Tome Ada R, Feitosa CM and Freitas RM. Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? Arquivos de Neuro-psiquiatria (2010) 68: 579-585.
8. Mao RR, Tian M, Yang YX, Zhou QX, Xu L and Cao J. Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory. Epilepsy Behav. (2009) 15: 441-444.
9. Ali BH and Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. (2003) 17: 299-305.
10. Hosseini M, Zakeri S, Khoshdast S, Yousefan FT, Rastegar M, Vafaee F, Kahdouee S, Ghorbani F, Rakhshandeh H and Kazemi SA. The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats. J. Pharm. Bioallied. Sci. (2012) 4: 219-25.
11. Perveen T, Haider S, Zubari NA, Saleem S, Sadaf S and Batool Z. Increased 5-HT levels following repeated administration of nigella sativa l.(black seed) oil produce antidepressant effects in rats. Sci. Pharm. (2013) 82: 161-170
12. Azzubaidi MS, Saxena AK, Talib NA, Ahmed QU and Dogarai BB. Protective effect of treatment with black cumin oil on spatial cognitive functions of rats that suffered global cerebrovascular hypoperfusion. Acta Neurobiol. Exp. (2012) 72: 154-165.
13. Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF and Rahman MR. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J. Ethnopharmacol. (2013) 148: 780-786.
14. Sahak MK, Mohamed AM, Hashim NH and Hasan Adli DS. Nigella sativa oil enhances the spatial working memory performance of rats on a radial arm maze. Evid. Based Compl. Altern. Med.(2013) 2013: 5.
15. Roghani M. The effect of Nigella sativa on learning and memory in male diabetic rats. Basic Clin. Neurosci. (2009) 1: 32-34.
16. Abdollahi Fard M and Shojaii A. Efficacy of Iranian traditional medicine in the treatment of epilepsy. Biomed. Res. Int. (2013)2013: 8.
17. Hosseinzadeh H, Parvardeh S, Nassiri-Asl M and Mansouri MT. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med. Sci. Monit. (2005) 11: 106-110.
18. Hosseinzadeh H and Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomed. (2004) 11: 56-64.
19. Akhondian J, Kianifar H, Raoofziaee M, Moayedpour A, Toosi MB and Khajedaluee M. The effect of thymoquinone on intractable pediatric seizures (pilot study). Epilepsy Res. (2011) 93: 39-43.
20. Akhondian J, Parsa A and Rakhshande H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med. Sci. Monit. (2007) 13: 555-559.
21. Shawki M, El Wakeel L, Shatla R, El-Saeed G, Ibrahim S and Badary O. The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study. Epileptic. Disord. (2013) 15: 295-301.
22. Noor NA, Aboul Ezz HS, Faraag AR and Khadrawy YA. Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. Epilepsy Behav. (2012) 24: 199-206.
23. Ismail M, Al-Naqeep G and Chan KW. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol. Med. (2010) 48: 664-672.
24. Uz E, Bayrak O, Kaya A, Bayrak R, Uz B, Turgut FH, Bavbek N, Kanbay M and Akcay A. Nigella sativa oil for prevention of chronic cyclosporine nephrotoxicity: an experimental model. Am. J. Nephrol. (2008) 28: 517-522.
25. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR and Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomed. (2007) 14: 621-627.
26. Ilhan A, Gurel A, Armutcu F, Kamisli S and Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacol. (2005) 49: 456-464.
27. Sandhu KS and Rana AC. Evaluation of antiparknsons activity of Nigella sativa(Kalonji) seeds in chlorpromazine induced experimental animal model. Int. J. Pharm. Pharm. Sci. (2013) 5: 884-888.
28. Ebrahimzadeh Bideskan AR, Hosseini M, Mohammadpour T, Karami R, Khodamoradi M, Nemati Karimooy H and Alavi H. Effects of soy extract on pentylenetetrazol-induced seizures in ovariectomized rats. Zhong Xi Yi Jie He Xue Bao (2011) 9: 611-618.
29. Sadeghian R, Fereidoni M, Soukhtanloo M, Azizi-Malekabadi H and Hosseini M. Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol. Arquivos de Neuro-psiquiatria (2012) 70: 874-879.
30. Assadian Narenji S, Naghdi N, Oryan Sh and Azadmanesh K. Intrahippocampal injection of 3α diol (a testosterone metabolite) and indomethacin (3α-hsd blocker), impair acquisition of spatial learning and memory in adult male rats. Iran. J. Pharm. Res. (2013) 12: 457-469.
31. Naghibi SM, Hosseini M, Khani F, Rahimi M, Vafaee F, Rakhshandeh H and Aghaie A. Effect of aqueous extract of crocus sativus l. on morphine-induced memory impairment. Adv. Pharmacol. Sci. (2012) 2012: 7.
32. Costello DJ and Delanty N. Oxidative injury in epilepsy: potential for antioxidant therapy? Expert. Rev. Neurother. (2004) 4: 541-553.
33. Mortazavi F, Ericson M, Story D, Hulce VD and Dunbar GL. Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. Epilepsy Behav. (2005) 7: 629-638.
34. Mohamed A, Afridi DM, Garani O and Tucci M. Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed. Sci. Inst. (2005) 41: 388.
35. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol. (2005) 5: 1749-1770.
36. Kanter M. Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem. Res. (2008) 33: 579-588.
37. Sedaghat R, Roghani M and Khalili M. neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model. Iran. J. Pharm. Res. (2014) 13: 227-234.
38. Kanter M, Coskun O, Kalayci M, Buyukbas S and Cagavi F. Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats. Hum. Exp. Toxicol. (2006) 25: 127-133.
39. Hamdy NM and Taha RA. Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacol. (2009) 84: 127-134.
40. Arafa NM, Abdel-Rahman M, El-khadragy MF and Kassab RB. Evaluation of the possible epileptogenic activity of ciprofoxacin: the role of Nigella sativa on amino acids neurotransmitters. Neurochem. Res. (2013) 38: 174-185.
41. El-Naggar T, Gomez-Serranillos MP, Palomino OM, Arce C and Carretero ME. Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in-vitro. J. Biomed. Biotechnol. (2010) 2010: 8.
42. Łuszczki JJ, Wlodarczyk M, Glensk M, Marzeda E, Durmowicz D and Floredk-Luszczki M. Effects of various naturally occurring compounds (arbutin, borneol, esculetin, esculin, ellagic acid, gallic acid, hesperidine, piperitol, piperonal, quercetin, thymoquinone and ursolic acid) against maximal electroshock-induced seizures in mice. Curr. Issues Pharm. Med. Sci. (2013) 26: 135-139.
43. Raza M, Alghasham AA, Alorainy MS and El-Hadiyah TM. Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors. Int. J. Health Sci. (2008) 2: 15-25.
44. Raza M, Alghasham AA, Alorainy MS and El-Hadiyah TM. Beneficial interaction of thymoquinone and sodium valproate in experimental models of epilepsy: reduction in hepatotoxicity of valproate. Scientia Pharm. (2006) 74: 159.
45. Abdel-Fattah AM, Matsumoto K and Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Europ. J. Pharmacol. (2000) 400: 89-97.
46. Anvari M, Seddigh A, Shafei MN, Rakhshandeh H, Talebi AH, Tahani MR, Saeedjalali SM and Hosseini M. Nigella sativa extract affects conditioned place preference induced by morphine in rats. Anc. Sci. Life (2012) 32: 82-88.
47. El-Obeid A, Al-Harbi S, Al-Jomah N and Hassib A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomed. (2006) 13: 324-333.
48. Avramidis N, Kourounakis A, Hadjipetrou L and Senchuk V. Anti-inflammatory and immunomodulating properties of grape melanin: inhibitory effects on paw edema and adjuvant induced disease. ArzneimittelForschung (1998) 48: 764-771.
49. Mohagheghpour N, Waleh N, Garger SJ, Dousman L, Grill LK and Tusé D. Synthetic Melanin Suppresses Production of Proinflammatory Cytokines. Cellular Immunol. (2000) 199: 25-36.