Neuronal damage and memory deficits after seizures are reversed by ascorbic acid?;O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico?

Arquivos de Neuro-Psiquiatria

Volumn 68, Issue 4, 2010, Pages 579-585

  Tomé, Adriana da Rocha ^a,b   Feitosa, Chistiane Mendes ^a   de Freitas, Rivelilson Mendes ^a,b  

^a FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^b STATE UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Ascorbic acid; Hippocampus; Memory; Neuronal damage; Pilocarpine; Seizures

Indexed keywords

ASCORBIC ACID; PILOCARPINE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; EPILEPTIC STATE; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MOTOR ACTIVITY; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; RAT; REFERENCE MEMORY; TASK PERFORMANCE; TREATMENT OUTCOME; WORKING MEMORY;

EID: 77957309987     PISSN: 0004282X     EISSN: 16784227     Source Type: Journal    
DOI: 10.1590/s0004-282x2010000400019     Document Type: Article

References (29)

1. Turski WA, Cavalheiro EA, Schwartz M, Czuczwar SJ, Kleinrok Z, Turski L. Limbic seizures produced by pilocarpine in rats: a behavioural, electroencephalographic and neuropathological study. Behav Brain Res 1983;9:315-335.
2. Marinho MMF, Sousa FCF, Bruin VMS, Aguiar LMV, Pinho RSN, Viana GSB. Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. Neurosc Lett 1997;235:13-16.
3. Turski WA, Czuczwar SJ, Kleinrok Z, Turski L. Cholinomimetics produce seizures and brain damage in rats. Experientia 1983;39:1408-1411.
4. Jope RS, Morisett RA, Snead OC. Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. Exper Neurol 1986;91:471-480.
5. Marinho MMF, Sousa FCF, Bruin VMS, Vale MR, Viana GSB. Effects of lithium, alone or associated with pilocarpine, on muscarinic and dopaminergic receptors and on phosphoinositide metabolism in rat hippocampus and striatum. Neurochem Int 1998;33:299-306.
6. Morrisett RA, Jope RS, Snead OC. Effects of drugs on the initiation and maintenance of status eplepticus induced by administration of pilocarpine to lithium-pretread rats. Exper Neurol 1987;97:193-200.
7. Clifford DB, Olney JW, Maniotis A, Collins RC, Zorumski CF. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. Neuroscience 1987;23:953-968.
8. Honchar MP, Olney JW, Sherman WR. Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science 1983;220:323-325.
9. Júnior HVN, Fonteles MMF, Freitas RM. Acute seizure activity promotes lipidperoxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum. Oxid Med Cell Long 2009;2:1-8.
10. Freitas RM, Sousa FCF, Vasconcelos SMM, Viana GSB, Fonteles MMF. Alterações agudas dos níveis de neurotransmissores em corpo estriado de ratos jovens após estado epiléptico induzido por pilocarpina. Arq Neuropsiquiatr 2003;61:430-433.
11. Santos IMS, Freitas RLM, Saldanha GB, Tomé AR, Jordan J, Freitas RM. Alterations on monoamines concentration in rat hippocampus produced by lipoic acid. Arq Neuropsiquiatr: in press.
12. D'Hooge R, De Deyn PP. Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 2001;36:60-90.
13. Morris RG, Garrud P, Rawlins JN, O'keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982;297:681-683.
14. Netto CA, Dias RD, Izquierdo I. Differential effect of post training naloxone beta-endorphin, leu-enkephalin and electroconvulsive shock administration upon memory of an open-field habituation and of a water-finding task. Psychoneuroendocrinology 1986;11:437-446.
15. Netto CA, Hodges H, Sinden JD, et al. Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze. Neuroscience1993;54:69-92.
16. Bureau YRJ, Peredery O, Persinger MA. Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures. Brain Research 1994;648:265-269.
17. Crawford CA, Rowllet JK, McDougall SA, Bardo MT. Age-dependent differences in the rate of recovery of striatal dopamine D1 and D2 receptors after inactivation with EEDQ. Eur J Pharmacol 1994;252:225-231.
18. Paxinos G, Watson C. The rat brain in stereotaxie coordenates. Academic Press: New York, 1986.
19. Labandeira-Garcia JL, Tobio JP, Guerra MJ. Comparison between normal developing striatum and developing striatal grafts using drug-induced Fos expression and neuron-specific enolase immunohistochemistry. Neuroscience 1994;60:399-415.
20. Mello LEAM, Del Bel EA, Gomes ELT, Oliveira JAC, Wakamatsu H, Cairasco NG. Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizures susceptible Wistar rats. Epilepsy Res 1996;26:177-192.
21. Mudd SH, Levy HL, Kraus JP. Disorders of trans sulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D (Eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, 8th Ed, 2001.
22. Ferreira PMP, Militão GCG, Freitas RM. Lipoic acid effects on lipid peroxidation level, superoxide dismutase activity and monoamines concentration in rat hippocampus. Neurosci Lett 2009;464:131-134.
23. Freitas RM, Vasconcelos SMM, Souza FCF, Viana GSB, Fonteles MMF. Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats. FEBS Journal 2005;272:1307-1312.
24. Augoustides-Savvopoulou P, Luka Z, Karyda S, et al. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J Inherit Metab Dis 2003;26:745-759.
25. Koçak G, Aktan F, Canbolat O, Özogul C, Elbeg S, Yildizoglu-Ari N, Karasu C. Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes. Diabetes Nutr Metab 2000;13:308-318.
26. Mesulam MM, Guillozet A, Shaw P, Levey A, Duysen A, Lockridge O. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience 2002; 170:627-639.
27. Peredery O, Blomme MA, Parker G. Absence of maternal behaviour in rats with lithium/pilocarpine seizure induced brain damage: support of Macleans triune brain theory. Physiol Behav 1992;52:665-671.
28. Holmes GL, Cha BH, Akman C, Silveira DC, Liu X. Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis. Brain Dev 2004;26: 394-397.
29. Devi PU, Manocha A, Vohora D. Seizures, antiepileptics, antioxidants and oxidative stress: an insight for researchers. Expert Opin Pharmacother 2008; 9:3169-3177.