Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in vitro

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  El Naggar, Tarek ^a   Gómez Serranillos, María Pilar ^a   Palomino, Olga María ^a   Arce, Carmen ^a   Carretero, María Emilia ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; DANSYL CHLORIDE; GLUTAMIC ACID; NIGELLA SATIVA EXTRACT; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMINO ACID; METHANOL; PLANT EXTRACT; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FETUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEUROTRANSMISSION; NONHUMAN; PLANT SEED; RAT; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; NERVE CELL; SECRETION;

NIGELLA SATIVA; RATTUS;

AMINO ACIDS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; METHANOL; NEURONS; NEUROTRANSMITTER AGENTS; PLANT EXTRACTS; POTASSIUM CHLORIDE; RATS; SEEDS;

EID: 77954558779     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/398312     Document Type: Article

References (42)

1. Swamy S. M. K., Tan B. K. H., Cytotoxic and immunopotentiating effects of ethanolic extract of N. sativa L. seeds Journal of Ethnopharmacology 2000 70 1 1 7
2. El-Tahir K. E., Ashour M. M., Al-Harbi M. M., The cardiovascular actions of the volatile oil of the black seeds (Nigella sativa) in rats: elucidation of the mechanism of action General Pharma Cology 1993 24 5 1123 1131
3. Abdel-Fattah A.-F. M., Matsumoto K., Watanabe H., Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice European Journal of Pharmacology 2000 400 1 89 97
4. Chakravarty N., Inhibition of histamine release from mast cells by nigellone Annals of Allergy 1993 70 3 237 242
5. Khan M. A., Chemical composition and medicinal properties of Nigella sativa Linn Inflammopharmacology 1999 7 1 15 35
6. Zaoui A., Cherrah Y., Lacaille-Dubois M. A., Settaf A., Amarouch H., Hassar M., Diuretic and hypotensive effects of Nigella sativa on the spontaneously hypertensive rat Therapie 2000 55 3 379 382
7. Al-Majed A. A., Daba M. H., Asiri Y. A., Al-Shabanah O. A., Mostafa A. A., El-Kashef H. A., Thymoquinone-induced relaxation of guinea-pig isolated trachea Research Communications in Molecular Pathology and Pharmacology 2001 110 5-6 333 345
8. Farah I. O., Begum R. A., Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells Biomedical Sciences Instrumentation 2003 39 359 364
9. El-Abhar H. S., Abdallah D. M., Saleh S., Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats Journal of Ethnopharmacology 2003 84 2-3 251 258
10. Kalus U., Pruss A., Bystron J., Jurecka M., Smekalova A., Lichius J. J., Kiesewetter H., Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases Phytotherapy Research 2003 17 10 1209 1214
11. Aqel M. B., The relaxing effect of the volatile oil of Nigella sativa seed onvascular smooth muscle Dirasat Series B, Pure Applied Science 1992 19 91 100
12. Reiter M., Brandt W., Relaxant effects on tracheal and ileal smooth muscles of the guinea pig Arzneimittel-Forschung/Drug Research 1985 35 1 A 408 414
13. Ilhan A., Gurel A., Armutcu F., Kamisli S., Iraz M., Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice Neuropharmacology 2005 49 4 456 464
14. Guha D., Biswas D., Purkayastha S., Suppression of penicillin-induced epileptiform activity by Nigella sativa: possible mediation by neurotransmitters Biogenic Amines 2005 19 46 309 321
15. Kanter M., Protective effects of Nigella sativa on the neuronal injury in frontal cortex and brain stem after chronic toluene exposure Neurochemical Research 2008 33 11 2241 2249
16. Kanter M., Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats Neurochemical Research 2008 33 3 579 588
17. Khan M. A. U., Ashfaq M. K., Zuberi H. S., Mahmood M. S., Gilani A. H., The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds Phytotherapy Research 2003 17 2 183 186
18. Hosseinzadeh H., Parvardeh S., Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice Phytomedicine 2004 11 1 56 64
19. Al-Jassir M. S., Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia Food Chemistry 1992 45 4 239 242
20. Perveen T., Haider S., Kanwal S., Haleem D. J., Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats Pakistan Journal of Pharmaceutical Sciences 2009 22 2 139 144
21. Hosseinzadeh H., Parvardeh S., Nassiri-Asl M., Mansouri M.-T., Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats Medical Science Monitor 2005 11 4 BR106 BR110
22. Muthu Kumara S. S., Kwong Huat B. T., Extraction, isolation and characterisation of antitumor principle, -hederin, from the seeds of Nigella sativa Planta Medica 2001 67 1 29 32
23. Atta-ur-Rahman, Malik S., Sadiq Hasan S., Iqbal Choudhary M., Ni C.-Z., Clardy J., Nigellidinea new indazole alkaloid from the seeds of Nigella sativa Tetrahedron Letters 1995 36 12 1993 1996
24. Merfort I., Wray V., Barakat H. H., Hussein S. A. M., Nawwar M. A. M., Willuhn G., Flavonol triglycosides from seeds of Nigella sativa Phytochemistry 1997 46 2 359 363
25. Ramadan M. F., Mrsel J. T., Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil Nahrung 2002 46 4 240 244
26. Al-Naggar T. B., Gmez-Serranillos M. P., Carretero M. E., Villar A. M., Neuropharmacological activity of Nigella sativa L. extracts Journal of Ethnopharmacology 2003 88 1 63 68
27. Santos M. S., Ferreira F., Cunha A. P., Carvalho A. P., Ribeiro C. F., Macedo T., Synaptosomal GABA release as influenced by valerian root extractinvolvement of the GABA carrier Archives Internationales de Pharmacodynamie et de Therapie 1994 327 2 220 231
28. Awad R., Arnason J. T., Trudeau V., Bergeron C., Budzinski J. W., Foster B. C., Merali Z., Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties Phytomedicine 2003 10 8 640 649
29. Levi G., Raiteri M., Carrier-mediated release of neurotransmitters Trends in Neurosciences 1993 16 10 415 419
30. Raiteri L., Stigliani S., Zedda L., Raiteri M., Bonanno G., Multiple mechanisms of transmitter release evoked by 'pathologically' elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calcium Journal of Neurochemistry 2002 80 4 706 714
31. Buckle D. R., Arch J. R. S., Bowring N. E., Foster K. A., Taylor J. F., Taylor S. G., Shaw D. J., Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660 Pulmonary Pharmacology 1993 6 1 77 86
32. Gilani A. H., Aziz N., Khurram I. M., Chaudhary K. S., Iqbal A., Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses Journal of the Pakistan Medical Association 2001 51 3 115 120
33. Boskabady M. H., Shafei M. N., Parsaee H., Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity Pharmazie 2005 60 12 943 948 (Pubitemid 41820763)
34. Boskabady M. H., Shirmohammadi B., Jandaghi P., Kiani S., Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig BMC Pharmacology 2004 4, article 3
35. Boskabady M. H., Shirmohammadi B., Effect of Nigella sativa on isolated guinea pig trachea Archives of Iranian Medicine 2002 5 2 103 107
36. CYTED: Programa Iberoamericano de Ciencia y Tecnologa para el Desarrollo. Manual de Tcnicas de Investigacin, 1993
37. Segal M., Rat hippocampal neurons in culture: responses to electrical and chemical stimuli Journal of Neurophysiology 1983 50 6 1249 1264
38. Mosmann T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 1983 65 1-2 55 63
39. Weislow O. S., Kiser R., Fine D. L., Bader J., Shoemaker R. H., Boyd M. R., New soluble-formazan assay for HIV-1 cytopathic effects: application to high-flux screening of synthetic and natural products for AIDS-antiviral activity Journal of the National Cancer Institute 1989 81 8 577 586
40. Roehm N. W., Rodgers G. H., Hatfield S. M., Glasebrook A. L., An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT Journal of Immunological Methods 1991 142 2 257 265
41. Mrquez F. J., Quesada A. R., Snchez-Jimnez F., Nez de Castro I., Determination of 27 dansyl amino acid derivatives in biological fluids by reversed-phase high-performance liquid chromatography Journal of ChromatographyBiomedical Applications 1986 380 2 275 283
42. Naval M. V., Gmez-Serranillos M. P., Carretero M. E., De Arce C., Value of high-performance liquid chromatographic analysis of amino acids in the determination of Panax ginseng radix extract effect in cultured neurons Journal of Chromatography A 2006 1121 2 242 247