Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats

Human and Experimental Toxicology

Volumn 25, Issue 3, 2006, Pages 127-133

  Kanter, Mehmet ^a   Coskun, O ^a   Kalayci, M ^b   Buyukbas, S ^c   Cagavi, F ^b  

^a TRAKYA UNIVERSITY   (Turkey)

^b ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

^c SELCUK UNIVERSITY   (Turkey)

Author keywords

Antioxidant enzymes; Lipid peroxidation; Methylprednisolone; Nigella sativa; Rat; Spinal cord injury

Indexed keywords

CARBONYL DERIVATIVE; CATALASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHYLPREDNISOLONE; NIGELLA SATIVA EXTRACT; PLACEBO; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; LAMINECTOMY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CATALASE; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; IMAGE PROCESSING, COMPUTER-ASSISTED; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; METHYLPREDNISOLONE; NEUROPROTECTIVE AGENTS; NIGELLA; PLANT OILS; RATS; RATS, WISTAR; SPINAL CORD INJURIES; SUPEROXIDE DISMUTASE;

ANIMALIA; NIGELLA SATIVA;

EID: 33645981973     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327106ht608oa     Document Type: Article

References (37)

1. Bracken MB, Shepard MJ, Collins WF, Holford TR, Young W, Baskin DS et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990; 322: 1405-11.
2. Bracken MB, Shepard MJ, Collins WF, Holford TR, Baskin DS, Eisenberg HM et al. Methylprednisolone or naloxone treatment after acute spinal cord injury. Results of the Second National Acute Spinal Cord Injury Study. J. Neurosurg. 1992; 76: 23-31.
3. Taoka Y, Okajima K. Spinal cord injury in rat. Prog Neurobiol 1998; 55: 1-18.
4. Fantone JC, Ward PA. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol 1982; 107: 395-418.
5. Anderson DK, Hall ED. Pathophysiology of spinal cord trauma. Ann Emerg Med 1993; 22: 987-92.
6. El-Dakhakhny M. Studies on the chemical constitution of Egyptian Nigella sativa L. seeds II. The essential oil. Planta Med 1963; 11: 465-70.
7. El-Kadi A, Kandil O. The black seed (Nigella sativa) and immunity: its effect on human T cell subset. Fed Proc 1987; 46: 1222.
8. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995; 61: 33-36.
9. El-Daly ES. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J Pharm Belg 1998; 53: 87-93.
10. Al-Hader A, Aqel M, Hasan Z. Hypoglycemic effects of the volatile oil of Nigella sativa seeds. Inter J Pharmacog 1993; 31: 96-100.
11. El-Shabrawy OA, Nada SA. Biological evaluation of multicomponent tea used as hypoglycemic in rats. Fitoterapia 1996; 67: 99-102.
12. Kanter M, Meral I, Yener Z, Ozbek H, Demir H. Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J Exp Med 2003; 201: 213-19.
13. El-Dakhakhny M, Mady N, Lembert N, Ammon HP. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 2002; 68: 465-66.
14. Rivlin AS, Tator CH. Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 1978; 10: 39-43.
15. Rivlin AS, Tator CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 1977; 47: 577-81.
16. Lowry OH, Rosebrough NJ, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-72.
17. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990; 186: 421-31.
18. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990; 186: 464-78.
19. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
20. Aebi H. Catalase. In Bergmeyer HU ed. Methods of enzymatic analysis. Academic Press, 1974: 673-77.
21. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
22. Gul S, Celik SE, Kalayci M, Tasyurekli M, Cokar N, Bilge T. Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats. Surg Neurol 2005; 64: 355-61.
23. +-ATPase activity, and tissue water content of spinal cord following experimental traumatic injury. J Neurochem 1987; 48: 1809-16.
24. Iwasa K, Ikata T, Fukuzawa K. Protective effect of vitamin E on spinal cord injury by compression and concurrent lipid peroxidation. Free Rad Biol Med 1989; 6: 599-606.
25. Liu D, Yang R, Yan X, Mcadoo DJ. Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: electrophysiological, histological, and neurochemical results. J Neurochem 1994; 62: 37-44.
26. Agrawal SK, Fehlings MG. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 1997; 17: 1055-63.
27. Means ED, Anderson DK. Neuronophagia by leukocytes in experimental spinal cord injury. J Neuropathol Exp Neurol 1983; 42: 707-19.
28. Reiter RJ, Poeggeler B, Dun-xian T, Chen LD, Manchester LC, Guerrero JM et al. Antioxidant capacity of melatonin: a novel action not requiring receptor. Neuroendocrinol Lett 1993; 15: 103-16.
29. Hall ED. Lipid antioxidants in acute central nervous system injury. Ann Emerg Med 1993; 22: 1022-27.
30. Saunders RD, Dugan LL, Demediuk P, Means ED, Horrocks LA, Anderson DK. Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue. J Neurochem 1987; 49: 24-31.
31. Demopoulos HB, Flamm ES, Pietonigro DD, Seligman ML. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl 1980; 492: 91-119.
32. Benzel EC. A new ventral spinal cord injury model. A ventral compression technique. J Spinal Disord 1990; 4: 334-38.
33. Means ED, Anderson DK, Waters TR, Kalaf L. Effect of methylprednisolone in compression trauma to the feline spinal cord. J Neurosurg 1981; 55: 200-208.
34. Al-Naggar TB, Gómez-Serranillos MP, Carretero ME, Villar AM. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol 2003; 88: 63-68.
35. Kanter M, Coskun O, Oter S, Korkmaz A. Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. Anatom Rec 2004; 279A: 685-91.
36. Mahmood MS, Gilani AH, Khwaja A, Rashid A, Ashfaq MK. The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production. Phytother Res 2003; 17: 921-24.
37. El-Missiry MA, El-Gindy AM. Amelioration of alloxan induced diabetes mellitus and oxidative stress in rats by oil of Eruca sativa seeds. Ann Nutr Metab 2000; 44: 97-100.