Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: Evidence for a loss-of-function mechanism

Neurobiology of Aging

Volumn 36, Issue 2, 2015, Pages 1121-1129

  Vanden Broeck, Lies ^a   Kleinberger, Gernot ^b,c   Chapuis, Julien ^d   Gistelinck, Marc ^a   Amouyel, Philippe ^d   Van Broeckhoven, Christine ^b,c   Lambert, Jean Charles ^d   Callaerts, Patrick ^a   Dermaut, Bart ^d,e  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d UNIV LILLE   (France)

^e GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

AD; ALS; Drosophila; FTD; Loss of function; TDP 43

Indexed keywords

ALANINE; ASPARTIC ACID; GLYCINE; SERINE; TAR DNA BINDING PROTEIN; THREONINE; VALINE; DNA BINDING PROTEIN; TDP-43 PROTEIN, HUMAN;

AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; DROSOPHILA; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; LETHALITY; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ONSET AGE; PATHOGENICITY; POPULATION RESEARCH; PUPA (LIFE CYCLE STAGE); SIGNAL TRANSDUCTION; SURVIVAL RATE; TARDBP GENE; TRANSGENE; WILD TYPE; ALLELE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; FORECASTING; FRONTOTEMPORAL DEMENTIA; GENETICS; MUTATION; NERVE CELL; PATHOLOGY; PHYSIOLOGY;

ALLELES; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; FEMALE; FORECASTING; FRONTOTEMPORAL DEMENTIA; GENETIC VARIATION; HUMANS; MALE; MUTATION; NEURONS;

EID: 84922898764     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.09.001     Document Type: Article

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