Intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: A unique action mode of saponin compounds with poor bioavailability

Biochemical Pharmacology

Volumn 94, Issue 1, 2015, Pages 30-38

  Wang, Ting ^a   Wei, Zhifeng ^a   Dou, Yannong ^a   Yang, Yan ^a   Leng, Dandan ^a   Kong, Lingyi ^a   Dai, Yue ^a   Xia, Yufeng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Interleukin 10; Madecassoside; Pharmacokinetics pharmacodynamics discrepancy; Rheumatoid arthritis; Small intestine

Indexed keywords

ANTIRHEUMATIC AGENT; IMMUNOGLOBULIN G; INTERLEUKIN 10; LEFLUNOMIDE; MADECASSIC ACID; MADECASSOSIDE; TRITERPENOID; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CENTELLA ASIATICA EXTRACT; SAPONIN; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFECT; FEMALE; IN VITRO STUDY; INTESTINE; LAMINA PROPRIA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; UPREGULATION; AGONISTS; ANIMAL; ARTHRITIS, EXPERIMENTAL; CHEMISTRY; DRUG EFFECTS; INTESTINE ABSORPTION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; FEMALE; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-10; INTESTINAL ABSORPTION; INTESTINES; RATS; RATS, WISTAR; SAPONINS; TRITERPENES;

EID: 84922752188     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.01.004     Document Type: Article

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