Circadian rhythms in anesthesia and critical care medicine: Potential importance of circadian disruptions

Seminars in Cardiothoracic and Vascular Anesthesia

Volumn 19, Issue 1, 2015, Pages 49-60

  Brainard, Jason ^a   Gobel, Merit ^a   Bartels, Karsten ^a   Scott, Benjamin ^a   Koeppen, Michael ^a,b   Eckle, Tobias ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

anesthesia; circadian rhythm; cognitive dysfunction; critical care medicine; diabetes mellitus; genetic determinants; glucose oxidation; hypertension; inflammation; Per2

Indexed keywords

CRYPTOCHROME; MELATONIN; TRANSCRIPTION FACTOR CLOCK;

ANESTHESIA; BIOLOGICAL RHYTHM; CENTRAL NERVOUS SYSTEM DISEASE; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; CLINICAL PRACTICE; COGNITION; DISEASE COURSE; HUMAN; INTENSIVE CARE; METABOLIC SYNDROME X; MOLECULAR DYNAMICS; PHOTOTHERAPY; REVIEW; SEPSIS; ANESTHESIOLOGY; INTENSIVE CARE UNIT; PHYSIOLOGY; PROCEDURES;

ANESTHESIA; ANESTHESIOLOGY; CIRCADIAN RHYTHM; CRITICAL CARE; HUMANS; INTENSIVE CARE UNITS;

EID: 84922671873     PISSN: 10892532     EISSN: 19405596     Source Type: Journal    
DOI: 10.1177/1089253214553066     Document Type: Review

References (142)

1. Edery I. Circadian rhythms in a nutshell. Physiol Genomics. 2000 ; 3: 59-74
2. Aschoff J. Circadian rhythms in man. Science. 1965 ; 148: 1427-1432
3. Arendt J, Aldhous M, Wright J. Synchronisation of a disturbed sleep-wake cycle in a blind man by melatonin treatment. Lancet. 1988 ; 1: 772-773
4. Tei H, Okamura H, Shigeyoshi Y, et al. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature. 1997 ; 389: 512-516
5. Cornelissen G, Halberg F, Halberg J, Schwartzkopff O, Cugini P. Remembering the father of chronobiology and chronomics: Franz Halberg, MD (5 July 1919-9 June 2013). Clin Ter. 2013 ; 164: I - VI
6. Aschoff J. Exogenous and endogenous components in circadian rhythms. Cold Spring Harb Symp Quant Biol. 1960 ; 25: 11-28
7. Wright KP, McHill AW, Birks BR, Griffin BR, Rusterholz T, Chinoy ED. Entrainment of the human circadian clock to the natural light-dark cycle. Curr Biol. 2013 ; 23: 1554-1558
8. Roenneberg T, Kumar CJ, Merrow M. The human circadian clock entrains to sun time. Curr Biol. 2007 ; 17: R44 - R45
9. Jakubcakova V, Oster H, Tamanini F, et al. Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Neuron. 2007 ; 54: 831-843
10. Takahashi JS, Hong HK, Ko CH, McDearmon EL. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008 ; 9: 764-775
11. Guler AD, Ecker JL, Lall GS, et al. Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature. 2008 ; 453: 102-105
12. Bendova Z, Sumova S. Photoperiodic regulation of PER1 and PER2 protein expression in rat peripheral tissues. Physiol Res. 2006 ; 55: 623-632
13. Eckle T, Hartmann K, Bonney S, et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 ; 18: 774-782
14. Zhang J, Kaasik K, Blackburn MR, Lee CC. Constant darkness is a circadian metabolic signal in mammals. Nature. 2006 ; 439: 340-343
15. Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac Period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 ; 45: 667-671
16. Carlson DE. Are you having a good day: a passing nicety or a fundamental question in the intensive care unit?. Crit Care Med. 2012 ; 40: 344-345
17. Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C. Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol. 2000 ; 526 (pt 3). 695-702
18. St Hilaire MA, Gooley JJ, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a 1 h pulse of bright white light. J Physiol. 2012 ; 590: 3035-3045
19. Dewan K, Benloucif S, Reid K, Wolfe LF, Zee PC. Light-induced changes of the circadian clock of humans: increasing duration is more effective than increasing light intensity. Sleep. 2011 ; 34: 593-599
20. Chang AM, Santhi N, St Hilaire M, et al. Human responses to bright light of different durations. J Physiol. 2012 ; 590: 3103-3112
21. Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002 ; 295: 1070-1073
22. Illnerova H, Vanecek J. Response of rat pineal serotonin N-acetyltransferase to one min light pulse at different night times. Brain Res. 1979 ; 167: 431-434
23. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science. 1980 ; 210: 1267-1269
24. Stevens RG. Light-at-night, circadian disruption and breast cancer: assessment of existing evidence. Int J Epidemiol. 2009 ; 38: 963-970
25. Kohyama J. A newly proposed disease condition produced by light exposure during night: asynchronization. Brain Dev. 2009 ; 31: 255-273
26. Driesen K, Jansen NW, Kant I, Mohren DC, van Amelsvoort LG. Depressed mood in the working population: associations with work schedules and working hours. Chronobiol Int. 2010 ; 27: 1062-1079
27. van Amelsvoort LG, Schouten EG, Kok FJ. Impact of one year of shift work on cardiovascular disease risk factors. J Occup Environ Med. 2004 ; 46: 699-706
28. Parkes KR. Shift work and age as interactive predictors of body mass index among offshore workers. Scand J Work Environ Health. 2002 ; 28: 64-71
29. Knutsson A. Health disorders of shift workers. Occup Med (Lond). 2003 ; 53: 103-108
30. Ha M, Park J. Shiftwork and metabolic risk factors of cardiovascular disease. J Occup Health. 2005 ; 47: 89-95
31. Obayashi K, Saeki K, Iwamoto J, et al. Exposure to light at night, nocturnal urinary melatonin excretion, and obesity/dyslipidemia in the elderly: a cross-sectional analysis of the HEIJO-KYO study. J Clin Endocrinol Metab. 2013 ; 98: 337-344
32. Nguyen J, Wright KP. Influence of weeks of circadian misalignment on leptin levels. Nat Sci Sleep. 2010 ; 2: 9-18
33. Toh KL, Jones CR, He Y, et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science. 2001 ; 291: 1040-1043
34. Keijzer H, Smits MG, Duffy JF, Curfs LM. Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep Med Rev. 2014 ; 18: 333-339
35. Knutson KL, Spiegel K, Penev P, Van Cauter E. The metabolic consequences of sleep deprivation. Sleep Med Rev. 2007 ; 11: 163-178
36. Kawakami N, Takatsuka N, Shimizu H. Sleep disturbance and onset of type 2 diabetes. Diabetes Care. 2004 ; 27: 282-283
37. Spiegel K, Tasali E, Leproult R, Van Cauter E. Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol. 2009 ; 5: 253-261
38. Suwazono Y, Dochi M, Sakata K, et al. A longitudinal study on the effect of shift work on weight gain in male Japanese workers. Obesity (Silver Spring). 2008 ; 16: 1887-1893
39. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999 ; 354: 1435-1439
40. Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004 ; 1: e62
41. Depner CM, Stothard ER, Wright KP. Metabolic consequences of sleep and circadian disorders. Curr Diab Rep. 2014 ; 14: 507
42. Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol (1985). 2005 ; 99: 2008-2019
43. Ptacek LJ, Jones CR, Fu YH. Novel insights from genetic and molecular characterization of the human clock. Cold Spring Harb Symp Quant Biol. 2007 ; 72: 273-277
44. Albrecht U. Circadian clocks and mood-related behaviors. Handb Exp Pharmacol. 2013 ; (217). 227-239
45. Cuninkova L, Brown SA. Peripheral circadian oscillators: interesting mechanisms and powerful tools. Ann N Y Acad Sci. 2008 ; 1129: 358-370
46. He Y, Jones CR, Fujiki N, et al. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009 ; 325: 866-870
47. Kivimaki M, Virtanen M, Elovainio M, Vaananen A, Keltikangas-Jarvinen L, Vahtera J. Prevalent cardiovascular disease, risk factors and selection out of shift work. Scand J Work Environ Health. 2006 ; 32: 204-208
48. Harma M. Shift work and cardiovascular disease - from etiologic studies to prevention through scheduling. Scand J Work Environ Health. 2001 ; 27: 85-86
49. Boggild H, Knutsson A. Shift work, risk factors and cardiovascular disease. Scand J Work Environ Health. 1999 ; 25: 85-99
50. Akerstedt T, Knutsson A, Alfredsson L, Theorell T. Shift work and cardiovascular disease. Scand J Work Environ Health. 1984 ; 10: 409-414
51. Akerstedt T, Knutsson A. Cardiovascular disease and shift work. Scand J Work Environ Health. 1997 ; 23: 241-242
52. Tuchsen F, Hannerz H, Burr H. A 12 year prospective study of circulatory disease among Danish shift workers. Occup Environ Med. 2006 ; 63: 451-455
53. Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, Fitzgerald GA. Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci U S A. 2007 ; 104: 3450-3455
54. Malik M, Farrell T, Camm AJ. Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability. Am J Cardiol. 1990 ; 66: 1049-1054
55. Tofler GH, Brezinski D, Schafer AI, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med. 1987 ; 316: 1514-1518
56. Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N Engl J Med. 1991 ; 325: 986-990
57. Staels B. When the Clock stops ticking, metabolic syndrome explodes. Nat Med. 2006 ; 12: 54-55
58. Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond). 2008 ; 32: 658-662
59. Sookoian S, Gemma C, Gianotti TF, Burgueno A, Castano G, Pirola CJ. Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr. 2008 ; 87: 1606-1615
60. Woon PY, Kaisaki PJ, Braganca J, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A. 2007 ; 104: 14412-14417
61. Englund A, Kovanen L, Saarikoski ST, et al. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. J Circadian Rhythms. 2009 ; 7: 5
62. Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009 ; 41: 89-94
63. Prokopenko I, Langenberg C, Florez JC, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009 ; 41: 77-81
64. Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009 ; 41: 82-88
65. Radziuk J, Pye S. Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?. Diabetologia. 2006 ; 49: 1619-1628
66. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 ; 106: 4453-4458
67. Pan X, Jiang XC, Hussain MM. Impaired cholesterol metabolism and enhanced atherosclerosis in clock mutant mice. Circulation. 2013 ; 128: 1758-1769
68. Marcheva B, Ramsey KM, Buhr ED, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 ; 466: 627-631
69. Doi M, Takahashi Y, Komatsu R, et al. Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med. 2010 ; 16: 67-74
70. Zhang EE, Liu Y, Dentin R, et al. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 ; 16: 1152-1156
71. Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013 ; 8: e71493
72. Braunwald E. On circadian variation of myocardial reperfusion injury. Circ Res. 2012 ; 110: 6-7
73. Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin Cardiothorac Vasc Anesth. 2012 ; 16: 123-132
74. Eltzschig HK, Bonney SK, Eckle T. Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med. 2013 ; 19: 345-354
75. Wang CY, Wen MS, Wang HW, et al. Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. Circulation. 2008 ; 118: 2166-2173
76. Jeyaraj D, Haldar SM, Wan X, et al. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 ; 483: 96-99
77. Eckle T, Eltzschig HK. Toll-like receptor signaling during myocardial ischemia. Anesthesiology. 2011 ; 114: 490-492
78. Silver AC, Arjona A, Walker WE, Fikrig E. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity. 2012 ; 36: 251-261
79. Yu X, Rollins D, Ruhn KA, et al. TH17 cell differentiation is regulated by the circadian clock. Science. 2013 ; 342: 727-730
80. Hermida RC, Ayala DE, Mojon A, Fernandez JR. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int. 2010 ; 27: 1629-1651
81. Eckel-Mahan K, Sassone-Corsi P. Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol. 2009 ; 16: 462-467
82. Chassard D, Duflo F, de Queiroz Siqueira M, Allaouchiche B, Boselli E. Chronobiology and anaesthesia. Curr Opin Anaesthesiol. 2007 ; 20: 186-190
83. Smolensky MH, Reinberg A. The chronotherapy of corticosteroids: practical application of chronobiologic findings to nursing. Nurs Clin North Am. 1976 ; 11: 609-619
84. Zhu LL, Zhou Q, Yan XF, Zeng S. Optimal time to take once-daily oral medications in clinical practice. Int J Clin Pract. 2008 ; 62: 1560-1571
85. De Giorgi A, Mallozzi Menegatti A, Fabbian F, Portaluppi F, Manfredini R. Circadian rhythms and medical diseases: does it matter when drugs are taken?. Eur J Intern Med. 2013 ; 24: 698-706
86. Hermida RC, Ayala DE, Smolensky MH, et al. Chronotherapy improves blood pressure control and reduces vascular risk in CKD. Nat Rev Nephrol. 2013 ; 9: 358-368
87. Egi M, Bellomo R, Stachowski E, French CJ, Hart G, Stow P. Circadian rhythm of blood glucose values in critically ill patients. Crit Care Med. 2007 ; 35: 416-421
88. Leelarathna L, English SW, Thabit H, et al. Feasibility of fully automated closed-loop glucose control using continuous subcutaneous glucose measurements in critical illness: a randomized controlled trial. Crit Care. 2013 ; 17: R159
89. MacLeod JB, Lefton J, Houghton D, et al. Prospective randomized control trial of intermittent versus continuous gastric feeds for critically ill trauma patients. J Trauma. 2007 ; 63: 57-61
90. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008 ; 358: 111-124
91. Bosmann M, Meta F, Ruemmler R, et al. Regulation of IL-17 family members by adrenal hormones during experimental sepsis in mice. Am J Pathol. 2013 ; 182: 1124-1130
92. Solt LA, Wang Y, Banerjee S, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012 ; 485: 62-68
93. Lutsch EF, Morris RW. Light reversal of a morphine-induced analgesia susceptibility rhythm in mice. Experientia. 1971 ; 27: 420-421
94. Morris RW, Lutsch EF. Susceptibility to morphine-induced analgesia in mice. Nature. 1967 ; 216: 494-495
95. Reinberg A, Reinberg MA. Circadian changes of the duration of action of local anaesthetic agents. Naunyn Schmiedebergs Arch Pharmacol. 1977 ; 297: 149-152
96. Guo X, Kuzumi E, Charman SC, Vuylsteke A. Perioperative melatonin secretion in patients undergoing coronary artery bypass grafting. Anesth Analg. 2002 ; 94: 1085-1091
97. Dispersyn G, Pain L, Challet E, Touitou Y. General anesthetics effects on circadian temporal structure: an update. Chronobiol Int. 2008 ; 25: 835-850
98. Karkela J, Vakkuri O, Kaukinen S, Huang WQ, Pasanen M. The influence of anaesthesia and surgery on the circadian rhythm of melatonin. Acta Anaesthesiol Scand. 2002 ; 46: 30-36
99. Lin SM, Liu CY, Wang CH, et al. The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med. 2004 ; 32: 2254-2259
100. Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004 ; 291: 1753-1762
101. Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009 ; 180: 1092-1097
102. van den Boogaard M, Schoonhoven L, Evers AW, van der Hoeven JG, van Achterberg T, Pickkers P. Delirium in critically ill patients: impact on long-term health-related quality of life and cognitive functioning. Crit Care Med. 2012 ; 40: 112-118
103. Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013 ; 369: 1306-1316
104. Bellapart J, Boots R. Potential use of melatonin in sleep and delirium in the critically ill. Br J Anaesth. 2012 ; 108: 572-580
105. Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ. Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med. 2001 ; 163: 451-457
106. Gabor JY, Cooper AB, Crombach SA, et al. Contribution of the intensive care unit environment to sleep disruption in mechanically ventilated patients and healthy subjects. Am J Respir Crit Care Med. 2003 ; 167: 708-715
107. Bienert A, Bartkowska-Sniatkowska A, Wiczling P, et al. Assessing circadian rhythms during prolonged midazolam infusion in the pediatric intensive care unit (PICU) children. Pharmacol Rep. 2013 ; 65: 107-121
108. Gehlbach BK, Chapotot F, Leproult R, et al. Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation. Sleep. 2012 ; 35: 1105-1114
109. Olofsson K, Alling C, Lundberg D, Malmros C. Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand. 2004 ; 48: 679-684
110. Pandharipande P, Ely EW. Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill. Crit Care Clin. 2006 ; 22: 313-327
111. Bourne RS, Mills GH. Sleep disruption in critically ill patients - pharmacological considerations. Anaesthesia. 2004 ; 59: 374-384
112. Trompeo AC, Vidi Y, Locane MD, et al. Sleep disturbances in the critically ill patients: role of delirium and sedative agents. Minerva Anestesiol. 2011 ; 77: 604-612
113. McPherson JA, Wagner CE, Boehm LM, et al. Delirium in the cardiovascular ICU: exploring modifiable risk factors. Crit Care Med. 2013 ; 41: 405-413
114. Pandharipande P, Shintani A, Peterson J, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006 ; 104: 21-26
115. Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013 ; 41: 263-306
116. Kondili E, Alexopoulou C, Xirouchaki N, Georgopoulos D. Effects of propofol on sleep quality in mechanically ventilated critically ill patients: a physiological study. Intensive Care Med. 2012 ; 38: 1640-1646
117. Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, Reitz BA. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009 ; 50: 206-217
118. Riker RR, Shehabi Y, Bokesch PM, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009 ; 301: 489-499
119. Pandharipande P, Cotton BA, Shintani A, et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma. 2008 ; 65: 34-41
120. Dasta JF, Kane-Gill SL, Pencina M, et al. A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit. Crit Care Med. 2010 ; 38: 497-503
121. Hatta K, Kishi Y, Wada K, et al. Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. JAMA Psychiatry. 2014 ; 71: 397-403
122. Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000 ; 284: 861-868
123. Gibbison B, Angelini GD, Lightman SL. Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery. Br J Anaesth. 2013 ; 111: 347-360
124. Paul T, Lemmer B. Disturbance of circadian rhythms in analgosedated intensive care unit patients with and without craniocerebral injury. Chronobiol Int. 2007 ; 24: 45-61
125. Cooper AB, Thornley KS, Young GB, Slutsky AS, Stewart TE, Hanly PJ. Sleep in critically ill patients requiring mechanical ventilation. Chest. 2000 ; 117: 809-818
126. Toublanc B, Rose D, Glerant JC, et al. Assist-control ventilation vs. low levels of pressure support ventilation on sleep quality in intubated ICU patients. Intensive Care Med. 2007 ; 33: 1148-1154
127. Chan MC, Spieth PM, Quinn K, Parotto M, Zhang H, Slutsky AS. Circadian rhythms: from basic mechanisms to the intensive care unit. Crit Care Med. 2012 ; 40: 246-253
128. Ruggieri AJ, Levy RJ, Deutschman CS. Mitochondrial dysfunction and resuscitation in sepsis. Crit Care Clin. 2010 ; 26: 567-575
129. Mundigler G, Delle-Karth G, Koreny M, et al. Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. Crit Care Med. 2002 ; 30: 536-540
130. Verceles AC, Silhan L, Terrin M, Netzer G, Shanholtz C, Scharf SM. Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. Intensive Care Med. 2012 ; 38: 804-810
131. Carlson DE, Chiu WC. The absence of circadian cues during recovery from sepsis modifies pituitary-adrenocortical function and impairs survival. Shock. 2008 ; 29: 127-132
132. Rosato E, Tauber E, Kyriacou CP. Molecular genetics of the fruit-fly circadian clock. Eur J Hum Genet. 2006 ; 14: 729-738
133. Marcantonio ER, Flacker JM, Wright RJ, Resnick NM. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc. 2001 ; 49: 516-522
134. Inouye SK, Bogardus ST, Charpentier PA, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999 ; 340: 669-676
135. Van Rompaey B, Elseviers MM, Van Drom W, Fromont V, Jorens PG. The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Crit Care. 2012 ; 16: R73
136. Le Guen M, Nicolas-Robin A, Lebard C, Arnulf I, Langeron O. Earplugs and eye masks vs routine care prevent sleep impairment in post-anaesthesia care unit: a randomized study. Br J Anaesth. 2014 ; 112: 89-95
137. Hu RF, Jiang XY, Zeng YM, Chen XY, Zhang YH. Effects of earplugs and eye masks on nocturnal sleep, melatonin and cortisol in a simulated intensive care unit environment. Crit Care. 2010 ; 14: R66
138. Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009 ; 373: 1874-1882
139. Needham DM, Korupolu R, Zanni JM, et al. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil. 2010 ; 91: 536-542
140. Cho H, Zhao X, Hatori M, et al. Regulation of circadian behaviour and metabolism by REV-ERB-± and REV-ERB-β. Nature. 2012 ; 485: 123-127
141. Boivin DB, Duffy JF, Kronauer RE, Czeisler CA. Dose-response relationships for resetting of human circadian clock by light. Nature. 1996 ; 379: 540-542
142. Gooley JJ, Rajaratnam SM, Brainard GC, Kronauer RE, Czeisler CA, Lockley SW. Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light. Sci Transl Med. 2010 ; 2: 31ra33