Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

Aging Cell

Volumn 10, Issue 5, 2011, Pages 798-806

  Shivshankar, Pooja ^a   Boyd, Angela R ^a   Le Saux, Claude J ^a   Yeh, I Tien ^b   Orihuela, Carlos J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Health Science Center at San Antonio   (United States)

Author keywords

Age associated inflammation; Aging; Cellular senescence; Infectious disease; Pneumonia; SASP

Indexed keywords

BLEOMYCIN; CYTOKERATIN 10; HISTONE H2A; LAMININ RECEPTOR; LIGAND; PROTEIN P16; RETINOBLASTOMA PROTEIN; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM ADHERENCE; CELL AGING; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; FEMALE; GENOTOXICITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; ONSET AGE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANIMALS; BACTERIAL ADHESION; BIOLOGICAL MARKERS; BLEOMYCIN; CELL AGING; CELL LINE, TUMOR; CYTOKINES; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KAPLAN-MEIER ESTIMATE; KERATIN-10; LUNG; MICE; MICE, INBRED BALB C; MIDDLE AGED; OXIDATIVE STRESS; PNEUMONIA, PNEUMOCOCCAL; RECEPTORS, LAMININ; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); MUS; STREPTOCOCCUS PNEUMONIAE;

EID: 80051995791     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00720.x     Document Type: Article

References (36)

1. Aoshiba K, Nagai A (2009) Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 6, 596-601.
2. Aoshiba K, Tsuji T, Nagai A (2003) Bleomycin induces cellular senescence in alveolar epithelial cells. Eur. Respir. J. 22, 436-443.
3. Avadhanula V, Rodriguez CA, Ulett GC, Bakaletz LO, Adderson EE (2006) Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression. Infect. Immun. 74, 830-838.
4. Barbier M, Oliver A, Rao J, Hanna SL, Goldberg JB, Alberti S (2008) Novel phosphorylcholine-containing protein of Pseudomonas aeruginosa chronic infection isolates interacts with airway epithelial cells. J. Infect. Dis. 197, 465-473.
5. Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522.
6. Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729-740.
7. Conners R, Hill DJ, Borodina E, Agnew C, Daniell SJ, Burton NM, Sessions RB, Clarke AR, Catto LE, Lammie D, Wess T, Brady RL, Virji M (2008) The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil. EMBO J. 27, 1779-1789.
8. Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, 2853-2868.
9. Coppe JP, Desprez PY, Krtolica A, Campisi J (2009) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118.
10. Cundell DR, Gerard NP, Gerard C, Idanpaan-Heikkila I, Tuomanen EI (1995) Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 377, 435-438.
11. Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O (2009) Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protoc. 4, 1798-1806.
12. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U S A 92, 9363-9367.
13. Garcia CK, Wright WE, Shay JW (2007) Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res. 35, 7406-7416.
14. Hinojosa E, Boyd AR, Orihuela CJ (2009) Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J. Infect. Dis. 200, 546-554.
15. Kinsella K, Velkoff VA (2001) An Aging World: 2001. (USC Bureau, ed.). Washington, DC: U.S. Goverment Printing Office.
16. Kline KA, Falker S, Dahlberg S, Normark S, Henriques-Normark B (2009) Bacterial adhesins in host-microbe interactions. Cell Host Microbe. 5, 580-592.
17. Kreiling JA, Tamamori-Adachi M, Sexton AN, Jeyapalan JC, Munoz-Najar U, Peterson AL, Manivannan J, Rogers ES, Pchelintsev NA, Adams PD, Sedivy JM (2011) Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell 10, 292-304.
18. Krtolica A, Campisi J (2002) Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int. J. Biochem. Cell Biol. 34, 1401-1414.
19. Lexau CA, Lynfield R, Danila R, Pilishvili T, Facklam R, Farley MM, Harrison LH, Schaffner W, Reingold A, Bennett NM, Hadler J, Cieslak PR, Whitney CG (2005) Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine. JAMA 294, 2043-2051.
20. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ (2006) Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367, 1747-1757.
21. Meyer KC, Ershler W, Rosenthal NS, Lu XG, Peterson K (1996) Immune dysregulation in the aging human lung. Am. J. Respir. Crit. Care Med. 153, 1072-1079.
22. Meyer KC, Rosenthal NS, Soergel P, Peterson K (1998) Neutrophils and low-grade inflammation in the seemingly normal aging human lung. Mech. Ageing Dev. 104, 169-181.
23. Obert C, Sublett J, Kaushal D, Hinojosa E, Barton T, Tuomanen EI, Orihuela CJ (2006) Identification of a candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect. Immun. 74, 4766-4777.
24. O'Brien LM, Walsh EJ, Massey RC, Peacock SJ, Foster TJ (2002) Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization. Cell Microbiol. 4, 759-770.
25. Orihuela CJ, Fogg G, DiRita VJ, Tuomanen E (2005) Bacterial interactions with mucosal epithelial cells. in Mucosal Immunology (Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, Mayer L, eds). Burlington, MA: Elsevier Academic Press, pp. 753-767.
26. Orihuela CJ, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DA, Tuomanen EI (2009) Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. J. Clin. Invest. 119, 1638-1646.
27. Paramio JM, Casanova ML, Segrelles C, Mittnacht S, Lane EB, Jorcano JL (1999) Modulation of cell proliferation by cytokeratins K10 and K16. Mol. Cell. Biol. 19, 3086-3094.
28. Paramio JM, Segrelles C, Ruiz S, Jorcano JL (2001) Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Mol. Cell. Biol. 21, 7449-7459.
29. Paterson GK, Orihuela CJ (2010) Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix. Mol. Microbiol. 77, 1-5.
30. Rose L, Shivshankar P, Hinojosa E, Rodriguez A, Sanchez CJ, Orihuela CJ (2008) Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge. J. Infect. Dis. 198, 375-383.
31. Shivshankar P, Sanchez C, Rose LF, Orihuela CJ (2009) The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells. Mol. Microbiol. 73, 663-679.
32. Swords WE, Buscher BA, Ver Steeg Ii K, Preston A, Nichols WA, Weiser JN, Gibson BW, Apicella MA (2000) Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol. Microbiol. 37, 13-27.
33. Tsuji T, Aoshiba K, Nagai A (2010) Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration 80, 59-70.
34. Weiner ML, Freeman C, Trochimowicz H, de Gerlache J, Jacobi S, Malinverno G, Mayr W, Regnier JF (2000) 13-week drinking water toxicity study of hydrogen peroxide with 6-week recovery period in catalase-deficient mice. Food Chem. Toxicol. 38, 607-615.
35. WHO (2009) Chronic Obstructive Pulmonary Disease (COPD). (WM centre, eds). World Health Organization.
36. Yende S, Tuomanen EI, Wunderink R, Kanaya A, Newman AB, Harris T, de Rekeneire N, Kritchevsky SB (2005) Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. Am. J. Respir. Crit. Care Med. 172, 1440-1446.