Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients

Journal of the American College of Cardiology

Volumn 65, Issue 2, 2015, Pages 163-173

  Chiang, David Y ^a   Lebesgue, Nicolas ^b,c   Beavers, David L ^a   Alsina, Katherina M ^a   Damen, J Mirjam A ^b,c   Voigt, Niels ^d   Dobrev, Dobromir ^d   Wehrens, Xander H T ^a   Scholten, Arjen ^b,c,e  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e Janssen Research and Development   (Netherlands)

Author keywords

Atrial fibrillation; Label free quantification; Mass spectrometry; PP1 regulatory subunits; Protein phosphatase 1; Proteomics

Indexed keywords

CALCIUM ION; COLD SHOCK DOMAIN PROTEIN A; ENZYME ANTIBODY; MEMBRANE PROTEIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE 5A; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1 ANTIBODY; PROTEIN PPP1R7; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CALCIUM METABOLISM; CELL HETEROGENEITY; CELL LYSATE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME DEFECT; ENZYME SUBUNIT; HEART; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAROXYSMAL HEART ATRIUM FIBRILLATION; PATHOGENESIS; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; HEART ATRIUM FIBRILLATION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PROCEDURES; PROTEOMICS;

ANIMALS; ATRIAL FIBRILLATION; HUMANS; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; MICE; MYOCYTES, CARDIAC; PROTEIN PHOSPHATASE 1; PROTEOMICS;

EID: 84922596155     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.10.042     Document Type: Article

References (36)

1. Nattel S. Experimental evidence for proarrhythmic mechanisms of antiarrhythmic drugs. Cardiovasc Res 1998;37:567-77.
2. Li N, Chiang DY, Wang S, et al. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation 2014;129: 1276-85.
3. Nattel S. New ideas about atrial fibrillation 50 years on. Nature 2002;415:219-26.
4. 2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases. Circulation 2004;110: 2651-7.
5. 2+ handling in human chronic atrial fibrillation. Circulation 2006;114:670-80.
6. Heijman J, Dewenter M, El-Armouche A, Dobrev D. Function and regulation of serine/ threonine phosphatases in the healthy and diseased heart. J Mol Cell Cardiol 2013;64: 90-8.
7. 2+ leak promotes atrial fibrillation in mice. J Clin Invest 2009;119:1940-51.
8. Ceulemans H, Bollen M. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev 2004;84:1-39.
9. Heroes E, Lesage B, Gornemann J, Beullens M, Van Meervelt L, Bollen M. The PP1 binding code: A molecular-lego strategy that governs specificity. FEBS J 2013;280:584-95.
10. Voigt N, Heijman J, Wang Q, et al. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation 2013;129:145-56.
11. Vizcaino JA, Cote RG, Csordas A, et al. The PRoteomics IDEntifications (PRIDE) database and associated tools: Status in 2013. Nucleic Acids Res 2013;41:D1063-9. Available at: http://www. proteomexchange.org, with identifier PXD000697. Accessed December 2014.
12. Peng M, Taouatas N, Cappadona S, et al. Protease bias in absolute protein quantitation. Nat Methods 2012;9:524-5.
13. El-Armouche A, Pamminger T, Ditz D, Zolk O, Eschenhagen T. Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts. Cardiovasc Res 2004;61:87-93.
14. Hendrickx A, Beullens M, Ceulemans H, et al. Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol 2009;16: 365-71.
15. Molina-Pinelo S, Ferrer I, Blanco-Aparicio C, et al. Down-regulation of spinophilin in lung tumours contributes to tumourigenesis. J Pathol 2011;225:73-82.
16. Luo X, Zhang Y, Ruan X, et al. Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes 2011;60:1435-45.
17. Geetha T, Langlais P, Luo M, et al. Label-free proteomic identification of endogenous, insulinstimulated interaction partners of insulin receptor substrate-1. J Am Soc Mass Spectrom 2011;22: 457-66.
18. Tsaytler P, Harding HP, Ron D, Bertolotti A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 2011;332:91-4.
19. Chiang DY, Li N, Wang Q, et al. Impaired local regulation of ryanodine receptor type-2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res 2014;103:178-87.
20. Gupta RC, Mishra S, Rastogi S, Imai M, Habib O, Sabbah HN. Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts. Am J Physiol Heart Circ Physiol 2003;285: H2373-81.
21. Carr AN, Schmidt AG, Suzuki Y, et al. Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol 2002;22:4124-35.
22. Pathak A, del Monte F, Zhao W, et al. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res 2005;96:756-66.
23. Nicolaou P, Rodriguez P, Ren X, et al. Inducible expression of activeprotein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res 2009;104: 1012-20.
24. Kirchhefer U, Baba HA, Boknik P, et al. Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2. Cardiovasc Res 2005;68:98-108.
25. Bruchert N, Mavila N, Boknik P, et al. Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality. Am J Physiol Heart Circ Physiol 2008;295:H1539-46.
26. El-Armouche A, Wittkopper K, Degenhardt F, et al. Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovasc Res 2008;80:396-406.
27. Grote-Wessels S, Baba HA, Boknik P, et al. Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. Cardiovasc Res 2008;79:464-71.
28. Aye TT, Soni S, van Veen TA, et al. Reorganized PKA-AKAP associations in the failing human heart. J Mol Cell Cardiol 2012;52:511-8.
29. Pedelini L, Marquina M, Arino J, et al. YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem 2007;282:3282-92.
30. Wolffe AP, Tafuri S, Ranjan M, Familari M. The Y-box factors: A family of nucleic acid binding proteins conserved from Escherichia coli to man. New Biol 1992;4:290-8.
31. Sears D, Luong P, Yuan M, et al. Functional phosphoproteomic analysis reveals cold-shock domain protein A to be a Bcr-Abl effectorregulating proliferation and transformation in chronicmyeloid leukemia.CellDeathDis 2010;1:e93.
32. Kharlap MS, Timofeeva AV, Goryunova LE, et al. Atrial appendage transcriptional profile in patients with atrial fibrillation with structural heart diseases. Ann N Y Acad Sci 2006;1091: 205-17.
33. Brundel BJ, Van Gelder IC, Henning RH, et al. Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: Differential regulation of protein and mRNA levels for K+ channels. J Am Coll Cardiol 2001;37:926-32.
34. Kudo S, Mattei MG, Fukuda M. Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain. Eur J Biochem 1995;231: 72-82.
35. Zhang M, Kass DA. Phosphodiesterases and cardiac cGMP: Evolving roles and controversies. Trends Pharmacol Sci 2011;32:360-5.
36. Molina CE, Leroy J, Richter W, et al. Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias. J Am Coll Cardiol 2012;59:2182-90.