Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model

Circulation

Volumn 129, Issue 12, 2014, Pages 1276-1285

  Li, Na ^a   Chiang, David Y ^a   Wang, Sufen ^e   Wang, Qiongling ^g   Sun, Liang ^a   Voigt, Niels ^c,d   Respress, Jonathan L ^a   Ather, Sameer ^a   Skapura, Darlene G ^a   Jordan, Valerie K ^a   Horrigan, Frank T ^a   Schmitz, Wilhelm ^b   Müller, Frank U ^e   Valderrabano, Miguel ^b   Nattel, Stanley ^f   Dobrev, Dobromir ^c,d   Wehrens, Xander H T ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HOUSTON METHODIST HOSPITAL   (United States)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF MÜNSTER   (Germany)

^f MONTREAL HEART INSTITUTE   (Canada)

^g Institute of Pharmacology and Toxicology University of Münster ^*

Author keywords

atrial fibrillation; calcium; mice; ryanodine receptor calcium release channel

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; RYANODINE RECEPTOR; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE COURSE; ELECTROCARDIOGRAM; ENZYME PHOSPHORYLATION; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; TELEMETRY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ATRIAL FIBRILLATION; CALCIUM; MICE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

AGE FACTORS; ANIMALS; ATRIAL FIBRILLATION; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HEART CONDUCTION SYSTEM; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCYTES, CARDIAC; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

EID: 84897111408     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.006611     Document Type: Article

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