메뉴 건너뛰기




Volumn 52, Issue 2, 2012, Pages 511-518

Reorganized PKA-AKAP associations in the failing human heart

Author keywords

AKAP; Chemical proteomics; Cyclic nucleotides; Heart failure; Label free quantitation; Novel therapeutics

Indexed keywords

A KINASE ANCHORING PROTEIN 1; A KINASE ANCHORING PROTEIN 13; A KINASE ANCHORING PROTEIN 7; A KINASE ANCHORING PROTEIN 9; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE 2 DELTA; CARDIAC MYOSIN BINDING PROTEIN C; CONNECTIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIALPHA; CYCLIC GMP DEPENDENT PROTEIN KINASE; MICROTUBULE ASSOCIATED PROTEIN 2; MYOSIN BINDING PROTEIN C; PALM2 A KINASE ANCHORING PROTEIN 2; PHOSPHODIESTERASE; PHOSPHODIESTERASE 2A; PROTEIN KINASE G IALPHA; SPHKAP PROTEIN; TROPONIN C; TROPONIN I; TROPONIN T; UNCLASSIFIED DRUG;

EID: 82255177626     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.06.003     Document Type: Article
Times cited : (59)

References (51)
  • 1
    • 43449135311 scopus 로고    scopus 로고
    • Message delivered: how myocytes control cAMP signaling
    • Kass D.A. Message delivered: how myocytes control cAMP signaling. Circ Res 2008, 102:1002-1004.
    • (2008) Circ Res , vol.102 , pp. 1002-1004
    • Kass, D.A.1
  • 2
    • 0022980843 scopus 로고
    • Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure
    • Bristow M.R., Ginsburg R., Umans V., Fowler M., Minobe W., Rasmussen R., et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res 1986, 59:297-309.
    • (1986) Circ Res , vol.59 , pp. 297-309
    • Bristow, M.R.1    Ginsburg, R.2    Umans, V.3    Fowler, M.4    Minobe, W.5    Rasmussen, R.6
  • 3
    • 33746624267 scopus 로고    scopus 로고
    • Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease
    • Anderson M.E., Higgins L.S., Schulman H. Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease. Nat Clin Pract Cardiovasc Med 2006, 3:437-445.
    • (2006) Nat Clin Pract Cardiovasc Med , vol.3 , pp. 437-445
    • Anderson, M.E.1    Higgins, L.S.2    Schulman, H.3
  • 4
    • 0033514391 scopus 로고    scopus 로고
    • Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy
    • Zakhary D.R., Moravec C.S., Stewart R.W., Bond M. Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy. Circulation 1999, 99:505-510.
    • (1999) Circulation , vol.99 , pp. 505-510
    • Zakhary, D.R.1    Moravec, C.S.2    Stewart, R.W.3    Bond, M.4
  • 5
    • 0033105384 scopus 로고    scopus 로고
    • Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation
    • Schwinger R.H., Munch G., Bolck B., Karczewski P., Krause E.G., Erdmann E. Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation. J Mol Cell Cardiol 1999, 31:479-491.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 479-491
    • Schwinger, R.H.1    Munch, G.2    Bolck, B.3    Karczewski, P.4    Krause, E.G.5    Erdmann, E.6
  • 7
    • 0034724376 scopus 로고    scopus 로고
    • Regulation of PKA binding to AKAPs in the heart: alterations in human heart failure
    • Zakhary D.R., Moravec C.S., Bond M. Regulation of PKA binding to AKAPs in the heart: alterations in human heart failure. Circulation 2000, 101:1459-1464.
    • (2000) Circulation , vol.101 , pp. 1459-1464
    • Zakhary, D.R.1    Moravec, C.S.2    Bond, M.3
  • 8
    • 2442457417 scopus 로고    scopus 로고
    • Altered cAMP-mediated signalling and its role in the pathogenesis of dilated cardiomyopathy
    • Movsesian M.A. Altered cAMP-mediated signalling and its role in the pathogenesis of dilated cardiomyopathy. Cardiovasc Res 2004, 62:450-459.
    • (2004) Cardiovasc Res , vol.62 , pp. 450-459
    • Movsesian, M.A.1
  • 9
    • 77950473713 scopus 로고    scopus 로고
    • A-kinase anchoring proteins: getting to the heart of the matter
    • Scott J.D., Santana L.F. A-kinase anchoring proteins: getting to the heart of the matter. Circulation 2010, 121:1264-1271.
    • (2010) Circulation , vol.121 , pp. 1264-1271
    • Scott, J.D.1    Santana, L.F.2
  • 10
    • 33745054119 scopus 로고    scopus 로고
    • Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP
    • Scholten A., Poh M.K., van Veen T.A., van Breukelen B., Vos M.A., Heck A.J. Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP. J Proteome Res 2006, 5:1435-1447.
    • (2006) J Proteome Res , vol.5 , pp. 1435-1447
    • Scholten, A.1    Poh, M.K.2    van Veen, T.A.3    van Breukelen, B.4    Vos, M.A.5    Heck, A.J.6
  • 11
    • 34249310964 scopus 로고    scopus 로고
    • Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue
    • Scholten A., van Veen T.A., Vos M.A., Heck A.J. Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue. J Proteome Res 2007, 6:1705-1717.
    • (2007) J Proteome Res , vol.6 , pp. 1705-1717
    • Scholten, A.1    van Veen, T.A.2    Vos, M.A.3    Heck, A.J.4
  • 12
    • 47949119804 scopus 로고    scopus 로고
    • The potential use of AKAP18delta as a drug target in heart failure patients
    • Lygren B., Tasken K. The potential use of AKAP18delta as a drug target in heart failure patients. Expert Opin Biol Ther 2008, 8:1099-1108.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1099-1108
    • Lygren, B.1    Tasken, K.2
  • 13
    • 0030850459 scopus 로고    scopus 로고
    • Recommendations guiding physicians in biomedical research involving human subjects
    • World Medical Association Declaration of Helsinki
    • World Medical Association Declaration of Helsinki Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 1997, 35:2-3.
    • (1997) Cardiovasc Res , vol.35 , pp. 2-3
  • 14
    • 67449105851 scopus 로고    scopus 로고
    • Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins
    • Aye T.T., Mohammed S., van den Toorn H.W., van Veen T.A., van der Heyden M.A., Scholten A., et al. Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Mol Cell Proteomics 2009, 8:1016-1028.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 1016-1028
    • Aye, T.T.1    Mohammed, S.2    van den Toorn, H.W.3    van Veen, T.A.4    van der Heyden, M.A.5    Scholten, A.6
  • 15
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    • Cox J., Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 2008, 26:1367-1372.
    • (2008) Nat Biotechnol , vol.26 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 16
    • 77952344256 scopus 로고    scopus 로고
    • Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions
    • Hubner N.C., Bird A.W., Cox J., Splettstoesser B., Bandilla P., Poser I., et al. Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions. J Cell Biol 2010, 189:739-754.
    • (2010) J Cell Biol , vol.189 , pp. 739-754
    • Hubner, N.C.1    Bird, A.W.2    Cox, J.3    Splettstoesser, B.4    Bandilla, P.5    Poser, I.6
  • 17
    • 34247642450 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors
    • Paoletti A.C., Parmely T.J., Tomomori-Sato C., Sato S., Zhu D., Conaway R.C., et al. Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors. Proc Natl Acad Sci USA 2006, 103:18928-18933.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18928-18933
    • Paoletti, A.C.1    Parmely, T.J.2    Tomomori-Sato, C.3    Sato, S.4    Zhu, D.5    Conaway, R.C.6
  • 19
    • 0033515617 scopus 로고    scopus 로고
    • Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium
    • Hoch B., Meyer R., Hetzer R., Krause E.G., Karczewski P. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res 1999, 84:713-721.
    • (1999) Circ Res , vol.84 , pp. 713-721
    • Hoch, B.1    Meyer, R.2    Hetzer, R.3    Krause, E.G.4    Karczewski, P.5
  • 20
    • 77951745863 scopus 로고    scopus 로고
    • Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase
    • Kovanich D., van der Heyden M.A., Aye T.T., van Veen T.A., Heck A.J., Scholten A. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. Chembiochem 2010, 11:963-971.
    • (2010) Chembiochem , vol.11 , pp. 963-971
    • Kovanich, D.1    van der Heyden, M.A.2    Aye, T.T.3    van Veen, T.A.4    Heck, A.J.5    Scholten, A.6
  • 22
    • 15244348075 scopus 로고    scopus 로고
    • Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner
    • Fukuda N., Wu Y., Nair P., Granzier H.L. Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner. J Gen Physiol 2005, 125:257-271.
    • (2005) J Gen Physiol , vol.125 , pp. 257-271
    • Fukuda, N.1    Wu, Y.2    Nair, P.3    Granzier, H.L.4
  • 23
    • 0017143827 scopus 로고
    • Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart
    • Solaro R.J., Moir A.J., Perry S.V. Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart. Nature 1976, 262:615-617.
    • (1976) Nature , vol.262 , pp. 615-617
    • Solaro, R.J.1    Moir, A.J.2    Perry, S.V.3
  • 24
    • 0019216704 scopus 로고
    • Phosphorylation of a myofibrillar protein of Mr 150 000 in perfused rat heart, and the tentative indentification of this as C-protein
    • Jeacocke S.A., England P.J. Phosphorylation of a myofibrillar protein of Mr 150 000 in perfused rat heart, and the tentative indentification of this as C-protein. FEBS Lett 1980, 122:129-132.
    • (1980) FEBS Lett , vol.122 , pp. 129-132
    • Jeacocke, S.A.1    England, P.J.2
  • 25
    • 0036083657 scopus 로고    scopus 로고
    • Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray
    • Barrans J.D., Allen P.D., Stamatiou D., Dzau V.J., Liew C.C. Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am J Pathol 2002, 160:2035-2043.
    • (2002) Am J Pathol , vol.160 , pp. 2035-2043
    • Barrans, J.D.1    Allen, P.D.2    Stamatiou, D.3    Dzau, V.J.4    Liew, C.C.5
  • 27
    • 0032078084 scopus 로고    scopus 로고
    • Primary structure and function of an A kinase anchoring protein associated with calcium channels
    • Gray P.C., Johnson B.D., Westenbroek R.E., Hays L.G., Yates J.R., Scheuer T., et al. Primary structure and function of an A kinase anchoring protein associated with calcium channels. Neuron 1998, 20:1017-1026.
    • (1998) Neuron , vol.20 , pp. 1017-1026
    • Gray, P.C.1    Johnson, B.D.2    Westenbroek, R.E.3    Hays, L.G.4    Yates, J.R.5    Scheuer, T.6
  • 28
    • 0034789448 scopus 로고    scopus 로고
    • MAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope
    • Kapiloff M.S., Jackson N., Airhart N. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci 2001, 114:3167-3176.
    • (2001) J Cell Sci , vol.114 , pp. 3167-3176
    • Kapiloff, M.S.1    Jackson, N.2    Airhart, N.3
  • 29
    • 0034705543 scopus 로고    scopus 로고
    • Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization
    • Lin F., Wang H., Malbon C.C. Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization. J Biol Chem 2000, 275:19025-19034.
    • (2000) J Biol Chem , vol.275 , pp. 19025-19034
    • Lin, F.1    Wang, H.2    Malbon, C.C.3
  • 30
    • 77957256718 scopus 로고    scopus 로고
    • Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-Type calcium channels
    • Nichols C.B., Rossow C.F., Navedo M.F., Westenbroek R.E., Catterall W.A., Santana L.F., et al. Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-Type calcium channels. Circ Res 2010, 107:747-756.
    • (2010) Circ Res , vol.107 , pp. 747-756
    • Nichols, C.B.1    Rossow, C.F.2    Navedo, M.F.3    Westenbroek, R.E.4    Catterall, W.A.5    Santana, L.F.6
  • 31
    • 0032102257 scopus 로고    scopus 로고
    • Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart
    • Fentzke R.C., Korcarz C.E., Lang R.M., Lin H., Leiden J.M. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest 1998, 101:2415-2426.
    • (1998) J Clin Invest , vol.101 , pp. 2415-2426
    • Fentzke, R.C.1    Korcarz, C.E.2    Lang, R.M.3    Lin, H.4    Leiden, J.M.5
  • 34
    • 0037389642 scopus 로고    scopus 로고
    • Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism
    • Kammerer S., Burns-Hamuro L.L., Ma Y., Hamon S.C., Canaves J.M., Shi M.M., et al. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci USA 2003, 100:4066-4071.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4066-4071
    • Kammerer, S.1    Burns-Hamuro, L.L.2    Ma, Y.3    Hamon, S.C.4    Canaves, J.M.5    Shi, M.M.6
  • 35
    • 10644295566 scopus 로고    scopus 로고
    • Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue
    • Saucerman J.J., Healy S.N., Belik M.E., Puglisi J.L., McCulloch A.D. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circ Res 2004, 95:1216-1224.
    • (2004) Circ Res , vol.95 , pp. 1216-1224
    • Saucerman, J.J.1    Healy, S.N.2    Belik, M.E.3    Puglisi, J.L.4    McCulloch, A.D.5
  • 36
    • 34250156365 scopus 로고    scopus 로고
    • CAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology
    • Zaccolo M., Movsesian M.A. cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology. Circ Res 2007, 100:1569-1578.
    • (2007) Circ Res , vol.100 , pp. 1569-1578
    • Zaccolo, M.1    Movsesian, M.A.2
  • 37
    • 10744225434 scopus 로고    scopus 로고
    • Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice
    • Schroder F., Klein G., Fiedler B., Bastein M., Schnasse N., Hillmer A., et al. Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice. Cardiovasc Res 2003, 60:268-277.
    • (2003) Cardiovasc Res , vol.60 , pp. 268-277
    • Schroder, F.1    Klein, G.2    Fiedler, B.3    Bastein, M.4    Schnasse, N.5    Hillmer, A.6
  • 38
    • 0036790852 scopus 로고    scopus 로고
    • The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding
    • Martinez S.E., Wu A.Y., Glavas N.A., Tang X.B., Turley S., Hol W.G., et al. The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci USA 2002, 99:13260-13265.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13260-13265
    • Martinez, S.E.1    Wu, A.Y.2    Glavas, N.A.3    Tang, X.B.4    Turley, S.5    Hol, W.G.6
  • 39
    • 33644865929 scopus 로고    scopus 로고
    • Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway
    • Mongillo M., Tocchetti C.G., Terrin A., Lissandron V., Cheung Y.F., Dostmann W.R., et al. Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res 2006, 98:226-234.
    • (2006) Circ Res , vol.98 , pp. 226-234
    • Mongillo, M.1    Tocchetti, C.G.2    Terrin, A.3    Lissandron, V.4    Cheung, Y.F.5    Dostmann, W.R.6
  • 41
    • 47249124173 scopus 로고    scopus 로고
    • A multi-angular mass spectrometric view at cyclic nucleotide dependent protein kinases: in vivo characterization and structure/function relationships
    • Scholten A., Aye T.T., Heck A.J. A multi-angular mass spectrometric view at cyclic nucleotide dependent protein kinases: in vivo characterization and structure/function relationships. Mass Spectrom Rev 2008, 27:331-353.
    • (2008) Mass Spectrom Rev , vol.27 , pp. 331-353
    • Scholten, A.1    Aye, T.T.2    Heck, A.J.3
  • 42
    • 0038464639 scopus 로고    scopus 로고
    • Phospholamban: a crucial regulator of cardiac contractility
    • MacLennan D.H., Kranias E.G. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 2003, 4:566-577.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 566-577
    • MacLennan, D.H.1    Kranias, E.G.2
  • 43
    • 69949174646 scopus 로고    scopus 로고
    • The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function
    • Chaturvedi D., Cohen M.S., Taunton J., Patel T.B. The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem 2009, 284:23670-23681.
    • (2009) J Biol Chem , vol.284 , pp. 23670-23681
    • Chaturvedi, D.1    Cohen, M.S.2    Taunton, J.3    Patel, T.B.4
  • 44
    • 0032550231 scopus 로고    scopus 로고
    • Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading
    • Tagawa H., Koide M., Sato H., Zile M.R., Carabello B.A., Cooper GT Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading. Circ Res 1998, 82:751-761.
    • (1998) Circ Res , vol.82 , pp. 751-761
    • Tagawa, H.1    Koide, M.2    Sato, H.3    Zile, M.R.4    Carabello, B.A.5    Cooper, G.T.6
  • 45
    • 62949152122 scopus 로고    scopus 로고
    • MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP
    • Leterrier J.F., Kurachi M., Tashiro T., Janmey P.A. MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP. Eur Biophys J 2009, 38:381-393.
    • (2009) Eur Biophys J , vol.38 , pp. 381-393
    • Leterrier, J.F.1    Kurachi, M.2    Tashiro, T.3    Janmey, P.A.4
  • 46
    • 0017894575 scopus 로고
    • Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells
    • Nath K., Shay J.W., Bollon A.P. Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells. Proc Natl Acad Sci USA 1978, 75:319-323.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 319-323
    • Nath, K.1    Shay, J.W.2    Bollon, A.P.3
  • 47
    • 0037127028 scopus 로고    scopus 로고
    • Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
    • Marx S.O., Kurokawa J., Reiken S., Motoike H., D'Armiento J., Marks A.R., et al. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 2002, 295:496-499.
    • (2002) Science , vol.295 , pp. 496-499
    • Marx, S.O.1    Kurokawa, J.2    Reiken, S.3    Motoike, H.4    D'Armiento, J.5    Marks, A.R.6
  • 48
    • 66149127296 scopus 로고    scopus 로고
    • The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3
    • Terrenoire C., Houslay M.D., Baillie G.S., Kass R.S. The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3. J Biol Chem 2009, 284:9140-9146.
    • (2009) J Biol Chem , vol.284 , pp. 9140-9146
    • Terrenoire, C.1    Houslay, M.D.2    Baillie, G.S.3    Kass, R.S.4
  • 50
    • 77955965008 scopus 로고    scopus 로고
    • Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias
    • Boulaksil M., Winckels S.K., Engelen M.A., Stein M., van Veen T.A., Jansen J.A., et al. Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias. Eur J Heart Fail 2010, 12:913-921.
    • (2010) Eur J Heart Fail , vol.12 , pp. 913-921
    • Boulaksil, M.1    Winckels, S.K.2    Engelen, M.A.3    Stein, M.4    van Veen, T.A.5    Jansen, J.A.6
  • 51
    • 77951622309 scopus 로고    scopus 로고
    • Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins
    • Sfichi-Duke L., Garcia-Cazarin M.L., Sumandea C.A., Sievert G.A., Balke C.W., Zhan D.Y., et al. Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins. J Mol Cell Cardiol 2010, 48:934-942.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 934-942
    • Sfichi-Duke, L.1    Garcia-Cazarin, M.L.2    Sumandea, C.A.3    Sievert, G.A.4    Balke, C.W.5    Zhan, D.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.