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Volumn 37, Issue 3, 1998, Pages 567-577

Experimental evidence for proarrhythmic mechanisms of antiarrhythmic drugs

Author keywords

Action potential duration; Cardiac arrhythmia; Early afterdepolarization; Ion channel blocker; Ischemic heart disease; Pharmacology; Potassium channel blocker; Sodium channel blocker

Indexed keywords

AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; DISOPYRAMIDE; ENCAINIDE; FLECAINIDE; ION CHANNEL; MORACIZINE; POTASSIUM CHANNEL BLOCKING AGENT; PROCAINAMIDE; QUINIDINE; SODIUM CHANNEL BLOCKING AGENT; SOTALOL;

EID: 0032029141     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00293-9     Document Type: Review
Times cited : (70)

References (100)
  • 1
    • 0024321898 scopus 로고
    • Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction
    • [1] The Cardiac Arrhythmia Suppression Trial (CAST) Investigators, Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 1989;3321:406-412.
    • (1989) N Engl J Med , vol.3321 , pp. 406-412
  • 2
    • 0026752875 scopus 로고
    • Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction
    • [2] The Cardiac Arrhythmia Suppression Trial II (CAST) Investigators, Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med 1992;327:227-233.
    • (1992) N Engl J Med , vol.327 , pp. 227-233
  • 3
    • 0021684972 scopus 로고
    • International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings
    • [3] IMPACT Research Group. International Mexiletine and Placebo Antiarrhythmic Coronary Trial: I. Report on arrhythmia and other findings. J Am Coll Cardiol 1984;4:1148-1163
    • (1984) J Am Coll Cardiol , vol.4 , pp. 1148-1163
  • 4
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction
    • for the SWORD Investigators
    • [4] Waldo AL, Camm AJ, deRuyter H, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 1996;348:7-12. for the SWORD Investigators.
    • (1996) Lancet , vol.348 , pp. 7-12
    • Waldo, A.L.1    Camm, A.J.2    Deruyter, H.3
  • 5
    • 0025542167 scopus 로고
    • Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials
    • [5] Coplen SE, Antman EM, Berlin JA, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials. Circulation 1990;82:1106-1116.
    • (1990) Circulation , vol.82 , pp. 1106-1116
    • Coplen, S.E.1    Antman, E.M.2    Berlin, J.A.3    Hewitt, P.4    Chalmers, T.C.5
  • 6
    • 0026649118 scopus 로고
    • Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation
    • on Behalf of the Stroke Prevention in Atrial Fibrillation Investigators
    • [6] Flaker GC, Blackshear JL, McBride R, et al. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. J Am Coll Cardiol 1992;20:527-532. on Behalf of the Stroke Prevention in Atrial Fibrillation Investigators.
    • (1992) J Am Coll Cardiol , vol.20 , pp. 527-532
    • Flaker, G.C.1    Blackshear, J.L.2    McBride, R.3
  • 7
    • 0027990339 scopus 로고
    • The treatment of atrial fibrillation. An evaluation of drug therapy, electrical modalities and therapeutic considerations
    • [7] Nattel S, Hadjis T, Talajic M. The treatment of atrial fibrillation. An evaluation of drug therapy, electrical modalities and therapeutic considerations. Drugs 1994;48:345-371.
    • (1994) Drugs , vol.48 , pp. 345-371
    • Nattel, S.1    Hadjis, T.2    Talajic, M.3
  • 8
    • 0025278177 scopus 로고
    • Effect of empiric antiarrhythmic therapy in resuscitated out-of-hospital cardiac arrest victims with coronary artery disease
    • [8] Moosvi AR, Goldstein S, VanderBrug Medendorp S, et al. Effect of empiric antiarrhythmic therapy in resuscitated out-of-hospital cardiac arrest victims with coronary artery disease. Am J Cardiol 1990;65:1192-1197.
    • (1990) Am J Cardiol , vol.65 , pp. 1192-1197
    • Moosvi, A.R.1    Goldstein, S.2    Vanderbrug Medendorp, S.3
  • 9
    • 0002304545 scopus 로고
    • Quinidine syncope - Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias
    • [9] Selzer A, Wray HW. Quinidine syncope - paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias. Circulation 1964;30:17-26.
    • (1964) Circulation , vol.30 , pp. 17-26
    • Selzer, A.1    Wray, H.W.2
  • 10
    • 0020644769 scopus 로고
    • Kinetics of onset of rate-dependent effects of class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification
    • [10] Campbell TJ. Kinetics of onset of rate-dependent effects of class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification. Cardiovasc Res 1983;17:344-352.
    • (1983) Cardiovasc Res , vol.17 , pp. 344-352
    • Campbell, T.J.1
  • 11
    • 0019480391 scopus 로고
    • Malignant ventricular tachyarrhythmias associated with the use of encainide
    • [11] Winkle RA, Mason JW, Griffin JC, Ross D. Malignant ventricular tachyarrhythmias associated with the use of encainide. Am Heart J 1981;102:857-863.
    • (1981) Am Heart J , vol.102 , pp. 857-863
    • Winkle, R.A.1    Mason, J.W.2    Griffin, J.C.3    Ross, D.4
  • 12
    • 0020076154 scopus 로고
    • Drug conversion of nonsustained ventricular tachycardia to sustained ventricular tachycardia during serial electrophysiologic studies: Identification of drugs that exacerbate tachycardia and potential mechanisms
    • [12] Rinkenberger RL, Prystowsky EN, Jackman WM, et al. Drug conversion of nonsustained ventricular tachycardia to sustained ventricular tachycardia during serial electrophysiologic studies: identification of drugs that exacerbate tachycardia and potential mechanisms. Am Heart J 1982;103:177-184.
    • (1982) Am Heart J , vol.103 , pp. 177-184
    • Rinkenberger, R.L.1    Prystowsky, E.N.2    Jackman, W.M.3
  • 13
    • 0021345989 scopus 로고
    • Flecainide: Its proarrhythmic effect and expected changes on the surface electrocardiogram
    • [13] Morganroth J, Horowitz LN. Flecainide: its proarrhythmic effect and expected changes on the surface electrocardiogram. Am J Cardiol 1984;53:89B-94B.
    • (1984) Am J Cardiol , vol.53
    • Morganroth, J.1    Horowitz, L.N.2
  • 14
    • 0023272292 scopus 로고
    • Risk factors for the development of proarrhythmic events
    • [14] Morganroth J. Risk factors for the development of proarrhythmic events. Am J Cardiol 1987;59:32E-37E.
    • (1987) Am J Cardiol , vol.59
    • Morganroth, J.1
  • 15
    • 0023932102 scopus 로고
    • Effects of class I drugs on reentrant ventricular tachycardia in a canine model of myocardial infarction: On their antiarrhythmic and proarrhythmic mechanisms
    • [15] Miyazaki T, Ogawa S, Sakai T, et al. Effects of class I drugs on reentrant ventricular tachycardia in a canine model of myocardial infarction: on their antiarrhythmic and proarrhythmic mechanisms. Jpn Circ J 1988;52:254-261.
    • (1988) Jpn Circ J , vol.52 , pp. 254-261
    • Miyazaki, T.1    Ogawa, S.2    Sakai, T.3
  • 16
    • 85047676260 scopus 로고
    • Electrophysiological effects of flecainide in a canine 7 day old myocardial infarction model
    • [16] Sakai T, Ogawa S, Hosokawa M, et al. Electrophysiological effects of flecainide in a canine 7 day old myocardial infarction model. Cardiovasc Res 1989;23:177-183.
    • (1989) Cardiovasc Res , vol.23 , pp. 177-183
    • Sakai, T.1    Ogawa, S.2    Hosokawa, M.3
  • 18
    • 0027407161 scopus 로고
    • Effects of flecainide and D-sotalol on myocardial conduction and refractoriness: Relation to antiarrhythmic and proarrhythmic drug effects
    • [18] Kidwell GA, Gonzalez MD. Effects of flecainide and D-sotalol on myocardial conduction and refractoriness: relation to antiarrhythmic and proarrhythmic drug effects. J Cardiovasc Pharmacol 1993;21:621-632.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 621-632
    • Kidwell, G.A.1    Gonzalez, M.D.2
  • 19
    • 0027401588 scopus 로고
    • Demonstration of proarrhythmic activity with the class IC antiarrhythmic agent encainide in a canine model of previous myocardial infarction
    • [19] Wallace AA, Stupienski RF III, Kothstein T, Gehret JR, Lynch JJ Jr.. Demonstration of proarrhythmic activity with the class IC antiarrhythmic agent encainide in a canine model of previous myocardial infarction. J Cardiovasc Pharmacol 1993;21:397-404.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 397-404
    • Wallace, A.A.1    Stupienski R.F. III2    Kothstein, T.3    Gehret, J.R.4    Lynch J.J., Jr.5
  • 20
    • 0029133471 scopus 로고
    • Determinants and mechanisms of flecainide-induced promotion of ventricular tachycardia in anesthetized dogs
    • [20] Ranger S, Nattel S. Determinants and mechanisms of flecainide-induced promotion of ventricular tachycardia in anesthetized dogs. Circulation 1995;92:1300-1311.
    • (1995) Circulation , vol.92 , pp. 1300-1311
    • Ranger, S.1    Nattel, S.2
  • 21
    • 0028950724 scopus 로고
    • Reentrant arrhythmias in the subacute infarction period. The proarrhythmic effect of flecainide acetate on functional reentrant circuits
    • [21] Restivo M, Yin H, Caref EB, et al. Reentrant arrhythmias in the subacute infarction period. The proarrhythmic effect of flecainide acetate on functional reentrant circuits. Circulation 1995;91:1236-1246.
    • (1995) Circulation , vol.91 , pp. 1236-1246
    • Restivo, M.1    Yin, H.2    Caref, E.B.3
  • 22
    • 0028898776 scopus 로고
    • Electrophysiological effects of flecainide on anisotropic conduction and reentry in infarcted canine hearts
    • [22] Coromilas J, Saltman AE, Waldecker B, Dillon SM, Wit AL. Electrophysiological effects of flecainide on anisotropic conduction and reentry in infarcted canine hearts. Circulation 1995;91:2245-2263.
    • (1995) Circulation , vol.91 , pp. 2245-2263
    • Coromilas, J.1    Saltman, A.E.2    Waldecker, B.3    Dillon, S.M.4    Wit, A.L.5
  • 23
    • 0017529623 scopus 로고
    • Cardiac electrophysiologic alterations during myocardial ischemia
    • [23] Elharrar V, Zipes DP. Cardiac electrophysiologic alterations during myocardial ischemia. Am J Physiol 1977;233:H329-H345.
    • (1977) Am J Physiol , vol.233
    • Elharrar, V.1    Zipes, D.P.2
  • 24
    • 0024325322 scopus 로고
    • Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction
    • [24] Janse MJ, Wit AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev 1989;69:1049-1169.
    • (1989) Physiol Rev , vol.69 , pp. 1049-1169
    • Janse, M.J.1    Wit, A.L.2
  • 25
    • 0017336723 scopus 로고
    • Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs
    • [25] Elharrar V, Gaum WE, Zipes DP. Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs. Am J Cardiol 1977;39:544-549.
    • (1977) Am J Cardiol , vol.39 , pp. 544-549
    • Elharrar, V.1    Gaum, W.E.2    Zipes, D.P.3
  • 26
    • 85047675410 scopus 로고
    • Alterations in regional myocardial distribution and arrhythmogenic effects of aprindine produced by coronary artery occlusion in the dog
    • [26] Nattel S, Pedersen DH, Zipes DP. Alterations in regional myocardial distribution and arrhythmogenic effects of aprindine produced by coronary artery occlusion in the dog. Cardiovasc Res 1981;15:80-85.
    • (1981) Cardiovasc Res , vol.15 , pp. 80-85
    • Nattel, S.1    Pedersen, D.H.2    Zipes, D.P.3
  • 27
    • 0022575395 scopus 로고
    • Relationship between an arrhythmogenic action of lidocaine and its effects on excitation patterns in acutely ischemic porcine myocardium
    • [27] Carson DL, Cardinal R, Savard P, et al. Relationship between an arrhythmogenic action of lidocaine and its effects on excitation patterns in acutely ischemic porcine myocardium. J Cardiovasc Pharmacol 1986;8:126-136.
    • (1986) J Cardiovasc Pharmacol , vol.8 , pp. 126-136
    • Carson, D.L.1    Cardinal, R.2    Savard, P.3
  • 28
    • 0028919535 scopus 로고
    • Profibrillatory effects of lidocaine in the acutely ischemic porcine heart
    • [28] Aupetit JF, Timour Q, Loufoua-Moundanga J, et al. Profibrillatory effects of lidocaine in the acutely ischemic porcine heart. J Cardiovasc Pharmacol 1995;25:810-816.
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 810-816
    • Aupetit, J.F.1    Timour, Q.2    Loufoua-Moundanga, J.3
  • 29
    • 0023134609 scopus 로고
    • Effect of flecainide acetate on prevention of electrical induction of ventricular tachycardia and occurrence of ischemic ventricular fibrillation during the early postmyocardial infarction period: Evaluation in a conscious canine model of sudden death
    • [29] Kou WH, Nelson SD, Lynch JJ, et al. Effect of flecainide acetate on prevention of electrical induction of ventricular tachycardia and occurrence of ischemic ventricular fibrillation during the early postmyocardial infarction period: evaluation in a conscious canine model of sudden death. J Am Coll Cardiol 1987;9:359-365.
    • (1987) J Am Coll Cardiol , vol.9 , pp. 359-365
    • Kou, W.H.1    Nelson, S.D.2    Lynch, J.J.3
  • 31
    • 0023143187 scopus 로고
    • Antiarrhythmic agents: Modulated receptor applications
    • [31] Hondeghem LM. Antiarrhythmic agents: modulated receptor applications. Circulation 1987;75:514-520.
    • (1987) Circulation , vol.75 , pp. 514-520
    • Hondeghem, L.M.1
  • 32
    • 0025925153 scopus 로고
    • Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments
    • [32] Starmer CF, Lastra AA, Nesterenko VV, Grant AO. Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments. Circulation 1991;84:1364-1377.
    • (1991) Circulation , vol.84 , pp. 1364-1377
    • Starmer, C.F.1    Lastra, A.A.2    Nesterenko, V.V.3    Grant, A.O.4
  • 33
    • 0027363517 scopus 로고
    • Vulnerability in an excitable medium: Analytical and numerical studies of initiating unidirectional propagation
    • [33] Starmer CF, Biktashev VN, Romashko DN, et al. Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation. Biophys J 1993;65:1775-1787.
    • (1993) Biophys J , vol.65 , pp. 1775-1787
    • Starmer, C.F.1    Biktashev, V.N.2    Romashko, D.N.3
  • 34
    • 0027530585 scopus 로고
    • Flecainide-induced arrhythmia in canine ventricular epicardium - Phase 2 reentry?
    • [34] Krishnan SC, Antzelevitch C. Flecainide-induced arrhythmia in canine ventricular epicardium - Phase 2 reentry?. Circulation 1993;87:562-572.
    • (1993) Circulation , vol.87 , pp. 562-572
    • Krishnan, S.C.1    Antzelevitch, C.2
  • 35
    • 0021358237 scopus 로고
    • Experimental amitriptyline intoxication: Electrophysiologic manifestations and management
    • [35] Nattel S, Keable H, Sasyniuk BJ. Experimental amitriptyline intoxication: electrophysiologic manifestations and management. J Cardiovasc Pharmacol 1984;6:83-89.
    • (1984) J Cardiovasc Pharmacol , vol.6 , pp. 83-89
    • Nattel, S.1    Keable, H.2    Sasyniuk, B.J.3
  • 36
    • 0022409485 scopus 로고
    • Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs
    • [36] Nattel S. Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs. Circulation 1985;72:898-906.
    • (1985) Circulation , vol.72 , pp. 898-906
    • Nattel, S.1
  • 37
    • 4244007571 scopus 로고
    • Reversal of flecainide-induced ventricular arrhythmia by hypertonic sodium bicarbonate vs. normal saline in dogs: A blinded randomized comparison
    • abstract
    • [37] Salerno DM, Murakami MAM, Asinger DA, et al. Reversal of flecainide-induced ventricular arrhythmia by hypertonic sodium bicarbonate vs. normal saline in dogs: a blinded randomized comparison. J Am Coll Cardiol 1991;17:43A. abstract.
    • (1991) J Am Coll Cardiol , vol.17
    • Salerno, D.M.1    Murakami, M.A.M.2    Asinger, D.A.3
  • 38
    • 0026506173 scopus 로고
    • A proarrhythmic response to sodium channel blockade: Modulation of the vulnerable period in guinea pig ventricular myocardium
    • [38] Nesterenko VV, Lastra AA, Rosenshtraukh LV, Starmer CF. A proarrhythmic response to sodium channel blockade: modulation of the vulnerable period in guinea pig ventricular myocardium. J Cardiovasc Pharmacol 1992;19:810-820.
    • (1992) J Cardiovasc Pharmacol , vol.19 , pp. 810-820
    • Nesterenko, V.V.1    Lastra, A.A.2    Rosenshtraukh, L.V.3    Starmer, C.F.4
  • 39
    • 0025990411 scopus 로고
    • Proarrhythmic effects of flecainide. Experimental evidence for increased susceptibility to reentrant arrhythmias
    • [39] Brugada J, Boersma L, Kirchhof C, Allessie M. Proarrhythmic effects of flecainide. Experimental evidence for increased susceptibility to reentrant arrhythmias. Circulation 1991;84:1808-1818.
    • (1991) Circulation , vol.84 , pp. 1808-1818
    • Brugada, J.1    Boersma, L.2    Kirchhof, C.3    Allessie, M.4
  • 40
    • 0025360284 scopus 로고
    • What is an antiarrhythmic drug? From clinical trials to fundamental concepts
    • [40] Nattel S, Waters D. What is an antiarrhythmic drug? From clinical trials to fundamental concepts. Am J Cardiol 1990;66:96-100.
    • (1990) Am J Cardiol , vol.66 , pp. 96-100
    • Nattel, S.1    Waters, D.2
  • 41
    • 0029560055 scopus 로고
    • Interaction of ischaemia and encainide/flecainide treatment: A proposed mechanism for the increased mortality in CAST I
    • [41] Greenberg HM, Dwyer EM Jr., Hochman JS, et al. Interaction of ischaemia and encainide/flecainide treatment: a proposed mechanism for the increased mortality in CAST I. Br Heart J 1995;74:631-635.
    • (1995) Br Heart J , vol.74 , pp. 631-635
    • Greenberg, H.M.1    Dwyer E.M., Jr.2    Hochman, J.S.3
  • 42
    • 0022537817 scopus 로고
    • Pharmacodynamics and side effects of flecainide acetate
    • [42] Salerno DM, Granrud G, Sharkey P, et al. Pharmacodynamics and side effects of flecainide acetate. Clin Pharmacol Ther 1986;40:101-107.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 101-107
    • Salerno, D.M.1    Granrud, G.2    Sharkey, P.3
  • 43
    • 4243973230 scopus 로고
    • What is the mechanism of flecainide's proarrhythmic effect in cast?
    • abstract
    • [43] Nattel S, DeBlasio E, Matthews C, Ranger S, Yue L. What is the mechanism of flecainide's proarrhythmic effect in cast?. Can J Cardiol 1994;10(Suppl. C): 131C. abstract.
    • (1994) Can J Cardiol , vol.10 , Issue.SUPPL. C
    • Nattel, S.1    Deblasio, E.2    Matthews, C.3    Ranger, S.4    Yue, L.5
  • 44
    • 0026350527 scopus 로고
    • Actions of intravenous magnesium on ventricular arrhythmias caused by acute myocardial infarction
    • [44] Nattel S, Tunnel N, MacLeod R, Solymoss BC. Actions of intravenous magnesium on ventricular arrhythmias caused by acute myocardial infarction. J Pharmacol Exp Ther 1991;259:939-946.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 939-946
    • Nattel, S.1    Tunnel, N.2    Macleod, R.3    Solymoss, B.C.4
  • 45
    • 0013881809 scopus 로고
    • La tachycardie ventriculaire à deux foyers opposés variables
    • [45] Dessertenne F. La tachycardie ventriculaire à deux foyers opposés variables. Arch Mal Coeur 1966;59:263-272.
    • (1966) Arch Mal Coeur , vol.59 , pp. 263-272
    • Dessertenne, F.1
  • 47
    • 0023705913 scopus 로고
    • The long QT syndrome: A critical review, new clinical observations and a unifying hypothesis
    • [47] Jackman WM, Friday KJ, Anderson JL, et al. The long QT syndrome: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 1988;31:115-172.
    • (1988) Prog Cardiovasc Dis , vol.31 , pp. 115-172
    • Jackman, W.M.1    Friday, K.J.2    Anderson, J.L.3
  • 48
    • 0019412734 scopus 로고
    • In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide
    • [48] Dangman KH, Hoffman BF. In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide. J Pharmacol Exp Ther 1981;217:851-862.
    • (1981) J Pharmacol Exp Ther , vol.217 , pp. 851-862
    • Dangman, K.H.1    Hoffman, B.F.2
  • 49
    • 0020501838 scopus 로고
    • Bradycardia-dependent triggered activity: Relevance to drug-induced multiform ventricular tachycardia
    • [49] Brachmann J, Scherlag BJ, Rosenshtraukh LV, Lazzara R. Bradycardia-dependent triggered activity: relevance to drug-induced multiform ventricular tachycardia. Circulation 1983;68:846-856.
    • (1983) Circulation , vol.68 , pp. 846-856
    • Brachmann, J.1    Scherlag, B.J.2    Rosenshtraukh, L.V.3    Lazzara, R.4
  • 50
    • 0021972633 scopus 로고
    • Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length
    • [50] Roden DM, Hoffman BF. Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length. Circ Res 1985;56:857-867.
    • (1985) Circ Res , vol.56 , pp. 857-867
    • Roden, D.M.1    Hoffman, B.F.2
  • 51
    • 85047675271 scopus 로고
    • Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: Insights into underlying ionic mechanisms
    • [51] Nattel S, Quantz MA. Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovasc Res 1988;22:808-817.
    • (1988) Cardiovasc Res , vol.22 , pp. 808-817
    • Nattel, S.1    Quantz, M.A.2
  • 52
    • 0024536109 scopus 로고
    • Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium
    • [52] Davidenko JM, Cohen L, Goodrow R, Antzelevitch C. Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium. Circulation 1989;79:674-686.
    • (1989) Circulation , vol.79 , pp. 674-686
    • Davidenko, J.M.1    Cohen, L.2    Goodrow, R.3    Antzelevitch, C.4
  • 53
    • 0027302455 scopus 로고
    • Action potential alternants and irregular dynamics in quinidine-intoxicated ventricular muscle cells. Implications for ventricular proarrhythmia
    • [53] Karagueuzian HS, Khan SS, Hong K, et al. Action potential alternants and irregular dynamics in quinidine-intoxicated ventricular muscle cells. Implications for ventricular proarrhythmia. Circulation 1993;87:1661-1672.
    • (1993) Circulation , vol.87 , pp. 1661-1672
    • Karagueuzian, H.S.1    Khan, S.S.2    Hong, K.3
  • 54
    • 0025829410 scopus 로고
    • A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell
    • [54] Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res 1991;68:1729-1741.
    • (1991) Circ Res , vol.68 , pp. 1729-1741
    • Sicouri, S.1    Antzelevitch, C.2
  • 55
    • 0028082351 scopus 로고
    • Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and Torsade de Pointes
    • [55] Antzelevitch C, Sicouri S. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and Torsade de Pointes. J Am Coll Cardiol 1994;23:259-277.
    • (1994) J Am Coll Cardiol , vol.23 , pp. 259-277
    • Antzelevitch, C.1    Sicouri, S.2
  • 56
    • 0022374740 scopus 로고
    • Cesium chloride-induced long QT syndrome: Demonstration of afterdepolarizations and triggered activity in vivo
    • [56] Levine JH, Spear JF, Guarnieri T, et al. Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo. Circulation 1985;72:1092-1103.
    • (1985) Circulation , vol.72 , pp. 1092-1103
    • Levine, J.H.1    Spear, J.F.2    Guarnieri, T.3
  • 57
    • 0023921614 scopus 로고
    • Autonomic modulation of ventricular arrhythmia in cesium chloride-induced long QT syndrome
    • [57] Hanich RF, Levine JH, Spear JF, Moore EN. Autonomic modulation of ventricular arrhythmia in cesium chloride-induced long QT syndrome. Circulation 1988;77:1149-1161.
    • (1988) Circulation , vol.77 , pp. 1149-1161
    • Hanich, R.F.1    Levine, J.H.2    Spear, J.F.3    Moore, E.N.4
  • 58
    • 0023888345 scopus 로고
    • Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs
    • [58] Bailie DS, Inoue H, Kaseda S, Ben-David J, Zipes DP. Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs. Circulation 1988;77:1395-1402.
    • (1988) Circulation , vol.77 , pp. 1395-1402
    • Bailie, D.S.1    Inoue, H.2    Kaseda, S.3    Ben-David, J.4    Zipes, D.P.5
  • 59
    • 0025215846 scopus 로고
    • Pharmacologic response of celsium-induced ventricular tachyarrhythmias in anesthetized dogs
    • [59] Nayebpour M, Nattel S. Pharmacologic response of celsium-induced ventricular tachyarrhythmias in anesthetized dogs. J Cardiovasc Pharmacol 1990;15:552-561.
    • (1990) J Cardiovasc Pharmacol , vol.15 , pp. 552-561
    • Nayebpour, M.1    Nattel, S.2
  • 60
    • 0026523892 scopus 로고
    • Effects of vagal stimulation on cesium-induced early afterdepolarizations and ventricular arrhythmias in rabbits
    • [60] Takahashi N, Ito M, Ishida S, et al. Effects of vagal stimulation on cesium-induced early afterdepolarizations and ventricular arrhythmias in rabbits. Circulation 1992;86:1987-1992.
    • (1992) Circulation , vol.86 , pp. 1987-1992
    • Takahashi, N.1    Ito, M.2    Ishida, S.3
  • 61
    • 0024381643 scopus 로고
    • Quinidine-induced long QTU interval and Torsade de Pointes: Role of bradycardia-dependent early afterdepolarizations
    • [61] El-Sherif N, Bekheit SS, Henkin R. Quinidine-induced long QTU interval and Torsade de Pointes: role of bradycardia-dependent early afterdepolarizations. J Am Coll Cardiol 1989;14:252-257.
    • (1989) J Am Coll Cardiol , vol.14 , pp. 252-257
    • El-Sherif, N.1    Bekheit, S.S.2    Henkin, R.3
  • 62
    • 85047677921 scopus 로고
    • Cardiovascular and metabolic effects of caesium chloride injection in dogs - Limitalions as a model for the long QT syndrome
    • [62] Nayebpour M, Solymoss BC, Nattel S. Cardiovascular and metabolic effects of caesium chloride injection in dogs - limitalions as a model for the long QT syndrome. Cardiovasc Res 1989;23:756-766.
    • (1989) Cardiovasc Res , vol.23 , pp. 756-766
    • Nayebpour, M.1    Solymoss, B.C.2    Nattel, S.3
  • 63
    • 0026319641 scopus 로고
    • Arrhythmogenic activities of antiarrhythmic drugs in conscious hypokalemic dogs with atrioventricular block: Comparison between quinidine, lido caine, flecainide, propranolol and sotalol
    • [63] Weissenburger J, Davy JM, Chézalviel F, et al. Arrhythmogenic activities of antiarrhythmic drugs in conscious hypokalemic dogs with atrioventricular block: comparison between quinidine, lido caine, flecainide, propranolol and sotalol. J Pharmacol Exp Ther 1991;259:871-883.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 871-883
    • Weissenburger, J.1    Davy, J.M.2    Chézalviel, F.3
  • 64
    • 0025835622 scopus 로고
    • Methods and limitations of an experimental model of long QT syndrome
    • [64] Weissenburger J, Chezalviel F, Davy JM, et al. Methods and limitations of an experimental model of long QT syndrome. J Pharmacol Methods 1991;26:23-42.
    • (1991) J Pharmacol Methods , vol.26 , pp. 23-42
    • Weissenburger, J.1    Chezalviel, F.2    Davy, J.M.3
  • 65
    • 0028890324 scopus 로고
    • Reproducible induction of early afterdepolarizations and Torsade de Pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block
    • [65] Vos MA, Verduyn SC, Gorgels APM, Lipcsei GC, Wellens HJJ. Reproducible induction of early afterdepolarizations and Torsade de Pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation 1995;91:864-872.
    • (1995) Circulation , vol.91 , pp. 864-872
    • Vos, M.A.1    Verduyn, S.C.2    Gorgels, A.P.M.3    Lipcsei, G.C.4    Wellens, H.J.J.5
  • 66
    • 0025333776 scopus 로고
    • QTU-prolongation and Torsades de Pointes induced by putative class III antiarrhythmic agents in the rabbit: Etiology and interventions
    • [66] Carlsson L, Almgren O, Duker G. QTU-prolongation and Torsades de Pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. J Cardiovasc Pharmacol 1990;16:276-285.
    • (1990) J Cardiovasc Pharmacol , vol.16 , pp. 276-285
    • Carlsson, L.1    Almgren, O.2    Duker, G.3
  • 67
    • 0027771044 scopus 로고
    • Proarrhythmic effects of the class III agent almokalant: Importance of infusion rate, QT dispersion, and early afterdepolarisations
    • [67] Carlsson L, Abrahamsson C, Andersson B, Duker G, Schiller-Linhardt G. Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations. Cardiovasc Res 1993;27:2186-2193.
    • (1993) Cardiovasc Res , vol.27 , pp. 2186-2193
    • Carlsson, L.1    Abrahamsson, C.2    Andersson, B.3    Duker, G.4    Schiller-Linhardt, G.5
  • 68
    • 0030969538 scopus 로고    scopus 로고
    • Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: Reversal by magnesium
    • [68] Verduyn SC, Vos MA, van der Zande J, van der Hulst FF, Wellens HJ. Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: reversal by magnesium. Cardiovasc Res 1997;34:453-463.
    • (1997) Cardiovasc Res , vol.34 , pp. 453-463
    • Verduyn, S.C.1    Vos, M.A.2    Van Der Zande, J.3    Van Der Hulst, F.F.4    Wellens, H.J.5
  • 70
    • 0022575132 scopus 로고
    • Epicardial activation patterns of Torsade de Pointes in canine hearts with quinidine-induced long QT interval but without myocardial infarction
    • [70] Inoue H, Murakawa Y, Toda I, et al. Epicardial activation patterns of Torsade de Pointes in canine hearts with quinidine-induced long QT interval but without myocardial infarction. Am Heart J 1986;111:1080-1087.
    • (1986) Am Heart J , vol.111 , pp. 1080-1087
    • Inoue, H.1    Murakawa, Y.2    Toda, I.3
  • 71
    • 0023784610 scopus 로고
    • QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Afterdepolarizations and ventricular arrhythmias
    • [71] El-Sherif N, Zeiler RH, Craelius W, Gough WB, Henkin R. QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Afterdepolarizations and ventricular arrhythmias. Circ Res 1988;63:286-305.
    • (1988) Circ Res , vol.63 , pp. 286-305
    • El-Sherif, N.1    Zeiler, R.H.2    Craelius, W.3    Gough, W.B.4    Henkin, R.5
  • 72
    • 0029835964 scopus 로고    scopus 로고
    • The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns
    • [72] El-Sherif N, Caref EB, Yin H, Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circ Res 1996;79:474-492.
    • (1996) Circ Res , vol.79 , pp. 474-492
    • El-Sherif, N.1    Caref, E.B.2    Yin, H.3    Restivo, M.4
  • 73
    • 0030888769 scopus 로고    scopus 로고
    • Optical mapping of drug-induced polymorphic arrhythmias and Torsade de Pointes in the isolated rabbit heart
    • [73] Asano Y, Davidenko JM, Baxter WT, Gray RA, Jalife J. Optical mapping of drug-induced polymorphic arrhythmias and Torsade de Pointes in the isolated rabbit heart. J Am Coll Cardiol 1997;29:831-842.
    • (1997) J Am Coll Cardiol , vol.29 , pp. 831-842
    • Asano, Y.1    Davidenko, J.M.2    Baxter, W.T.3    Gray, R.A.4    Jalife, J.5
  • 74
    • 0029114060 scopus 로고
    • Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias
    • [74] Starmer CF, Romashko DN, Reddy RS, et al. Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias. Circulation 1995;92:595-605.
    • (1995) Circulation , vol.92 , pp. 595-605
    • Starmer, C.F.1    Romashko, D.N.2    Reddy, R.S.3
  • 75
    • 0029044207 scopus 로고
    • Genetic approaches to cardiovascular disease. Supravalvular aortic stenosis, Williams syndrome, and long-QT syndrome
    • [75] Keating MT. Genetic approaches to cardiovascular disease. Supravalvular aortic stenosis, Williams syndrome, and long-QT syndrome. Circulation 1995;92:142-147.
    • (1995) Circulation , vol.92 , pp. 142-147
    • Keating, M.T.1
  • 76
    • 0028884109 scopus 로고
    • Recent advances in understanding the molecular mechanisms of the long QT syndrome
    • [76] Roden DM, George AL Jr., Bennett PB. Recent advances in understanding the molecular mechanisms of the long QT syndrome. J Cardiovasc Electrophysiol 1995;6:1023-1031.
    • (1995) J Cardiovasc Electrophysiol , vol.6 , pp. 1023-1031
    • Roden, D.M.1    George A.L., Jr.2    Bennett, P.B.3
  • 77
    • 0030247934 scopus 로고    scopus 로고
    • The roles of ion channels in an inherited heart disease: Molecular genetics of the long QT syndrome
    • [77] Kass RS, Davies MP. The roles of ion channels in an inherited heart disease: molecular genetics of the long QT syndrome. Cardiovasc Res 1996;32:443-454.
    • (1996) Cardiovasc Res , vol.32 , pp. 443-454
    • Kass, R.S.1    Davies, M.P.2
  • 79
    • 0029097799 scopus 로고
    • Molecular mechanism for an inherited cardiac arrhythmia
    • [79] Bennett PB, Yazawa K, Makita N, George AL Jr.. Molecular mechanism for an inherited cardiac arrhythmia. Nature 1995;376:683-685.
    • (1995) Nature , vol.376 , pp. 683-685
    • Bennett, P.B.1    Yazawa, K.2    Makita, N.3    George A.L., Jr.4
  • 83
    • 0029825403 scopus 로고    scopus 로고
    • Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide
    • [83] Kiehn J, Lacerda AE, Wible B, Brown AM. Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. Circulation 1996;94:2572-2579.
    • (1996) Circulation , vol.94 , pp. 2572-2579
    • Kiehn, J.1    Lacerda, A.E.2    Wible, B.3    Brown, A.M.4
  • 84
    • 0029761822 scopus 로고    scopus 로고
    • HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
    • [84] Roy ML, Dumaine R, Brown AM. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation 1996;94:817-823.
    • (1996) Circulation , vol.94 , pp. 817-823
    • Roy, M.L.1    Dumaine, R.2    Brown, A.M.3
  • 85
    • 0029994611 scopus 로고    scopus 로고
    • Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonist terfenadine and astemizole
    • [85] Suessbrich H, Waldegger S, Lang F, Busch AE. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonist terfenadine and astemizole. FEBS Lett 1996;385:77-80.
    • (1996) FEBS Lett , vol.385 , pp. 77-80
    • Suessbrich, H.1    Waldegger, S.2    Lang, F.3    Busch, A.E.4
  • 86
    • 0024273407 scopus 로고
    • Recorded sudden cardiac death: Relationship to antiarrhythmic therapy
    • [86] Hohnloser SH, Meinertz T. Recorded sudden cardiac death: relationship to antiarrhythmic therapy. Eur Heart J 1988;9(Suppl. B):27-31.
    • (1988) Eur Heart J , vol.9 , Issue.SUPPL. B , pp. 27-31
    • Hohnloser, S.H.1    Meinertz, T.2
  • 87
    • 85047676973 scopus 로고
    • The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium
    • [87] Gough WB, El-Sherif N. The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium. Cardiovasc Res 1989;23:554-559.
    • (1989) Cardiovasc Res , vol.23 , pp. 554-559
    • Gough, W.B.1    El-Sherif, N.2
  • 88
    • 0023201957 scopus 로고
    • Why patients with congestive heart failure die: Arrhythmias and sudden cardiac death
    • [88] Bigger JT. Why patients with congestive heart failure die: arrhythmias and sudden cardiac death. Circulation 1987;75(Suppl. IV):28-35.
    • (1987) Circulation , vol.75 , Issue.SUPPL. IV , pp. 28-35
    • Bigger, J.T.1
  • 89
    • 0029975345 scopus 로고    scopus 로고
    • Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy
    • [89] Thuringer D, Deroubaix E, Coulombe A, Coraboeuf E, Mercadier JJ. Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy. Cardiovasc Res 1996;31:747-757.
    • (1996) Cardiovasc Res , vol.31 , pp. 747-757
    • Thuringer, D.1    Deroubaix, E.2    Coulombe, A.3    Coraboeuf, E.4    Mercadier, J.J.5
  • 90
    • 0030031969 scopus 로고    scopus 로고
    • Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure
    • [90] Kääb S, Nuss HB, Chiamvimonvat N, et al. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 1996;78:262-273.
    • (1996) Circ Res , vol.78 , pp. 262-273
    • Kääb, S.1    Nuss, H.B.2    Chiamvimonvat, N.3
  • 91
    • 0027376226 scopus 로고
    • + current similar to Kv1.5 cloned channel currents
    • + current similar to Kv1.5 cloned channel currents. Circ Res 1993;73:1061-1076.
    • (1993) Circ Res , vol.73 , pp. 1061-1076
    • Wang, Z.1    Fermini, B.2    Nattel, S.3
  • 92
    • 0029997391 scopus 로고    scopus 로고
    • Evidence for two components of delayed rectifier potassium current in human ventricular myocytes
    • [92] Li GR, Feng J, Yue L, Carrier M, Nattel S. Evidence for two components of delayed rectifier potassium current in human ventricular myocytes. Circ Res 1996;78:689-696.
    • (1996) Circ Res , vol.78 , pp. 689-696
    • Li, G.R.1    Feng, J.2    Yue, L.3    Carrier, M.4    Nattel, S.5
  • 93
    • 0010334160 scopus 로고
    • Computer aided development of antiarrhythmic drugs with class IIIa properties
    • [93] Hondeghem LM. Computer aided development of antiarrhythmic drugs with class IIIa properties. J Cardiovasc Electrophysiol 1994;5:5711-5721.
    • (1994) J Cardiovasc Electrophysiol , vol.5 , pp. 5711-5721
    • Hondeghem, L.M.1
  • 94
    • 0026603450 scopus 로고
    • Time-, voltage-, and state-dependent block by quidinine of a cloned human cardiac potassium channel
    • [94] Snyders DJ, Knoth KM, Roberds SL, Tamkin MM. Time-, voltage-, and state-dependent block by quidinine of a cloned human cardiac potassium channel. Mol Pharmacol 1992;41:322-330.
    • (1992) Mol Pharmacol , vol.41 , pp. 322-330
    • Snyders, D.J.1    Knoth, K.M.2    Roberds, S.L.3    Tamkin, M.M.4
  • 95
    • 0027451485 scopus 로고
    • Potassium channel blocking properties of propafenone in rabbit atrial myocytes
    • [95] Duan D, Fermini B, Nattel S. Potassium channel blocking properties of propafenone in rabbit atrial myocytes. J Pharmacol Exp Ther 1993;264:1113-1123.
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 1113-1123
    • Duan, D.1    Fermini, B.2    Nattel, S.3
  • 96
    • 0027429933 scopus 로고
    • + current by almokalant in rabbit ventricular myocytes
    • + current by almokalant in rabbit ventricular myocytes. Circ Res 1993;73:857-868.
    • (1993) Circ Res , vol.73 , pp. 857-868
    • Carmeliet, E.1
  • 97
    • 0027186122 scopus 로고
    • Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent
    • [97] Jurkiewicz NK, Sanguinetti MC. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Circ Res 1993;72:75-83.
    • (1993) Circ Res , vol.72 , pp. 75-83
    • Jurkiewicz, N.K.1    Sanguinetti, M.C.2
  • 98
    • 0028020993 scopus 로고
    • Class III antiarrhythmic drug action in experimental atrial fibrillation. Differences in reverse use dependence and effectiveness between d-sotalol and the new antiarrhythmic drug ambasilide
    • [98] Wang J, Feng J, Nattel S. Class III antiarrhythmic drug action in experimental atrial fibrillation. Differences in reverse use dependence and effectiveness between d-sotalol and the new antiarrhythmic drug ambasilide. Circulation 1994;90:2032-2040.
    • (1994) Circulation , vol.90 , pp. 2032-2040
    • Wang, J.1    Feng, J.2    Nattel, S.3
  • 100
    • 0029163243 scopus 로고
    • Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: Block of delayed rectifier potassium and L-type calcium currents
    • [100] Fermini B, Jurkiewicz NK, Jow B, et al. Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. J Cardiovasc Pharmacol 1995;26:259-271.
    • (1995) J Cardiovasc Pharmacol , vol.26 , pp. 259-271
    • Fermini, B.1    Jurkiewicz, N.K.2    Jow, B.3


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