Cytoplasmic sensing of viral nucleic acids

Current Opinion in Virology

Volumn 11, Issue , 2015, Pages 31-37

  Habjan, Matthias ^a   Pichlmair, Andreas ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CELL DNA; CYTOKINE; EXTRACHROMOSOMAL DNA; NUCLEIC ACID; VIRUS DNA; IMMUNOGLOBULIN RECEPTOR;

ADAPTIVE IMMUNITY; ARTICLE; CELL FUNCTION; CELLULAR IMMUNITY; CYTOPLASM; CYTOPLASMIC SENSING; DNA DEGRADATION; GENE EXPRESSION; HUMAN; INNATE IMMUNITY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA VIRUS; STEREOSPECIFICITY; VIROGENESIS; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS PATHOGENESIS; VIRUS REPLICATION; ANIMAL; IMMUNOLOGY; MAMMAL; METABOLISM; VIROLOGY; VIRUS;

ANIMALS; CYTOPLASM; HUMANS; IMMUNITY, INNATE; MAMMALS; NUCLEIC ACIDS; RECEPTORS, IMMUNOLOGIC; VIRUSES;

EID: 84922569235     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2015.01.012     Document Type: Review

References (57)

1. D. Hare, and K.L. Mossman Novel paradigms of innate immune sensing of viral infections Cytokine 63 2013 219 224
2. J.C. Rassa, and S.R. Ross Viruses and Toll-like receptors Microbes Infect 5 2003 961 968
3. D. Sancho, and C. Reis e Sousa Sensing of cell death by myeloid C-type lectin receptors Curr Opin Immunol 25 2013 46 52
4. D. Goubau, S. Deddouche, and C. Reis e Sousa Cytosolic sensing of viruses Immunity 38 2013 855 869
5. P. Resa-Infante, N. Jorba, R. Coloma, and J. Ortin The influenza virus RNA synthesis machine: advances in its structure and function RNA Biol 8 2011 207 215
6. I. Topisirovic, Y.V. Svitkin, N. Sonenberg, and A.J. Shatkin Cap and cap-binding proteins in the control of gene expression Wiley Interdiscip Rev RNA 2 2011 277 298
7. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter Molecular Biology of the Cell fourth edition 2002 Garland Publishing New York
8. A. Pichlmair, O. Schulz, C.P. Tan, J. Rehwinkel, H. Kato, O. Takeuchi, S. Akira, M. Way, G. Schiavo, and C. Reis e Sousa Activation of MDA5 requires higher-order RNA structures generated during virus infection J Virol 83 2009 10761 10769
9. M. Habjan, I. Andersson, J. Klingstrom, M. Schumann, A. Martin, P. Zimmermann, V. Wagner, A. Pichlmair, U. Schneider, E. Muhlberger, et al. Processing of genome 5′ termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction PLoS ONE 3 2008 e2032
10. E. Decroly, F. Ferron, J. Lescar, and B. Canard Conventional and unconventional mechanisms for capping viral mRNA Nat Rev Microbiol 10 2012 51 65
11. S. Daffis, K.J. Szretter, J. Schriewer, J. Li, S. Youn, J. Errett, T.Y. Lin, S. Schneller, R. Zust, H. Dong, et al. 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members Nature 468 2010 452 456
12. M. Habjan, P. Hubel, L. Lacerda, C. Benda, C. Holze, C.H. Eberl, A. Mann, E. Kindler, C. Gil-Cruz, J. Ziebuhr, et al. Sequestration by IFIT1 impairs translation of 2′O-unmethylated capped RNA PLoS Pathog 9 2013 e1003663
13. M. Gullerova, and N.J. Proudfoot Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells Nat Struct Mol Biol 19 2012 1193 1201
14. C.R. Capshew, K.L. Dusenbury, and H.A. Hundley Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing Nucleic Acids Res 40 2012 8637 8645
15. E. White, M. Schlackow, K. Kamieniarz-Gdula, N.J. Proudfoot, and M. Gullerova Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA Nat Struct Mol Biol 21 2014 552 559
16. M.H. Orzalli, N.A. DeLuca, and D.M. Knipe Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein Proc Natl Acad Sci USA 109 2012 E3008 E3017
17. H. Kato, K. Takahasi, and T. Fujita RIG-I-like receptors: cytoplasmic sensors for non-self RNA Immunol Rev 243 2011 91 98
18. S. Cui, K. Eisenacher, A. Kirchhofer, K. Brzozka, A. Lammens, K. Lammens, T. Fujita, K.K. Conzelmann, A. Krug, and K.P. Hopfner The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I Mol Cell 29 2008 169 179
19. Y. Wang, J. Ludwig, C. Schuberth, M. Goldeck, M. Schlee, H. Li, S. Juranek, G. Sheng, R. Micura, T. Tuschl, et al. Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I Nat Struct Mol Biol 17 2010 781 787
20. D. Goubau, M. Schlee, S. Deddouche, A.J. Pruijssers, T. Zillinger, M. Goldeck, C. Schuberth, A.G. Van der Veen, T. Fujimura, J. Rehwinkel, et al. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates Nature 514 2014 372 375
21. A. Peisley, B. Wu, H. Yao, T. Walz, and S. Hur RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner Mol Cell 51 2013 573 583
22. B. Wu, A. Peisley, D. Tetrault, Z. Li, E.H. Egelman, K.E. Magor, T. Walz, P.A. Penczek, and S. Hur Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I Mol Cell 55 2014 511 523
23. E. Wies, M.K. Wang, N.P. Maharaj, K. Chen, S. Zhou, R.W. Finberg, and M.U. Gack Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling Immunity 38 2013 437 449
24. T. Satoh, H. Kato, Y. Kumagai, M. Yoneyama, S. Sato, K. Matsushita, T. Tsujimura, T. Fujita, S. Akira, and O. Takeuchi LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses Proc Natl Acad Sci USA 107 2010 1512 1517
25. S. Deddouche, D. Goubau, J. Rehwinkel, P. Chakravarty, S. Begum, P.V. Maillard, A. Borg, N. Matthews, Q. Feng, F.J. van Kuppeveld, et al. Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells Elife 3 2014 e01535
26. H. Kato, O. Takeuchi, E. Mikamo-Satoh, R. Hirai, T. Kawai, K. Matsushita, A. Hiiragi, T.S. Dermody, T. Fujita, and S. Akira Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 J Exp Med 205 2008 1601 1610
27. M. Binder, F. Eberle, S. Seitz, N. Mucke, C.M. Huber, N. Kiani, L. Kaderali, V. Lohmann, A. Dalpke, and R. Bartenschlager Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I) J Biol Chem 286 2011 27278 27287
28. K. Triantafilou, E. Vakakis, S. Kar, E. Richer, G.L. Evans, and M. Triantafilou Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses J Cell Sci 125 2012 4761 4769
29. Q. Feng, S.V. Hato, M.A. Langereis, J. Zoll, R. Virgen-Slane, A. Peisley, S. Hur, B.L. Semler, R.P. van Rij, and F.J. van Kuppeveld MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells Cell Rep 2 2012 1187 1196
30. S. Runge, K.M. Sparrer, C. Lassig, K. Hembach, A. Baum, A. Garcia-Sastre, J. Soding, K.K. Conzelmann, and K.P. Hopfner In vivo ligands of MDA5 and RIG-I in measles virus-infected cells PLoS Pathog 10 2014 e1004081
31. R. Zust, L. Cervantes-Barragan, M. Habjan, R. Maier, B.W. Neuman, J. Ziebuhr, K.J. Szretter, S.C. Baker, W. Barchet, M.S. Diamond, et al. Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 Nat Immunol 12 2011 137 143
32. B. Wu, A. Peisley, C. Richards, H. Yao, X. Zeng, C. Lin, F. Chu, T. Walz, and S. Hur Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5 Cell 152 2013 276 289
33. A. Takaoka, Z. Wang, M.K. Choi, H. Yanai, H. Negishi, T. Ban, Y. Lu, M. Miyagishi, T. Kodama, K. Honda, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response Nature 448 2007 501 505
34. L. Unterholzner, S.E. Keating, M. Baran, K.A. Horan, S.B. Jensen, S. Sharma, C.M. Sirois, T. Jin, E. Latz, T.S. Xiao, et al. IFI16 is an innate immune sensor for intracellular DNA Nat Immunol 11 2010 997 1004
35. M.R. Jakobsen, R.O. Bak, A. Andersen, R.K. Berg, S.B. Jensen, J. Tengchuan, A. Laustsen, K. Hansen, L. Ostergaard, K.A. Fitzgerald, et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication Proc Natl Acad Sci USA 110 2013 E4571 E4580
36. Y.H. Chiu, J.B. Macmillan, and Z.J. Chen RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway Cell 138 2009 576 591
37. A. Ablasser, F. Bauernfeind, G. Hartmann, E. Latz, K.A. Fitzgerald, and V. Hornung RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate Nat Immunol 10 2009 1065 1072
38. L. Sun, J. Wu, F. Du, X. Chen, and Z.J. Chen Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway Science 339 2013 786 791
39. F. Civril, T. Deimling, C.C. de Oliveira Mann, A. Ablasser, M. Moldt, G. Witte, V. Hornung, and K.P. Hopfner Structural mechanism of cytosolic DNA sensing by cGAS Nature 498 2013 332 337
40. A. Ablasser, M. Goldeck, T. Cavlar, T. Deimling, G. Witte, I. Rohl, K.P. Hopfner, J. Ludwig, and V. Hornung cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING Nature 498 2013 380 384
41. P. Gao, M. Ascano, Y. Wu, W. Barchet, B.L. Gaffney, T. Zillinger, A.A. Serganov, Y. Liu, R.A. Jones, G. Hartmann, et al. Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase Cell 153 2013 1094 1107
42. V. Hornung, R. Hartmann, A. Ablasser, and K.P. Hopfner OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids Nat Rev Immunol 14 2014 521 528
43. A. Ablasser, J.L. Schmid-Burgk, I. Hemmerling, G.L. Horvath, T. Schmidt, E. Latz, and V. Hornung Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP Nature 503 2013 530 534
44. X.D. Li, J. Wu, D. Gao, H. Wang, L. Sun, and Z.J. Chen Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects Science 341 2013 1390 1394
45. C.K. Pfaller, Z. Li, C.X. George, and C.E. Samuel Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response Curr Opin Immunol 23 2011 573 582
46. S.R. Nallagatla, J. Hwang, R. Toroney, X. Zheng, C.E. Cameron, and P.C. Bevilacqua 5′-Triphosphate-dependent activation of PKR by RNAs with short stem-loops Science 318 2007 1455 1458
47. T. Fernandes-Alnemri, J.W. Yu, P. Datta, J. Wu, and E.S. Alnemri AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA Nature 458 2009 509 513
48. H. Poeck, M. Bscheider, O. Gross, K. Finger, S. Roth, M. Rebsamen, N. Hannesschlager, M. Schlee, S. Rothenfusser, W. Barchet, et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production Nat Immunol 11 2010 63 69
49. H. Mitoma, S. Hanabuchi, T. Kim, M. Bao, Z. Zhang, N. Sugimoto, and Y.J. Liu The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome Immunity 39 2013 123 135
50. A. Pichlmair, C. Lassnig, C.A. Eberle, M.W. Gorna, C.L. Baumann, T.R. Burkard, T. Burckstummer, A. Stefanovic, S. Krieger, K.L. Bennett, et al. IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA Nat Immunol 12 2011 624 630
51. Y.M. Abbas, A. Pichlmair, M.W. Gorna, G. Superti-Furga, and B. Nagar Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins Nature 494 2013 60 64
52. P. Kumar, T.R. Sweeney, M.A. Skabkin, O.V. Skabkina, C.U. Hellen, and T.V. Pestova Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5′-terminal regions of cap0-, cap1- and 5′ppp-mRNAs Nucleic Acids Res 42 2014 3228 3245
53. M.H. Malim APOBEC proteins and intrinsic resistance to HIV-1 infection Philos Trans R Soc Lond B Biol Sci 364 2009 675 687
54. J. Lucifora, Y. Xia, F. Reisinger, K. Zhang, D. Stadler, X. Cheng, M.F. Sprinzl, H. Koppensteiner, Z. Makowska, T. Volz, et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA Science 343 2014 1221 1228
55. X. Guo, J. Ma, J. Sun, and G. Gao The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA Proc Natl Acad Sci USA 104 2007 151 156
56. D.B. Stetson, J.S. Ko, T. Heidmann, and R. Medzhitov Trex1 prevents cell-intrinsic initiation of autoimmunity Cell 134 2008 587 598
57. S.C. Eckard, G.I. Rice, A. Fabre, C. Badens, E.E. Gray, J.L. Hartley, Y.J. Crow, and D.B. Stetson The SKIV2L RNA exosome limits activation of the RIG-I-like receptors Nat Immunol 15 2014 839 845