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Volumn 10, Issue 12, 2014, Pages 3522-3530

Immune-based treatment and prevention of Clostridium difficile infection

Author keywords

Bacterial toxins; Clostridium difficile infection (CDI); Immunotherapy; Monoclonal antibody; Vaccine

Indexed keywords

BACTERIAL VACCINE; CLOSTRIDIUM DIFFICILE TOXIN A ANTIBODY; CLOSTRIDIUM DIFFICILE TOXIN B ANTIBODY; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; ULOCUPLUMAB; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY;

EID: 84922540799     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/21645515.2014.980193     Document Type: Review
Times cited : (13)

References (110)
  • 1
    • 0029915545 scopus 로고    scopus 로고
    • Clostridial enteric diseases of domestic animals
    • PMID:8964036
    • Songer JG. Clostridial enteric diseases of domestic animals. Clin Microbiol Rev 1996; 9:216-34; PMID:8964036
    • (1996) Clin Microbiol Rev , vol.9 , pp. 216-234
    • Songer, J.G.1
  • 2
    • 33646439545 scopus 로고    scopus 로고
    • The comparative pathology of Clostridium difficile-associated disease
    • PMID:16672570
    • Keel MK, Songer JG. The comparative pathology of Clostridium difficile-associated disease. Vet Pathol 2006; 43:225-40; PMID:16672570; http://dx.doi.org/10.1354/vp.43-3-225
    • (2006) Vet Pathol , vol.43 , pp. 225-240
    • Keel, M.K.1    Songer, J.G.2
  • 3
    • 0020619419 scopus 로고
    • Clostridium difficile and its toxin in healthy neonates
    • PMID:6412868
    • Richardson SA, Alcock PA, Gray J. Clostridium difficile and its toxin in healthy neonates. Brit Med J 1983; 287:878; PMID:6412868; http://dx.doi.org/10.1136/bmj.287.6396.878
    • (1983) Brit Med J , vol.287 , pp. 878
    • Richardson, S.A.1    Alcock, P.A.2    Gray, J.3
  • 4
    • 76949132491 scopus 로고
    • INTESTINAL flora of infants
    • PMID:14957293
    • INTESTINAL flora of infants. Nutr Rev 1952; 10:198-9; PMID:14957293
    • (1952) Nutr Rev , vol.10 , pp. 198-199
  • 5
    • 67649391053 scopus 로고    scopus 로고
    • Clostridium difficile infection: New developments in epidemiology and pathogenesis
    • PMID:19528959
    • Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 2009; 7:526-36; PMID:19528959; http://dx.doi.org/10.1038/nrmicro2164
    • (2009) Nat Rev Microbiol , vol.7 , pp. 526-536
    • Rupnik, M.1    Wilcox, M.H.2    Gerding, D.N.3
  • 6
    • 0031958706 scopus 로고    scopus 로고
    • Clostridium difficile infection
    • PMID:9509270
    • Kelly CP, La Mont JT. Clostridium difficile infection. Annu Rev Med 1998; 49:375-90; PMID:9509270; http://dx.doi.org/10.1146/annurev.med.49.1.375
    • (1998) Annu Rev Med , vol.49 , pp. 375-390
    • Kelly, C.P.1    La Mont, J.T.2
  • 7
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of clostridium difficileâ€"associated diarrhea, stratified by disease severity
    • PMID:17599306
    • Zar F, Bakkanagari S, Moorthi KMLST, Davis M. A comparison of vancomycin and metronidazole for the treatment of clostridium difficileâ€"associated diarrhea, stratified by disease severity. Clin Infect Dis 2007; 45:302-7; PMID:17599306; http://dx.doi.org/10.1086/519265
    • (2007) Clin Infect Dis , vol.45 , pp. 302-307
    • Zar, F.1    Bakkanagari, S.2    Moorthi, K.M.L.S.T.3    Davis, M.4
  • 8
    • 77953375147 scopus 로고    scopus 로고
    • Future novel therapeutic agents for Clostridium difficile infection
    • PMID:20521993
    • Koo HL, Garey KW, Dupont HL. Future novel therapeutic agents for Clostridium difficile infection. Expert Opin Invest Drugs 2010; 19:825-36; PMID:20521993; http://dx.doi.org/10.1517/13543784.2010.495386
    • (2010) Expert Opin Invest Drugs , vol.19 , pp. 825-836
    • Koo, H.L.1    Garey, K.W.2    Dupont, H.L.3
  • 9
    • 0034050010 scopus 로고    scopus 로고
    • Epidemiology of recurrences or reinfections of Clostridium difficile-associated diarrhea
    • PMID:10835010
    • Barbut F, Richard A, Hamadi K, Chomette V, Burghoffer B, Petit JC. Epidemiology of recurrences or reinfections of Clostridium difficile-associated diarrhea. J Clin Microbiol 2000; 38:2386-8; PMID:10835010
    • (2000) J Clin Microbiol , vol.38 , pp. 2386-2388
    • Barbut, F.1    Richard, A.2    Hamadi, K.3    Chomette, V.4    Burghoffer, B.5    Petit, J.C.6
  • 10
    • 20644443513 scopus 로고    scopus 로고
    • Pathogenesis and treatment of Clostridium difficile infection
    • PMID:15937201[http://dx.doi.org/10.1136/pgmj.2004.028480
    • Tonna I, Welsby PD. Pathogenesis and treatment of Clostridium difficile infection. Postgrad Med J 2005; 81:367-9; PMID:15937201[http://dx.doi.org/10.1136/pgmj.2004.028480
    • (2005) Postgrad Med J , vol.81 , pp. 367-369
    • Tonna, I.1    Welsby, P.D.2
  • 11
    • 80054736926 scopus 로고    scopus 로고
    • Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection
    • PMID:22002980
    • Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011; 53:994-1002; PMID:22002980; http://dx.doi.org/10.1093/cid/cir632
    • (2011) Clin Infect Dis , vol.53 , pp. 994-1002
    • Gough, E.1    Shaikh, H.2    Manges, A.R.3
  • 12
    • 77951700268 scopus 로고    scopus 로고
    • Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea
    • PMID:20048681
    • Khoruts A, Dicksved J, Jansson JK, Sadowsky MJ. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol 2010; 44:354-60; PMID:20048681
    • (2010) J Clin Gastroenterol , vol.44 , pp. 354-360
    • Khoruts, A.1    Dicksved, J.2    Jansson, J.K.3    Sadowsky, M.J.4
  • 13
    • 84876326963 scopus 로고    scopus 로고
    • Faecal transplantation for recurrent C difficile diarrhoea
    • PMID:23550305
    • Senior K. Faecal transplantation for recurrent C difficile diarrhoea. Lancet Infect Dis 2013; 13:200-1; PMID:23550305; http://dx.doi.org/10.1016/S1473-3099(13)70052-5
    • (2013) Lancet Infect Dis , vol.13 , pp. 200-201
    • Senior, K.1
  • 14
    • 79551522234 scopus 로고    scopus 로고
    • Current status of nonantibiotic and adjunct therapies for clostridium difficile infection
    • PMID:21308451
    • Suwantarat N, Bobak DA. Current Status of Nonantibiotic and Adjunct Therapies for Clostridium difficile Infection. Curr Infect Dis Rep 2011; 13:21-7; PMID:21308451; http://dx.doi.org/10.1007/s11908-010-0155-7
    • (2011) Curr Infect Dis Rep , vol.13 , pp. 21-27
    • Suwantarat, N.1    Bobak, D.A.2
  • 15
    • 84900333912 scopus 로고    scopus 로고
    • Clostridium difficile spores: A major threat to the hospital environment
    • PMID:24810347
    • Barra-Carrasco J, Paredes-Sabja D. Clostridium difficile spores: a major threat to the hospital environment. Fut Microbiol 2014; 9:475-86; PMID:24810347; http://dx.doi.org/10.2217/fmb.14.2
    • (2014) Fut Microbiol , vol.9 , pp. 475-486
    • Barra-Carrasco, J.1    Paredes-Sabja, D.2
  • 16
    • 84876925856 scopus 로고    scopus 로고
    • Role of the environment in the transmission of Clostridium difficile in health care facilities
    • PMID:23622740
    • Weber DJ, Anderson DJ, Sexton DJ, Rutala WA. Role of the environment in the transmission of Clostridium difficile in health care facilities. Am J Infect Control 2013; 41:S105-10; PMID:23622740; http://dx.doi.org/10.1016/j.ajic.2012.12.009
    • (2013) Am J Infect Control , vol.41 , pp. S105-S110
    • Weber, D.J.1    Anderson, D.J.2    Sexton, D.J.3    Rutala, W.A.4
  • 17
    • 84883552215 scopus 로고    scopus 로고
    • Transmission of Clostridium difficile in foods
    • PMID:24011836
    • Hoover DG, Rodriguez-Palacios A. Transmission of Clostridium difficile in foods. Infect Dis Clin N Am 2013; 27:675-85; PMID:24011836; http://dx.doi.org/10.1016/j.idc.2013.05.004
    • (2013) Infect Dis Clin N Am , vol.27 , pp. 675-685
    • Hoover, D.G.1    Rodriguez-Palacios, A.2
  • 18
    • 84857731427 scopus 로고    scopus 로고
    • Clostridium: Transmission difficile?
    • PMID:22346737
    • Harbarth S, Samore MH. Clostridium: transmission difficile? PLoS Med 2012; 9:e1001171; PMID:22346737; http://dx.doi.org/10.1371/journal. pmed.1001171
    • (2012) PLoS Med , vol.9 , pp. e1001171
    • Harbarth, S.1    Samore, M.H.2
  • 19
    • 79955965391 scopus 로고    scopus 로고
    • Low risk of transmission of Clostridium difficile to humans at petting farms
    • PMID:21411249
    • Hopman NE, Sanders IM, Kuijper EJ, Lipman LJ. Low risk of transmission of Clostridium difficile to humans at petting farms. Vet Microbiol 2011; 150:416-7; PMID:21411249; http://dx.doi.org/10.1016/j.vetmic.2011.02.015
    • (2011) Vet Microbiol , vol.150 , pp. 416-417
    • Hopman, N.E.1    Sanders, I.M.2    Kuijper, E.J.3    Lipman, L.J.4
  • 20
    • 84862770598 scopus 로고    scopus 로고
    • Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
    • PMID:22595318
    • Britton RA, Young VB. Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol 2012; 20:313-9; PMID:22595318; http://dx.doi.org/10.1016/j. tim.2012.04.001
    • (2012) Trends Microbiol , vol.20 , pp. 313-319
    • Britton, R.A.1    Young, V.B.2
  • 21
    • 84898771460 scopus 로고    scopus 로고
    • Role of the intestinal microbiota in resistance to colonization by clostridium difficle
    • PMID:24503131
    • Britton RA, Young VB. Role of the intestinal microbiota in resistance to colonization by clostridium difficle. Gastroenterology 2014; 146:1547-53; PMID:24503131; http://dx.doi.org/10.1053/j. gastro.2014.01.059
    • (2014) Gastroenterology , vol.146 , pp. 1547-1553
    • Britton, R.A.1    Young, V.B.2
  • 22
    • 35048837277 scopus 로고    scopus 로고
    • Cwp84, a surface-associated protein of Clostridium difficile, is a cysteine protease with degrading activity on extracellular matrix proteins
    • PMID:17693508
    • Janoir C, Pechine S, Grosdidier C, Collignon A. Cwp84, a surface-associated protein of Clostridium difficile, is a cysteine protease with degrading activity on extracellular matrix proteins. J Bacteriol 2007; 189:7174-80; PMID:17693508; http://dx.doi.org/10.1128/JB.00578-07
    • (2007) J Bacteriol , vol.189 , pp. 7174-7180
    • Janoir, C.1    Pechine, S.2    Grosdidier, C.3    Collignon, A.4
  • 23
    • 0034971793 scopus 로고    scopus 로고
    • Molecular characterization of the surface layer proteins from Clostridium difficile
    • PMID:11401722
    • Calabi E, Ward S, Wren B, Paxton T, Panico M, Morris H, Dell A, Dougan G, Fairweather N. Molecular characterization of the surface layer proteins from Clostridium difficile. Mol Microbiol 2001; 40:1187-99; PMID:11401722; http://dx.doi.org/10.1046/j.1365-2958.2001.02461.x
    • (2001) Mol Microbiol , vol.40 , pp. 1187-1199
    • Calabi, E.1    Ward, S.2    Wren, B.3    Paxton, T.4    Panico, M.5    Morris, H.6    Dell, A.7    Dougan, G.8    Fairweather, N.9
  • 24
    • 0035077376 scopus 로고    scopus 로고
    • Characterization of a cell surface protein of Clostridium difficile with adhesive properties
    • PMID:11254569
    • Waligora AJ, Hennequin C, Mullany P, Bourlioux P, Collignon A, Karjalainen T. Characterization of a cell surface protein of Clostridium difficile with adhesive properties. Infect Immun 2001; 69:2144-53; PMID:11254569; http://dx.doi.org/10.1128/IAI.69. 4.2144-2153.2001
    • (2001) Infect Immun , vol.69 , pp. 2144-2153
    • Waligora, A.J.1    Hennequin, C.2    Mullany, P.3    Bourlioux, P.4    Collignon, A.5    Karjalainen, T.6
  • 26
    • 0035189181 scopus 로고    scopus 로고
    • Role of FliC and FliD flagellar proteins of Clostridium difficile in adherence and gut colonization
    • PMID:11705981
    • Tasteyre A, Barc MC, Collignon A, Boureau H, Karjalainen T. Role of FliC and FliD flagellar proteins of Clostridium difficile in adherence and gut colonization. Infect Immun 2001; 69:7937-40; PMID:11705981; http://dx.doi.org/10.1128/IAI.69. 12.7937-7940.2001
    • (2001) Infect Immun , vol.69 , pp. 7937-7940
    • Tasteyre, A.1    Barc, M.C.2    Collignon, A.3    Boureau, H.4    Karjalainen, T.5
  • 27
    • 34447538386 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhoea
    • PMID:17640189
    • Elliott B, Chang BJ, Golledge CL, Riley TV. Clostridium difficile-associated diarrhoea. Intern Med J 2007; 37:561-8; PMID:17640189; http://dx.doi.org/10.1111/j.1445-5994.2007.01403.x
    • (2007) Intern Med J , vol.37 , pp. 561-568
    • Elliott, B.1    Chang, B.J.2    Golledge, C.L.3    Riley, T.V.4
  • 28
    • 0028044948 scopus 로고
    • Clostridium difficile colitis
    • PMID:8043060
    • Kelly CP, Pothoulakis C, La Mont JT. Clostridium difficile colitis. New Engl J Med 1994; 330:257-62; PMID:8043060; http://dx.doi.org/10.1056/NEJM199401273300406
    • (1994) New Engl J Med , vol.330 , pp. 257-262
    • Kelly, C.P.1    Pothoulakis, C.2    La Mont, J.T.3
  • 29
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mechanism of action and role in disease
    • PMID:15831824
    • Voth DE, Ballard JD. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 2005; 18:247-63; PMID:15831824; http://dx.doi.org/10.1128/CMR.18.2.247-263.2005
    • (2005) Clin Microbiol Rev , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 30
    • 42749095602 scopus 로고    scopus 로고
    • Structure and mode of action of clostridial glucosylating toxins: The ABCD model
    • PMID:18394902
    • Jank T, Aktories K. Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol 2008; 16:222-9; PMID:18394902; http://dx.doi.org/10.1016/j.tim.2008.01.011
    • (2008) Trends Microbiol , vol.16 , pp. 222-229
    • Jank, T.1    Aktories, K.2
  • 31
    • 84878486491 scopus 로고    scopus 로고
    • Toward a structural understanding of Clostridium difficile toxins A and B
    • PMID:22919620
    • Pruitt RN, Lacy DB. Toward a structural understanding of Clostridium difficile toxins A and B. Front Cell Infect Microbiol 2012; 2:28; PMID:22919620; http://dx.doi.org/10.3389/fcimb.2012.00028
    • (2012) Front Cell Infect Microbiol , vol.2 , pp. 28
    • Pruitt, R.N.1    Lacy, D.B.2
  • 32
    • 84874593375 scopus 로고    scopus 로고
    • A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity
    • PMID:23484044
    • Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, Zhu Ge R, Savidge T, Wang X, Feng H. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PloS One 2013; 8:e58634; PMID:23484044; http://dx.doi.org/10.1371/journal.pone.0058634
    • (2013) PloS One , vol.8 , pp. e58634
    • Zhang, Y.1    Shi, L.2    Li, S.3    Yang, Z.4    Standley, C.5    Yang, Z.6    Zhu Ge, R.7    Savidge, T.8    Wang, X.9    Feng, H.10
  • 34
    • 33745086500 scopus 로고    scopus 로고
    • Carbohydrate recognition by Clostridium difficile toxin A
    • PMID:16622409
    • Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK. Carbohydrate recognition by Clostridium difficile toxin A. Nat Struct Mol Biol 2006; 13:460-1; PMID:16622409; http://dx.doi.org/10.1038/nsmb1084
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 460-461
    • Greco, A.1    Ho, J.G.2    Lin, S.J.3    Palcic, M.M.4    Rupnik, M.5    Ng, K.K.6
  • 35
    • 0029054398 scopus 로고
    • Glucosylation of Rho proteins by Clostridium difficile toxin B
    • PMID:7777059
    • Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K. Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 1995; 375:500-3; PMID:7777059; http://dx.doi.org/10.1038/375500a0
    • (1995) Nature , vol.375 , pp. 500-503
    • Just, I.1    Selzer, J.2    Wilm, M.3    Von Eichel-Streiber, C.4    Mann, M.5    Aktories, K.6
  • 36
    • 84857790535 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mediators of inflammation
    • PMID:22237401
    • Shen A. Clostridium difficile toxins: mediators of inflammation. J Innate Immun 2012; 4:149-58; PMID:22237401; http://dx.doi.org/10.1159/000332946
    • (2012) J Innate Immun , vol.4 , pp. 149-158
    • Shen, A.1
  • 37
    • 0242509106 scopus 로고    scopus 로고
    • Frequency of binary toxin genes among Clostridium difficile strains that do not produce large clostridial toxins
    • PMID:14605169
    • Geric B, Johnson S, Gerding DN, Grabnar M, Rupnik M. Frequency of binary toxin genes among Clostridium difficile strains that do not produce large clostridial toxins. J Clin Microbiol 2003; 41:5227-32; PMID:14605169; http://dx.doi.org/10.1128/JCM.41.11.5227-5232.2003
    • (2003) J Clin Microbiol , vol.41 , pp. 5227-5232
    • Geric, B.1    Johnson, S.2    Gerding, D.N.3    Grabnar, M.4    Rupnik, M.5
  • 38
    • 0034607782 scopus 로고    scopus 로고
    • Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile
    • PMID:10802189
    • Stubbs S, Rupnik M, Gibert M, Brazier J, Duerden B, Popoff M. Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile. FEMS Microbiol Lett 2000; 186:307-12; PMID:10802189; http://dx.doi.org/10.1111/j.1574-6968.2000.tb09122.x
    • (2000) FEMS Microbiol Lett , vol.186 , pp. 307-312
    • Stubbs, S.1    Rupnik, M.2    Gibert, M.3    Brazier, J.4    Duerden, B.5    Popoff, M.6
  • 39
    • 4544264417 scopus 로고    scopus 로고
    • Binary bacterial toxins: Biochemistry, biology, and applications of common Clostridium and Bacillus proteins
    • table of contents; PMID:15353562
    • Barth H, Aktories K, Popoff MR, Stiles BG. Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev: MMBR 2004; 68:373-402, table of contents; PMID:15353562; http://dx.doi.org/10.1128/MMBR.68.3.373-402.2004
    • (2004) Microbiol Mol Biol Rev: MMBR , vol.68 , pp. 373-402
    • Barth, H.1    Aktories, K.2    Popoff, M.R.3    Stiles, B.G.4
  • 40
    • 2442420091 scopus 로고    scopus 로고
    • Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile
    • PMID:15131151
    • Goncalves C, Decre D, Barbut F, Burghoffer B, Petit JC. Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile. J Clin Microbiol 2004; 42:1933-9; PMID:15131151; http://dx.doi.org/10.1128/JCM. 42.5.1933-1939.2004
    • (2004) J Clin Microbiol , vol.42 , pp. 1933-1939
    • Goncalves, C.1    Decre, D.2    Barbut, F.3    Burghoffer, B.4    Petit, J.C.5
  • 41
    • 33748563622 scopus 로고    scopus 로고
    • Emergence of clostridium difficileassociated disease in North America and Europe
    • PMID:16965399
    • Kuijper EJ, Coignard B, Tull P, difficile ESGfC, States EUM, European Centre for Disease P, EU Member States, European Centre for Disease Prevention and Control. Emergence of Clostridium difficileassociated disease in North America and Europe. Clin Microbiol Infect: Off Pub Eur Soc Clin Microbiol Infect Dis 2006; 12 Suppl 6:2-18; PMID:16965399; http://dx.doi.org/10.1111/j.1469-0691.2006.01580.x
    • (2006) Clin Microbiol Infect: Off Pub Eur Soc Clin Microbiol Infect Dis , vol.12 , pp. 2-18
    • Kuijper, E.J.1    Coignard, B.2    Tull, P.3
  • 43
    • 77954848009 scopus 로고    scopus 로고
    • The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives
    • PMID:20664812
    • Carter GP, Rood JI, Lyras D. The role of toxin A and toxin B in Clostridium difficile-associated disease: past and present perspectives. Gut Microbes 2010; 1:58-64; PMID:20664812; http://dx.doi.org/10.4161/gmic.1.1.10768
    • (2010) Gut Microbes , vol.1 , pp. 58-64
    • Carter, G.P.1    Rood, J.I.2    Lyras, D.3
  • 46
    • 84903216693 scopus 로고    scopus 로고
    • Strain types and antimicrobial resistance patterns of clostridium difficile isolates from the United States: 2011-2013
    • PMID:24752264
    • Tickler IA, Goering RV, Whitmore JD, Lynn AN, Persing DH, Tenover FC, Healthcare Associated Infection Consortium. Strain types and antimicrobial resistance patterns of clostridium difficile isolates from the United States: 2011-2013. Antimicrob Agents Chemoth 2014; 58:4214-8; PMID:24752264; http://dx.doi.org/10.1128/AAC.02775-13
    • (2014) Antimicrob Agents Chemoth , vol.58 , pp. 4214-4218
    • Tickler, I.A.1    Goering, R.V.2    Whitmore, J.D.3    Lynn, A.N.4    Persing, D.H.5    Tenover, F.C.6
  • 47
    • 33644837200 scopus 로고    scopus 로고
    • Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, Canada
    • PMID:16477549
    • Pepin J, Routhier S, Gagnon S, Brazeau I. Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, Canada. Clin Infect Dis: Off Pub Infect Dis Soc Am 2006; 42:758-64; PMID:16477549; http://dx.doi.org/10.1086/501126
    • (2006) Clin Infect Dis: Off Pub Infect Dis Soc Am , vol.42 , pp. 758-764
    • Pepin, J.1    Routhier, S.2    Gagnon, S.3    Brazeau, I.4
  • 48
    • 79958148446 scopus 로고    scopus 로고
    • Effective utilization of evolving methods for the laboratory diagnosis of Clostridium difficile infection
    • PMID:21628487
    • Kufelnicka AM, Kirn TJ. Effective utilization of evolving methods for the laboratory diagnosis of Clostridium difficile infection. Clin Infect Dis: Off Pub Infect Dis Soc Am 2011; 52:1451-7; PMID:21628487; http://dx.doi.org/10.1093/cid/cir201
    • (2011) Clin Infect Dis: Off Pub Infect Dis Soc Am , vol.52 , pp. 1451-1457
    • Kufelnicka, A.M.1    Kirn, T.J.2
  • 49
    • 84900434000 scopus 로고    scopus 로고
    • Cost-effectiveness of competing strategies for management of recurrent clostridium difficile infection: A decision analysis
    • PMID:24692533
    • Konijeti GG, Sauk J, Shrime MG, Gupta M, Ananthakrishnan AN. Cost-effectiveness of competing strategies for management of recurrent clostridium difficile infection: a decision analysis. Clin Infect Dis: Off Pub Infect Dis Soc Am 2014; 58:1507-14; PMID:24692533; http://dx.doi.org/10.1093/cid/ciu128
    • (2014) Clin Infect Dis: Off Pub Infect Dis Soc Am , vol.58 , pp. 1507-1514
    • Konijeti, G.G.1    Sauk, J.2    Shrime, M.G.3    Gupta, M.4    Ananthakrishnan, A.N.5
  • 50
    • 84898542092 scopus 로고    scopus 로고
    • Treatment of recurrent Clostridium difficile infection: A systematic review
    • PMID:23839210
    • O'Horo JC, Jindai K, Kunzer B, Safdar N. Treatment of recurrent Clostridium difficile infection: a systematic review. Infection 2014; 42:43-59; PMID:23839210; http://dx.doi.org/10.1007/s15010-013-0496-x
    • (2014) Infection , vol.42 , pp. 43-59
    • O'Horo, J.C.1    Jindai, K.2    Kunzer, B.3    Safdar, N.4
  • 51
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: Treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • PMID:12135033
    • McFarland LV, Elmer GW, Surawicz CM. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 2002; 97:1769-75; PMID:12135033; http://dx.doi.org/10.1111/j.1572-0241.2002.05839.x
    • (2002) Am J Gastroenterol , vol.97 , pp. 1769-1775
    • McFarland, L.V.1    Elmer, G.W.2    Surawicz, C.M.3
  • 52
    • 0021836686 scopus 로고
    • Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea
    • PMID:4030111
    • Aronsson B, Granstrom M, Mollby R, Nord CE. Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea. Infection 1985; 13:97-101; PMID:4030111; http://dx.doi.org/10.1007/BF01642866
    • (1985) Infection , vol.13 , pp. 97-101
    • Aronsson, B.1    Granstrom, M.2    Mollby, R.3    Nord, C.E.4
  • 53
    • 0026453188 scopus 로고
    • Systemic and mucosal antibody responses to toxin A in patients infected with Clostridium difficile
    • PMID:1431247
    • Johnson S, Gerding DN, Janoff EN. Systemic and mucosal antibody responses to toxin A in patients infected with Clostridium difficile. J Infect Dis 1992; 166:1287-94; PMID:1431247; http://dx.doi.org/10.1093/infdis/166.6.1287
    • (1992) J Infect Dis , vol.166 , pp. 1287-1294
    • Johnson, S.1    Gerding, D.N.2    Janoff, E.N.3
  • 54
    • 0027158148 scopus 로고
    • Elevated levels of serum immunoglobulins in asymptomatic carriers of Clostridium difficile
    • PMID:8324125
    • Mulligan ME, Miller SD, McFarland LV, Fung HC, Kwok RY. Elevated levels of serum immunoglobulins in asymptomatic carriers of Clostridium difficile. Clin Infect Dis: Off Pub Infect Dis Soc Am 1993; 16 Suppl 4:S239-44; PMID:8324125; http://dx.doi.org/10.1093/clinids/16.Supplement-4.S239
    • (1993) Clin Infect Dis: Off Pub Infect Dis Soc Am , vol.16 , pp. S239-S244
    • Mulligan, M.E.1    Miller, S.D.2    McFarland, L.V.3    Fung, H.C.4    Kwok, R.Y.5
  • 55
    • 0028089161 scopus 로고
    • Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection
    • PMID:8300199
    • Warny M, Vaerman JP, Avesani V, Delmee M. Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection. Infect Immun 1994; 62:384-9; PMID:8300199
    • (1994) Infect Immun , vol.62 , pp. 384-389
    • Warny, M.1    Vaerman, J.P.2    Avesani, V.3    Delmee, M.4
  • 56
    • 84903987886 scopus 로고    scopus 로고
    • Asymptomatic clostridium difficile colonization as a reservoir for Clostridium difficile infection
    • PMID:24848084
    • Galdys AL, Curry SR, Harrison LH. Asymptomatic Clostridium difficile colonization as a reservoir for Clostridium difficile infection. Expert Rev Anti-Infect Ther 2014; 12:967-80; PMID:24848084; http://dx. doi.org/10.1586/14787210.2014.920252
    • (2014) Expert Rev Anti-Infect Ther , vol.12 , pp. 967-980
    • Galdys, A.L.1    Curry, S.R.2    Harrison, L.H.3
  • 57
    • 84877812026 scopus 로고    scopus 로고
    • High antitoxin A antibody levels are associated with protection against recurrent Clostridium difficile diarrhea
    • Kyne L, Warny M, Qamar A, Kelly CP. High antitoxin A antibody levels are associated with protection against recurrent Clostridium difficile diarrhea. Gastroenterology 2000; 118:A885-A; ; http://dx.doi.org/10.1016/S0016-5085(00)85679-6
    • (2000) Gastroenterology , vol.118 , pp. A885-A
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 58
    • 0035915688 scopus 로고    scopus 로고
    • Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea
    • PMID:11213096
    • Kyne L, Warny M, Qamar A, Kelly CP. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet 2001; 357:189-93; PMID:11213096; http://dx.doi.org/10.1016/S0140-6736(00)03592-3
    • (2001) Lancet , vol.357 , pp. 189-193
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 59
    • 74249096590 scopus 로고    scopus 로고
    • Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)
    • PMID:19941990
    • Leav BA, Blair B, Leney M, Knauber M, Reilly C, Lowy I, Gerding DN, Kelly CP, Katchar K, Baxter R, et al. Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI). Vaccine 2010; 28:965-9; PMID:19941990; http://dx.doi.org/10.1016/j.vaccine.2009.10.144
    • (2010) Vaccine , vol.28 , pp. 965-969
    • Leav, B.A.1    Blair, B.2    Leney, M.3    Knauber, M.4    Reilly, C.5    Lowy, I.6    Gerding, D.N.7    Kelly, C.P.8    Katchar, K.9    Baxter, R.10
  • 60
    • 0034628426 scopus 로고    scopus 로고
    • Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A
    • PMID:10666429
    • Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. New Engl J Med 2000; 342:390-7; PMID:10666429; http://dx.doi.org/10.1056/NEJM200002103420604
    • (2000) New Engl J Med , vol.342 , pp. 390-397
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 62
    • 33845580482 scopus 로고    scopus 로고
    • Toxin A-negative, toxin B-positive Clostridium difficile
    • PMID:16857405
    • Drudy D, Fanning S, Kyne L. Toxin A-negative, toxin B-positive Clostridium difficile. Int J Infect Dis: IJID: Off Pub Int Soc Infect Dis 2007; 11:5-10; PMID:16857405; http://dx.doi.org/10.1016/j.ijid. 2006.04.003
    • (2007) Int J Infect Dis: IJID: Off Pub Int Soc Infect Dis , vol.11 , pp. 5-10
    • Drudy, D.1    Fanning, S.2    Kyne, L.3
  • 63
    • 0035909092 scopus 로고    scopus 로고
    • Fatal pseudomembranous colitis associated with a variant clostridium difficile strain not detected by toxin A immunoassay
    • PMID:11560456
    • Johnson S, Kent SA, O'Leary KJ, Merrigan MM, Sambol SP, Peterson LR, Gerding DN. Fatal pseudomembranous colitis associated with a variant clostridium difficile strain not detected by toxin A immunoassay. Ann Intern Med 2001; 135:434-8; PMID:11560456; http://dx.doi.org/10.7326/0003-4819-135-6-200109180-00012
    • (2001) Ann Intern Med , vol.135 , pp. 434-438
    • Johnson, S.1    Kent, S.A.2    O'Leary, K.J.3    Merrigan, M.M.4    Sambol, S.P.5    Peterson, L.R.6    Gerding, D.N.7
  • 64
    • 84860573425 scopus 로고    scopus 로고
    • Immunization strategies for Clostridium difficile infections
    • PMID:22551032
    • Rebeaud F, Bachmann MF. Immunization strategies for Clostridium difficile infections. Expert Rev Vaccines 2012; 11:469-79; PMID:22551032; http://dx. doi.org/10.1586/erv.12.18
    • (2012) Expert Rev Vaccines , vol.11 , pp. 469-479
    • Rebeaud, F.1    Bachmann, M.F.2
  • 66
    • 0025804091 scopus 로고
    • Passive immunization of hamsters against disease caused by Clostridium difficile by use of bovine immunoglobulin G concentrate
    • PMID:2037383
    • Lyerly DM, Bostwick EF, Binion SB, Wilkins TD. Passive immunization of hamsters against disease caused by Clostridium difficile by use of bovine immunoglobulin G concentrate. Infect Immun 1991; 59:2215-8; PMID:2037383
    • (1991) Infect Immun , vol.59 , pp. 2215-2218
    • Lyerly, D.M.1    Bostwick, E.F.2    Binion, S.B.3    Wilkins, T.D.4
  • 67
    • 0031948840 scopus 로고    scopus 로고
    • Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. Difficile-associated disease in a hamster model of infection
    • PMID:9573084
    • Kink JA, Williams JA. Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. difficile-associated disease in a hamster model of infection. Infect Immun 1998; 66:2018-25; PMID:9573084
    • (1998) Infect Immun , vol.66 , pp. 2018-2025
    • Kink, J.A.1    Williams, J.A.2
  • 68
    • 74949110785 scopus 로고    scopus 로고
    • Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: An observational study and review of the literature
    • PMID:20063275
    • Abougergi MS, Broor A, Cui W, Jaar BG. Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: an observational study and review of the literature. J Hosp Med: Off Pub Soc Hosp Med 2010; 5:E1-9; PMID:20063275; http://dx.doi.org/10.1002/jhm.542
    • (2010) J Hosp Med: Off Pub Soc Hosp Med , vol.5 , pp. E1-9
    • Abougergi, M.S.1    Broor, A.2    Cui, W.3    Jaar, B.G.4
  • 70
    • 34547097261 scopus 로고    scopus 로고
    • Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis
    • PMID:17608247
    • Hassoun A, Ibrahim F. Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis. Am J Geriat Pharmacother 2007; 5:48-51; PMID:17608247; http://dx.doi.org/10.1016/j. amjopharm.2007.03.001
    • (2007) Am J Geriat Pharmacother , vol.5 , pp. 48-51
    • Hassoun, A.1    Ibrahim, F.2
  • 71
    • 2442705389 scopus 로고    scopus 로고
    • Descriptive study of intravenous immunoglobulin for the treatment of recurrent Clostridium difficile diarrhoea
    • PMID:15073160
    • Wilcox MH. Descriptive study of intravenous immunoglobulin for the treatment of recurrent Clostridium difficile diarrhoea. J Antimicrob Chemoth 2004; 53:882-4; PMID:15073160; http://dx.doi.org/10.1093/jac/dkh176
    • (2004) J Antimicrob Chemoth , vol.53 , pp. 882-884
    • Wilcox, M.H.1
  • 72
    • 0027472397 scopus 로고
    • Oral immunoglobulin A supplement in treatment of Clostridium difficile enteritis
    • PMID:8095616
    • Tjellstrom B, Stenhammar L, Eriksson S, Magnusson KE. Oral immunoglobulin A supplement in treatment of Clostridium difficile enteritis. Lancet 1993; 341:701-2; PMID:8095616; http://dx.doi.org/10.1016/0140-6736(93)90477-X
    • (1993) Lancet , vol.341 , pp. 701-702
    • Tjellstrom, B.1    Stenhammar, L.2    Eriksson, S.3    Magnusson, K.E.4
  • 74
    • 15544372508 scopus 로고    scopus 로고
    • Bovine antibody-enriched whey to aid in the prevention of a relapse of Clostridium difficile-associated diarrhoea: Preclinical and preliminary clinical data
    • PMID:15673517
    • van Dissel JT, de Groot N, Hensgens CM, Numan S, Kuijper EJ, Veldkamp P, van 't Wout J. Bovine antibody-enriched whey to aid in the prevention of a relapse of Clostridium difficile-associated diarrhoea: preclinical and preliminary clinical data. J Med Microbiol 2005; 54:197-205; PMID:15673517; http://dx.doi.org/10.1099/jmm.0.45773-0
    • (2005) J Med Microbiol , vol.54 , pp. 197-205
    • Van Dissel, J.T.1    De Groot, N.2    Hensgens, C.M.3    Numan, S.4    Kuijper, E.J.5    Veldkamp, P.6    Van 'T Wout, J.7
  • 75
    • 34249813402 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhoea: Bovine anti-Clostridium difficile whey protein to help aid the prevention of relapses
    • PMID:17519495
    • Numan SC, Veldkamp P, Kuijper EJ, van den Berg RJ, van Dissel JT. Clostridium difficile-associated diarrhoea: bovine anti-Clostridium difficile whey protein to help aid the prevention of relapses. Gut 2007; 56:888-9; PMID:17519495; http://dx.doi.org/10.1136/gut.2006.119016
    • (2007) Gut , vol.56 , pp. 888-889
    • Numan, S.C.1    Veldkamp, P.2    Kuijper, E.J.3    Van Den Berg, R.J.4    Van Dissel, J.T.5
  • 76
    • 0022460391 scopus 로고
    • Characterization of toxins A and B of Clostridium difficile with monoclonal antibodies
    • PMID:2428753
    • Lyerly DM, Phelps CJ, Toth J, Wilkins TD. Characterization of toxins A and B of Clostridium difficile with monoclonal antibodies. Infect Immun 1986; 54:70-6; PMID:2428753
    • (1986) Infect Immun , vol.54 , pp. 70-76
    • Lyerly, D.M.1    Phelps, C.J.2    Toth, J.3    Wilkins, T.D.4
  • 77
    • 0026089562 scopus 로고
    • Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A
    • PMID:1900059
    • Corthier G, Muller MC, Wilkins TD, Lyerly D, L'Haridon R. Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A. Infect Immun 1991; 59:1192-5; PMID:1900059
    • (1991) Infect Immun , vol.59 , pp. 1192-1195
    • Corthier, G.1    Muller, M.C.2    Wilkins, T.D.3    Lyerly, D.4    L'Haridon, R.5
  • 80
    • 77951230980 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies against Clostridium difficile toxins
    • author reply -6; PMID:20397290
    • Dawson AE, Shumak SL, Redelmeier DA. Treatment with monoclonal antibodies against Clostridium difficile toxins. New Engl J Med 2010; 362:1445; author reply -6; PMID:20397290
    • (2010) New Engl J Med , vol.362 , pp. 1445
    • Dawson, A.E.1    Shumak, S.L.2    Redelmeier, D.A.3
  • 81
    • 79952062024 scopus 로고    scopus 로고
    • Toxin-specific antibodies for the treatment of Clostridium difficile: Current status and future perspectives
    • PMID:22069622
    • Hussack G, Tanha J. Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives. Toxins 2010; 2:998-1018; PMID:22069622; http://dx.doi.org/10.3390/toxins2050998
    • (2010) Toxins , vol.2 , pp. 998-1018
    • Hussack, G.1    Tanha, J.2
  • 82
    • 84861975931 scopus 로고    scopus 로고
    • Clostridium difficile: Development of a novel candidate vaccine
    • PMID:22682287
    • Foglia G, Shah S, Luxemburger C, Pietrobon PJ. Clostridium difficile: development of a novel candidate vaccine. Vaccine 2012; 30:4307-9; PMID:22682287; http://dx.doi.org/10.1016/j. vaccine.2012.01.056
    • (2012) Vaccine , vol.30 , pp. 4307-4309
    • Foglia, G.1    Shah, S.2    Luxemburger, C.3    Pietrobon, P.J.4
  • 83
    • 55749090214 scopus 로고    scopus 로고
    • Preformulation studies of Clostridium difficile toxoids A and B
    • PMID:18228584
    • Salnikova MS, Joshi SB, Rytting JH, Warny M, Middaugh CR. Preformulation studies of Clostridium difficile toxoids A and B. J Pharm Sci 2008; 97:4194-207; PMID:18228584; http://dx.doi.org/10.1002/jps.21300
    • (2008) J Pharm Sci , vol.97 , pp. 4194-4207
    • Salnikova, M.S.1    Joshi, S.B.2    Rytting, J.H.3    Warny, M.4    Middaugh, C.R.5
  • 86
    • 0035145510 scopus 로고    scopus 로고
    • Safety and immunogenicity of increasing doses of a Clostridium difficile toxoid vaccine administered to healthy adults
    • PMID:11159994
    • Kotloff KL, Wasserman SS, Losonsky GA, Thomas W, Jr., Nichols R, Edelman R, Bridwell M, Monath TP. Safety and immunogenicity of increasing doses of a Clostridium difficile toxoid vaccine administered to healthy adults. Infect Immun 2001; 69:988-95; PMID:11159994; http://dx.doi.org/10.1128/IAI.69. 2.988-995.2001
    • (2001) Infect Immun , vol.69 , pp. 988-995
    • Kotloff, K.L.1    Wasserman, S.S.2    Losonsky, G.A.3    Thomas, W.4    Nichols, R.5    Edelman, R.6    Bridwell, M.7    Monath, T.P.8
  • 88
    • 0032900382 scopus 로고    scopus 로고
    • Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A
    • PMID:10225867
    • Ward SJ, Douce G, Figueiredo D, Dougan G, Wren BW. Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A. Infect Immun 1999; 67:2145-52; PMID:10225867
    • (1999) Infect Immun , vol.67 , pp. 2145-2152
    • Ward, S.J.1    Douce, G.2    Figueiredo, D.3    Dougan, G.4    Wren, B.W.5
  • 89
    • 84861661669 scopus 로고    scopus 로고
    • A novel fusion protein containing the receptor binding domains of C. Difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models
    • PMID:22537987
    • Tian JH, Fuhrmann SR, Kluepfel-Stahl S, Carman RJ, Ellingsworth L, Flyer DC. A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models. Vaccine 2012; 30:4249-58; PMID:22537987; http://dx.doi.org/10.1016/j. vaccine.2012.04.045
    • (2012) Vaccine , vol.30 , pp. 4249-4258
    • Tian, J.H.1    Fuhrmann, S.R.2    Kluepfel-Stahl, S.3    Carman, R.J.4    Ellingsworth, L.5    Flyer, D.C.6
  • 90
    • 84927797566 scopus 로고    scopus 로고
    • Use of Bacillus subtilis PXN21 spores for suppression of Clostridium difficile infection symptoms in a murine model
    • PMID:24828432
    • Colenutt C, Cutting SM. Use of Bacillus subtilis PXN21 spores for suppression of Clostridium difficile infection symptoms in a murine model. FEMS Microbiol Lett 2014; PMID:24828432
    • (2014) FEMS Microbiol Lett
    • Colenutt, C.1    Cutting, S.M.2
  • 91
    • 84878258719 scopus 로고    scopus 로고
    • Clostridial binary toxins: Iota and C2 family portraits
    • PMID:22919577
    • Stiles BG, Wigelsworth DJ, Popoff MR, Barth H. Clostridial binary toxins: iota and C2 family portraits. Front Cell Infect Microbiol 2011; 1:11; PMID:22919577; http://dx.doi.org/10.3389/fcimb. 2011.00011
    • (2011) Front Cell Infect Microbiol , vol.1 , pp. 11
    • Stiles, B.G.1    Wigelsworth, D.J.2    Popoff, M.R.3    Barth, H.4
  • 92
    • 84871951172 scopus 로고    scopus 로고
    • Predicting recurrence of C. Difficile colitis using bacterial virulence factors: Binary toxin is the key
    • discussion p 24-5; PMID:23086451
    • Stewart DB, Berg A, Hegarty J. Predicting recurrence of C. difficile colitis using bacterial virulence factors: binary toxin is the key. J Gastr Surg: Off J Soc Surg Aliment Tract 2013; 17:118-24; discussion p 24-5; PMID:23086451; http://dx.doi.org/10.1007/s11605-012-2056-6
    • (2013) J Gastr Surg: Off J Soc Surg Aliment Tract , vol.17 , pp. 118-124
    • Stewart, D.B.1    Berg, A.2    Hegarty, J.3
  • 93
    • 0024545882 scopus 로고
    • Nosocomial acquisition of Clostridium difficile infection
    • PMID:2911306
    • McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. New Engl J Med 1989; 320:204-10; PMID:2911306; http://dx.doi.org/10.1056/NEJM198901263200402
    • (1989) New Engl J Med , vol.320 , pp. 204-210
    • McFarland, L.V.1    Mulligan, M.E.2    Kwok, R.Y.3    Stamm, W.E.4
  • 94
    • 34848846245 scopus 로고    scopus 로고
    • Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents
    • PMID:17879913
    • Riggs MM, Sethi AK, Zabarsky TF, Eckstein EC, Jump RL, Donskey CJ. Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis: Off Pub Infect Dis Soc Am 2007; 45:992-8; PMID:17879913; http://dx.doi.org/10.1086/521854
    • (2007) Clin Infect Dis: Off Pub Infect Dis Soc Am , vol.45 , pp. 992-998
    • Riggs, M.M.1    Sethi, A.K.2    Zabarsky, T.F.3    Eckstein, E.C.4    Jump, R.L.5    Donskey, C.J.6
  • 95
    • 0023503051 scopus 로고
    • Immunization of adult hamsters against Clostridium difficile-associated ileocecitis and transfer of protection to infant hamsters
    • PMID:3679541
    • Kim PH, Iaconis JP, Rolfe RD. Immunization of adult hamsters against Clostridium difficile-associated ileocecitis and transfer of protection to infant hamsters. Infect Immun 1987; 55:2984-92; PMID:3679541
    • (1987) Infect Immun , vol.55 , pp. 2984-2992
    • Kim, P.H.1    Iaconis, J.P.2    Rolfe, R.D.3
  • 96
    • 34548124567 scopus 로고    scopus 로고
    • The ClosTron: A universal gene knockout system for the genus Clostridium
    • PMID:17658189
    • Heap JT, Pennington OJ, Cartman ST, Carter GP, Minton NP. The ClosTron: a universal gene knockout system for the genus Clostridium. J Microbiol Methods 2007; 70:452-64; PMID:17658189; http://dx.doi.org/10.1016/j.mimet.2007.05.021
    • (2007) J Microbiol Methods , vol.70 , pp. 452-464
    • Heap, J.T.1    Pennington, O.J.2    Cartman, S.T.3    Carter, G.P.4    Minton, N.P.5
  • 97
    • 20644450358 scopus 로고    scopus 로고
    • Proteomic analysis of cell surface proteins from Clostridium difficile
    • PMID:15887182
    • Wright A, Wait R, Begum S, Crossett B, Nagy J, Brown K, Fairweather N. Proteomic analysis of cell surface proteins from Clostridium difficile. Proteomics 2005; 5:2443-52; PMID:15887182; http://dx. doi.org/10.1002/pmic.200401179
    • (2005) Proteomics , vol.5 , pp. 2443-2452
    • Wright, A.1    Wait, R.2    Begum, S.3    Crossett, B.4    Nagy, J.5    Brown, K.6    Fairweather, N.7
  • 98
    • 60649099858 scopus 로고    scopus 로고
    • Structural insights into the molecular organization of the S-layer from Clostridium difficile
    • PMID:19183279
    • Fagan RP, Albesa-Jove D, Qazi O, Svergun DI, Brown KA, Fairweather NF. Structural insights into the molecular organization of the S-layer from Clostridium difficile. Mol Microbiol 2009; 71:1308-22; PMID:19183279; http://dx.doi.org/10.1111/j.1365-2958.2009.06603.x
    • (2009) Mol Microbiol , vol.71 , pp. 1308-1322
    • Fagan, R.P.1    Albesa-Jove, D.2    Qazi, O.3    Svergun, D.I.4    Brown, K.A.5    Fairweather, N.F.6
  • 99
    • 39049167109 scopus 로고    scopus 로고
    • Active immunization of hamsters against Clostridium difficile infection using surface-layer protein
    • PMID:18093141
    • Ni Eidhin DB, O'Brien JB, McCabe MS, Athie-Morales V, Kelleher DP. Active immunization of hamsters against Clostridium difficile infection using surface-layer protein. FEMS Immunol Med Microbiol 2008; 52:207-18; PMID:18093141; http://dx.doi.org/10.1111/j.1574-695X.2007.00363.x
    • (2008) FEMS Immunol Med Microbiol , vol.52 , pp. 207-218
    • Ni Eidhin, D.B.1    O'Brien, J.B.2    McCabe, M.S.3    Athie-Morales, V.4    Kelleher, D.P.5
  • 100
    • 0035098129 scopus 로고    scopus 로고
    • Molecular characterization of fliD gene encoding flagellar cap and its expression among Clostridium difficile isolates from different serogroups
    • PMID:11230454
    • Tasteyre A, Karjalainen T, Avesani V, Delmee M, Collignon A, Bourlioux P, Barc MC. Molecular characterization of fliD gene encoding flagellar cap and its expression among Clostridium difficile isolates from different serogroups. J Clin Microbiol 2001; 39:1178-83; PMID:11230454; http://dx.doi.org/10.1128/JCM.39.3.1178-1183.2001
    • (2001) J Clin Microbiol , vol.39 , pp. 1178-1183
    • Tasteyre, A.1    Karjalainen, T.2    Avesani, V.3    Delmee, M.4    Collignon, A.5    Bourlioux, P.6    Barc, M.C.7
  • 101
    • 0033831622 scopus 로고    scopus 로고
    • Phenotypic and genotypic diversity of the flagellin gene (fliC) among Clostridium difficile isolates from different serogroups
    • PMID:10970353
    • Tasteyre A, Karjalainen T, Avesani V, Delmee M, Collignon A, Bourlioux P, Barc MC. Phenotypic and genotypic diversity of the flagellin gene (fliC) among Clostridium difficile isolates from different serogroups. J Clin Microbiol 2000; 38:3179-86; PMID:10970353
    • (2000) J Clin Microbiol , vol.38 , pp. 3179-3186
    • Tasteyre, A.1    Karjalainen, T.2    Avesani, V.3    Delmee, M.4    Collignon, A.5    Bourlioux, P.6    Barc, M.C.7
  • 103
    • 34247178951 scopus 로고    scopus 로고
    • Diminished intestinal colonization by Clostridium difficile and immune response in mice after mucosal immunization with surface proteins of Clostridium difficile
    • PMID:17433506
    • Pechine S, Janoir C, Boureau H, Gleizes A, Tsapis N, Hoys S, Fattal E, Collignon A. Diminished intestinal colonization by Clostridium difficile and immune response in mice after mucosal immunization with surface proteins of Clostridium difficile. Vaccine 2007; 25:3946-54; PMID:17433506; http://dx.doi.org/10.1016/j.vaccine.2007.02.055
    • (2007) Vaccine , vol.25 , pp. 3946-3954
    • Pechine, S.1    Janoir, C.2    Boureau, H.3    Gleizes, A.4    Tsapis, N.5    Hoys, S.6    Fattal, E.7    Collignon, A.8
  • 104
    • 39649116922 scopus 로고    scopus 로고
    • Clostridium difficile cell-surface polysaccharides composed of pentaglycosyl and hexaglycosyl phosphate repeating units
    • PMID:18237724
    • Ganeshapillai J, Vinogradov E, Rousseau J, Weese JS, Monteiro MA. Clostridium difficile cell-surface polysaccharides composed of pentaglycosyl and hexaglycosyl phosphate repeating units. Carbohyd Res 2008; 343:703-10; PMID:18237724; http://dx.doi.org/10.1016/j.carres.2008.01.002
    • (2008) Carbohyd Res , vol.343 , pp. 703-710
    • Ganeshapillai, J.1    Vinogradov, E.2    Rousseau, J.3    Weese, J.S.4    Monteiro, M.A.5
  • 105
    • 79957532830 scopus 로고    scopus 로고
    • A possible oligosaccharideconjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic
    • PMID:21609839
    • Oberli MA, Hecht ML, Bindschadler P, Adibekian A, Adam T, Seeberger PH. A possible oligosaccharideconjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic. Chem Biol 2011; 18:580-8; PMID:21609839; http://dx.doi.org/10.1016/j.chembiol.2011.03.009
    • (2011) Chem Biol , vol.18 , pp. 580-588
    • Oberli, M.A.1    Hecht, M.L.2    Bindschadler, P.3    Adibekian, A.4    Adam, T.5    Seeberger, P.H.6
  • 107
    • 0016389899 scopus 로고
    • Diagnostic features of clindamycin-associated pseudomembranous colitis
    • PMID:4855527
    • Tedesco FJ, Stanley RJ, Alpers DH. Diagnostic features of clindamycin-associated pseudomembranous colitis. New Engl J Med 1974; 290:841-3; PMID:4855527; http://dx.doi.org/10.1056/NEJM197404112901508
    • (1974) New Engl J Med , vol.290 , pp. 841-843
    • Tedesco, F.J.1    Stanley, R.J.2    Alpers, D.H.3
  • 108
    • 0017801430 scopus 로고
    • Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia
    • PMID:625309
    • Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. New Engl J Med 1978; 298:531-4; PMID:625309; http://dx.doi.org/10.1056/NEJM197803092981003
    • (1978) New Engl J Med , vol.298 , pp. 531-534
    • Bartlett, J.G.1    Chang, T.W.2    Gurwith, M.3    Gorbach, S.L.4    Onderdonk, A.B.5
  • 109
    • 84857793535 scopus 로고    scopus 로고
    • Phase I dose finding studies of an adjuvanted Clostridium difficile toxoid vaccine
    • PMID:22306375
    • Greenberg RN, Marbury TC, Foglia G, Warny M. Phase I dose finding studies of an adjuvanted Clostridium difficile toxoid vaccine. Vaccine 2012; 30:2245-9; PMID:22306375; http://dx.doi.org/10.1016/j. vaccine.2012.01.065
    • (2012) Vaccine , vol.30 , pp. 2245-2249
    • Greenberg, R.N.1    Marbury, T.C.2    Foglia, G.3    Warny, M.4
  • 110
    • 26944469989 scopus 로고    scopus 로고
    • Variability of Clostridium difficile surface proteins and specific serum antibody response in patients with Clostridium difficile-associated disease
    • PMID:16207956
    • Pechine S, Janoir C, Collignon A. Variability of Clostridium difficile surface proteins and specific serum antibody response in patients with Clostridium difficile-associated disease. J Clin Microbiol 2005; 43:5018-25; PMID:16207956; http://dx.doi.org/10.1128/JCM.43.10.5018-5025.2005
    • (2005) J Clin Microbiol , vol.43 , pp. 5018-5025
    • Pechine, S.1    Janoir, C.2    Collignon, A.3


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